PubMed

Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection.

Li Q, Smith AJ, Schacker TW, Carlis JV, Duan L, Reilly CS, Haase AT.

J Immunol. 2009 Aug 1;183(3):1975-82. Epub 2009 Jul 13.PMID: 19596987 [PubMed - indexed for MEDLINE]Related articles

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.

Nat Med. 2009 Aug;15(8):893-900. Epub 2009 Jun 21.PMID: 19543283 [PubMed - indexed for MEDLINE]Related articles

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire.

Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11241-5. Epub 2009 Jun 18.PMID: 19541603 [PubMed - indexed for MEDLINE]Related articles

A step ahead on the HIV collaboratory.

Murphy RL, Autran B, Katlama C, Brucker G, Debre P, Calvez V, Clotet B, Clumeck N, Costagliola D, Deeks SG, Dorrell L, Gatell J, Haase A, Klein M, Lazzarin A, McMichael AJ, Papagno L, Schacker TW, Wain-Hobson S, Walker BD, Youle M.

Science. 2009 Jun 5;324(5932):1264-5. No abstract available. PMID: 19498149 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy.

Nies-Kraske E, Schacker TW, Condoluci D, Orenstein J, Brenchley J, Fox C, Daucher M, Dewar R, Urban E, Hill B, Guenaga J, Hoover S, Maldarelli F, Hallahan CW, Horn J, Kottilil S, Chun TW, Folino M, Palmer S, Wiegand A, O'Shea MA, Metcalf JA, Douek DC, Coffin J, Haase A, Fauci AS, Dybul M.

J Infect Dis. 2009 Jun 1;199(11):1648-56.PMID: 19432547 [PubMed - indexed for MEDLINE]Related articles

High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage.

Brenchley JM, Knox KS, Asher AI, Price DA, Kohli LM, Gostick E, Hill BJ, Hage CA, Brahmi Z, Khoruts A, Twigg HL 3rd, Schacker TW, Douek DC.

Mucosal Immunol. 2008 Jan;1(1):49-58.PMID: 19079160 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of secondary lymphatic tissue in immune deficiency of HIV infection.

Schacker T.

AIDS. 2008 Sep;22 Suppl 3:S13-8.PMID: 18845917 [PubMed - indexed for MEDLINE]Related articles

Points of recombination in Epstein-Barr virus (EBV) strain P3HR-1-derived heterogeneous DNA as indexes to EBV DNA recombinogenic events in vivo.

Ikuta K, Srinivas SK, Schacker T, Miyagi J, Scott RS, Sixbey JW.

J Virol. 2008 Dec;82(23):11516-25. Epub 2008 Sep 25.PMID: 18818321 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.

Brenchley JM, Paiardini M, Knox KS, Asher AI, Cervasi B, Asher TE, Scheinberg P, Price DA, Hage CA, Kholi LM, Khoruts A, Frank I, Else J, Schacker T, Silvestri G, Douek DC.

Blood. 2008 Oct 1;112(7):2826-35. Epub 2008 Jul 29.PMID: 18664624 [PubMed - indexed for MEDLINE]Related articlesFree article

Collagen deposition limits immune reconstitution in the gut.

Estes J, Baker JV, Brenchley JM, Khoruts A, Barthold JL, Bantle A, Reilly CS, Beilman GJ, George ME, Douek DC, Haase AT, Schacker TW.

J Infect Dis. 2008 Aug 15;198(4):456-64.PMID: 18598193 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche.

Estes JD, Haase AT, Schacker TW.

Semin Immunol. 2008 Jun;20(3):181-6. Epub 2008 Jul 2. Review.PMID: 18595731 [PubMed - indexed for MEDLINE]Related articlesFree article

ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand.

Weivoda S, Andersen JD, Skogen A, Schlievert PM, Fontana D, Schacker T, Tuite P, Dubinsky JM, Jemmerson R.

J Immunol Methods. 2008 Jul 20;336(1):22-9. Epub 2008 Apr 4.PMID: 18436231 [PubMed - indexed for MEDLINE]Related articles

Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection.

Li Q, Estes JD, Duan L, Jessurun J, Pambuccian S, Forster C, Wietgrefe S, Zupancic M, Schacker T, Reilly C, Carlis JV, Haase AT.

J Infect Dis. 2008 Feb 1;197(3):420-9.PMID: 18199035 [PubMed - indexed for MEDLINE]Related articles

Accuracy of herpes simplex virus detection in liquid-based (SurePath) Papanicolaou tests: a comparison with polymerase chain reaction.

Aslan DL, Pambuccian SE, Prekker FL, Schacker TW, Southern P, Savik K, McKeon D, Gulbahce HE.

Diagn Cytopathol. 2008 Feb;36(2):94-103.PMID: 18181191 [PubMed - indexed for MEDLINE]Related articles

An update on short-course episodic and prevention therapies for herpes genitalis.

Corey L, Bodsworth N, Mindel A, Patel R, Schacker T, Stanberry L.

Herpes. 2007 Jun;14 Suppl 1:5A-11A. Review.PMID: 17877886 [PubMed - indexed for MEDLINE]Related articles

Inguinal lymph node biopsy in patients infected with the human immunodeficiency virus is safe.

Skarda DE, Taylor JH, Chipman JG, Larson M, Baker JV, Schacker TW, Beilman GJ.

Surg Infect (Larchmt). 2007 Apr;8(2):173-8.PMID: 17437362 [PubMed - indexed for MEDLINE]Related articles

Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.

Estes JD, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, Milush JM, Lifson JD, Sodora DL, Carlis JV, Haase AT.

J Infect Dis. 2007 Feb 15;195(4):551-61. Epub 2007 Jan 8.PMID: 17230415 [PubMed - indexed for MEDLINE]Related articles

Microbial translocation is a cause of systemic immune activation in chronic HIV infection.

Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC.

Nat Med. 2006 Dec;12(12):1365-71. Epub 2006 Nov 19.PMID: 17115046 [PubMed - indexed for MEDLINE]Related articles

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.

Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup RA.

J Exp Med. 2006 Oct 2;203(10):2281-92. Epub 2006 Sep 5.PMID: 16954372 [PubMed - indexed for MEDLINE]Related articlesFree article

Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.

Schacker TW, Brenchley JM, Beilman GJ, Reilly C, Pambuccian SE, Taylor J, Skarda D, Larson M, Douek DC, Haase AT.

Clin Vaccine Immunol. 2006 May;13(5):556-60.PMID: 16682476 [PubMed - indexed for MEDLINE]Related articlesFree article

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.

Estes JD, Li Q, Reynolds MR, Wietgrefe S, Duan L, Schacker T, Picker LJ, Watkins DI, Lifson JD, Reilly C, Carlis J, Haase AT.

J Infect Dis. 2006 Mar 1;193(5):703-12. Epub 2006 Jan 30.PMID: 16453267 [PubMed - indexed for MEDLINE]Related articles

Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects.

Krathwohl MD, Schacker TW, Anderson JL.

J Infect Dis. 2006 Feb 15;193(4):494-504. Epub 2006 Jan 19.PMID: 16425128 [PubMed - indexed for MEDLINE]Related articles

Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count.

Schacker TW, Reilly C, Beilman GJ, Taylor J, Skarda D, Krason D, Larson M, Haase AT.

AIDS. 2005 Dec 2;19(18):2169-71.PMID: 16284469 [PubMed - indexed for MEDLINE]Related articles

Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.

Li Q, Lifson JD, Duan L, Schacker TW, Reilly C, Carlis J, Estes JD, Haase AT.

J Infect Dis. 2005 Oct 1;192(7):1269-76. Epub 2005 Aug 25.PMID: 16136472 [PubMed - indexed for MEDLINE]Related articles

HIV binding, penetration, and primary infection in human cervicovaginal tissue.

Maher D, Wu X, Schacker T, Horbul J, Southern P.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11504-9. Epub 2005 Aug 1.PMID: 16061810 [PubMed - indexed for MEDLINE]Related articlesFree article

Ex vivo modeling of oral HIV transmission in human palatine tonsil.

Maher DM, Zhang ZQ, Schacker TW, Southern PJ.

J Histochem Cytochem. 2005 May;53(5):631-42.PMID: 15872056 [PubMed - indexed for MEDLINE]Related articlesFree article

A model system of oral HIV exposure, using human palatine tonsil, reveals extensive binding of HIV infectivity, with limited progression to primary infection.

Maher D, Wu X, Schacker T, Larson M, Southern P.

J Infect Dis. 2004 Dec 1;190(11):1989-97. Epub 2004 Nov 3.PMID: 15529264 [PubMed - indexed for MEDLINE]Related articles

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract.

Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC.

J Exp Med. 2004 Sep 20;200(6):749-59. Epub 2004 Sep 13.PMID: 15365096 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy.

Li Q, Schacker T, Carlis J, Beilman G, Nguyen P, Haase AT.

J Infect Dis. 2004 Feb 15;189(4):572-82. Epub 2004 Feb 5.PMID: 14767808 [PubMed - indexed for MEDLINE]Related articles

Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjects.

DeJesus E, Wald A, Warren T, Schacker TW, Trottier S, Shahmanesh M, Hill JL, Brennan CA; Valacyclovir International HSV Study Group.

J Infect Dis. 2003 Oct 1;188(7):1009-16. Epub 2003 Sep 10. Erratum in: J Infect Dis. 2003 Nov 1;188(9):1404. PMID: 14513421 [PubMed - indexed for MEDLINE]Related articles

Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression.

Schacker T, Zeh J, Hu H, Shaughnessy M, Corey L.

J Infect Dis. 2002 Dec 15;186(12):1718-25. Epub 2002 Nov 22.PMID: 12447756 [PubMed - indexed for MEDLINE]Related articles

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis.

Schacker TW, Nguyen PL, Beilman GJ, Wolinsky S, Larson M, Reilly C, Haase AT.

J Clin Invest. 2002 Oct;110(8):1133-9.PMID: 12393849 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy.

Schacker TW, Nguyen PL, Martinez E, Reilly C, Gatell JM, Horban A, Bakowska E, Berzins B, van Leeuwen R, Wolinsky S, Haase AT, Murphy RL.

J Infect Dis. 2002 Oct 15;186(8):1092-7. Epub 2002 Sep 20.PMID: 12355359 [PubMed - indexed for MEDLINE]Related articles

Imiquimod 5-percent cream does not alter the natural history of recurrent herpes genitalis: a phase II, randomized, double-blind, placebo-controlled study.

Schacker TW, Conant M, Thoming C, Stanczak T, Wang Z, Smith M.

Antimicrob Agents Chemother. 2002 Oct;46(10):3243-8.PMID: 12234851 [PubMed - indexed for MEDLINE]Related articlesFree article

Imiquimod and genital herpes.

Slade HB, Schacker T, Conant M, Thoming C.

Arch Dermatol. 2002 Apr;138(4):534; author reply 534-5. No abstract available. PMID: 11939822 [PubMed - indexed for MEDLINE]Related articles

Concentration-controlled compared with conventional antiretroviral therapy for HIV infection.

Fletcher CV, Anderson PL, Kakuda TN, Schacker TW, Henry K, Gross CR, Brundage RC.

AIDS. 2002 Mar 8;16(4):551-60.PMID: 11872998 [PubMed - indexed for MEDLINE]Related articles

The role of HSV in the transmission and progression of HIV.

Schacker T.

Herpes. 2001 Jul;8(2):46-9. Review.PMID: 11867018 [PubMed - indexed for MEDLINE]Related articlesFree article

Valaciclovir versus aciclovir for herpes simplex virus infection in HIV-infected individuals: two randomized trials.

Conant MA, Schacker TW, Murphy RL, Gold J, Crutchfield LT, Crooks RJ; International Valaciclovir HSV Study Group.

Int J STD AIDS. 2002 Jan;13(1):12-21.PMID: 11802924 [PubMed - indexed for MEDLINE]Related articles

Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS.

Berrey MM, Schacker T, Collier AC, Shea T, Brodie SJ, Mayers D, Coombs R, Krieger J, Chun TW, Fauci A, Self SG, Corey L.

J Infect Dis. 2001 May 15;183(10):1466-75. Epub 2001 Apr 24. Erratum in: J Infect Dis. 2008 Mar 15;197(6):934. PMID: 11319682 [PubMed - indexed for MEDLINE]Related articles

Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection.

Schacker T, Little S, Connick E, Gebhard K, Zhang ZQ, Krieger J, Pryor J, Havlir D, Wong JK, Schooley RT, Richman D, Corey L, Haase AT.

J Infect Dis. 2001 Feb 15;183(4):555-62. Epub 2001 Jan 17.PMID: 11170980 [PubMed - indexed for MEDLINE]Related articles

Pharmacological basis for concentration-controlled therapy with zidovudine, lamivudine, and indinavir.

Kakuda TN, Page LM, Anderson PL, Henry K, Schacker TW, Rhame FS, Acosta EP, Brundage RC, Fletcher CV.

Antimicrob Agents Chemother. 2001 Jan;45(1):236-42.PMID: 11120972 [PubMed - indexed for MEDLINE]Related articlesFree article

Mucosal shedding of human herpesvirus 8 in men.

Pauk J, Huang ML, Brodie SJ, Wald A, Koelle DM, Schacker T, Celum C, Selke S, Corey L.

N Engl J Med. 2000 Nov 9;343(19):1369-77.PMID: 11070101 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy.

Schacker T, Little S, Connick E, Gebhard-Mitchell K, Zhang ZQ, Krieger J, Pryor J, Havlir D, Wong JK, Richman D, Corey L, Haase AT.

J Infect Dis. 2000 Jan;181(1):354-7.PMID: 10608788 [PubMed - indexed for MEDLINE]Related articles

Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection.

Malhotra U, Berrey MM, Huang Y, Markee J, Brown DJ, Ap S, Musey L, Schacker T, Corey L, McElrath MJ.

J Infect Dis. 2000 Jan;181(1):121-31.PMID: 10608758 [PubMed - indexed for MEDLINE]Related articles

Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.

Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, Reimann KA, Reinhart TA, Rogan M, Cavert W, Miller CJ, Veazey RS, Notermans D, Little S, Danner SA, Richman DD, Havlir D, Wong J, Jordan HL, Schacker TW, Racz P, Tenner-Racz K, Letvin NL, Wolinsky S, Haase AT.

Science. 1999 Nov 12;286(5443):1353-7. Erratum in: Science 1999 Dec 17;286(5448):2273. PMID: 10558989 [PubMed - indexed for MEDLINE]Related articlesFree article

Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection.

Musey LK, Krieger JN, Hughes JP, Schacker TW, Corey L, McElrath MJ.

J Infect Dis. 1999 Aug;180(2):278-84.PMID: 10395840 [PubMed - indexed for MEDLINE]Related articles

Reversibility of the pathological changes in the follicular dendritic cell network with treatment of HIV-1 infection.

Zhang ZQ, Schuler T, Cavert W, Notermans DW, Gebhard K, Henry K, Havlir DV, Günthard HF, Wong JK, Little S, Feinberg MB, Polis MA, Schrager LK, Schacker TW, Richman DD, Corey L, Danner SA, Haase AT.

Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5169-72.PMID: 10220437 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential for the transmission of HIV-1 despite highly active antiretroviral therapy.

Haase AT, Schacker TW.

N Engl J Med. 1998 Dec 17;339(25):1846-8. No abstract available. PMID: 9854123 [PubMed - indexed for MEDLINE]Related articles

Biological and virologic characteristics of primary HIV infection.

Schacker TW, Hughes JP, Shea T, Coombs RW, Corey L.

Ann Intern Med. 1998 Apr 15;128(8):613-20.PMID: 9537934 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men.

Schacker T, Zeh J, Hu HL, Hill E, Corey L.

J Infect Dis. 1998 Dec;178(6):1616-22.PMID: 9815213 [PubMed - indexed for MEDLINE]Related articles