PubMed

Challenges in developing endpoints for type 1 diabetes intervention studies.

Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Fleming GA, Pozzilli P, Little R, Schloot NC, Leslie RD, Skyler JS, Palmer JP.

Diabetes Metab Res Rev. 2009 Nov;25(8):694-704.PMID: 19771545 [PubMed - in process]Related articles

Interferon beta treatment does not induce organ-specific autoantibodies in multiple sclerosis.

Menge T, Schloot NC, Schott M, Hemmer B, Wiendl H, Roden M, Hartung HP, Kieseier BC.

Neurology. 2009 Sep 15;73(11):900-2. No abstract available. PMID: 19752459 [PubMed - indexed for MEDLINE]Related articles

Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients.

Pfleger C, Meierhoff G, Kolb H, Schloot NC; for the p520/521 Study Group.

J Autoimmun. 2009 Sep 9. [Epub ahead of print]PMID: 19744828 [PubMed - as supplied by publisher]Related articles

Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study.

Herder C, Brunner EJ, Rathmann W, Strassburger K, Tabák AG, Schloot NC, Witte DR.

Diabetes Care. 2009 Mar;32(3):421-3. Epub 2008 Dec 10.PMID: 19073760 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes classification: grey zones, sound and smoke: Action LADA 1.

Leslie RD, Kolb H, Schloot NC, Buzzetti R, Mauricio D, De Leiva A, Yderstraede K, Sarti C, Thivolet C, Hadden D, Hunter S, Schernthaner G, Scherbaum W, Williams R, Pozzilli P.

Diabetes Metab Res Rev. 2008 Oct;24(7):511-9. Review.PMID: 18615859 [PubMed - indexed for MEDLINE]Related articles

Distinct monocyte gene-expression profiles in autoimmune diabetes.

Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJ, de Ridder D, Aanstoot HJ, Lam-Tse WK, de Wit H, de Herder C, Drexhage RC, Menart B, Leslie RD, Drexhage HA; LADA Consortium.

Diabetes. 2008 Oct;57(10):2768-73. Epub 2008 Jul 3.PMID: 18599519 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, Kolb H, Roep BO, Mortensen HB, Schloot NC; Hvidøre Study Group On Childhood Diabetes.

Clin Immunol. 2008 Jul;128(1):57-65. Epub 2008 Apr 22.PMID: 18434252 [PubMed - indexed for MEDLINE]Related articles

Circulating chemokines in patients with autoimmune thyroid diseases.

Domberg J, Liu C, Papewalis C, Pfleger C, Xu K, Willenberg HS, Hermsen D, Scherbaum WA, Schloot NC, Schott M.

Horm Metab Res. 2008 Jun;40(6):416-21. Epub 2008 Apr 14. Erratum in: Horm Metab Res. 2008 Jun;40(6):433. Chao, L [corrected to Liu, C]. PMID: 18415893 [PubMed - indexed for MEDLINE]Related articles

Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.

Pfleger C, Mortensen HB, Hansen L, Herder C, Roep BO, Hoey H, Aanstoot HJ, Kocova M, Schloot NC; Hvidøre Study Group on Childhood Diabetes.

Diabetes. 2008 Apr;57(4):929-37. Epub 2008 Feb 25.PMID: 18299313 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficient heat shock protein 70 response to stress in leukocytes at onset of type 1 diabetes.

Burkart V, Germaschewski L, Schloot NC, Bellmann K, Kolb H.

Biochem Biophys Res Commun. 2008 May 2;369(2):421-5. Epub 2008 Feb 20.PMID: 18282468 [PubMed - indexed for MEDLINE]Related articles

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.

Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T.

Diabet Med. 2007 May;24(5):512-20. Epub 2007 Mar 22.PMID: 17381505 [PubMed - indexed for MEDLINE]Related articles

Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.

Schloot NC, Meierhoff G, Lengyel C, Vándorfi G, Takács J, Pánczél P, Barkai L, Madácsy L, Oroszlán T, Kovács P, Sütö G, Battelino T, Hosszufalusi N, Jermendy G.

Diabetes Metab Res Rev. 2007 May;23(4):276-85.PMID: 17103487 [PubMed - indexed for MEDLINE]Related articles

Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.

Alizadeh BZ, Hanifi-Moghaddam P, Eerligh P, van der Slik AR, Kolb H, Kharagjitsingh AV, Pereira Arias AM, Ronkainen M, Knip M, Bonfanti R, Bonifacio E, Devendra D, Wilkin T, Giphart MJ, Koeleman BP, Nolsøe R, Mandrup Poulsen T, Schloot NC, Roep BO; DIABMARKER Study Group.

Clin Exp Immunol. 2006 Sep;145(3):480-4.PMID: 16907917 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.

Zhernakova A, Alizadeh BZ, Eerligh P, Hanifi-Moghaddam P, Schloot NC, Diosdado B, Wijmenga C, Roep BO, Koeleman BP.

Genes Immun. 2006 Oct;7(7):544-9. Epub 2006 Jul 20.PMID: 16855620 [PubMed - indexed for MEDLINE]Related articles

Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus.

Hanifi-Moghaddam P, Kappler S, Seissler J, Müller-Scholze S, Martin S, Roep BO, Strassburger K, Kolb H, Schloot NC.

Diabet Med. 2006 Feb;23(2):156-63.PMID: 16433713 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent induction of IL-6 by plant-derived proteases in vitro.

Rose B, Herder C, Löffler H, Meierhoff G, Schloot NC, Walz M, Martin S.

Clin Exp Immunol. 2006 Jan;143(1):85-92.PMID: 16367938 [PubMed - indexed for MEDLINE]Related articlesFree article

Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus.

Naik RG, Beckers C, Wentwoord R, Frenken A, Duinkerken G, Brooks-Worrell B, Schloot NC, Palmer JP, Roep BO.

J Autoimmun. 2004 Aug;23(1):55-61.PMID: 15236753 [PubMed - indexed for MEDLINE]Related articles

[Prerenal kidney failure in type 1 diabetes mellitus]

Schloot NC, Hübinger A, Scherbaum WA.

Dtsch Med Wochenschr. 2003 Dec 5;128(49):2588-90. German. PMID: 14655075 [PubMed - indexed for MEDLINE]Related articles

Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.

Schloot NC, Meierhoff G, Karlsson Faresjö M, Ott P, Putnam A, Lehmann P, Gottlieb P, Roep BO, Peakman M, Tree T.

J Autoimmun. 2003 Dec;21(4):365-76.PMID: 14624759 [PubMed - indexed for MEDLINE]Related articles

An association of autoantibody status and serum cytokine levels in type 1 diabetes.

Hanifi-Moghaddam P, Schloot NC, Kappler S, Seissler J, Kolb H.

Diabetes. 2003 May;52(5):1137-42.PMID: 12716743 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes.

Meierhoff G, Ott PA, Lehmann PV, Schloot NC.

Diabetes Metab Res Rev. 2002 Sep-Oct;18(5):367-80. Review.PMID: 12397579 [PubMed - indexed for MEDLINE]Related articles

Molecular mimicry in type 1 diabetes: immune cross-reactivity between islet autoantigen and human cytomegalovirus but not Coxsackie virus.

Roep BO, Hiemstra HS, Schloot NC, De Vries RR, Chaudhuri A, Behan PO, Drijfhout JW.

Ann N Y Acad Sci. 2002 Apr;958:163-5.PMID: 12021098 [PubMed - indexed for MEDLINE]Related articles

Serum IFN-gamma and IL-10 levels are associated with disease progression in non-obese diabetic mice.

Schloot NC, Hanifi-Moghaddam P, Goebel C, Shatavi SV, Flohé S, Kolb H, Rothe H.

Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):64-70.PMID: 11921420 [PubMed - indexed for MEDLINE]Related articles

Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart.

Schloot NC, Willemen SJ, Duinkerken G, Drijfhout JW, de Vries RR, Roep BO.

Hum Immunol. 2001 Apr;62(4):299-309.PMID: 11295462 [PubMed - indexed for MEDLINE]Related articles

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.

Hiemstra HS, Schloot NC, van Veelen PA, Willemen SJ, Franken KL, van Rood JJ, de Vries RR, Chaudhuri A, Behan PO, Drijfhout JW, Roep BO.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3988-91.PMID: 11274421 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute onset of type I diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways.

Vreugdenhil GR, Schloot NC, Hoorens A, Rongen C, Pipeleers DG, Melchers WJ, Roep BO, Galama JM.

Clin Infect Dis. 2000 Oct;31(4):1025-31. Epub 2000 Oct 25.PMID: 11049787 [PubMed - indexed for MEDLINE]Related articles

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

Hawkes CJ, Schloot NC, Marks J, Willemen SJ, Drijfhout JW, Mayer EK, Christie MR, Roep BO.

Diabetes. 2000 Mar;49(3):356-66.PMID: 10868956 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of insulin-specific autoreactive T-cells by sulphatide which is variably expressed in beta cells.

Buschard K, Schloot NC, Kaas A, Bock T, Horn T, Fredman P, Roep BO.

Diabetologia. 1999 Oct;42(10):1212-8.PMID: 10525662 [PubMed - indexed for MEDLINE]Related articles

Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes.

Hiemstra HS, van Veelen PA, Geluk A, Schloot NC, de Vries RR, Ottenhoff TH, Roep BO, Drijfhout JW.

Vaccine. 1999 Sep;18(3-4):204-8.PMID: 10506643 [PubMed - indexed for MEDLINE]Related articles

Immune markers for monitoring the progression of autoimmune disease.

Schloot NC, Pozzilli P, Mandrup-Poulsen T.

Diabetes Metab Res Rev. 1999 Mar-Apr;15(2):141-5. Review.PMID: 10362461 [PubMed - indexed for MEDLINE]Related articles

GAD65-Reactive T cells in a non-diabetic stiff-man syndrome patient.

Schloot NC, Batstra MC, Duinkerken G, De Vries RR, Dyrberg T, Chaudhuri A, Behan PO, Roep BO.

J Autoimmun. 1999 Jun;12(4):289-96.PMID: 10330300 [PubMed - indexed for MEDLINE]Related articles

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

Hiemstra HS, van Veelen PA, Schloot NC, Geluk A, van Meijgaarden KE, Willemen SJ, Leunissen JA, Benckhuijsen WE, Amons R, de Vries RR, Roep BO, Ottenhoff TH, Drijfhout JW.

J Immunol. 1998 Oct 15;161(8):4078-82.PMID: 9780178 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DR binding analysis of peptides from islet antigens in IDDM.

Geluk A, van Meijgaarden KE, Schloot NC, Drijfhout JW, Ottenhoff TH, Roep BO.

Diabetes. 1998 Oct;47(10):1594-601.PMID: 9753297 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain.

Schloot NC, Willemen S, Duinkerken G, de Vries RR, Roep BO.

J Autoimmun. 1998 Apr;11(2):169-75.PMID: 9650096 [PubMed - indexed for MEDLINE]Related articles

Islet antigen-specific T cell clones in autoimmune diabetes: from mice to men.

Schloot NC, Roep BO.

Diabetes Metab Rev. 1997 Sep;13(3):127-38. Review. No abstract available. PMID: 9307886 [PubMed - indexed for MEDLINE]Related articles

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects.

Schloot NC, Roep BO, Wegmann D, Yu L, Chase HP, Wang T, Eisenbarth GS.

Diabetologia. 1997 May;40(5):564-72.PMID: 9165225 [PubMed - indexed for MEDLINE]Related articles

T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects.

Schloot NC, Roep BO, Wegmann DR, Yu L, Wang TB, Eisenbarth GS.

Diabetologia. 1997 Mar;40(3):332-8.PMID: 9084973 [PubMed - indexed for MEDLINE]Related articles

Peripheral T cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicity.

Schloot NC, Daniel D, Norbury-Glaser M, Wegmann DR.

J Autoimmun. 1996 Jun;9(3):357-63.PMID: 8816971 [PubMed - indexed for MEDLINE]Related articles