PubMed

Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure.

Jablonski KL, Gates PE, Pierce GL, Seals DR.

Ther Adv Cardiovasc Dis. 2009 Oct;3(5):347-56. Epub 2009 Sep 1.PMID: 19723834 [PubMed - in process]Related articles

Habitual Exercise and Vascular Aging.

Seals DR, Walker AE, Pierce GL, Lesniewski LA.

J Physiol. 2009 Sep 1. [Epub ahead of print]PMID: 19723776 [PubMed - as supplied by publisher]Related articles

Protein Expression in Vascular Endothelial Cells Obtained from Human Peripheral Arteries and Veins.

Silver AE, Christou DD, Donato AJ, Beske SD, Moreau KL, Magerko KA, Seals DR.

J Vasc Res. 2009 Aug 6;47(1):1-8. [Epub ahead of print]PMID: 19672102 [PubMed - as supplied by publisher]Related articles

Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women.

Gavin KM, Seals DR, Silver AE, Moreau KL.

J Clin Endocrinol Metab. 2009 Sep;94(9):3513-20. Epub 2009 Jun 9.PMID: 19509105 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase.

Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H425-32. Epub 2009 May 22.PMID: 19465546 [PubMed - indexed for MEDLINE]Related articles

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.

Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA.

J Physiol. 2009 Jul 1;587(Pt 13):3271-85. Epub 2009 May 5.PMID: 19417091 [PubMed - indexed for MEDLINE]Related articles

Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.

Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR.

Circulation. 2009 Mar 10;119(9):1284-92. Epub 2009 Feb 23.PMID: 19237660 [PubMed - indexed for MEDLINE]Related articles

B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.

Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR.

J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):9-20. Epub 2009 Feb 10.PMID: 19211548 [PubMed - indexed for MEDLINE]Related articles

Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise.

Walker AE, Eskurza I, Pierce GL, Gates PE, Seals DR.

Am J Hypertens. 2009 Mar;22(3):250-6. Epub 2008 Dec 25.PMID: 19114985 [PubMed - indexed for MEDLINE]Related articles

Aging is associated with greater nuclear NFkappaB, reduced IkappaBalpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.

Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR.

Aging Cell. 2008 Dec;7(6):805-12. Epub 2008 Sep 8.PMID: 18782346 [PubMed - in process]Related articles

Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans.

Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR.

J Appl Physiol. 2008 Oct;105(4):1359-63. Epub 2008 Jul 31.PMID: 18669935 [PubMed - indexed for MEDLINE]Related articlesFree article

Habitual exercise and arterial aging.

Seals DR, Desouza CA, Donato AJ, Tanaka H.

J Appl Physiol. 2008 Oct;105(4):1323-32. Epub 2008 Jun 26. Review.PMID: 18583377 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults.

Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ, Seals DR.

Hypertension. 2008 Jul;52(1):72-9. Epub 2008 May 26.PMID: 18504322 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate.

Christou DD, Seals DR.

J Appl Physiol. 2008 Jul;105(1):24-9. Epub 2008 May 15.PMID: 18483165 [PubMed - indexed for MEDLINE]Related articlesFree article

High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men.

Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ.

J Appl Physiol. 2007 Nov;103(5):1715-21.PMID: 17965239 [PubMed - indexed for MEDLINE]Related articlesFree article

Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms.

Tanaka H, Seals DR.

J Physiol. 2008 Jan 1;586(1):55-63. Epub 2007 Aug 23. Review.PMID: 17717011 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density.

Stob NR, Seals DR, Jørgen J, van Baak MA, Steig AJ, Lindstrom RC, Bikman BT, Bell C.

Exp Physiol. 2007 Sep;92(5):823-30. Epub 2007 Jun 15.PMID: 17573413 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.

Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR.

Circ Res. 2007 Jun 8;100(11):1659-66. Epub 2007 May 3.PMID: 17478731 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans.

Stob NR, Bell C, van Baak MA, Seals DR.

J Appl Physiol. 2007 Aug;103(2):616-22. Epub 2007 Apr 26.PMID: 17463294 [PubMed - indexed for MEDLINE]Related articlesFree article

Commentary on Viewpoint "Human experimentation: no accurate, quantitative data?".

Seals DR, Donato AJ, Pierce GL, Walker AE.

J Appl Physiol. 2007 Mar;102(3):1294. No abstract available. PMID: 17341743 [PubMed - indexed for MEDLINE]Related articlesFree article

Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress.

Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR.

Circulation. 2007 Feb 6;115(5):627-37. Epub 2007 Jan 22.PMID: 17242275 [PubMed - indexed for MEDLINE]Related articlesFree article

A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise.

Bryan A, Hutchison KE, Seals DR, Allen DL.

Health Psychol. 2007 Jan;26(1):30-9.PMID: 17209695 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women.

Moreau KL, DePaulis AR, Gavin KM, Seals DR.

J Appl Physiol. 2007 Mar;102(3):890-5. Epub 2006 Nov 16.PMID: 17110511 [PubMed - indexed for MEDLINE]Related articlesFree article

Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women.

Moreau KL, Silver AE, Dinenno FA, Seals DR.

Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):805-11.PMID: 17001222 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women.

Moreau KL, Gavin KM, Plum AE, Seals DR.

Menopause. 2006 Nov-Dec;13(6):951-8.PMID: 16977254 [PubMed - indexed for MEDLINE]Related articles

Decline in large elastic artery compliance with age: a therapeutic target for habitual exercise.

Gates PE, Seals DR.

Br J Sports Med. 2006 Nov;40(11):897-9. Epub 2006 Sep 5. No abstract available. PMID: 16954129 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.

Gates PE, Boucher ML, Silver AE, Monahan KD, Seals DR.

J Appl Physiol. 2007 Jan;102(1):63-71. Epub 2006 Aug 31.PMID: 16946027 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulatory influences on ageing of the vasculature in healthy humans.

Seals DR, Moreau KL, Gates PE, Eskurza I.

Exp Gerontol. 2006 May;41(5):501-7. Epub 2006 Mar 14. Review.PMID: 16537099 [PubMed - indexed for MEDLINE]Related articles

Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing.

Eskurza I, Kahn ZD, Seals DR.

J Physiol. 2006 Mar 15;571(Pt 3):661-8. Epub 2006 Jan 26.PMID: 16439428 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training.

Kukielka M, Seals DR, Billman GE.

Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1680-5. Epub 2005 Dec 9.PMID: 16339826 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress.

Bell C, Stob NR, Seals DR.

J Physiol. 2006 Feb 1;570(Pt 3):629-35. Epub 2005 Nov 24.PMID: 16308351 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor.

Bell C, Stob NR, Seals DR.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E703-7. Epub 2005 Nov 8.PMID: 16278251 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.

Eskurza I, Myerburgh LA, Kahn ZD, Seals DR.

J Physiol. 2005 Nov 1;568(Pt 3):1057-65. Epub 2005 Sep 1.PMID: 16141271 [PubMed - indexed for MEDLINE]Related articlesFree article

Aortic input impedance increases with age in healthy men and women.

Mazzaro L, Almasi SJ, Shandas R, Seals DR, Gates PE.

Hypertension. 2005 Jun;45(6):1101-6. Epub 2005 May 2.PMID: 15867143 [PubMed - indexed for MEDLINE]Related articlesFree article

Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women.

Moreau KL, Gavin KM, Plum AE, Seals DR.

Hypertension. 2005 Jun;45(6):1107-12. Epub 2005 May 2.PMID: 15867135 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men.

Christou DD, Gentile CL, DeSouza CA, Seals DR, Gates PE.

Circulation. 2005 Apr 19;111(15):1904-14.PMID: 15837943 [PubMed - indexed for MEDLINE]Related articlesFree article

Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.

Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR.

Circulation. 2005 Feb 1;111(4):494-8.PMID: 15687139 [PubMed - indexed for MEDLINE]Related articlesFree article

Stiffening our resolve against adult weight gain.

Seals DR, Gates PE.

Hypertension. 2005 Feb;45(2):175-7. Epub 2004 Dec 27. No abstract available. PMID: 15623541 [PubMed - indexed for MEDLINE]Related articlesFree article

Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults.

Bell C, Carson JM, Motte NW, Seals DR.

J Appl Physiol. 2005 Mar;98(3):845-9. Epub 2004 Oct 22.PMID: 15501926 [PubMed - indexed for MEDLINE]Related articlesFree article

Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging.

Seals DR, Dinenno FA.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H1895-905. Review.PMID: 15475526 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food.

Jones PP, Van Pelt RE, Johnson DG, Seals DR.

J Clin Endocrinol Metab. 2004 Oct;89(10):5138-44.PMID: 15472218 [PubMed - indexed for MEDLINE]Related articlesFree article

High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults.

Bell C, Day DS, Jones PP, Christou DD, Petitt DS, Osterberg K, Melby CL, Seals DR.

J Clin Endocrinol Metab. 2004 Jul;89(7):3573-8.PMID: 15240648 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging.

Christou DD, Jones PP, Pimentel AE, Seals DR.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1530-7. Epub 2004 Jun 3.PMID: 15178547 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension.

Gates PE, Tanaka H, Hiatt WR, Seals DR.

Hypertension. 2004 Jul;44(1):35-41. Epub 2004 Jun 1.PMID: 15173128 [PubMed - indexed for MEDLINE]Related articlesFree article

Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men.

Eskurza I, Monahan KD, Robinson JA, Seals DR.

Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1528-34.PMID: 15020306 [PubMed - indexed for MEDLINE]Related articlesFree article

Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.

Monahan KD, Eskurza I, Seals DR.

Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2113-7. Epub 2004 Feb 12.PMID: 14962830 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing.

Eskurza I, Monahan KD, Robinson JA, Seals DR.

J Physiol. 2004 Apr 1;556(Pt 1):315-24. Epub 2004 Jan 30. Erratum in: J Physiol. 2004 May 1;556(Pt 3):1014. PMID: 14754992 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic sympathetic activation: consequence and cause of age-associated obesity?

Seals DR, Bell C.

Diabetes. 2004 Feb;53(2):276-84. Review.PMID: 14747276 [PubMed - indexed for MEDLINE]Related articlesFree article

Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness.

Gates PE, Tanaka H, Graves J, Seals DR.

Eur Heart J. 2003 Dec;24(24):2213-20.PMID: 14659773 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of adiposity on tonic sympathetic support of resting metabolism in healthy adults.

Bell C, Petitt DS, Jones PP, Seals DR.

Int J Obes Relat Metab Disord. 2003 Nov;27(11):1315-8.PMID: 14574340 [PubMed - indexed for MEDLINE]Related articles