PubMed

Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis.

Matheny M, Zhang Y, Shapiro A, Tümer N, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. Epub 2009 Sep 2.PMID: 19726711 [PubMed - in process]Related articles

Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation.

Erdos B, Broxson CS, Cudykier I, Basgut B, Whidden M, Landa T, Scarpace PJ, Tümer N.

Hypertens Res. 2009 Nov;32(11):983-8. Epub 2009 Aug 28.PMID: 19713964 [PubMed - in process]Related articles

Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.

Judge MK, Zhang Y, Scarpace PJ.

J Endocrinol. 2009 Nov;203(2):281-90. Epub 2009 Aug 13.PMID: 19679649 [PubMed - indexed for MEDLINE]Related articles

The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.

Zhang J, Scarpace PJ.

Br J Pharmacol. 2009 Sep;158(2):475-82. Epub 2009 May 6.PMID: 19422379 [PubMed - in process]Related articles

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ.

Mol Ther. 2009 Jun;17(6):980-91. Epub 2009 Mar 10.PMID: 19277011 [PubMed - indexed for MEDLINE]Related articles

Leptin resistance: a prediposing factor for diet-induced obesity.

Scarpace PJ, Zhang Y.

Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R493-500. Epub 2008 Dec 17. Review.PMID: 19091915 [PubMed - indexed for MEDLINE]Related articles

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.

Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1370-5. Epub 2008 Aug 13.PMID: 18703413 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity.

Judge MK, Zhang J, Tümer N, Carter C, Daniels MJ, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R773-80. Epub 2008 Jul 2.PMID: 18596107 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.

Shapiro A, Matheny M, Zhang Y, Tümer N, Cheng KY, Rogrigues E, Zolotukhin S, Scarpace PJ.

Diabetes. 2008 Mar;57(3):614-22. Epub 2007 Dec 17.PMID: 18086903 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.

Tümer N, Erdös B, Matheny M, Cudykier I, Scarpace PJ.

J Hypertens. 2007 Dec;25(12):2471-8.PMID: 17984669 [PubMed - indexed for MEDLINE]Related articles

Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus.

Erdös B, Broxson CS, Landa T, Scarpace PJ, Leeuwenburgh C, Zhang Y, Tümer N.

Exp Gerontol. 2007 Aug;42(8):745-52. Epub 2007 Apr 24.PMID: 17540525 [PubMed - indexed for MEDLINE]Related articlesFree article

Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness.

Li G, Zhang Y, Cheng KY, Scarpace PJ.

Diabetologia. 2007 Jul;50(7):1490-9. Epub 2007 May 16.PMID: 17505816 [PubMed - indexed for MEDLINE]Related articles

Elevated leptin: consequence or cause of obesity?

Scarpace PJ, Zhang Y.

Front Biosci. 2007 May 1;12:3531-44. Review.PMID: 17485319 [PubMed - indexed for MEDLINE]Related articles

Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.

Li G, Zhang Y, Rodrigues E, Zheng D, Matheny M, Cheng KY, Scarpace PJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E252-8. Epub 2007 Mar 27.PMID: 17389713 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.

Scarpace PJ, Matheny M, Zhang Y, Cheng KY, Tümer N.

J Pharmacol Exp Ther. 2007 Feb;320(2):706-12. Epub 2006 Nov 2.PMID: 17082312 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.

Zhang J, Matheny MK, Tümer N, Mitchell MK, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R868-74. Epub 2006 Oct 5.PMID: 17023670 [PubMed - indexed for MEDLINE]Related articles

The role of leptin in leptin resistance and obesity.

Zhang Y, Scarpace PJ.

Physiol Behav. 2006 Jun 30;88(3):249-56. Epub 2006 Jun 16. Review.PMID: 16782141 [PubMed - indexed for MEDLINE]Related articles

Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei.

Erdös B, Broxson CS, King MA, Scarpace PJ, Tümer N.

J Hypertens. 2006 Jan;24(1):109-16.PMID: 16331108 [PubMed - indexed for MEDLINE]Related articles

Circumventing central leptin resistance: lessons from central leptin and POMC gene delivery.

Zhang Y, Scarpace PJ.

Peptides. 2006 Feb;27(2):350-64. Epub 2005 Nov 4. Review.PMID: 16274846 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.

Li G, Zhang Y, Wilsey JT, Scarpace PJ.

Diabetologia. 2005 Nov;48(11):2376-85. Epub 2005 Oct 5.PMID: 16205885 [PubMed - indexed for MEDLINE]Related articles

Oral vanadium enhances the catabolic effects of central leptin in young adult rats.

Wilsey J, Matheny MK, Scarpace PJ.

Endocrinology. 2006 Jan;147(1):493-501. Epub 2005 Sep 29.PMID: 16195403 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity.

Tümer N, Scarpace PJ, Dogan MD, Broxson CS, Matheny M, Yurek DM, Peden CS, Burger C, Muzyczka N, Mandel RJ.

Neurobiol Aging. 2006 Mar;27(3):459-70. Epub 2005 Jun 16.PMID: 15964099 [PubMed - indexed for MEDLINE]Related articles

Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.

Scarpace PJ, Matheny M, Tümer N, Cheng KY, Zhang Y.

Diabetologia. 2005 Jun;48(6):1075-83. Epub 2005 Apr 30.PMID: 15864530 [PubMed - indexed for MEDLINE]Related articles

Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance.

Zhang Y, Matheny M, Tümer N, Scarpace PJ.

Neurobiol Aging. 2004 Nov-Dec;25(10):1349-60.PMID: 15465633 [PubMed - indexed for MEDLINE]Related articles

Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.

Li G, Zhang Y, Wilsey JT, Scarpace PJ.

J Endocrinol. 2004 Jul;182(1):123-32.PMID: 15225137 [PubMed - indexed for MEDLINE]Related articlesFree article

Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression.

Wilsey J, Scarpace PJ.

J Endocrinol. 2004 May;181(2):297-306.PMID: 15128278 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression.

Prima V, Tennant M, Gorbatyuk OS, Muzyczka N, Scarpace PJ, Zolotukhin S.

Endocrinology. 2004 Apr;145(4):2035-45. Epub 2004 Jan 8.PMID: 14715713 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.

Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace PJ, Zolotukhin S.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14217-22. Epub 2003 Nov 14.PMID: 14617771 [PubMed - indexed for MEDLINE]Related articlesFree article

Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity.

Wilsey J, Zolotukhin S, Prima V, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1011-20.PMID: 14557234 [PubMed - indexed for MEDLINE]Related articles

Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.

Li G, Mobbs CV, Scarpace PJ.

Diabetes. 2003 Aug;52(8):1951-7.PMID: 12882910 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II.

Scarpace PJ, Matheny M, Zolotukhin S, Tümer N, Zhang Y.

Neuropharmacology. 2003 Aug;45(2):211-9.PMID: 12842127 [PubMed - indexed for MEDLINE]Related articles

Repeated fasting/refeeding elevates plasma leptin without increasing fat mass in rats.

Kim YW, Scarpace PJ.

Physiol Behav. 2003 Mar;78(3):459-64.PMID: 12676282 [PubMed - indexed for MEDLINE]Related articles

Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats.

Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ.

Neuroscience. 2002;115(3):879-89.PMID: 12435426 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses.

Wilsey J, Zolotukhin S, Prima V, Shek EW, Matheny MK, Scarpace PJ.

Gene Ther. 2002 Nov;9(22):1492-9.PMID: 12407421 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting.

Zhang Y, Matheny M, Zolotukhin S, Tumer N, Scarpace PJ.

Biochim Biophys Acta. 2002 Oct 10;1584(2-3):115-22.PMID: 12385894 [PubMed - indexed for MEDLINE]Related articles

Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinemia in rats.

Zhang Y, Wilsey JT, Frase CD, Matheny MM, Bender BS, Zolotukhin S, Scarpace PJ.

J Endocrinol. 2002 Sep;174(3):455-61.PMID: 12208666 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance.

Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tümer N.

Endocrinology. 2002 Aug;143(8):3026-35.PMID: 12130569 [PubMed - indexed for MEDLINE]Related articlesFree article

Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats.

Scarpace PJ, Matheny M, Zhang Y, Tümer N, Frase CD, Shek EW, Hong B, Prima V, Zolotukhin S.

Neuropharmacology. 2002 Mar;42(4):548-61.PMID: 11955525 [PubMed - indexed for MEDLINE]Related articles

Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats.

Borst SE, Snellen HG, Ross H, Scarpace PJ, Kim YW.

Biochem Biophys Res Commun. 2002 Mar 1;291(3):722-6.PMID: 11855850 [PubMed - indexed for MEDLINE]Related articles

Peripheral and hypothalamic leptin resistance with age-related obesity.

Scarpace PJ, Tümer N.

Physiol Behav. 2001 Nov-Dec;74(4-5):721-7.PMID: 11790435 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of uncoupling protein-2 gene expression in L6 myotubes.

Hatakeyama Y, Scarpace PJ.

Int J Obes Relat Metab Disord. 2001 Nov;25(11):1619-24.PMID: 11753581 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats.

Scarpace PJ, Matheny M, Tümer N.

Neuroscience. 2001;104(4):1111-7.PMID: 11457594 [PubMed - indexed for MEDLINE]Related articles

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.

Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS.

Regul Pept. 2001 Jun 15;99(2-3):69-77.PMID: 11384767 [PubMed - indexed for MEDLINE]Related articles

Mechanism for obesity-induced increase in myocardial lipid peroxidation.

Vincent HK, Powers SK, Dirks AJ, Scarpace PJ.

Int J Obes Relat Metab Disord. 2001 Mar;25(3):378-88.PMID: 11319636 [PubMed - indexed for MEDLINE]Related articlesFree article

Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats.

Koller MM, Purushotham KR, Maeda N, Scarpace PJ, Humphreys-Beher MG.

Life Sci. 2000 Dec 15;68(4):445-55.PMID: 11205893 [PubMed - indexed for MEDLINE]Related articles

An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats.

Koller MM, Cowman RA, Humphreys-Beher MG, Scarpace PJ.

Exp Gerontol. 2001 Jan;36(1):141-57.PMID: 11162918 [PubMed - indexed for MEDLINE]Related articles

Uncoupling proteins 2 and 3 with age: regulation by fasting and beta3-adrenergic agonist treatment.

Scarpace PJ, Kumar MV, Li H, Tümer N.

J Gerontol A Biol Sci Med Sci. 2000 Dec;55(12):B588-92.PMID: 11129388 [PubMed - indexed for MEDLINE]Related articles

An analysis of submandibular salivary gland function with desipramine and age in female NIA Fischer 344 rats.

Koller MM, Cowman RA, Humphreys-Beher MG, Scarpace PJ.

Mech Ageing Dev. 2000 Nov 15;119(3):131-47.PMID: 11080533 [PubMed - indexed for MEDLINE]Related articles

Desipramine changes salivary gland function, oral microbiota, and oral health in rats.

Koller MM, Maeda N, Scarpace PJ, Humphreys-Beher MG.

Eur J Pharmacol. 2000 Nov 10;408(1):91-8.PMID: 11070187 [PubMed - indexed for MEDLINE]Related articles

Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats.

Shek EW, Scarpace PJ.

Regul Pept. 2000 Aug 25;92(1-3):65-71.PMID: 11024567 [PubMed - indexed for MEDLINE]Related articles