PubMed

The hexosamine biosynthesis pathway is essential for pancreatic beta cell development.

Filhoulaud G, Guillemain G, Scharfmann R.

J Biol Chem. 2009 Sep 4;284(36):24583-94. Epub 2009 Jul 7.PMID: 19586915 [PubMed - indexed for MEDLINE]Related articles

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors.

Ravassard P, Emilie Bricout-Neveu, Hazhouz Y, Pechberty S, Mallet J, Czernichow P, Scharfmann R.

PLoS One. 2009;4(3):e4731. Epub 2009 Mar 6.PMID: 19266046 [PubMed - indexed for MEDLINE]Related articlesFree article

Directing cell differentiation with small-molecule histone deacetylase inhibitors: the example of promoting pancreatic endocrine cells.

Haumaitre C, Lenoir O, Scharfmann R.

Cell Cycle. 2009 Feb 15;8(4):536-44. Epub 2009 Feb 11. Review.PMID: 19197155 [PubMed - indexed for MEDLINE]Related articles

Beta cells within single human islets originate from multiple progenitors.

Scharfmann R, Xiao X, Heimberg H, Mallet J, Ravassard P.

PLoS One. 2008;3(10):e3559. Epub 2008 Oct 29.PMID: 18958289 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell development: the role of intercellular signals.

Scharfmann R, Duvillie B, Stetsyuk V, Attali M, Filhoulaud G, Guillemain G.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:195-200. Review.PMID: 18834447 [PubMed - indexed for MEDLINE]Related articles

Tumour suppressor menin is essential for development of the pancreatic endocrine cells.

Fontanière S, Duvillié B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX.

J Endocrinol. 2008 Nov;199(2):287-98. Epub 2008 Sep 4.PMID: 18772165 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors.

Haumaitre C, Lenoir O, Scharfmann R.

Mol Cell Biol. 2008 Oct;28(20):6373-83. Epub 2008 Aug 18.PMID: 18710955 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of pancreatic development by intercellular signals.

Duvillié B, Stetsyuk V, Filhoulaud G, Guillemain G, Scharfmann R.

Biochem Soc Trans. 2008 Jun;36(Pt 3):276-9. Review.PMID: 18481941 [PubMed - indexed for MEDLINE]Related articles

Neonatal hyperglycaemia and abnormal development of the pancreas.

Flechtner I, Vaxillaire M, Cavé H, Scharfmann R, Froguel P, Polak M.

Best Pract Res Clin Endocrinol Metab. 2008 Feb;22(1):17-40. Review.PMID: 18279778 [PubMed - indexed for MEDLINE]Related articles

Expanding human beta cells.

Scharfmann R.

Diabetologia. 2008 Apr;51(4):692-3. Epub 2008 Feb 15. No abstract available. PMID: 18274727 [PubMed - indexed for MEDLINE]Related articles

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H.

Cell. 2008 Jan 25;132(2):197-207.PMID: 18243096 [PubMed - indexed for MEDLINE]Related articles

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group.

Polak M, Dechaume A, Cavé H, Nimri R, Crosnier H, Sulmont V, de Kerdanet M, Scharfmann R, Lebenthal Y, Froguel P, Vaxillaire M; French ND (Neonatal Diabetes) Study Group.

Diabetes. 2008 Apr;57(4):1115-9. Epub 2008 Jan 2.PMID: 18171712 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

Flechtner I, Vaxillaire M, Cavé H, Scharfmann R, Froguel P, Polak M.

Endocr Dev. 2007;12:86-98.PMID: 17923772 [PubMed - indexed for MEDLINE]Related articles

Pancreatic development as a basis for the definition of new therapies for diabetes.

Scharfmann R.

Endocr Dev. 2007;12:1-11. Review.PMID: 17923764 [PubMed - indexed for MEDLINE]Related articles

MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines.

Baroukh N, Ravier MA, Loder MK, Hill EV, Bounacer A, Scharfmann R, Rutter GA, Van Obberghen E.

J Biol Chem. 2007 Jul 6;282(27):19575-88. Epub 2007 Apr 26.PMID: 17462994 [PubMed - indexed for MEDLINE]Related articlesFree article

Calsenilin is required for endocrine pancreas development in zebrafish.

Stetsyuk V, Peers B, Mavropoulos A, Verbruggen V, Thisse B, Thisse C, Motte P, Duvillié B, Scharfmann R.

Dev Dyn. 2007 Jun;236(6):1517-25.PMID: 17450605 [PubMed - indexed for MEDLINE]Related articlesFree article

New ABCC8 mutations in relapsing neonatal diabetes and clinical features.

Vaxillaire M, Dechaume A, Busiah K, Cavé H, Pereira S, Scharfmann R, de Nanclares GP, Castano L, Froguel P, Polak M; SUR1-Neonatal Diabetes Study Group.

Diabetes. 2007 Jun;56(6):1737-41. Epub 2007 Mar 27.PMID: 17389331 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose is necessary for embryonic pancreatic endocrine cell differentiation.

Guillemain G, Filhoulaud G, Da Silva-Xavier G, Rutter GA, Scharfmann R.

J Biol Chem. 2007 May 18;282(20):15228-37. Epub 2007 Mar 21.PMID: 17376780 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of beta-cell differentiation by the pancreatic mesenchyme.

Attali M, Stetsyuk V, Basmaciogullari A, Aiello V, Zanta-Boussif MA, Duvillie B, Scharfmann R.

Diabetes. 2007 May;56(5):1248-58. Epub 2007 Feb 23.PMID: 17322477 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans.

Zertal-Zidani S, Bounacer A, Scharfmann R.

Diabetologia. 2007 Mar;50(3):585-95. Epub 2007 Jan 13.PMID: 17221210 [PubMed - indexed for MEDLINE]Related articles

How to make beta cells from embryonic cells.

Scharfmann R.

Diabetologia. 2006 Nov;49(11):2535-6. No abstract available. PMID: 17047918 [PubMed - indexed for MEDLINE]Related articles

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.

Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Frühbeck G, Froguel P.

Diabetes. 2006 Oct;55(10):2903-8.PMID: 17003360 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.

Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B.

Diabetologia. 2006 Dec;49(12):2939-47. Epub 2006 Sep 26.PMID: 17001468 [PubMed - indexed for MEDLINE]Related articlesFree article

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.

Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P.

N Engl J Med. 2006 Aug 3;355(5):456-66.PMID: 16885549 [PubMed - indexed for MEDLINE]Related articlesFree article

The mesenchyme controls the timing of pancreatic beta-cell differentiation.

Duvillié B, Attali M, Bounacer A, Ravassard P, Basmaciogullari A, Scharfmann R.

Diabetes. 2006 Mar;55(3):582-9.PMID: 16505219 [PubMed - indexed for MEDLINE]Related articlesFree article

Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas.

Castaing M, Duvillié B, Quemeneur E, Basmaciogullari A, Scharfmann R.

Dev Dyn. 2005 Oct;234(2):339-45.PMID: 16134081 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells.

Castaing M, Guerci A, Mallet J, Czernichow P, Ravassard P, Scharfmann R.

Diabetologia. 2005 Apr;48(4):709-19. Epub 2005 Mar 10.PMID: 15759109 [PubMed - indexed for MEDLINE]Related articles

Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.

Ye F, Duvillié B, Scharfmann R.

Diabetologia. 2005 Feb;48(2):277-81. Epub 2005 Feb 3.PMID: 15690149 [PubMed - indexed for MEDLINE]Related articles

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H.

Lab Invest. 2005 Jan;85(1):65-74.PMID: 15543206 [PubMed - indexed for MEDLINE]Related articlesFree article

[Do pancreatic stem cells exist?]

Scharfmann R.

Med Sci (Paris). 2004 Aug-Sep;20(8-9):732-4. French. No abstract available. PMID: 15361332 [PubMed - indexed for MEDLINE]Related articlesFree article

[What is a pancreatic stem cell?]

Scharfmann R.

Med Sci (Paris). 2003 Jun-Jul;19(6-7):695. French. No abstract available. PMID: 12942438 [PubMed - indexed for MEDLINE]Related articlesFree article

Label-retaining cells in the rat pancreas: location and differentiation potential in vitro.

Duvillié B, Attali M, Aiello V, Quemeneur E, Scharfmann R.

Diabetes. 2003 Aug;52(8):2035-42.PMID: 12882920 [PubMed - indexed for MEDLINE]Related articlesFree article

[Control of pancreatic development]

Scharfmann R, Cras-Méneur C, Basmaciogullari A, Duvillié B.

Journ Annu Diabetol Hotel Dieu. 2003:17-22. Review. French. No abstract available. PMID: 12868297 [PubMed - indexed for MEDLINE]Related articles

Alternative sources of beta cells for cell therapy of diabetes.

Scharfmann R.

Eur J Clin Invest. 2003 Jul;33(7):595-600. Review.PMID: 12814397 [PubMed - indexed for MEDLINE]Related articles

Role for VPAC2 receptor-mediated signals in pancreas development.

Rachdi L, Marie JC, Scharfmann R.

Diabetes. 2003 Jan;52(1):85-92.PMID: 12502497 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of the pancreas in medaka.

Assouline B, Nguyen V, Mahé S, Bourrat F, Scharfmann R.

Mech Dev. 2002 Sep;117(1-2):299-303.PMID: 12204274 [PubMed - indexed for MEDLINE]Related articles

FGFR1-IIIb is a putative marker of pancreatic progenitor cells.

Cras-Méneur C, Scharfmann R.

Mech Dev. 2002 Aug;116(1-2):205-8.PMID: 12128225 [PubMed - indexed for MEDLINE]Related articles

Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation.

Elghazi L, Cras-Méneur C, Czernichow P, Scharfmann R.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3884-9. Epub 2002 Mar 12.PMID: 11891329 [PubMed - indexed for MEDLINE]Related articlesFree article

Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.

Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R.

Development. 2001 Dec;128(24):5109-17.PMID: 11748146 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice.

Castaing M, Péault B, Basmaciogullari A, Casal I, Czernichow P, Scharfmann R.

Diabetologia. 2001 Nov;44(11):2066-76.PMID: 11719839 [PubMed - indexed for MEDLINE]Related articles

Expression of the receptor tyrosine kinase KIT in mature beta-cells and in the pancreas in development.

Rachdi L, El Ghazi L, Bernex F, Panthier JJ, Czernichow P, Scharfmann R.

Diabetes. 2001 Sep;50(9):2021-8.PMID: 11522667 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.

Cras-Méneur C, Elghazi L, Czernichow P, Scharfmann R.

Diabetes. 2001 Jul;50(7):1571-9.PMID: 11423478 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.

Dupont S, Hani EH, Cras-Méneur C, De Matos F, Lobbens S, Lecoeur C, Vaxillaire M, Scharfmann R, Froguel P.

Diabetes. 2001 May;50(5):1219-21.PMID: 11334431 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme.

Scharfmann R.

Diabetologia. 2000 Sep;43(9):1083-92. Review.PMID: 11043853 [PubMed - indexed for MEDLINE]Related articles

Pancreatic pattern of expression of thyrotropin-releasing hormone during rat embryonic development.

Basmaciogullari A, Cras-Meneur C, Czernichow P, Scharfmann R.

J Endocrinol. 2000 Sep;166(3):481-8.PMID: 10974642 [PubMed - indexed for MEDLINE]Related articlesFree article

Early pattern of differentiation in the human pancreas.

Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P.

Diabetes. 2000 Feb;49(2):225-32.PMID: 10868939 [PubMed - indexed for MEDLINE]Related articlesFree article

[Apollinaire Bouchardat Award 1999. Development of endocrine pancreas cells]

Scharfmann R.

Journ Annu Diabetol Hotel Dieu. 1999:47-54. French. No abstract available. PMID: 10732404 [PubMed - indexed for MEDLINE]Related articles

TGF-beta activates genes identified by differential mRNA display in pancreatic rudiments.

Battelino T, Miralles F, Krzisnik C, Scharfmann R, Czernichow P.

Pflugers Arch. 2000;439(3 Suppl):R26-8.PMID: 10653130 [PubMed - indexed for MEDLINE]Related articles

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas.

Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6267-72.PMID: 10339576 [PubMed - indexed for MEDLINE]Related articlesFree article