PubMed

Transplant Nephrectomy Associates with Improved Survival in Patients with Failed Renal Allograft.

Ayus JC, Achinger SG, Lee S, Sayegh MH, Go AS.

J Am Soc Nephrol. 2009 Oct 29. [Epub ahead of print]PMID: 19875809 [PubMed - as supplied by publisher]Related articles

Paradoxical Functions of B7: CD28 Costimulation in a MHC Class II-Mismatched Cardiac Transplant Model.

Yang J, Riella LV, Boenisch O, Popoola J, Robles S, Watanabe T, Vanguri V, Yuan X, Guleria I, Turka LA, Sayegh MH, Chandraker A.

Am J Transplant. 2009 Oct 21. [Epub ahead of print]PMID: 19845593 [PubMed - as supplied by publisher]Related articles

Clinical Transplantation Tolerance: A Myth No More, But...

Azzi J, Sayegh MH.

Am J Kidney Dis. 2009 Oct 8. [Epub ahead of print]PMID: 19819055 [PubMed - as supplied by publisher]Related articles

Immunosuppressive drugs and Tregs: a critical evaluation!

De Serres SA, Sayegh MH, Najafian N.

Clin J Am Soc Nephrol. 2009 Oct;4(10):1661-9. Epub 2009 Aug 20.PMID: 19696218 [PubMed - in process]Related articles

Regulatory T cells in transplantation: what we know and what we do not know.

Yeung MY, Sayegh MH.

Transplant Proc. 2009 Jul-Aug;41(6 Suppl):S21-6. Epub 2009 Jul 10.PMID: 19651291 [PubMed - in process]Related articles

Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants.

Illigens BM, Yamada A, Anosova N, Dong VM, Sayegh MH, Benichou G.

Eur J Immunol. 2009 Aug 5;39(11):3000-3009. [Epub ahead of print]PMID: 19658090 [PubMed - as supplied by publisher]Related articles

Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.

Fiorina P, Jurewicz M, Augello A, Vergani A, Dada S, La Rosa S, Selig M, Godwin J, Law K, Placidi C, Smith RN, Capella C, Rodig S, Adra CN, Atkinson M, Sayegh MH, Abdi R.

J Immunol. 2009 Jul 15;183(2):993-1004. Epub 2009 Jun 26.PMID: 19561093 [PubMed - indexed for MEDLINE]Related articles

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10734-9. Epub 2009 Jun 15.PMID: 19528638 [PubMed - indexed for MEDLINE]Related articles

Costimulatory pathways in transplantation: challenges and new developments.

Li XC, Rothstein DM, Sayegh MH.

Immunol Rev. 2009 May;229(1):271-93. Review.PMID: 19426228 [PubMed - indexed for MEDLINE]Related articles

Looking into the crystal ball: kidney transplantation in 2025.

Sayegh MH.

Nat Clin Pract Nephrol. 2009 Mar;5(3):117. No abstract available. PMID: 19240727 [PubMed - indexed for MEDLINE]Related articles

Introduction: Nephrology Hall of Fame for CJASN.

Bennett WM, Feldman HI, Sayegh MH.

Clin J Am Soc Nephrol. 2008 Dec 17. [Epub ahead of print] No abstract available. PMID: 19092129 [PubMed - as supplied by publisher]Related articles

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.

Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ.

J Exp Med. 2008 Dec 22;205(13):3133-44. Epub 2008 Dec 1.PMID: 19047438 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement dances with T cells.

Ansari MJ, Sayegh MH.

Blood. 2008 Sep 1;112(5):1551-2. No abstract available. PMID: 18725570 [PubMed]Related articlesFree article

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, Law K, Wu E, Tian Z, Abdi R, Guleria I, Rodig S, Dunussi-Joannopoulos K, Bluestone J, Sayegh MH.

Diabetes. 2008 Nov;57(11):3013-24. Epub 2008 Aug 8.PMID: 18689692 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative T-cell costimulatory pathways: their role in regulating alloimmune responses.

Boenisch O, Sayegh MH, Najafian N.

Curr Opin Organ Transplant. 2008 Aug;13(4):373-8.PMID: 18685332 [PubMed - in process]Related articles

A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients.

Womer KL, Magee CC, Najafian N, Vella JP, Milford EL, Sayegh MH, Carpenter CB.

Clin Transplant. 2008 Nov-Dec;22(6):754-9. Epub 2008 Jul 18.PMID: 18647327 [PubMed - indexed for MEDLINE]Related articles

Mechanisms underlying blockade of allograft acceptance by TLR ligands.

Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA.

J Immunol. 2008 Aug 1;181(3):1692-9.PMID: 18641305 [PubMed - indexed for MEDLINE]Related articlesFree article

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells.

Wang L, Pino-Lagos K, de Vries VC, Guleria I, Sayegh MH, Noelle RJ.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9331-6. Epub 2008 Jul 2.PMID: 18599457 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes.

Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH.

Diabetes. 2008 Jul;57(7):1759-67. Review.PMID: 18586907 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.

Elyaman W, Kivisäkk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ.

Am J Pathol. 2008 Aug;173(2):411-22. Epub 2008 Jun 26.PMID: 18583313 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.

Fiorina P, Jurewicz M, Vergani A, Augello A, Paez J, Ricchiuti V, Tchipachvili V, Sayegh MH, Abdi R.

Transplantation. 2008 Apr 15;85(7):1030-8.PMID: 18408585 [PubMed - indexed for MEDLINE]Related articles

Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells.

Tian C, Yuan X, Bagley J, Blazar BR, Sayegh MH, Iacomini J.

Clin Immunol. 2008 May;127(2):130-7. Epub 2008 Feb 15.PMID: 18280792 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulating rejection with cell therapy.

Sayegh MH, Weiner HL.

Nat Biotechnol. 2008 Feb;26(2):191-2. No abstract available. PMID: 18259174 [PubMed - indexed for MEDLINE]Related articles

Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.

Yang J, Popoola J, Khandwala S, Vadivel N, Vanguri V, Yuan X, Dada S, Guleria I, Tian C, Ansari MJ, Shin T, Yagita H, Azuma M, Sayegh MH, Chandraker A.

Circulation. 2008 Feb 5;117(5):660-9. Epub 2008 Jan 22.PMID: 18212277 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of cells initiating human melanomas.

Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.

Nature. 2008 Jan 17;451(7176):345-9.PMID: 18202660 [PubMed - indexed for MEDLINE]Related articles

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.

Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH.

J Clin Invest. 2008 Feb;118(2):742-51.PMID: 18172549 [PubMed - indexed for MEDLINE]Related articlesFree article

Harnessing negative T-cell costimulatory pathways to promote engraftment.

Popoola J, Sayegh MH.

Transpl Int. 2008 Jan;21(1):18-20. Review. No abstract available. PMID: 18076632 [PubMed - indexed for MEDLINE]Related articles

Allograft rejection mediated by memory T cells is resistant to regulation.

Yang J, Brook MO, Carvalho-Gaspar M, Zhang J, Ramon HE, Sayegh MH, Wood KJ, Turka LA, Jones ND.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19954-9. Epub 2007 Nov 27.PMID: 18042727 [PubMed - indexed for MEDLINE]Related articlesFree article

The evolution of the immunobiology of co-stimulatory pathways: clinical implications.

Trikudanathan S, Sayegh MH.

Clin Exp Rheumatol. 2007 Sep-Oct;25(5 Suppl 46):S12-21. Review.PMID: 17977484 [PubMed - indexed for MEDLINE]Related articles

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.

Tian C, Ansari MJ, Paez-Cortez J, Bagley J, Godwin J, Donnarumma M, Sayegh MH, Iacomini J.

J Immunol. 2007 Nov 15;179(10):6762-9.PMID: 17982066 [PubMed - indexed for MEDLINE]Related articlesFree article

Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo.

Habicht A, Kewalaramani R, Vu MD, Demirci G, Blazar BR, Sayegh MH, Li XC.

Am J Transplant. 2007 Dec;7(12):2683-92. Epub 2007 Oct 9.PMID: 17924994 [PubMed - indexed for MEDLINE]Related articles

A link between PDL1 and T regulatory cells in fetomaternal tolerance.

Habicht A, Dada S, Jurewicz M, Fife BT, Yagita H, Azuma M, Sayegh MH, Guleria I.

J Immunol. 2007 Oct 15;179(8):5211-9.PMID: 17911606 [PubMed - indexed for MEDLINE]Related articlesFree article

PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.

Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin T, Blazar BR, Rothstein DM, Sayegh MH, Najafian N.

J Immunol. 2007 Oct 15;179(8):5204-10.PMID: 17911605 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.

Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH.

Clin Immunol. 2008 Feb;126(2):140-7. Epub 2007 Sep 24.PMID: 17889619 [PubMed - indexed for MEDLINE]Related articles

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R.

Nat Med. 2007 Aug;13(8):952-61. Epub 2007 Jul 29.PMID: 17660828 [PubMed - indexed for MEDLINE]Related articles

The arduous road to achieving an immunosuppression-free state in kidney transplant recipients.

Ansari MJ, Sayegh MH.

Nat Clin Pract Nephrol. 2007 Sep;3(9):464-5. Epub 2007 Jul 24. Review. No abstract available. PMID: 17646858 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of PDL1-mediated regulation of autoimmune diabetes.

Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH.

Clin Immunol. 2007 Oct;125(1):16-25. Epub 2007 Jul 12.PMID: 17627890 [PubMed - indexed for MEDLINE]Related articles

New insights in CD28-independent allograft rejection.

Habicht A, Najafian N, Yagita H, Sayegh MH, Clarkson MR.

Am J Transplant. 2007 Aug;7(8):1917-26.PMID: 17617854 [PubMed - indexed for MEDLINE]Related articles

A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.

Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N.

J Immunol. 2007 Jul 15;179(2):786-96.PMID: 17617568 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.

Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK.

J Exp Med. 2007 Jul 9;204(7):1691-702. Epub 2007 Jul 2.PMID: 17606630 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical update: immunosuppression minimisation.

Sayegh MH, Remuzzi G.

Lancet. 2007 May 19;369(9574):1676-8. No abstract available. PMID: 17512842 [PubMed - indexed for MEDLINE]Related articles

Clinical transplantation tolerance: many rivers to cross.

Salama AD, Womer KL, Sayegh MH.

J Immunol. 2007 May 1;178(9):5419-23. Review.PMID: 17442921 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.

Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H Jr, Sayegh MH, Hynes RO, Abdi R.

Am J Transplant. 2007 May;7(5):1080-90. Epub 2007 Mar 12.PMID: 17359504 [PubMed - indexed for MEDLINE]Related articles

Maternal acceptance of the fetus: true human tolerance.

Guleria I, Sayegh MH.

J Immunol. 2007 Mar 15;178(6):3345-51. Review.PMID: 17339426 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival.

Fiorina P, Jurewicz M, Tanaka K, Behazin N, Augello A, Vergani A, von Andrian UH, Smith NR, Sayegh MH, Abdi R.

Diabetes. 2007 Apr;56(4):912-20. Epub 2007 Feb 7. Erratum in: Diabetes. 2007 Jun;56(6):1747. Von Adrian, Uli [corrected to von Andrian, Ulrich H]. PMID: 17287465 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic models.

Methe H, Groothuis A, Sayegh MH, Edelman ER.

FASEB J. 2007 May;21(7):1515-26. Epub 2007 Jan 30.PMID: 17264166 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA.

J Exp Med. 2006 Nov 27;203(12):2737-47. Epub 2006 Nov 20.PMID: 17116737 [PubMed - indexed for MEDLINE]Related articlesFree article

P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation.

Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH.

Am J Transplant. 2006 Dec;6(12):2884-93.PMID: 17083370 [PubMed - indexed for MEDLINE]Related articles

New reagents on the horizon for immune tolerance.

St Clair EW, Turka LA, Saxon A, Matthews JB, Sayegh MH, Eisenbarth GS, Bluestone J.

Annu Rev Med. 2007;58:329-46. Review.PMID: 16987079 [PubMed - indexed for MEDLINE]Related articles

Does belatacept provide equivalent suppression of acute renal transplant rejection to ciclosporin?

Sayegh MH, Chandraker A.

Nat Clin Pract Nephrol. 2006 Mar;2(3):134-5. No abstract available. PMID: 16932411 [PubMed]Related articles