PubMed

Measures of response in clinical trials of systemic sclerosis: the combined response index for systemic sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension related to Systemic Sclerosis (EPOSS).

Khanna D, Distler O, Avouac J, Behrens F, Clements PJ, Denton C, Foeldvari I, Giannini E, Huscher D, Kowal-Bielecka O, Lovell D, Matucci-Cerinic M, Mayes M, Merkel PA, Nash P, Opitz CF, Pittrow D, Rubin L, Seibold JR, Steen V, Strand CV, Tugwell PS, Varga J, Zink A, Furst DE; CRISS; EPOSS.

J Rheumatol. 2009 Oct;36(10):2356-61.PMID: 19820225 [PubMed - in process]Related articles

Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis.

Schiopu E, Hsu VM, Impens AJ, Rothman JA, McCloskey DA, Wilson JE, Phillips K, Seibold JR.

J Rheumatol. 2009 Oct;36(10):2264-8. Epub 2009 Sep 15.PMID: 19755613 [PubMed - in process]Related articles

Reliability and validity of the University of California, Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument.

Khanna D, Hays RD, Maranian P, Seibold JR, Impens A, Mayes MD, Clements PJ, Getzug T, Fathi N, Bechtel A, Furst DE.

Arthritis Rheum. 2009 Sep 15;61(9):1257-63.PMID: 19714600 [PubMed - indexed for MEDLINE]Related articles

Sensitivity to change of the modified Rodnan skin score in diffuse systemic sclerosis--assessment of individual body sites in two large randomized controlled trials.

Kaldas M, Khanna PP, Furst DE, Clements PJ, Kee Wong W, Seibold JR, Postlethwaite AE, Khanna D; investigators of the human recombinant relaxin and oral bovine collagen clinical trials.

Rheumatology (Oxford). 2009 Sep;48(9):1143-6. Epub 2009 Jul 14.PMID: 19605370 [PubMed - indexed for MEDLINE]Related articles

The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1.

Rabquer BJ, Hou Y, Del Galdo F, Kenneth Haines G 3rd, Gerber ML, Jimenez SA, Seibold JR, Koch AE.

Rheumatology (Oxford). 2009 Jul;48(7):734-40. Epub 2009 May 13.PMID: 19439502 [PubMed - indexed for MEDLINE]Related articles

Rapidly progressive fatal interstitial lung disease in a patient with systemic sclerosis.

Phillips K, Byrne-Dugan C, Batterson E, Seibold JR.

Nat Rev Rheumatol. 2009 Apr;5(4):225-8.PMID: 19337287 [PubMed - indexed for MEDLINE]Related articles

Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial.

Khanna D, Clements PJ, Furst DE, Korn JH, Ellman M, Rothfield N, Wigley FM, Moreland LW, Silver R, Kim YH, Steen VD, Firestein GS, Kavanaugh AF, Weisman M, Mayes MD, Collier D, Csuka ME, Simms R, Merkel PA, Medsger TA Jr, Sanders ME, Maranian P, Seibold JR; Relaxin Investigators and the Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2009 Apr;60(4):1102-11.PMID: 19333948 [PubMed - indexed for MEDLINE]Related articles

Junctional adhesion molecule-A is abnormally expressed in diffuse cutaneous systemic sclerosis skin and mediates myeloid cell adhesion.

Hou Y, Rabquer BJ, Gerber ML, Del Galdo F, Jimenez SA, Haines GK 3rd, Barr WG, Massa MC, Seibold JR, Koch AE.

Ann Rheum Dis. 2009 Jan 19. [Epub ahead of print]PMID: 19153103 [PubMed - as supplied by publisher]Related articles

The 6-minute walk test in scleroderma--how measuring everything measures nothing.

Impens AJ, Wangkaew S, Seibold JR.

Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v68-9.PMID: 18784152 [PubMed - indexed for MEDLINE]Related articles

Trial design: how must we move ahead?

Seibold JR, Tyndall A, Furst DE.

Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v57-8.PMID: 18784148 [PubMed - indexed for MEDLINE]Related articlesFree article

Digital ulcers and outcomes assessment in scleroderma.

Matucci-Cerinic M, Seibold JR.

Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v46-7. Review.PMID: 18784143 [PubMed - indexed for MEDLINE]Related articles

A path to the future in scleroderma.

Distler O, Matucci-Cerinic M, Müller-Ladner U, Seibold JR.

Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v1. No abstract available. PMID: 18784125 [PubMed - indexed for MEDLINE]Related articles

Defining appropriate outcome measures in pulmonary arterial hypertension related to systemic sclerosis: a Delphi consensus study with cluster analysis.

Distler O, Behrens F, Pittrow D, Huscher D, Denton CP, Foeldvari I, Humbert M, Matucci-Cerinic M, Nash P, Opitz CF, Rubin LJ, Seibold JR, Furst DE; EPOSS-Omeract Group.

Arthritis Rheum. 2008 Jun 15;59(6):867-75. Erratum in: Arthritis Rheum. 2008 Aug 15;59(8):1202. PMID: 18512721 [PubMed - indexed for MEDLINE]Related articlesFree article

Scleroderma lung disease: "if you don't know where you are going, any road will take you there".

Strange C, Seibold JR.

Am J Respir Crit Care Med. 2008 Jun 1;177(11):1178-9. No abstract available. PMID: 18487619 [PubMed - indexed for MEDLINE]Related articlesFree article

Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial.

Merkel PA, Silliman NP, Denton CP, Furst DE, Khanna D, Emery P, Hsu VM, Streisand JB, Polisson RP, Akesson A, Coppock J, van den Hoogen F, Herrick A, Mayes MD, Veale D, Seibold JR, Black CM, Korn JH; CAT-192 Research Group; Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2008 May 15;59(5):699-705.PMID: 18438905 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right-heart catheterization.

Hsu VM, Moreyra AE, Wilson AC, Shinnar M, Shindler DM, Wilson JE, Desai A, Seibold JR.

J Rheumatol. 2008 Mar;35(3):458-65. Epub 2008 Jan 15.PMID: 18203320 [PubMed - indexed for MEDLINE]Related articles

Development of a provisional core set of response measures for clinical trials of systemic sclerosis.

Khanna D, Lovell DJ, Giannini E, Clements PJ, Merkel PA, Seibold JR, Matucci-Cerinic M, Denton CP, Mayes MD, Steen VD, Varga J, Furst DE; Scleroderma Clinical Trials Consortium co-authors.

Ann Rheum Dis. 2008 May;67(5):703-9. Epub 2007 Sep 24.PMID: 17893248 [PubMed - indexed for MEDLINE]Related articles

Clinical trials in systemic sclerosis: lessons learned and outcomes.

Matucci-Cerinic M, Steen VD, Furst DE, Seibold JR.

Arthritis Res Ther. 2007;9 Suppl 2:S7. Review.PMID: 17767745 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease.

Rubin LJ, Black CM, Denton CP, Seibold JR.

Arthritis Res Ther. 2007;9 Suppl 2:S10. Review.PMID: 17767739 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease.

Tashkin DP, Elashoff R, Clements PJ, Roth MD, Furst DE, Silver RM, Goldin J, Arriola E, Strange C, Bolster MB, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel D, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M, Khanna D, Li N, Li G; Scleroderma Lung Study Research Group.

Am J Respir Crit Care Med. 2007 Nov 15;176(10):1026-34. Epub 2007 Aug 23.PMID: 17717203 [PubMed - indexed for MEDLINE]Related articlesFree article

Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis.

Clements PJ, Roth MD, Elashoff R, Tashkin DP, Goldin J, Silver RM, Sterz M, Seibold JR, Schraufnagel D, Simms RW, Bolster M, Wise RA, Steen V, Mayes MD, Connelly K, Metersky M, Furst DE; Scleroderma Lung Study Group.

Ann Rheum Dis. 2007 Dec;66(12):1641-7. Epub 2007 May 7.PMID: 17485423 [PubMed - indexed for MEDLINE]Related articles

Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease.

Girgis RE, Frost AE, Hill NS, Horn EM, Langleben D, McLaughlin VV, Oudiz RJ, Robbins IM, Seibold JR, Shapiro S, Tapson VF, Barst RJ.

Ann Rheum Dis. 2007 Nov;66(11):1467-72. Epub 2007 May 1.PMID: 17472992 [PubMed - indexed for MEDLINE]Related articles

Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study.

Khanna D, Yan X, Tashkin DP, Furst DE, Elashoff R, Roth MD, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M, Clements PJ; Scleroderma Lung Study Group.

Arthritis Rheum. 2007 May;56(5):1676-84.PMID: 17469162 [PubMed - indexed for MEDLINE]Related articlesFree article

High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study.

Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS, Godwin JD, Gooley TA, Holmberg L, Henstorf G, LeMaistre CF, Mayes MD, McDonagh KT, McLaughlin B, Molitor JA, Nelson JL, Shulman H, Storb R, Viganego F, Wener MH, Seibold JR, Sullivan KM, Furst DE.

Blood. 2007 Aug 15;110(4):1388-96. Epub 2007 Apr 23.PMID: 17452515 [PubMed - indexed for MEDLINE]Related articlesFree article

Are endothelin-receptor antagonists the preferred treatment for PAH associated with scleroderma?

Seibold JR.

Nat Clin Pract Rheumatol. 2007 Apr;3(4):204-5. Epub 2007 Feb 27. No abstract available. PMID: 17325728 [PubMed]Related articles

Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192.

Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, Hsu VM, Silliman N, Streisand J, Powell J, Akesson A, Coppock J, Hoogen F, Herrick A, Mayes MD, Veale D, Haas J, Ledbetter S, Korn JH, Black CM, Seibold JR; Cat-192 Study Group; Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2007 Jan;56(1):323-33.PMID: 17195236 [PubMed - indexed for MEDLINE]Related articlesFree article

Submaximal exercise testing in the assessment of interstitial lung disease secondary to systemic sclerosis: reproducibility and correlations of the 6-min walk test.

Buch MH, Denton CP, Furst DE, Guillevin L, Rubin LJ, Wells AU, Matucci-Cerinic M, Riemekasten G, Emery P, Chadha-Boreham H, Charef P, Roux S, Black CM, Seibold JR.

Ann Rheum Dis. 2007 Feb;66(2):169-73. Epub 2006 Jul 25.PMID: 16868020 [PubMed - indexed for MEDLINE]Related articles

Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patients.

Cole JC, Khanna D, Clements PJ, Seibold JR, Tashkin DP, Paulus HE, Irwin MR, Motivala SJ, Furst DE.

Qual Life Res. 2006 Oct;15(8):1383-94. Epub 2006 Jul 7.PMID: 16826439 [PubMed - indexed for MEDLINE]Related articles

Cyclophosphamide versus placebo in scleroderma lung disease.

Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE, Arriola E, Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J, Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M; Scleroderma Lung Study Research Group.

N Engl J Med. 2006 Jun 22;354(25):2655-66.PMID: 16790698 [PubMed - indexed for MEDLINE]Related articlesFree article

Minimally important difference in diffuse systemic sclerosis: results from the D-penicillamine study.

Khanna D, Furst DE, Hays RD, Park GS, Wong WK, Seibold JR, Mayes MD, White B, Wigley FF, Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen VD, Martin RW, Collier D, Weinstein A, Lally EV, Varga J, Weiner SR, Andrews B, Abeles M, Clements PJ.

Ann Rheum Dis. 2006 Oct;65(10):1325-9. Epub 2006 Mar 15.PMID: 16540546 [PubMed - indexed for MEDLINE]Related articlesFree article

Bosentan in pulmonary arterial hypertension secondary to scleroderma.

Joglekar A, Tsai FS, McCloskey DA, Wilson JE, Seibold JR, Riley DJ.

J Rheumatol. 2006 Jan;33(1):61-8.PMID: 16395751 [PubMed - indexed for MEDLINE]Related articles

Responsiveness of the SF-36 and the Health Assessment Questionnaire Disability Index in a systemic sclerosis clinical trial.

Khanna D, Furst DE, Clements PJ, Park GS, Hays RD, Yoon J, Korn JH, Merkel PA, Rothfield N, Wigley FM, Moreland LW, Silver R, Steen VD, Weisman M, Mayes MD, Collier DH, Medsger TA Jr, Seibold JR; Relaxin Study Group; Scleroderma Clinical Trials Consortium.

J Rheumatol. 2005 May;32(5):832-40.PMID: 15868618 [PubMed - indexed for MEDLINE]Related articles

Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study.

Khanna D, Clements PJ, Furst DE, Chon Y, Elashoff R, Roth MD, Sterz MG, Chung J, FitzGerald JD, Seibold JR, Varga J, Theodore A, Wigley FM, Silver RM, Steen VD, Mayes MD, Connolly MK, Fessler BJ, Rothfield NF, Mubarak K, Molitor J, Tashkin DP; Scleroderma Lung Study Group.

Arthritis Rheum. 2005 Feb;52(2):592-600.PMID: 15692967 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogens and neuropeptides in Raynaud's phenomenon.

Generini S, Seibold JR, Matucci-Cerinic M.

Rheum Dis Clin North Am. 2005 Feb;31(1):177-86, x-xi. Review.PMID: 15639062 [PubMed - indexed for MEDLINE]Related articles

Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.

Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E, Rich E, Carpentier P, Molitor J, Seibold JR, Hsu V, Guillevin L, Chatterjee S, Peter HH, Coppock J, Herrick A, Merkel PA, Simms R, Denton CP, Furst D, Nguyen N, Gaitonde M, Black C.

Arthritis Rheum. 2004 Dec;50(12):3985-93.PMID: 15593188 [PubMed - indexed for MEDLINE]Related articlesFree article

Erectile dysfunction associated with scleroderma: a case-control study of men with scleroderma and rheumatoid arthritis.

Hong P, Pope JE, Ouimet JM, Rullan E, Seibold JR.

J Rheumatol. 2004 Mar;31(3):508-13.PMID: 14994396 [PubMed - indexed for MEDLINE]Related articles

High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial: lessons learned.

Clements PJ, Seibold JR, Furst DE, Mayes M, White B, Wigley F, Weisman MD, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Wong WK.

Semin Arthritis Rheum. 2004 Feb;33(4):249-63.PMID: 14978663 [PubMed - indexed for MEDLINE]Related articles

Assessment of skin, joint, tendon and muscle involvement.

Akesson A, Fiori G, Krieg T, van den Hoogen FH, Seibold JR.

Clin Exp Rheumatol. 2003;21(3 Suppl 29):S5-8. Review.PMID: 12889214 [PubMed - indexed for MEDLINE]Related articles

Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial.

DeMarco PJ, Weisman MH, Seibold JR, Furst DE, Wong WK, Hurwitz EL, Mayes M, White B, Wigley F, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Clements PJ.

Arthritis Rheum. 2002 Nov;46(11):2983-9.PMID: 12428241 [PubMed - indexed for MEDLINE]Related articlesFree article

Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon.

Merkel PA, Herlyn K, Martin RW, Anderson JJ, Mayes MD, Bell P, Korn JH, Simms RW, Csuka ME, Medsger TA Jr, Rothfield NF, Ellman MH, Collier DH, Weinstein A, Furst DE, Jiménez SA, White B, Seibold JR, Wigley FM; Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2002 Sep;46(9):2410-20.PMID: 12355489 [PubMed - indexed for MEDLINE]Related articlesFree article

Relaxins: lessons and limitations.

Seibold JR.

Curr Rheumatol Rep. 2002 Aug;4(4):275-6. No abstract available. PMID: 12126574 [PubMed - indexed for MEDLINE]Related articles

Clinical trials: types, design, and end-points.

Seibold JR.

Curr Opin Rheumatol. 2001 Nov;13(6):512-5. Review.PMID: 11698730 [PubMed - indexed for MEDLINE]Related articles

Effects of the American College of Rheumatology systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial.

Furst DE, Clements PJ, Wong WK, Mayes MD, Wigley F, White B, Weisman M, Barr W, Moreland L, Martin R, Medsger TA Jr, Steen V, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Peter JB, Seibold JR.

Rheumatology (Oxford). 2001 Jun;40(6):615-22.PMID: 11426017 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma.

Pope JE, Bellamy N, Seibold JR, Baron M, Ellman M, Carette S, Smith CD, Chalmers IM, Hong P, O'Hanlon D, Kaminska E, Markland J, Sibley J, Catoggio L, Furst DE.

Arthritis Rheum. 2001 Jun;44(6):1351-8.PMID: 11407694 [PubMed - indexed for MEDLINE]Related articlesFree article

The Disability Index of the Health Assessment Questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial.

Clements PJ, Wong WK, Hurwitz EL, Furst DE, Mayes M, White B, Wigley F, Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen V, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Seibold JR.

Arthritis Rheum. 2001 Mar;44(3):653-61.PMID: 11263780 [PubMed - indexed for MEDLINE]Related articlesFree article

Skin thickness score as a predictor and correlate of outcome in systemic sclerosis: high-dose versus low-dose penicillamine trial.

Clements PJ, Hurwitz EL, Wong WK, Seibold JR, Mayes M, White B, Wigley F, Weisman M, Barr W, Moreland L, Medsger TA Jr, Steen VD, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Furst DE.

Arthritis Rheum. 2000 Nov;43(11):2445-54.PMID: 11083267 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial.

Seibold JR, Korn JH, Simms R, Clements PJ, Moreland LW, Mayes MD, Furst DE, Rothfield N, Steen V, Weisman M, Collier D, Wigley FM, Merkel PA, Csuka ME, Hsu V, Rocco S, Erikson M, Hannigan J, Harkonen WS, Sanders ME.

Ann Intern Med. 2000 Jun 6;132(11):871-9.PMID: 10836913 [PubMed - indexed for MEDLINE]Related articlesFree article

The steady-state disposition of indinavir is not altered by the concomitant administration of clarithromycin.

Boruchoff SE, Sturgill MG, Grasing KW, Seibold JR, McCrea J, Winchell GA, Kusma SE, Deutsch PJ.

Clin Pharmacol Ther. 2000 Apr;67(4):351-9.PMID: 10801243 [PubMed - indexed for MEDLINE]Related articles

Trimethoprim/sulfamethoxazole does not affect the steady-state disposition of indinavir.

Sturgill MG, Seibold JR, Boruchoff SE, Yeh KC, Haddix H, Deutsch P.

J Clin Pharmacol. 1999 Oct;39(10):1077-84.PMID: 10516943 [PubMed - indexed for MEDLINE]Related articles

Successful treatment of methotrexate induced nodulosis with D-penicillamine.

Dash S, Seibold JR, Tiku ML.

J Rheumatol. 1999 Jun;26(6):1396-9.PMID: 10381063 [PubMed - indexed for MEDLINE]Related articles