PubMed

Ten-year change in plasma amyloid beta levels and late-life cognitive decline.

Okereke OI, Xia W, Selkoe DJ, Grodstein F.

Arch Neurol. 2009 Oct;66(10):1247-53.PMID: 19822780 [PubMed - indexed for MEDLINE]Related articles

HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.

Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A.

J Immunol. 2009 Sep 1;183(5):3522-30. Epub 2009 Aug 12.PMID: 19675171 [PubMed - indexed for MEDLINE]Related articles

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.

Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM.

Neurobiol Dis. 2009 Nov;36(2):293-302. Epub 2009 Aug 4.PMID: 19660551 [PubMed - in process]Related articles

Amyloid deposition is associated with impaired default network function in older persons without dementia.

Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA.

Neuron. 2009 Jul 30;63(2):178-88.PMID: 19640477 [PubMed - indexed for MEDLINE]Related articles

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.

Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ.

J Neurochem. 2009 Oct;111(1):15-25. Epub 2009 Jul 17.PMID: 19627450 [PubMed - indexed for MEDLINE]Related articles

gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.

Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM.

Brain Res. 2009 Mar 25;1262:89-99. Epub 2009 Jan 18.PMID: 19401174 [PubMed - indexed for MEDLINE]Related articles

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.

Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA.

PLoS One. 2009;4(4):e5274. Epub 2009 Apr 22.PMID: 19384407 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward structural elucidation of the gamma-secretase complex.

Li H, Wolfe MS, Selkoe DJ.

Structure. 2009 Mar 11;17(3):326-34. Review.PMID: 19278647 [PubMed - indexed for MEDLINE]Related articles

Performance characteristics of plasma amyloid-beta 40 and 42 assays.

Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F.

J Alzheimers Dis. 2009 Feb;16(2):277-85.PMID: 19221417 [PubMed - indexed for MEDLINE]Related articles

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.

Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ.

Arch Neurol. 2009 Feb;66(2):190-9.PMID: 19204155 [PubMed - indexed for MEDLINE]Related articles

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.

Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ.

Biochemistry. 2009 Mar 10;48(9):2045-52.PMID: 19152501 [PubMed - indexed for MEDLINE]Related articles

Evidence that alpha-synuclein does not inhibit phospholipase D.

Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ.

Biochemistry. 2009 Feb 10;48(5):1077-83.PMID: 19146388 [PubMed - indexed for MEDLINE]Related articles

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.

Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H.

J Mol Biol. 2009 Jan 16;385(2):642-52. Epub 2008 Nov 5.PMID: 19013469 [PubMed - indexed for MEDLINE]Related articles

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling.

Ben Gedalya T, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R.

Traffic. 2009 Feb;10(2):218-34. Epub 2008 Oct 31.PMID: 18980610 [PubMed - indexed for MEDLINE]Related articles

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ.

PLoS Biol. 2008 Oct 21;6(10):e257.PMID: 18942891 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemistry and Molecular Biology of Amyloid beta-Protein and the Mechanism of Alzheimer's Disease.

Selkoe DJ.

Handb Clin Neurol. 2008;89:245-60. No abstract available. PMID: 18631749 [PubMed - in process]Related articles

Molecular basis for the thiol sensitivity of insulin-degrading enzyme.

Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9582-7. Epub 2008 Jul 8.PMID: 18621727 [PubMed - indexed for MEDLINE]Related articlesFree article

A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation.

Okereke OI, Selkoe DJ, Pollak MN, Stampfer MJ, Hu FB, Hankinson SE, Grodstein F.

Int J Geriatr Psychiatry. 2009 Feb;24(2):177-82.PMID: 18612998 [PubMed - indexed for MEDLINE]Related articles

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM.

Neurobiol Dis. 2008 Sep;31(3):442-50. Epub 2008 Jun 17.PMID: 18602473 [PubMed - indexed for MEDLINE]Related articles

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ.

Neural Dev. 2008 Jun 23;3:15.PMID: 18573216 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ.

Nat Med. 2008 Aug;14(8):837-42. Epub 2008 Jun 22.PMID: 18568035 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct and potent regulation of gamma-secretase by its lipid microenvironment.

Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ.

J Biol Chem. 2008 Aug 15;283(33):22529-40. Epub 2008 Jun 6.PMID: 18539594 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ.

J Neurosci. 2008 Apr 16;28(16):4231-7.PMID: 18417702 [PubMed - indexed for MEDLINE]Related articlesFree article

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.

Selkoe DJ.

Behav Brain Res. 2008 Sep 1;192(1):106-13. Epub 2008 Feb 17. Review.PMID: 18359102 [PubMed - indexed for MEDLINE]Related articlesFree article

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model.

Nazer B, Hong S, Selkoe DJ.

Neurobiol Dis. 2008 Apr;30(1):94-102. Epub 2008 Jan 5.PMID: 18289866 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes.

Okereke OI, Pollak MN, Hu FB, Hankinson SE, Selkoe DJ, Grodstein F.

Psychoneuroendocrinology. 2008 May;33(4):455-61. Epub 2008 Feb 7.PMID: 18261857 [PubMed - indexed for MEDLINE]Related articlesFree article

Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease.

Selkoe DJ.

Nutr Rev. 2007 Dec;65(12 Pt 2):S239-43. Review.PMID: 18240556 [PubMed - indexed for MEDLINE]Related articles

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.

Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ.

J Neurosci. 2007 Dec 26;27(52):14459-69.PMID: 18160654 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.

Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R.

Am J Pathol. 2007 Dec;171(6):2000-11. Epub 2007 Nov 30. Erratum in: Am J Pathol. 2008 Apr;172(4):1153. PMID: 18055555 [PubMed - indexed for MEDLINE]Related articlesFree article

Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ.

Hum Mol Genet. 2008 Feb 15;17(4):602-16. Epub 2007 Nov 14.PMID: 18003639 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.

Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC.

J Neurochem. 2008 Jan;104(1):210-20. Epub 2007 Nov 6.PMID: 17986218 [PubMed - indexed for MEDLINE]Related articles

Presenilin: running with scissors in the membrane.

Selkoe DJ, Wolfe MS.

Cell. 2007 Oct 19;131(2):215-21. Review.PMID: 17956719 [PubMed - indexed for MEDLINE]Related articles

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

Townsend M, Mehta T, Selkoe DJ.

J Biol Chem. 2007 Nov 16;282(46):33305-12. Epub 2007 Sep 13.PMID: 17855343 [PubMed - indexed for MEDLINE]Related articlesFree article

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ.

PLoS Med. 2007 Aug;4(8):e262.PMID: 17760499 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.

Am J Pathol. 2007 Jul;171(1):241-51.PMID: 17591969 [PubMed - indexed for MEDLINE]Related articlesFree article

The APP family of proteins: similarities and differences.

Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ.

Biochem Soc Trans. 2007 Apr;35(Pt 2):416-20.PMID: 17371289 [PubMed - indexed for MEDLINE]Related articles

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.

Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL.

J Neurosci. 2007 Mar 14;27(11):2866-75.PMID: 17360908 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease.

Hemming ML, Selkoe DJ, Farris W.

Neurobiol Dis. 2007 Apr;26(1):273-81. Epub 2007 Jan 25.PMID: 17321748 [PubMed - indexed for MEDLINE]Related articlesFree article

Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554.

Chen AC, Selkoe DJ.

Neuron. 2007 Feb 15;53(4):479-83. No abstract available. PMID: 17296549 [PubMed - indexed for MEDLINE]Related articles

A beta oligomers - a decade of discovery.

Walsh DM, Selkoe DJ.

J Neurochem. 2007 Jun;101(5):1172-84. Epub 2007 Feb 5. Review.PMID: 17286590 [PubMed - indexed for MEDLINE]Related articles

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass C, Selkoe DJ.

Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12. Review.PMID: 17245412 [PubMed - indexed for MEDLINE]Related articles

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.

Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE.

J Biol Chem. 2007 Mar 16;282(11):7825-32. Epub 2007 Jan 22.PMID: 17244626 [PubMed - indexed for MEDLINE]Related articlesFree article

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ.

Ann Neurol. 2006 Dec;60(6):668-76.PMID: 17192927 [PubMed - indexed for MEDLINE]Related articles

Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.

Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M.

Int J Geriatr Psychiatry. 2007 Jun;22(6):536-42.PMID: 17096467 [PubMed - indexed for MEDLINE]Related articles

Structural biology: enzyme target to latch on to.

Leissring MA, Selkoe DJ.

Nature. 2006 Oct 19;443(7113):761-2. No abstract available. PMID: 17051198 [PubMed - indexed for MEDLINE]Related articles

Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA.

J Neurosci. 2006 Oct 4;26(40):10222-31.PMID: 17021177 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise.

Selkoe DJ.

J Alzheimers Dis. 2006;9(3 Suppl):163-8.PMID: 16914855 [PubMed - indexed for MEDLINE]Related articles

The ups and downs of Abeta.

Selkoe DJ.

Nat Med. 2006 Jul;12(7):758-9; discussion 759. No abstract available. PMID: 16829932 [PubMed - indexed for MEDLINE]Related articles

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.

Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6889-94. Epub 2006 Apr 24.PMID: 16636269 [PubMed - indexed for MEDLINE]Related articlesFree article

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.

Traffic. 2006 Mar;7(3):354-64.PMID: 16497228 [PubMed - indexed for MEDLINE]Related articles