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Mouse models of inherited lipodystrophy.

Savage DB.

Dis Model Mech. 2009 Nov-Dec;2(11-12):554-62.PMID: 19892886 [PubMed - in process]Related articles

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.

Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, Leonetti F, Capoccia D, Incani M, Maglio C, Iacovino M, O'Rahilly S, Baroni MG.

Int J Obes (Lond). 2009 Oct 20. [Epub ahead of print]PMID: 19844213 [PubMed - as supplied by publisher]Related articles

Leptin therapy in lipodystrophy.

Savage DB, O'Rahilly S.

Diabetologia. 2009 Oct 4. [Epub ahead of print] No abstract available. PMID: 19802712 [PubMed - as supplied by publisher]Related articles

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.

Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ; (on behalf of the European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group), Savage DB.

Diabetologia. 2009 Sep 12. [Epub ahead of print]PMID: 19756488 [PubMed - as supplied by publisher]Related articlesFree article

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial.

Finucane FM, Horton J, Purslow LR, Savage DB, Brage S, Besson H, Horton K, Rolfe Ede L, Sleigh A, Sharp SJ, Martin HJ, Sayer AA, Cooper C, Ekelund U, Griffin SJ, Wareham NJ.

BMC Endocr Disord. 2009 Jun 19;9:15.PMID: 19545359 [PubMed - in process]Related articlesFree article

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, Lienhard GE, O'Rahilly S, Savage DB.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. Epub 2009 May 22.PMID: 19470471 [PubMed - indexed for MEDLINE]Related articles

IRS2 variants and syndromes of severe insulin resistance.

Bottomley WE, Soos MA, Adams C, Guran T, Howlett TA, Mackie A, Miell J, Monson JP, Temple R, Tenenbaum-Rakover Y, Tymms J, Savage DB, Semple RK, O'Rahilly S, Barroso I.

Diabetologia. 2009 Jun;52(6):1208-11. Epub 2009 Apr 18. No abstract available. PMID: 19377890 [PubMed - indexed for MEDLINE]Related articles

Inherited susceptibility to non-alcoholic fatty liver disease.

Loos RJ, Savage DB.

Diabetologia. 2009 Jun;52(6):1000-2. Epub 2009 Mar 25. No abstract available. PMID: 19319505 [PubMed - indexed for MEDLINE]Related articles

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB.

J Clin Invest. 2009 Feb;119(2):315-22. doi: 10.1172/JCI37432. Epub 2009 Jan 26.PMID: 19164855 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement abnormalities in acquired lipodystrophy revisited.

Savage DB, Semple RK, Clatworthy MR, Lyons PA, Morgan BP, Cochran EK, Gorden P, Raymond-Barker P, Murgatroyd PR, Adams C, Scobie I, Mufti GJ, Alexander GJ, Thiru S, Murano I, Cinti S, Chaudhry AN, Smith KG, O'Rahilly S.

J Clin Endocrinol Metab. 2009 Jan;94(1):10-6. Epub 2008 Oct 14.PMID: 18854390 [PubMed - indexed for MEDLINE]Related articles

Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. Epub 2008 Aug 19.PMID: 18713822 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.

Semple RK, Cochran EK, Soos MA, Burling KA, Savage DB, Gorden P, O'Rahilly S.

Diabetes Care. 2008 May;31(5):977-9. Epub 2008 Feb 25.PMID: 18299442 [PubMed - indexed for MEDLINE]Related articlesFree article

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA.

PLoS Med. 2008 Jan 29;5(1):e27. Erratum in: PLoS Med. 2008 Dec;5(12):e246.. Solanky, Bhavana [added]; Deelchand, Dinesh [added]. PMID: 18232732 [PubMed - indexed for MEDLINE]Related articlesFree article

A clinical approach to severe insulin resistance.

Savage DB, Semple RK, Chatterjee VK, Wales JK, Ross RJ, O'Rahilly S.

Endocr Dev. 2007;11:122-32. Review.PMID: 17986832 [PubMed - indexed for MEDLINE]Related articles

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.PMID: 17923673 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94. Epub 2007 Jul 18.PMID: 17640906 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.PMID: 17526931 [PubMed - indexed for MEDLINE]Related articlesFree article

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage DB, Petersen KF, Shulman GI.

Physiol Rev. 2007 Apr;87(2):507-20. Review.PMID: 17429039 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.PMID: 17416797 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Clin Invest. 2006 Mar;116(3):817-24. Epub 2006 Feb 16.PMID: 16485039 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.

Risérus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F.

Diabetes. 2005 May;54(5):1379-84.PMID: 15855323 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of insulin resistance in humans and possible links with inflammation.

Savage DB, Petersen KF, Shulman GI.

Hypertension. 2005 May;45(5):828-33. Epub 2005 Apr 11. Review.PMID: 15824195 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.

Savage DB.

Expert Rev Mol Med. 2005 Jan 25;7(1):1-16. Review.PMID: 15673477 [PubMed - indexed for MEDLINE]Related articles

Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy.

Savage DB, Murgatroyd PR, Chatterjee VK, O'Rahilly S.

J Clin Endocrinol Metab. 2005 Mar;90(3):1446-52. Epub 2004 Dec 21.PMID: 15613417 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene.

Savage DB, Soos MA, Powlson A, O'Rahilly S, McFarlane I, Halsall DJ, Barroso I, Thomas EL, Bell JD, Scobie I, Belchetz PE, Kelly WF, Schafer AJ.

Diabetologia. 2004 Apr;47(4):753-6. No abstract available. PMID: 15298354 [PubMed - indexed for MEDLINE]Related articles

Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy.

Javor ED, Moran SA, Young JR, Cochran EK, DePaoli AM, Oral EA, Turman MA, Blackett PR, Savage DB, O'Rahilly S, Balow JE, Gorden P.

J Clin Endocrinol Metab. 2004 Jul;89(7):3199-207.PMID: 15240593 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

Agostini M, Gurnell M, Savage DB, Wood EM, Smith AG, Rajanayagam O, Garnes KT, Levinson SH, Xu HE, Schwabe JW, Willson TM, O'Rahilly S, Chatterjee VK.

Endocrinology. 2004 Apr;145(4):1527-38. Epub 2003 Dec 4.PMID: 14657011 [PubMed - indexed for MEDLINE]Related articlesFree article

The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation.

Gurnell M, Savage DB, Chatterjee VK, O'Rahilly S.

J Clin Endocrinol Metab. 2003 Jun;88(6):2412-21. Review.PMID: 12788836 [PubMed - indexed for MEDLINE]Related articlesFree article

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma.

Savage DB, Tan GD, Acerini CL, Jebb SA, Agostini M, Gurnell M, Williams RL, Umpleby AM, Thomas EL, Bell JD, Dixon AK, Dunne F, Boiani R, Cinti S, Vidal-Puig A, Karpe F, Chatterjee VK, O'Rahilly S.

Diabetes. 2003 Apr;52(4):910-7.PMID: 12663460 [PubMed - indexed for MEDLINE]Related articlesFree article

Digenic inheritance of severe insulin resistance in a human pedigree.

Savage DB, Agostini M, Barroso I, Gurnell M, Luan J, Meirhaeghe A, Harding AH, Ihrke G, Rajanayagam O, Soos MA, George S, Berger D, Thomas EL, Bell JD, Meeran K, Ross RJ, Vidal-Puig A, Wareham NJ, O'Rahilly S, Chatterjee VK, Schafer AJ.

Nat Genet. 2002 Aug;31(4):379-84. Epub 2002 Jul 15. Erratum in: Nat Genet 2002 Sep;32(1):211. PMID: 12118251 [PubMed - indexed for MEDLINE]Related articles

Leptin: a novel therapeutic role in lipodystrophy.

Savage DB, O'Rahilly S.

J Clin Invest. 2002 May;109(10):1285-6. No abstract available. PMID: 12021242 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization.

Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, Charron MJ, Scherer PE, Moller DE.

Endocrinology. 2002 Mar;143(3):998-1007.PMID: 11861525 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.

Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, O'Rahilly S.

Diabetes. 2001 Oct;50(10):2199-202.PMID: 11574398 [PubMed - indexed for MEDLINE]Related articlesFree article