PubMed

Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

Ramalho JS, Lopes VS, Tarafder AK, Seabra MC, Hume AN.

Pigment Cell Melanoma Res. 2009 Aug;22(4):461-73. Epub 2009 Mar 21.PMID: 19317802 [PubMed - in process]Related articles

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF.

Blood. 2009 May 14;113(20):5010-8. Epub 2009 Mar 6.PMID: 19270261 [PubMed - indexed for MEDLINE]Related articlesFree article

Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia.

Moosajee M, Tulloch M, Baron RA, Gregory-Evans CY, Pereira-Leal JB, Seabra MC.

Invest Ophthalmol Vis Sci. 2009 Jun;50(6):3009-16. Epub 2008 Dec 30.PMID: 19117920 [PubMed - indexed for MEDLINE]Related articles

Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.

Baron RA, Tavaré R, Figueiredo AC, Błazewska KM, Kashemirov BA, McKenna CE, Ebetino FH, Taylor A, Rogers MJ, Coxon FP, Seabra MC.

J Biol Chem. 2009 Mar 13;284(11):6861-8. Epub 2008 Dec 11.PMID: 19074143 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanosomes at a glance.

Wasmeier C, Hume AN, Bolasco G, Seabra MC.

J Cell Sci. 2008 Dec 15;121(Pt 24):3995-9. No abstract available. PMID: 19056669 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.

Hume AN, Buttgereit J, Al-Awadhi AM, Al-Suwaidi SS, John A, Bader M, Seabra MC, Al-Gazali L, Ali BR.

Hum Mol Genet. 2009 Jan 15;18(2):267-77. Epub 2008 Oct 22.PMID: 18945719 [PubMed - indexed for MEDLINE]Related articles

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.

Moosajee M, Gregory-Evans K, Ellis CD, Seabra MC, Gregory-Evans CY.

Hum Mol Genet. 2008 Dec 15;17(24):3987-4000. Epub 2008 Sep 22.PMID: 18809619 [PubMed - indexed for MEDLINE]Related articles

Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.

Figueiredo AC, Wasmeier C, Tarafder AK, Ramalho JS, Baron RA, Seabra MC.

J Biol Chem. 2008 Aug 22;283(34):23209-16. Epub 2008 Jun 17.PMID: 18559336 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.

Baron RA, Seabra MC.

Biochem J. 2008 Oct 1;415(1):67-75.PMID: 18532927 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes.

Hume AN, Ushakov DS, Tarafder AK, Ferenczi MA, Seabra MC.

J Cell Sci. 2007 Sep 1;120(Pt 17):3111-22. Epub 2007 Aug 14.PMID: 17698919 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.

Lopes VS, Wasmeier C, Seabra MC, Futter CE.

Mol Biol Cell. 2007 Oct;18(10):3914-27. Epub 2007 Aug 1.PMID: 17671165 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab27b regulates mast cell granule dynamics and secretion.

Mizuno K, Tolmachova T, Ushakov DS, Romao M, Abrink M, Ferenczi MA, Raposo G, Seabra MC.

Traffic. 2007 Jul;8(7):883-92.PMID: 17587407 [PubMed - indexed for MEDLINE]Related articlesFree article

The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.

Lopes VS, Ramalho JS, Owen DM, Karl MO, Strauss O, Futter CE, Seabra MC.

Traffic. 2007 May;8(5):486-99.PMID: 17451552 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab27b regulates number and secretion of platelet dense granules.

Tolmachova T, Abrink M, Futter CE, Authi KS, Seabra MC.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5872-7. Epub 2007 Mar 23.PMID: 17384153 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.

Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S.

Nat Cell Biol. 2007 Apr;9(4):367-78. Epub 2007 Mar 11.PMID: 17351642 [PubMed - indexed for MEDLINE]Related articles

Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM.

J Immunol. 2006 Dec 15;177(12):8476-83.PMID: 17142745 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.

Leung KF, Baron R, Ali BR, Magee AI, Seabra MC.

J Biol Chem. 2007 Jan 12;282(2):1487-97. Epub 2006 Nov 18.PMID: 17114793 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.

Wasmeier C, Romao M, Plowright L, Bennett DC, Raposo G, Seabra MC.

J Cell Biol. 2006 Oct 23;175(2):271-81. Epub 2006 Oct 16.PMID: 17043139 [PubMed - indexed for MEDLINE]Related articlesFree article

A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.

Hume AN, Tarafder AK, Ramalho JS, Sviderskaya EV, Seabra MC.

Mol Biol Cell. 2006 Nov;17(11):4720-35. Epub 2006 Aug 16.PMID: 16914517 [PubMed - indexed for MEDLINE]Related articlesFree article

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Duménil AM, Seabra MC, Raposo G, Amigorena S.

Cell. 2006 Jul 14;126(1):205-18.PMID: 16839887 [PubMed - indexed for MEDLINE]Related articles

Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.

Tolmachova T, Anders R, Abrink M, Bugeon L, Dallman MJ, Futter CE, Ramalho JS, Tonagel F, Tanimoto N, Seeliger MW, Huxley C, Seabra MC.

J Clin Invest. 2006 Feb;116(2):386-94. Epub 2006 Jan 12.PMID: 16410831 [PubMed - indexed for MEDLINE]Related articlesFree article

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

Leung KF, Baron R, Seabra MC.

J Lipid Res. 2006 Mar;47(3):467-75. Epub 2006 Jan 9. Review.PMID: 16401880 [PubMed - indexed for MEDLINE]Related articlesFree article

ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome.

Chen Y, Bellamy WP, Seabra MC, Field MC, Ali BR.

Hum Mol Genet. 2005 Sep 1;14(17):2559-69. Epub 2005 Jul 27.PMID: 16049033 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of Rab GTPases to cellular membranes.

Ali BR, Seabra MC.

Biochem Soc Trans. 2005 Aug;33(Pt 4):652-6. Review.PMID: 16042566 [PubMed - indexed for MEDLINE]Related articles

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.

Coxon FP, Ebetino FH, Mules EH, Seabra MC, McKenna CE, Rogers MJ.

Bone. 2005 Sep;37(3):349-58.PMID: 16006204 [PubMed - indexed for MEDLINE]Related articles

The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.

Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD.

Biochem J. 2005 Nov 1;391(Pt 3):699-710.PMID: 16004602 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acylation and prenylation of proteins: what's hot in fat.

Magee T, Seabra MC.

Curr Opin Cell Biol. 2005 Apr;17(2):190-6. Review.PMID: 15780596 [PubMed - indexed for MEDLINE]Related articles

Multiple regions contribute to membrane targeting of Rab GTPases.

Ali BR, Wasmeier C, Lamoreux L, Strom M, Seabra MC.

J Cell Sci. 2004 Dec 15;117(Pt 26):6401-12. Epub 2004 Nov 23.PMID: 15561774 [PubMed - indexed for MEDLINE]Related articlesFree article

Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts.

Westbroek W, Lambert J, De Schepper S, Kleta R, Van Den Bossche K, Seabra MC, Huizing M, Mommaas M, Naeyaert JM.

Pigment Cell Res. 2004 Oct;17(5):498-505.PMID: 15357836 [PubMed - indexed for MEDLINE]Related articles

Controlling the location and activation of Rab GTPases.

Seabra MC, Wasmeier C.

Curr Opin Cell Biol. 2004 Aug;16(4):451-7. Review.PMID: 15261679 [PubMed - indexed for MEDLINE]Related articles

Rab GTPases and myosin motors in organelle motility.

Seabra MC, Coudrier E.

Traffic. 2004 Jun;5(6):393-9. Review.PMID: 15117313 [PubMed - indexed for MEDLINE]Related articles

The melanosome as a model to study organelle motility in mammals.

Barral DC, Seabra MC.

Pigment Cell Res. 2004 Apr;17(2):111-8. Review.PMID: 15016299 [PubMed - indexed for MEDLINE]Related articles

The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells.

Futter CE, Ramalho JS, Jaissle GB, Seeliger MW, Seabra MC.

Mol Biol Cell. 2004 May;15(5):2264-75. Epub 2004 Feb 20.PMID: 14978221 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.

Ramalho JS, Gregory-Evans K, Huxley C, Seabra MC.

Br J Ophthalmol. 2004 Mar;88(3):428-32.PMID: 14977782 [PubMed - indexed for MEDLINE]Related articlesFree article

Are prenyl groups on proteins sticky fingers or greasy handles?

Magee AI, Seabra MC.

Biochem J. 2003 Dec 1;376(Pt 2):e3-4.PMID: 14627432 [PubMed - indexed for MEDLINE]Related articlesFree article

A general role for Rab27a in secretory cells.

Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C, Seabra MC.

Mol Biol Cell. 2004 Jan;15(1):332-44. Epub 2003 Nov 14.PMID: 14617806 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.

Larijani B, Hume AN, Tarafder AK, Seabra MC.

J Biol Chem. 2003 Nov 21;278(47):46798-804. Epub 2003 Aug 25.PMID: 12941939 [PubMed - indexed for MEDLINE]Related articlesFree article

Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type.

Hannah MJ, Hume AN, Arribas M, Williams R, Hewlett LJ, Seabra MC, Cutler DF.

J Cell Sci. 2003 Oct 1;116(Pt 19):3939-48. Epub 2003 Aug 19.PMID: 12928333 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for Rab27b in NF-E2-dependent pathways of platelet formation.

Tiwari S, Italiano JE Jr, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA.

Blood. 2003 Dec 1;102(12):3970-9. Epub 2003 Aug 7.PMID: 12907454 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane targeting of Rab GTPases is influenced by the prenylation motif.

Gomes AQ, Ali BR, Ramalho JS, Godfrey RF, Barral DC, Hume AN, Seabra MC.

Mol Biol Cell. 2003 May;14(5):1882-99. Epub 2003 Feb 6.PMID: 12802062 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus.

Anand V, Barral DC, Zeng Y, Brunsmann F, Maguire AM, Seabra MC, Bennett J.

Vision Res. 2003 Apr;43(8):919-26.PMID: 12668061 [PubMed - indexed for MEDLINE]Related articles

Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface.

Pereira-Leal JB, Strom M, Godfrey RF, Seabra MC.

Biochem Biophys Res Commun. 2003 Jan 31;301(1):92-7.PMID: 12535645 [PubMed - indexed for MEDLINE]Related articles

Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.

Ramalho JS, Anders R, Jaissle GB, Seeliger MW, Huxley C, Seabra MC.

BMC Cell Biol. 2002 Oct 28;3:26. Epub 2002 Oct 28.PMID: 12401133 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome.

Barral DC, Ramalho JS, Anders R, Hume AN, Knapton HJ, Tolmachova T, Collinson LM, Goulding D, Authi KS, Seabra MC.

J Clin Invest. 2002 Jul;110(2):247-57. Erratum in: J Clin Invest 2002 Oct;110(8):1213. PMID: 12122117 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase.

Pereira-Leal JB, Gomes AQ, Seabra MC.

Methods Mol Biol. 2002;189:157-65. No abstract available. PMID: 12094584 [PubMed - indexed for MEDLINE]Related articles

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.

Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC.

J Biol Chem. 2002 Jul 12;277(28):25423-30. Epub 2002 Apr 29.PMID: 11980908 [PubMed - indexed for MEDLINE]Related articlesFree article

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.

Hume AN, Collinson LM, Hopkins CR, Strom M, Barral DC, Bossi G, Griffiths GM, Seabra MC.

Traffic. 2002 Mar;3(3):193-202.PMID: 11886590 [PubMed - indexed for MEDLINE]Related articles

Rab GTPases, intracellular traffic and disease.

Seabra MC, Mules EH, Hume AN.

Trends Mol Med. 2002 Jan;8(1):23-30. Review.PMID: 11796263 [PubMed - indexed for MEDLINE]Related articles

Evolution of the Rab family of small GTP-binding proteins.

Pereira-Leal JB, Seabra MC.

J Mol Biol. 2001 Nov 2;313(4):889-901.PMID: 11697911 [PubMed - indexed for MEDLINE]Related articles

The melanosome: membrane dynamics in black and white.

Marks MS, Seabra MC.

Nat Rev Mol Cell Biol. 2001 Oct;2(10):738-48. Review.PMID: 11584301 [PubMed - indexed for MEDLINE]Related articles