PubMed

Crystal Structures of an Oligopeptide Binding Protein from the Biosynthetic Pathway of the beta-Lactamase Inhibitor Clavulanic Acid.

Mackenzie AK, Valegard K, Iqbal A, Caines ME, Kershaw NJ, Jensen SE, Schofield CJ, Andersson I.

J Mol Biol. 2009 Nov 23. [Epub ahead of print]PMID: 19941870 [PubMed - as supplied by publisher]

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N{varepsilon}-dimethyl lysine demethylase.

Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ.

Hum Mol Genet. 2009 Oct 19. [Epub ahead of print]PMID: 19843542 [PubMed - as supplied by publisher]Related articles

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ.

Chem Commun (Camb). 2009 Nov 14;(42):6376-8. Epub 2009 Sep 28.PMID: 19841782 [PubMed - in process]Related articles

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Mecinović J, Loenarz C, Chowdhury R, Schofield CJ.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. Epub 2009 Sep 6.PMID: 19775891 [PubMed - in process]Related articles

Therapeutic Manipulation of the HIF Hydroxylases.

Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM, Schofield CJ.

Antioxid Redox Signal. 2009 Sep 15. [Epub ahead of print]PMID: 19754349 [PubMed - as supplied by publisher]Related articles

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ.

J Med Chem. 2009 Oct 8;52(19):6097-106.PMID: 19731939 [PubMed - indexed for MEDLINE]Related articles

Decreasing amputation rates in patients with diabetes-a population-based study.

Schofield CJ, Yu N, Jain AS, Leese GP.

Diabet Med. 2009 Aug;26(8):773-7.PMID: 19709146 [PubMed - in process]Related articles

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD.

PLoS Genet. 2009 Aug;5(8):e1000599. Epub 2009 Aug 14.PMID: 19680540 [PubMed - indexed for MEDLINE]Related articlesFree article

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ.

J Mol Biol. 2009 Oct 2;392(4):994-1006. Epub 2009 Jul 30.PMID: 19646994 [PubMed - indexed for MEDLINE]Related articles

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ.

Structure. 2009 Jul 15;17(7):981-9.PMID: 19604478 [PubMed - in process]Related articles

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ.

J Biol Chem. 2009 Sep 25;284(39):26831-8. Epub 2009 Jul 9.PMID: 19589782 [PubMed - indexed for MEDLINE]Related articles

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR 3rd, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A.

Science. 2009 Jul 3;325(5936):90-3.PMID: 19574390 [PubMed - indexed for MEDLINE]Related articles

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

Mecinović J, Chowdhury R, Flashman E, Schofield CJ.

Anal Biochem. 2009 Oct 15;393(2):215-21. Epub 2009 Jun 27.PMID: 19563769 [PubMed - indexed for MEDLINE]Related articles

Oxygenase catalyzed 5-methylcytosine hydroxylation.

Loenarz C, Schofield CJ.

Chem Biol. 2009 Jun 26;16(6):580-3.PMID: 19549596 [PubMed - indexed for MEDLINE]Related articles

Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

Ducho C, Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ.

Org Biomol Chem. 2009 Jul 7;7(13):2770-9. Epub 2009 May 11.PMID: 19532994 [PubMed - indexed for MEDLINE]Related articles

Direct analysis of enzyme-catalyzed DNA demethylation.

Karkhanina AA, Mecinović J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN.

Anal Chem. 2009 Jul 15;81(14):5871-5.PMID: 19518090 [PubMed - indexed for MEDLINE]Related articles

Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.

Caines ME, Sorensen JL, Schofield CJ.

Biochem Biophys Res Commun. 2009 Aug 7;385(4):512-7. Epub 2009 May 27.PMID: 19477162 [PubMed - indexed for MEDLINE]Related articles

Classification, evolution, and species groups within the Triatominae.

Schofield CJ, Galvão C.

Acta Trop. 2009 May-Jun;110(2-3):88-100. Review.PMID: 19385053 [PubMed - indexed for MEDLINE]Related articles

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E.

J Med Chem. 2009 May 14;52(9):2799-805.PMID: 19364117 [PubMed - indexed for MEDLINE]Related articles

Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water.

Mecinović J, Hamed RB, Schofield CJ.

Angew Chem Int Ed Engl. 2009;48(15):2796-800.PMID: 19280617 [PubMed - indexed for MEDLINE]Related articles

Evidence for a stereoelectronic effect in human oxygen sensing.

Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ.

Angew Chem Int Ed Engl. 2009;48(10):1784-7.PMID: 19180614 [PubMed - indexed for MEDLINE]Related articles

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

Iqbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TD, Wharton CW, Schofield CJ.

J Am Chem Soc. 2009 Jan 21;131(2):749-57.PMID: 19105697 [PubMed - indexed for MEDLINE]Related articles

Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.

Hamed RB, Batchelar ET, Mecinović J, Claridge TD, Schofield CJ.

Chembiochem. 2009 Jan 26;10(2):246-50. No abstract available. PMID: 19090510 [PubMed - indexed for MEDLINE]Related articles

Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns.

Kaewpet M, Odell B, King MA, Banerji B, Schofield CJ, Claridge TD.

Org Biomol Chem. 2008 Oct 7;6(19):3476-85. Epub 2008 Aug 7.PMID: 19082148 [PubMed - indexed for MEDLINE]Related articles

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.

Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ.

Mol Biosyst. 2009 Jan;5(1):52-8. Epub 2008 Oct 29.PMID: 19081931 [PubMed - indexed for MEDLINE]Related articles

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ.

Chem Commun (Camb). 2008 Dec 21;(47):6393-5. Epub 2008 Nov 5.PMID: 19048166 [PubMed - indexed for MEDLINE]Related articles

Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.

Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ.

Angew Chem Int Ed Engl. 2008;47(48):9322-5. No abstract available. PMID: 18972478 [PubMed - indexed for MEDLINE]Related articles

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ.

J Med Chem. 2008 Nov 27;51(22):7053-6.PMID: 18942826 [PubMed - indexed for MEDLINE]Related articles

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ.

Biochem J. 2008 Dec 15;416(3):387-94.PMID: 18713068 [PubMed - indexed for MEDLINE]Related articles

Trypanosomiasis vector control in Africa and Latin America.

Schofield CJ, Kabayo JP.

Parasit Vectors. 2008 Aug 1;1(1):24.PMID: 18673535 [PubMed - in process]Related articlesFree article

Dynamic states of the DNA repair enzyme AlkB regulate product release.

Bleijlevens B, Shivarattan T, Flashman E, Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ.

EMBO Rep. 2008 Sep;9(9):872-7. Epub 2008 Jul 11.PMID: 18617893 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA.

J Biol Chem. 2008 Sep 19;283(38):25971-8. Epub 2008 Jul 8.PMID: 18611856 [PubMed - indexed for MEDLINE]Related articlesFree article

The human oxygen sensing machinery and its manipulation.

Chowdhury R, Hardy A, Schofield CJ.

Chem Soc Rev. 2008 Jul;37(7):1308-19. Epub 2008 May 27. Review.PMID: 18568157 [PubMed - indexed for MEDLINE]Related articles

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ.

Org Biomol Chem. 2008 Jul 7;6(13):2282-94. Epub 2008 May 7.PMID: 18563261 [PubMed - indexed for MEDLINE]Related articles

Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity.

Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ.

Cell Mol Life Sci. 2008 Aug;65(16):2507-27. Review.PMID: 18470480 [PubMed - indexed for MEDLINE]Related articles

Phylogeography and Genetic Variation of Triatoma dimidiata, the Main Chagas Disease Vector in Central America, and Its Position within the Genus Triatoma.

Bargues MD, Klisiowicz DR, Gonzalez-Candelas F, Ramsey JM, Monroy C, Ponce C, Salazar-Schettino PM, Panzera F, Abad-Franch F, Sousa OE, Schofield CJ, Dujardin JP, Guhl F, Mas-Coma S.

PLoS Negl Trop Dis. 2008 May 7;2(5):e233.PMID: 18461141 [PubMed - in process]Related articlesFree article

Expanding chemical biology of 2-oxoglutarate oxygenases.

Loenarz C, Schofield CJ.

Nat Chem Biol. 2008 Mar;4(3):152-6.PMID: 18277970 [PubMed - indexed for MEDLINE]Related articles

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ.

J Med Chem. 2008 Feb 14;51(3):684-8. Epub 2008 Jan 19.PMID: 18205296 [PubMed - indexed for MEDLINE]Related articles

Macular oedema is not predicted by perifoveal single blot haemorrhages.

Schofield CJ, Ellis JD, Ellingford A, Morris AD, Leese GP.

Diabet Med. 2008 Feb;25(2):129-33. Epub 2008 Jan 14.PMID: 18201214 [PubMed - indexed for MEDLINE]Related articles

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ.

J Biol Chem. 2008 Feb 15;283(7):3808-15. Epub 2007 Dec 5.PMID: 18063574 [PubMed - indexed for MEDLINE]Related articlesFree article

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.

Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ.

ChemMedChem. 2008 Apr;3(4):569-72. No abstract available. PMID: 18058781 [PubMed - indexed for MEDLINE]Related articles

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.

Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ.

DNA Repair (Amst). 2008 Feb 1;7(2):230-8. Epub 2007 Nov 19.PMID: 18006388 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Hewitson KS, Schofield CJ, Ratcliffe PJ.

Methods Enzymol. 2007;435:25-42.PMID: 17998047 [PubMed - indexed for MEDLINE]Related articles

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.PMID: 17991826 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).

Schofield CJ, McDonough MA.

Biochem Soc Trans. 2007 Nov;35(Pt 5):870-5. Review.PMID: 17956235 [PubMed - indexed for MEDLINE]Related articles

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ.

Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5.PMID: 17676039 [PubMed - indexed for MEDLINE]Related articles

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U.

Nature. 2007 Jul 5;448(7149):87-91. Epub 2007 Jun 24.PMID: 17589501 [PubMed - indexed for MEDLINE]Related articles

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2007 Aug 17;282(33):24027-38. Epub 2007 Jun 15.PMID: 17573339 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies.

Borowski T, de Marothy S, Broclawik E, Schofield CJ, Siegbahn PE.

Biochemistry. 2007 Mar 27;46(12):3682-91. Epub 2007 Feb 27.PMID: 17323933 [PubMed - indexed for MEDLINE]Related articles

Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.

Horsfall LE, Garau G, Liénard BM, Dideberg O, Schofield CJ, Frère JM, Galleni M.

Antimicrob Agents Chemother. 2007 Jun;51(6):2136-42. Epub 2007 Feb 16.PMID: 17307979 [PubMed - indexed for MEDLINE]Related articlesFree article