PubMed

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. Epub 2009 Oct 9.PMID: 19819943 [PubMed - in process]Related articles

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7. Epub 2009 Aug 18.PMID: 19706465 [PubMed - indexed for MEDLINE]Related articles

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

Evidence for co-evolution between human microRNAs and Alu-repeats.

Lehnert S, Van Loo P, Thilakarathne PJ, Marynen P, Verbeke G, Schuit FC.

PLoS One. 2009;4(2):e4456. Epub 2009 Feb 11.PMID: 19209240 [PubMed - indexed for MEDLINE]Related articlesFree article

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.

Bensellam M, Van Lommel L, Overbergh L, Schuit FC, Jonas JC.

Diabetologia. 2009 Mar;52(3):463-76. Epub 2009 Jan 23.PMID: 19165461 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell replication by loosening the brakes of glucagon-like peptide-1 receptor signaling.

Schuit FC, Drucker DJ.

Diabetes. 2008 Mar;57(3):529-31. No abstract available. PMID: 18305147 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

Elouil H, Bensellam M, Guiot Y, Vander Mierde D, Pascal SM, Schuit FC, Jonas JC.

Diabetologia. 2007 Jul;50(7):1442-52. Epub 2007 May 12.PMID: 17497122 [PubMed - indexed for MEDLINE]Related articles

Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.

Van Lommel L, Janssens K, Quintens R, Tsukamoto K, Vander Mierde D, Lemaire K, Denef C, Jonas JC, Martens G, Pipeleers D, Schuit FC.

Diabetes. 2006 Dec;55(12):3214-20.PMID: 17130463 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC.

Endocrinology. 2007 Feb;148(2):609-17. Epub 2006 Nov 2.PMID: 17082262 [PubMed - indexed for MEDLINE]Related articlesFree article

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Fransson U, Rosengren AH, Schuit FC, Renström E, Mulder H.

Diabetologia. 2006 Jul;49(7):1578-86. Epub 2006 Apr 26.PMID: 16752176 [PubMed - indexed for MEDLINE]Related articles

Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin.

Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renström E, Schuit FC.

Diabetes. 2005 Jul;54(7):2132-42.PMID: 15983215 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.

Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ.

Nat Med. 2005 Jul;11(7):757-64. Epub 2005 Jun 26.PMID: 15980866 [PubMed - indexed for MEDLINE]Related articles

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.

Hinke SA, Hellemans K, Schuit FC.

J Physiol. 2004 Jul 15;558(Pt 2):369-80. Epub 2004 Jun 4. Review.PMID: 15181163 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Flamez D, Mu J, Wojtaszewski JF, Schuit FC, Birnbaum M, Richter E, Burcelin R, Vaulont S.

Biochem Soc Trans. 2003 Feb;31(Pt 1):216-9. Review.PMID: 12546688 [PubMed - indexed for MEDLINE]Related articles

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S.

J Clin Invest. 2003 Jan;111(1):91-8.PMID: 12511592 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2 autoantibodies predict impending type I diabetes in siblings of patients.

Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12.PMID: 12488955 [PubMed - indexed for MEDLINE]Related articles

Critical role for cataplerosis via citrate in glucose-regulated insulin release.

Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit FC.

Diabetes. 2002 Jul;51(7):2018-24.PMID: 12086928 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood.

Weets I, Siraux V, Daubresse JC, De Leeuw IH, Féry F, Keymeulen B, Krzentowski G, Letiexhe M, Mathieu C, Nobels F, Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van der Auwera B, Rui M, De Pauw P, Kaufman L, Gorus FK; Belgian Diabetes Registry.

J Clin Endocrinol Metab. 2002 Jun;87(6):2597-605.PMID: 12050221 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies.

Van der Auwera BJ, Schuit FC, Weets I, Ivens A, Van Autreve JE, Gorus FK; Belgian Diabetes Registry.

Hum Immunol. 2002 Jan;63(1):40-50.PMID: 11916169 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice.

Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC.

Virchows Arch. 2001 Apr;438(4):382-7.PMID: 11355173 [PubMed - indexed for MEDLINE]Related articles

Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.

Weets I, Van Autreve J, Van der Auwera BJ, Schuit FC, Du Caju MV, Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Dorchy H, Quartier E, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2001 Jan;44(1):40-7.PMID: 11206410 [PubMed - indexed for MEDLINE]Related articles

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.

Schuit FC, Huypens P, Heimberg H, Pipeleers DG.

Diabetes. 2001 Jan;50(1):1-11. Review.PMID: 11147773 [PubMed - indexed for MEDLINE]Related articlesFree article

Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.

Dillon JS, Yaney GC, Zhou Y, Voilley N, Bowen S, Chipkin S, Bliss CR, Schultz V, Schuit FC, Prentki M, Waxman DJ, Corkey BE.

Diabetes. 2000 Dec;49(12):2012-20.PMID: 11118002 [PubMed - indexed for MEDLINE]Related articlesFree article

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.

Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK.

Clin Exp Immunol. 1997 Oct;110(1):98-103.PMID: 9353155 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.

Vandewalle CL, Coeckelberghs MI, De Leeuw IH, Du Caju MV, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1556-61.PMID: 9314635 [PubMed - indexed for MEDLINE]Related articles

Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.

Vandewalle CL, Falorni A, Lernmark A, Goubert P, Dorchy H, Coucke W, Semakula C, Van der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1547-52.PMID: 9314633 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced B-cell recruitment and the expression of hexokinase isoenzymes.

Schuit FC, De Vos A, Moens K, Quartier E, Heimberg H.

Adv Exp Med Biol. 1997;426:259-66. Review. No abstract available. PMID: 9544283 [PubMed - indexed for MEDLINE]Related articles

Is GLUT2 required for glucose sensing?

Schuit FC.

Diabetologia. 1997 Jan;40(1):104-11. Review. No abstract available. PMID: 9028726 [PubMed - indexed for MEDLINE]Related articles

Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells.

Ling Z, Kiekens R, Mahler T, Schuit FC, Pipeleers-Marichal M, Sener A, Kloppel G, Malaisse WJ, Pipeleers DG.

Diabetes. 1996 Dec;45(12):1774-82.PMID: 8922365 [PubMed - indexed for MEDLINE]Related articles

Abnormal circulating pancreatic enzyme activities in more than twenty-five percent of recent-onset insulin-dependent diabetic patients: association of hyperlipasemia with high-titer islet cell antibodies. Belgian Diabetes Registry.

Semakula C, Vandewalle CL, Van Schravendijk CF, Sodoyez JC, Schuit FC, Foriers A, Falorni A, Craen M, Decraene P, Pipeleers DG, Gorus FK.

Pancreas. 1996 May;12(4):321-33.PMID: 8740397 [PubMed - indexed for MEDLINE]Related articles

Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells.

Schuit FC.

Horm Res. 1996;46(3):99-106. Review.PMID: 8894663 [PubMed - indexed for MEDLINE]Related articles

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DAQ1*0301-DQB1*0302 in siblings of patients with type 1 (insulin-dependent) diabetes mellitus. Belgian Diabetes Registry.

Gorus FK, Vandewalle CL, Dorchy H, Van Crombrugge P, Schuit FC, Pipeleers DG.

J Clin Endocrinol Metab. 1994 May;78(5):1172-8.PMID: 8175975 [PubMed - indexed for MEDLINE]Related articles

Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.

Vandewalle CL, Decraene T, Schuit FC, De Leeuw IH, Pipeleers DG, Gorus FK.

Diabetologia. 1993 Nov;36(11):1155-62.PMID: 8270130 [PubMed - indexed for MEDLINE]Related articles

5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.

van der Auwera BJ, Heimberg H, Schrevens AF, van Waeyenberge C, Flament J, Schuit FC.

Diabetes. 1993 Jun;42(6):851-4.PMID: 8495808 [PubMed - indexed for MEDLINE]Related articles

Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.

Heimberg H, Nagy ZP, Somers G, De Leeuw I, Schuit FC.

Hum Immunol. 1992 Jan;33(1):10-7.PMID: 1548146 [PubMed - indexed for MEDLINE]Related articles

Measuring the balance between insulin synthesis and insulin release.

Schuit FC, Kiekens R, Pipeleers DG.

Biochem Biophys Res Commun. 1991 Aug 15;178(3):1182-7.PMID: 1872837 [PubMed - indexed for MEDLINE]Related articles

Preferential stimulation by glucose of its oxidation relative to glycolysis in purified insulin-producing cells.

De Vos A, Schuit FC, Malaisse WJ.

Biochem Int. 1991 May;24(1):117-21.PMID: 1768250 [PubMed - indexed for MEDLINE]Related articles

Sensitivity of rat pancreatic A and B cells to somatostatin.

Schuit FC, Derde MP, Pipeleers DG.

Diabetologia. 1989 Mar;32(3):207-12.PMID: 2568961 [PubMed - indexed for MEDLINE]Related articles

Interaction of sulfonylureas with pancreatic beta-cells. A study with glyburide.

Gorus FK, Schuit FC, In't Veld PA, Gepts W, Pipeleers DG.

Diabetes. 1988 Aug;37(8):1090-5.PMID: 2839387 [PubMed - indexed for MEDLINE]Related articles

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells.

Schuit FC, In't Veld PA, Pipeleers DG.

Proc Natl Acad Sci U S A. 1988 Jun;85(11):3865-9.PMID: 3287379 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in adrenergic recognition by pancreatic A and B cells.

Schuit FC, Pipeleers DG.

Science. 1986 May 16;232(4752):875-7.PMID: 2871625 [PubMed - indexed for MEDLINE]Related articles

Interplay of nutrients and hormones in the regulation of insulin release.

Pipeleers DG, Schuit FC, in't Veld PA, Maes E, Hooghe-Peters EL, Van de Winkel M, Gepts W.

Endocrinology. 1985 Sep;117(3):824-33.PMID: 2862021 [PubMed - indexed for MEDLINE]Related articles

Interplay of nutrients and hormones in the regulation of glucagon release.

Pipeleers DG, Schuit FC, Van Schravendijk CF, Van de Winkel M.

Endocrinology. 1985 Sep;117(3):817-23.PMID: 2862020 [PubMed - indexed for MEDLINE]Related articles

A new in vitro model for the study of pancreatic A and B cells.

Pipeleers DG, in't Veld PA, Van de Winkel M, Maes E, Schuit FC, Gepts W.

Endocrinology. 1985 Sep;117(3):806-16.PMID: 2862019 [PubMed - indexed for MEDLINE]Related articles

Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell.

Schuit FC, Pipeleers DG.

Endocrinology. 1985 Sep;117(3):834-40.PMID: 2410241 [PubMed - indexed for MEDLINE]Related articles