PubMed

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. Epub 2009 Oct 9.PMID: 19819943 [PubMed - in process]Related articles

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7. Epub 2009 Aug 18.PMID: 19706465 [PubMed - indexed for MEDLINE]Related articles

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis.

Arijs I, Li K, Toedter G, Quintens R, Van Lommel L, Van Steen K, Leemans P, De Hertogh G, Lemaire K, Ferrante M, Schnitzler F, Thorrez L, Ma K, Song XY, Marano C, Van Assche G, Vermeire S, Geboes K, Schuit F, Baribaud F, Rutgeerts P.

Gut. 2009 Dec;58(12):1612-9. Epub 2009 Aug 20.PMID: 19700435 [PubMed - in process]Related articles

Testing the hypothesis of tissue selectivity: the intersection-union test and a Bayesian approach.

Van Deun K, Hoijtink H, Thorrez L, Van Lommel L, Schuit F, Van Mechelen I.

Bioinformatics. 2009 Oct 1;25(19):2588-94. Epub 2009 Aug 11.PMID: 19671693 [PubMed - in process]Related articlesFree article

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

Chromosome instability is common in human cleavage-stage embryos.

Vanneste E, Voet T, Le Caignec C, Ampe M, Konings P, Melotte C, Debrock S, Amyere M, Vikkula M, Schuit F, Fryns JP, Verbeke G, D'Hooghe T, Moreau Y, Vermeesch JR.

Nat Med. 2009 May;15(5):577-83. Epub 2009 Apr 26.PMID: 19396175 [PubMed - indexed for MEDLINE]Related articles

Evidence for co-evolution between human microRNAs and Alu-repeats.

Lehnert S, Van Loo P, Thilakarathne PJ, Marynen P, Verbeke G, Schuit FC.

PLoS One. 2009;4(2):e4456. Epub 2009 Feb 11.PMID: 19209240 [PubMed - indexed for MEDLINE]Related articlesFree article

In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression.

Van Vaerenbergh I, Van Lommel L, Ghislain V, In't Veld P, Schuit F, Fatemi HM, Devroey P, Bourgain C.

Hum Reprod. 2009 May;24(5):1085-91. Epub 2009 Jan 27.PMID: 19176542 [PubMed - indexed for MEDLINE]Related articles

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.

Bensellam M, Van Lommel L, Overbergh L, Schuit FC, Jonas JC.

Diabetologia. 2009 Mar;52(3):463-76. Epub 2009 Jan 23.PMID: 19165461 [PubMed - indexed for MEDLINE]Related articles

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.

Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M, Delplanque J, Lobbens S, Rocheleau G, Durand E, De Graeve F, Chèvre JC, Borch-Johnsen K, Hartikainen AL, Ruokonen A, Tichet J, Marre M, Weill J, Heude B, Tauber M, Lemaire K, Schuit F, Elliott P, Jørgensen T, Charpentier G, Hadjadj S, Cauchi S, Vaxillaire M, Sladek R, Visvikis-Siest S, Balkau B, Lévy-Marchal C, Pattou F, Meyre D, Blakemore AI, Jarvelin MR, Walley AJ, Hansen T, Dina C, Pedersen O, Froguel P.

Nat Genet. 2009 Jan;41(1):89-94. Epub 2008 Dec 7.PMID: 19060909 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. Epub 2008 Aug 21.PMID: 18719127 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.

Louagie E, Taylor NA, Flamez D, Roebroek AJ, Bright NA, Meulemans S, Quintens R, Herrera PL, Schuit F, Van de Ven WJ, Creemers JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12319-24. Epub 2008 Aug 19.PMID: 18713856 [PubMed - indexed for MEDLINE]Related articlesFree article

No REST for healthy beta cells.

Thiel G, Schuit F.

Diabetologia. 2008 Aug;51(8):1343-6. No abstract available. PMID: 18493735 [PubMed - indexed for MEDLINE]Related articles

Why expression of some genes is disallowed in beta-cells.

Quintens R, Hendrickx N, Lemaire K, Schuit F.

Biochem Soc Trans. 2008 Jun;36(Pt 3):300-5.PMID: 18481946 [PubMed - indexed for MEDLINE]Related articles

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proença C, Marchand M, Hartikainen AL, Sovio U, De Graeve F, Rung J, Vaxillaire M, Tichet J, Marre M, Balkau B, Weill J, Elliott P, Jarvelin MR, Meyre D, Polychronakos C, Dina C, Sladek R, Froguel P.

Science. 2008 May 23;320(5879):1085-8. Epub 2008 May 1.PMID: 18451265 [PubMed - indexed for MEDLINE]Related articlesFree article

Using ribosomal protein genes as reference: a tale of caution.

Thorrez L, Van Deun K, Tranchevent LC, Van Lommel L, Engelen K, Marchal K, Moreau Y, Van Mechelen I, Schuit F.

PLoS One. 2008 Mar 26;3(3):e1854.PMID: 18365009 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell replication by loosening the brakes of glucagon-like peptide-1 receptor signaling.

Schuit FC, Drucker DJ.

Diabetes. 2008 Mar;57(3):529-31. No abstract available. PMID: 18305147 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest.

Ekici M, Hohl M, Schuit F, Martínez-Serrano A, Thiel G.

J Biol Chem. 2008 Apr 4;283(14):9257-68. Epub 2008 Jan 30.PMID: 18234667 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-alpha-enolase antibodies in patients with inflammatory Bowel disease.

Vermeulen N, Arijs I, Joossens S, Vermeire S, Clerens S, Van den Bergh K, Michiels G, Arckens L, Schuit F, Van Lommel L, Rutgeerts P, Bossuyt X.

Clin Chem. 2008 Mar;54(3):534-41. Epub 2008 Jan 24.PMID: 18218721 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.

Nat Genet. 2008 Feb;40(2):170-80. Epub 2008 Jan 6.PMID: 18176562 [PubMed - indexed for MEDLINE]Related articles

Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.

Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA.

Cell Metab. 2007 Nov;6(5):406-13.PMID: 17983586 [PubMed - indexed for MEDLINE]Related articles

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.

Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipilä I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J.

Am J Hum Genet. 2007 Sep;81(3):467-74. Epub 2007 Jul 26.PMID: 17701893 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

Elouil H, Bensellam M, Guiot Y, Vander Mierde D, Pascal SM, Schuit FC, Jonas JC.

Diabetologia. 2007 Jul;50(7):1442-52. Epub 2007 May 12.PMID: 17497122 [PubMed - indexed for MEDLINE]Related articles

Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release.

Martens GA, Vervoort A, Van de Casteele M, Stangé G, Hellemans K, Van Thi HV, Schuit F, Pipeleers D.

J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.PMID: 17491019 [PubMed - indexed for MEDLINE]Related articlesFree article

Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.

Van Lommel L, Janssens K, Quintens R, Tsukamoto K, Vander Mierde D, Lemaire K, Denef C, Jonas JC, Martens G, Pipeleers D, Schuit FC.

Diabetes. 2006 Dec;55(12):3214-20.PMID: 17130463 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC.

Endocrinology. 2007 Feb;148(2):609-17. Epub 2006 Nov 2.PMID: 17082262 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion.

Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M.

J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206. Epub 2006 Sep 19.PMID: 16984975 [PubMed - indexed for MEDLINE]Related articlesFree article

A glucose sensor role for glucokinase in anterior pituitary cells.

Zelent D, Golson ML, Koeberlein B, Quintens R, van Lommel L, Buettger C, Weik-Collins H, Taub R, Grimsby J, Schuit F, Kaestner KH, Matschinsky FM.

Diabetes. 2006 Jul;55(7):1923-9.PMID: 16804059 [PubMed - indexed for MEDLINE]Related articlesFree article

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Fransson U, Rosengren AH, Schuit FC, Renström E, Mulder H.

Diabetologia. 2006 Jul;49(7):1578-86. Epub 2006 Apr 26.PMID: 16752176 [PubMed - indexed for MEDLINE]Related articles

10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?

Schuit F, Halban P, Rhodes C.

Diabetologia. 2005 Nov;48(11):R93-101. No abstract available. PMID: 16372395 [PubMed - indexed for MEDLINE]Related articles

Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis.

Venken K, Schuit F, Van Lommel L, Tsukamoto K, Kopchick JJ, Coschigano K, Ohlsson C, Movérare S, Boonen S, Bouillon R, Vanderschueren D.

J Bone Miner Res. 2005 Dec;20(12):2138-49. Epub 2005 Aug 8.PMID: 16294267 [PubMed - indexed for MEDLINE]Related articles

Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin.

Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renström E, Schuit FC.

Diabetes. 2005 Jul;54(7):2132-42.PMID: 15983215 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.

Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ.

Nat Med. 2005 Jul;11(7):757-64. Epub 2005 Jun 26.PMID: 15980866 [PubMed - indexed for MEDLINE]Related articles

Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout.

Bardoux P, Zhang P, Flamez D, Perilhou A, Lavin TA, Tanti JF, Hellemans K, Gomas E, Godard C, Andreelli F, Buccheri MA, Kahn A, Le Marchand-Brustel Y, Burcelin R, Schuit F, Vasseur-Cognet M.

Diabetes. 2005 May;54(5):1357-63.PMID: 15855320 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.

Beauvois MC, Arredouani A, Jonas JC, Rolland JF, Schuit F, Henquin JC, Gilon P.

J Physiol. 2004 Aug 15;559(Pt 1):141-56. Epub 2004 Jun 24.PMID: 15218077 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture.

Lardon J, De Breuck S, Rooman I, Van Lommel L, Kruhøffer M, Orntoft T, Schuit F, Bouwens L.

Hepatology. 2004 Jun;39(6):1499-507.PMID: 15185290 [PubMed - indexed for MEDLINE]Related articles

Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness.

Delmeire D, Flamez D, Moens K, Hinke SA, Van Schravendijk C, Pipeleers D, Schuit F.

Biochem Pharmacol. 2004 Jul 1;68(1):33-9.PMID: 15183115 [PubMed - indexed for MEDLINE]Related articles

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.

Hinke SA, Hellemans K, Schuit FC.

J Physiol. 2004 Jul 15;558(Pt 2):369-80. Epub 2004 Jun 4. Review.PMID: 15181163 [PubMed - indexed for MEDLINE]Related articlesFree article

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids.

Hellemans K, Verbuyst P, Quartier E, Schuit F, Rombouts K, Chandraratna RA, Schuppan D, Geerts A.

Hepatology. 2004 Jan;39(1):97-108.PMID: 14752828 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene.

Boushey RP, Abadir A, Flamez D, Baggio LL, Li Y, Berger V, Marshall BA, Finegood D, Wang TC, Schuit F, Drucker DJ.

Gastroenterology. 2003 Oct;125(4):1164-74.PMID: 14517799 [PubMed - indexed for MEDLINE]Related articles

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

Ling Z, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D.

Diabetes. 2003 Oct;52(10):2497-502.PMID: 14514632 [PubMed - indexed for MEDLINE]Related articlesFree article

Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.

Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F.

Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.PMID: 13680124 [PubMed - indexed for MEDLINE]Related articles

PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.

Hellemans K, Rombouts K, Quartier E, Dittié AS, Knorr A, Michalik L, Rogiers V, Schuit F, Wahli W, Geerts A.

J Lipid Res. 2003 Feb;44(2):280-95. Epub 2002 Nov 16.PMID: 12576510 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Flamez D, Mu J, Wojtaszewski JF, Schuit FC, Birnbaum M, Richter E, Burcelin R, Vaulont S.

Biochem Soc Trans. 2003 Feb;31(Pt 1):216-9. Review.PMID: 12546688 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

Hellemans K, Michalik L, Dittie A, Knorr A, Rombouts K, De Jong J, Heirman C, Quartier E, Schuit F, Wahli W, Geerts A.

Gastroenterology. 2003 Jan;124(1):184-201.PMID: 12512042 [PubMed - indexed for MEDLINE]Related articles

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.

Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S.

J Clin Invest. 2003 Jan;111(1):91-8.PMID: 12511592 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2 autoantibodies predict impending type I diabetes in siblings of patients.

Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12.PMID: 12488955 [PubMed - indexed for MEDLINE]Related articles

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells.

Schuit F, Flamez D, De Vos A, Pipeleers D.

Diabetes. 2002 Dec;51 Suppl 3:S326-32. Review.PMID: 12475771 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role for cataplerosis via citrate in glucose-regulated insulin release.

Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit FC.

Diabetes. 2002 Jul;51(7):2018-24.PMID: 12086928 [PubMed - indexed for MEDLINE]Related articlesFree article