PubMed

Hyperkalaemia.

Nyirenda MJ, Tang JI, Padfield PL, Seckl JR.

BMJ. 2009 Oct 23;339:b4114. doi: 10.1136/bmj.b4114. Review. No abstract available. PMID: 19854840 [PubMed - indexed for MEDLINE]Related articles

Higher systolic blood pressure is associated with increased water diffusivity in normal-appearing white matter.

Maclullich AM, Ferguson KJ, Reid LM, Deary IJ, Starr JM, Seckl JR, Bastin ME, Wardlaw JM.

Stroke. 2009 Dec;40(12):3869-71. Epub 2009 Oct 22.PMID: 19850898 [PubMed - in process]Related articles

Prenatal stress, glucocorticoids and the programming of adult disease.

Cottrell EC, Seckl JR.

Front Behav Neurosci. 2009;3:19. Epub 2009 Sep 7.PMID: 19826624 [PubMed - in process]Related articlesFree article

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.

Drake AJ, van den Driesche S, Scott HM, Hutchison GR, Seckl JR, Sharpe RM.

Endocrinology. 2009 Nov;150(11):5055-64. Epub 2009 Oct 9.PMID: 19819957 [PubMed - indexed for MEDLINE]Related articles

Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children.

Räikkönen K, Pesonen AK, Heinonen K, Lahti J, Komsi N, Eriksson JG, Seckl JR, Järvenpää AL, Strandberg TE.

Am J Epidemiol. 2009 Nov 1;170(9):1137-46. Epub 2009 Oct 4.PMID: 19808634 [PubMed - indexed for MEDLINE]Related articles

Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11beta-hydroxysteroid dehydrogenase type 1.

Nyirenda MJ, Carter R, Tang JI, de Vries A, Schlumbohm C, Hillier SG, Streit F, Oellerich M, Armstrong VW, Fuchs E, Seckl JR.

Diabetes. 2009 Dec;58(12):2873-9. Epub 2009 Aug 31.PMID: 19720800 [PubMed - in process]Related articles

CMIP and ATP2C2 modulate phonological short-term memory in language impairment.

Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL, Clark A, Cohen W, Cowie H, Dworzynski K, Everitt A, Goodyer IM, Hennessy E, Kindley AD, Miller LL, Nasir J, O'Hare A, Shaw D, Simkin Z, Simonoff E, Slonims V, Watson J, Ragoussis J, Fisher SE, Seckl JR, Helms PJ, Bolton PF, Pickles A, Conti-Ramsden G, Baird G, Bishop DV, Monaco AP.

Am J Hum Genet. 2009 Aug;85(2):264-72. Epub 2009 Jul 30.PMID: 19646677 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent.

Carter RN, Paterson JM, Tworowska U, Stenvers DJ, Mullins JJ, Seckl JR, Holmes MC.

J Neuroendocrinol. 2009 Nov;21(11):879-87. Epub 2009 Jul 7.PMID: 19602102 [PubMed - in process]Related articles

Differential regulation of 11beta-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia.

Sai S, Nakagawa Y, Sakaguchi K, Okada S, Takahashi H, Hongo T, Seckl JR, Chapman KE, Ohzeki T.

Leuk Res. 2009 Dec;33(12):1696-8. Epub 2009 May 14.PMID: 19446331 [PubMed - in process]Related articles

Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant.

Kang P, Rogalska J, Walker CA, Burke M, Seckl JR, Macleod MR, Lai M.

Mol Cell Endocrinol. 2009 Jun 16;305(1-2):56-62. Epub 2009 Feb 28.PMID: 19433261 [PubMed - indexed for MEDLINE]Related articles

Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001.

Yehuda R, Bierer LM, Sarapas C, Makotkine I, Andrew R, Seckl JR.

Psychoneuroendocrinology. 2009 Oct;34(9):1304-13. Epub 2009 May 2.PMID: 19411143 [PubMed - in process]Related articles

Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women.

Goedecke JH, Levitt NS, Lambert EV, Utzschneider KM, Faulenbach MV, Dave JA, West S, Victor H, Evans J, Olsson T, Walker BR, Seckl JR, Kahn SE.

Obesity (Silver Spring). 2009 Aug;17(8):1506-12. Epub 2009 Mar 19.PMID: 19300428 [PubMed - indexed for MEDLINE]Related articles

Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia.

Lai M, Bae SE, Bell JE, Seckl JR, Macleod MR.

Neuropathol Appl Neurobiol. 2009 Apr;35(2):156-64.PMID: 19284477 [PubMed - indexed for MEDLINE]Related articles

Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African women.

Goedecke JH, Dave JA, Faulenbach MV, Utzschneider KM, Lambert EV, West S, Collins M, Olsson T, Walker BR, Seckl JR, Kahn SE, Levitt NS.

Diabetes Care. 2009 May;32(5):860-5. Epub 2009 Feb 5.PMID: 19196884 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia.

de Vries A, Hazlewood L, Fitch PM, Seckl JR, Foster P, Howie SE.

Clin Exp Allergy. 2009 May;39(5):731-9. Epub 2009 Jan 22.PMID: 19178536 [PubMed - indexed for MEDLINE]Related articles

Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors.

Yehuda R, Bierer LM, Andrew R, Schmeidler J, Seckl JR.

J Psychiatr Res. 2009 Jun;43(9):877-83. Epub 2009 Jan 21.PMID: 19162277 [PubMed - indexed for MEDLINE]Related articles

Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2.

Lucassen PJ, Bosch OJ, Jousma E, Krömer SA, Andrew R, Seckl JR, Neumann ID.

Eur J Neurosci. 2009 Jan;29(1):97-103. Epub 2008 Nov 21.PMID: 19032587 [PubMed - indexed for MEDLINE]Related articles

The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response.

Chapman KE, Coutinho AE, Gray M, Gilmour JS, Savill JS, Seckl JR.

Mol Cell Endocrinol. 2009 Mar 25;301(1-2):123-31. Epub 2008 Oct 8. Review.PMID: 18973788 [PubMed - indexed for MEDLINE]Related articles

Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice.

Wyrwoll CS, Seckl JR, Holmes MC.

Endocrinology. 2009 Mar;150(3):1287-93. Epub 2008 Oct 9.PMID: 18845627 [PubMed - indexed for MEDLINE]Related articles

7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.

Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR.

Endocrinology. 2008 Dec;149(12):5909-18. Epub 2008 Aug 28.PMID: 18755798 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between umbilical cord glucocorticoids and blood pressure at age 3 years.

Huh SY, Andrew R, Rich-Edwards JW, Kleinman KP, Seckl JR, Gillman MW.

BMC Med. 2008 Aug 28;6:25.PMID: 18755017 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.

Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, Cockett K, Kelly V, Ramage L, Al-Dujaili EA, Ross M, Maraki I, Newton K, Holmes MC, Seckl JR, Morton NM, Kenyon CJ, Chapman KE.

FASEB J. 2008 Nov;22(11):3896-907. Epub 2008 Aug 12.PMID: 18697839 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta.

Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, Nakagawa Y, Ohzeki T, Seckl JR, Chapman KE.

Mol Endocrinol. 2008 Sep;22(9):2049-60. Epub 2008 Jul 10.PMID: 18617597 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone inhibits the 11 beta-Hydroxysteroid dehydrogenase type 1 gene promoter activity via insulin-like growth factor I in HepG2 cells.

Li RS, Nakagawa Y, Liu YJ, Fujisawa Y, Sai S, Nakanishi T, Chapman KE, Seckl JR, Ohzeki T.

Horm Metab Res. 2008 Apr;40(4):286-8. No abstract available. PMID: 18548388 [PubMed - indexed for MEDLINE]Related articles

Diabetes and cognitive decline: are steroids the missing link?

MacLullich AM, Seckl JR.

Cell Metab. 2008 Apr;7(4):286-7.PMID: 18396133 [PubMed - indexed for MEDLINE]Related articles

Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring.

O'Regan D, Kenyon CJ, Seckl JR, Holmes MC.

J Endocrinol. 2008 Feb;196(2):343-52.PMID: 18252958 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system.

Ye P, Kenyon CJ, Mackenzie SM, Nichol K, Seckl JR, Fraser R, Connell JM, Davies E.

J Endocrinol. 2008 Feb;196(2):305-11.PMID: 18252953 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.

De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM.

Endocrinology. 2008 Apr;149(4):1861-8. Epub 2008 Jan 3.PMID: 18174284 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids, developmental 'programming' and the risk of affective dysfunction.

Seckl JR.

Prog Brain Res. 2008;167:17-34. Review.PMID: 18037004 [PubMed - indexed for MEDLINE]Related articles

A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.

Bailey MA, Paterson JM, Hadoke PW, Wrobel N, Bellamy CO, Brownstein DG, Seckl JR, Mullins JJ.

J Am Soc Nephrol. 2008 Jan;19(1):47-58. Epub 2007 Nov 21.PMID: 18032795 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function.

Chapman KE, Seckl JR.

Neurochem Res. 2008 Apr;33(4):624-36. Epub 2007 Oct 25. Review.PMID: 17963039 [PubMed - indexed for MEDLINE]Related articles

Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.

Yau JL, McNair KM, Noble J, Brownstein D, Hibberd C, Morton N, Mullins JJ, Morris RG, Cobb S, Seckl JR.

J Neurosci. 2007 Sep 26;27(39):10487-96.PMID: 17898220 [PubMed - indexed for MEDLINE]Related articlesFree article

Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors.

Yehuda R, Teicher MH, Seckl JR, Grossman RA, Morris A, Bierer LM.

Arch Gen Psychiatry. 2007 Sep;64(9):1040-8.PMID: 17768269 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target.

Wamil M, Seckl JR.

Drug Discov Today. 2007 Jul;12(13-14):504-20. Epub 2007 Jun 27. Review.PMID: 17631244 [PubMed - indexed for MEDLINE]Related articles

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.

Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O'Rahilly S, Seckl JR, Chapman KE.

J Endocrinol. 2007 Jul;194(1):161-70.PMID: 17592030 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.

Meaney MJ, Szyf M, Seckl JR.

Trends Mol Med. 2007 Jul;13(7):269-77. Epub 2007 Jun 4.PMID: 17544850 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology.

Seckl JR, Holmes MC.

Nat Clin Pract Endocrinol Metab. 2007 Jun;3(6):479-88. Review.PMID: 17515892 [PubMed - indexed for MEDLINE]Related articles

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.

Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.

Obesity (Silver Spring). 2007 May;15(5):1155-63.PMID: 17495191 [PubMed - indexed for MEDLINE]Related articles

Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice.

Sheward WJ, Maywood ES, French KL, Horn JM, Hastings MH, Seckl JR, Holmes MC, Harmar AJ.

J Neurosci. 2007 Apr 18;27(16):4351-8.PMID: 17442819 [PubMed - indexed for MEDLINE]Related articlesFree article

Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.

Lai M, Horsburgh K, Bae SE, Carter RN, Stenvers DJ, Fowler JH, Yau JL, Gomez-Sanchez CE, Holmes MC, Kenyon CJ, Seckl JR, Macleod MR.

Eur J Neurosci. 2007 Mar;25(6):1832-42.PMID: 17432969 [PubMed - indexed for MEDLINE]Related articles

Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function.

de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, Wolfe-Coote S, Meaney MJ, Levitt NS, Seckl JR.

J Clin Invest. 2007 Apr;117(4):1058-67. Epub 2007 Mar 22.PMID: 17380204 [PubMed - indexed for MEDLINE]Related articlesFree article

The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice.

Yau JL, Noble J, Thomas S, Kerwin R, Morgan PE, Lightman S, Seckl JR, Pariante CM.

Neuropsychopharmacology. 2007 Dec;32(12):2520-9. Epub 2007 Mar 14.PMID: 17356567 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.

Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR.

Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. Epub 2007 Feb 25.PMID: 17350260 [PubMed - indexed for MEDLINE]Related articles

The role of the IDDM2 locus in the susceptibility of UK APS1 subjects to type 1 diabetes mellitus.

Adamson KA, Cheetham TD, Kendall-Taylor P, Seckl JR, Pearce SH.

Int J Immunogenet. 2007 Feb;34(1):17-21.PMID: 17284223 [PubMed - indexed for MEDLINE]Related articles

Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response.

Chapman KE, Coutinho A, Gray M, Gilmour JS, Savill JS, Seckl JR.

Ann N Y Acad Sci. 2006 Nov;1088:265-73. Review.PMID: 17192572 [PubMed - indexed for MEDLINE]Related articles

Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice.

Paterson JM, Holmes MC, Kenyon CJ, Carter R, Mullins JJ, Seckl JR.

Endocrinology. 2007 Mar;148(3):961-6. Epub 2006 Dec 14.PMID: 17170103 [PubMed - indexed for MEDLINE]Related articlesFree article

Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats.

Yau JL, Noble J, Graham M, Seckl JR.

J Neurosci. 2006 Oct 25;26(43):11034-40.PMID: 17065445 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid "programming" and PTSD risk.

Seckl JR, Meaney MJ.

Ann N Y Acad Sci. 2006 Jul;1071:351-78. Review.PMID: 16891583 [PubMed - indexed for MEDLINE]Related articles

Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation.

Paterson JM, Short D, Flatman PW, Seckl JR, Aitken A, Dutia MB.

J Physiol. 2006 Sep 15;575(Pt 3):777-88. Epub 2006 Jul 6.PMID: 16825307 [PubMed - indexed for MEDLINE]Related articlesFree article