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    Results: 1 to 50 of 838

    1.

    A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study.

    Ogihara T, Saruta T, Shimada K, Kuramoto K.

    Hypertens Res. 2009 Oct 9. [Epub ahead of print]PMID: 19816505 [PubMed - as supplied by publisher]Related articles

    2.

    Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(varepsilon)-carboxymethyl lysine.

    Kawai T, Takei I, Tokui M, Funae O, Miyamoto K, Tabata M, Hirata T, Saruta T, Shimada A, Itoh H.

    J Diabetes Complications. 2009 Aug 26. [Epub ahead of print]PMID: 19716319 [PubMed - as supplied by publisher]Related articles

    3.

    Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design.

    Eguchi T, Maruyama T, Ohno Y, Morii T, Hirao K, Hirose H, Kawabe H, Saito I, Hayashi M, Saruta T.

    Hypertens Res. 2009 Sep;32(9):775-9. Epub 2009 Jun 26.PMID: 19557004 [PubMed - in process]Related articles

    4.

    Prevention and regression of hypertension: role of renal microvascular protection.

    Sasamura H, Hayashi K, Ishiguro K, Nakaya H, Saruta T, Itoh H.

    Hypertens Res. 2009 Aug;32(8):658-64. Epub 2009 Jun 12.PMID: 19521419 [PubMed - in process]Related articles

    5.

    CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men.

    Morii T, Ohno Y, Kato N, Hirose H, Kawabe H, Hirao K, Eguchi T, Maruyama T, Hayashi M, Saito I, Yazaki Y, Saruta T.

    Biomarkers. 2009 Jun;14(4):207-12.PMID: 19489681 [PubMed - indexed for MEDLINE]Related articles

    6.

    Clinical significance of left ventricular hypertrophy and changes in left ventricular mass in high-risk hypertensive patients: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan trial.

    Yasuno S, Ueshima K, Oba K, Fujimoto A, Ogihara T, Saruta T, Nakao K.

    J Hypertens. 2009 Aug;27(8):1705-12.PMID: 19412127 [PubMed - indexed for MEDLINE]Related articles

    7.

    Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease: subanalysis of the CASE-J Study.

    Saruta T, Hayashi K, Ogihara T, Nakao K, Fukui T, Fukiyama K; CASE-J Study Group.

    Hypertens Res. 2009 Jun;32(6):505-12. Epub 2009 Apr 24.PMID: 19390535 [PubMed - in process]Related articles

    8.

    [The contribution of ARB to medical treatment]

    Saruta T.

    Nippon Rinsho. 2009 Apr;67(4):662-7. Review. Japanese. PMID: 19348225 [PubMed - indexed for MEDLINE]Related articles

    9.

    Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications: a sub-analysis of the CASE-J trial.

    Ogihara T, Saruta T, Rakugi H, Fujimoto A, Ueshima K, Yasuno S, Oba K, Takeda K, Higaki J, Nakao K; CASE-J trial Group.

    Hypertens Res. 2009 Apr;32(4):248-54.PMID: 19347033 [PubMed - in process]Related articles

    10.

    Effects of cardiac complications on cardiovascular events in Japanese high-risk hypertensive patients: subanalysis of the CASE-J trial.

    Ueshima K, Yasuno S, Oba K, Fujimoto A, Ogihara T, Saruta T, Nakao K.

    Circ J. 2009 Jun;73(6):1080-5. Epub 2009 Mar 12.PMID: 19282611 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients.

    Ogihara T, Saruta T, Rakugi H, Shimamoto K, Ito S, Matsuoka H, Horiuchi M, Imaizumi T, Takishita S, Higaki J, Katayama S, Saito I, Shimada K; COLM study investigators.

    Hypertens Res. 2009 Feb;32(2):163-7. Epub 2009 Jan 23.PMID: 19262477 [PubMed - in process]Related articles

    12.

    The Phase III, double-blind, parallel-group controlled study of amlodipine 10 mg once daily in Japanese patients with essential hypertension who insufficiently responded to amlodipine 5 mg once daily.

    Fujiwara T, Ii Y, Hatsuzawa J, Murase H, Watanabe T, Murakami M, Kimura N, Buch J, Tsuchihashi T, Saruta T.

    J Hum Hypertens. 2009 Aug;23(8):521-9. Epub 2009 Jan 15.PMID: 19148107 [PubMed - indexed for MEDLINE]Related articles

    13.

    Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla.

    Iigaya K, Kumagai H, Nabika T, Harada Y, Onimaru H, Oshima N, Takimoto C, Kamayachi T, Saruta T, Itoh H.

    Hypertension. 2009 Jan;53(1):42-8. Epub 2008 Dec 1.PMID: 19047583 [PubMed - indexed for MEDLINE]Related articles

    14.

    Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats.

    Takimoto C, Kumagai H, Osaka M, Sakata K, Onami T, Kamayachi T, Iigaya K, Hayashi K, Saruta T, Itoh H.

    Hypertens Res. 2008 Oct;31(10):1941-51.PMID: 19015602 [PubMed - indexed for MEDLINE]Related articles

    15.

    The optimal target blood pressure for antihypertensive treatment in Japanese elderly patients with high-risk hypertension: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial.

    Ogihara T, Nakao K, Fukui T, Fukiyama K, Fujimoto A, Ueshima K, Oba K, Shimamoto K, Matsuoka H, Saruta T; CASE-J Trial Group.

    Hypertens Res. 2008 Aug;31(8):1595-601.PMID: 18971535 [PubMed - indexed for MEDLINE]Related articles

    16.

    Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings.

    Oshima N, Kumagai H, Onimaru H, Kawai A, Pilowsky PM, Iigaya K, Takimoto C, Hayashi K, Saruta T, Itoh H.

    Hypertens Res. 2008 Jul;31(7):1445-54.PMID: 18957816 [PubMed - indexed for MEDLINE]Related articles

    17.

    Cost-effectiveness analysis: controlled-release nifedipine and valsartan combination therapy in patients with essential hypertension: the adalat CR and valsartan cost-effectiveness combination (ADVANCE-Combi) study.

    Saito I, Fujikawa K, Saruta T; ADVANCE-Combi Study Group.

    Hypertens Res. 2008 Jul;31(7):1399-405.PMID: 18957811 [PubMed - indexed for MEDLINE]Related articles

    18.

    Cost-utility analysis of antihypertensive combination therapy in Japan by a Monte Carlo simulation model.

    Saito I, Kobayashi M, Matsushita Y, Mori A, Kawasugi K, Saruta T.

    Hypertens Res. 2008 Jul;31(7):1373-83.PMID: 18957808 [PubMed - indexed for MEDLINE]Related articles

    19.

    ARB candesartan and CCB amlodipine in hypertensive patients: the CASE-J trial.

    Ogihara T, Fujimoto A, Nakao K, Saruta T; CASE-J Trial Group.

    Expert Rev Cardiovasc Ther. 2008 Oct;6(9):1195-201.PMID: 18939907 [PubMed - indexed for MEDLINE]Related articles

    20.

    Long-term effects of candesartan and amlodipine on cardiovascular mortality and morbidity in Japanese high-risk hypertensive patients: rationale, design, and characteristics of candesartan antihypertensive survival evaluation in Japan extension (CASE-J Ex).

    Ueshima K, Oba K, Yasuno S, Fujimoto A, Sato T, Fukiyama K, Azuma J, Ogihara T, Saruta T, Nakao K; Candesartan Antihypertensive Survival Evaluation in Japan Trial Group.

    Contemp Clin Trials. 2009 Jan;30(1):97-101. Epub 2008 Sep 13.PMID: 18824134 [PubMed - indexed for MEDLINE]Related articles

    21.

    [Definition and clinical characteristics of mild hypertension]

    Saruta T.

    Nippon Rinsho. 2008 Aug;66(8):1449-52. Review. Japanese. PMID: 18700540 [PubMed - indexed for MEDLINE]Related articles

    22.

    Expert recommendations on the challenges of hypertension in Asia.

    Chung N, Baek S, Chen MF, Liau CS, Park CG, Park J, Saruta T, Shimamoto K, Wu Z, Zhu J, Fujita T.

    Int J Clin Pract. 2008 Sep;62(9):1306-12. Epub 2008 Jul 16.PMID: 18643931 [PubMed - indexed for MEDLINE]Related articles

    23.

    Differential effects of transient treatment of spontaneously hypertensive rats with various antihypertensive agents on the subsequent development of diabetic nephropathy.

    Ishiguro K, Sasamura H, Sakamaki Y, Hayashi K, Saruta T, Itoh H.

    Nephron Exp Nephrol. 2008;109(1):e20-8. Epub 2008 May 28.PMID: 18506109 [PubMed - indexed for MEDLINE]Related articles

    24.

    Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients.

    Ogihara T, Saruta T, Shimamoto K, Matsuoka H, Rakugi H.

    Hypertens Res. 2008 Feb;31(2):281-7.PMID: 18360048 [PubMed - indexed for MEDLINE]Related articles

    25.

    Renal cytochrome P450 as a determinant of impaired natriuresis by PPAR-gamma ligands in ovariectomized obese rats.

    Yoshioka K, Wakino S, Homma K, Kanda T, Tatematsu S, Hasegawa K, Sugano N, Ito O, Omata K, Saruta T, Hayashi K.

    Obesity (Silver Spring). 2008 May;16(5):965-71. Epub 2008 Feb 14.PMID: 18277387 [PubMed - indexed for MEDLINE]Related articles

    26.

    [Effect of calcium channel blocker in combination with an angiotensin II receptor blocker in Japanese patients with hypertension]

    Saruta T.

    Drugs. 2006;66 Spec No 1:19-21. Review. Japanese. Erratum in: Drugs. 2007;67(13):1849. PMID: 18200774 [PubMed - indexed for MEDLINE]Related articles

    27.

    T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy.

    Sugano N, Wakino S, Kanda T, Tatematsu S, Homma K, Yoshioka K, Hasegawa K, Hara Y, Suetsugu Y, Yoshizawa T, Hara Y, Utsunomiya Y, Tokudome G, Hosoya T, Saruta T, Hayashi K.

    Kidney Int. 2008 Apr;73(7):826-34. Epub 2008 Jan 16.PMID: 18200001 [PubMed - indexed for MEDLINE]Related articles

    28.

    Effects of candesartan compared with amlodipine in hypertensive patients with high cardiovascular risks: candesartan antihypertensive survival evaluation in Japan trial.

    Ogihara T, Nakao K, Fukui T, Fukiyama K, Ueshima K, Oba K, Sato T, Saruta T; Candesartan Antihypertensive Survival Evaluation in Japan Trial Group.

    Hypertension. 2008 Feb;51(2):393-8. Epub 2008 Jan 2.PMID: 18172059 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Combined Bowen disease and extramammary Paget disease.

    Matsumoto M, Ishiguro M, Ikeno F, Ikeda M, Kamijima R, Hirata Y, Saruta T, Kodama H.

    J Cutan Pathol. 2007 Dec;34 Suppl 1:47-51.PMID: 17997739 [PubMed - indexed for MEDLINE]Related articles

    30.

    High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.

    Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H.

    Hum Mol Genet. 2008 Feb 15;17(4):617-27. Epub 2007 Nov 14.PMID: 18003638 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension.

    Saruta T, Ogihara T, Matsuoka H, Suzuki H, Toki M, Hirayama Y, Nonaka K, Takahashi K.

    Hypertens Res. 2007 Aug;30(8):729-39.PMID: 17917321 [PubMed - indexed for MEDLINE]Related articles

    32.

    "Low dose" metformin improves hyperglycemia better than acarbose in type 2 diabetics.

    Yajima K, Shimada A, Hirose H, Kasuga A, Saruta T.

    Rev Diabet Stud. 2004 Summer;1(2):89-94. Epub 2004 Aug 10.PMID: 17491670 [PubMed]Related articlesFree article

    33.

    Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects.

    Saisho Y, Maruyama T, Hirose H, Saruta T.

    Diabetes Res Clin Pract. 2007 Nov;78(2):182-8. Epub 2007 Apr 30.PMID: 17467843 [PubMed - indexed for MEDLINE]Related articles

    34.

    Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury.

    Ishiguro K, Sasamura H, Sakamaki Y, Itoh H, Saruta T.

    Hypertens Res. 2007 Jan;30(1):63-75.PMID: 17460373 [PubMed - indexed for MEDLINE]Related articles

    35.

    [Effects of ARB in metabolic syndrome]

    Kumagai H, Takimoto C, Iigaya K, Kamayachi T, Saruta T, Itoh H.

    Nippon Rinsho. 2006 Dec 28;64 Suppl 9:599-606. Review. Japanese. No abstract available. PMID: 17458289 [PubMed - indexed for MEDLINE]Related articles

    36.

    Sodium and kidney disease.

    Suzuki H, Takenaka T, Kanno Y, Ohno Y, Saruta T.

    Contrib Nephrol. 2007;155:90-101. Review.PMID: 17369717 [PubMed - indexed for MEDLINE]Related articles

    37.

    Ca2+ channel subtypes and pharmacology in the kidney.

    Hayashi K, Wakino S, Sugano N, Ozawa Y, Homma K, Saruta T.

    Circ Res. 2007 Feb 16;100(3):342-53. Review.PMID: 17307972 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Controlled release nifedipine and valsartan combination therapy in patients with essential hypertension: the adalat CR and valsartan cost-effectiveness combination (ADVANCE-combi) study.

    Saito I, Saruta T; ADVANCE-Combi Study Group.

    Hypertens Res. 2006 Oct;29(10):789-96.PMID: 17283866 [PubMed - indexed for MEDLINE]Related articles

    39.

    Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease.

    Tatematsu S, Wakino S, Kanda T, Homma K, Yoshioka K, Hasegawa K, Sugano N, Kimoto M, Saruta T, Hayashi K.

    J Am Soc Nephrol. 2007 Mar;18(3):741-9. Epub 2007 Jan 31.PMID: 17267746 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Congenic substitution mapping for intracellular Ca2+ in spontaneously hypertensive rats.

    Ohno Y, Ando Y, Maruyama T, Morii T, Eguchi T, Hirao K, Takenaka T, Kanno Y, Suzuki H, Saruta T.

    Am J Hypertens. 2007 Feb;20(2):172-6.PMID: 17261463 [PubMed - indexed for MEDLINE]Related articles

    41.

    Effects of nighttime alcohol intake on evening and next morning home blood pressure in Japanese normotensives.

    Kawabe H, Saito I, Saruta T.

    Clin Exp Hypertens. 2007 Jan;29(1):43-9.PMID: 17190730 [PubMed - indexed for MEDLINE]Related articles

    42.

    Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9.

    Yokota K, Shibata H, Kurihara I, Kobayashi S, Suda N, Murai-Takeda A, Saito I, Kitagawa H, Kato S, Saruta T, Itoh H.

    J Biol Chem. 2007 Jan 19;282(3):1998-2010. Epub 2006 Nov 14.PMID: 17105732 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column.

    Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Kamayachi T, Hayashi K, Saruta T, Itoh H.

    Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R927-36. Epub 2006 Nov 2.PMID: 17082356 [PubMed - indexed for MEDLINE]Related articles

    44.

    Primary malignant hepatic pheochromocytoma with negative adrenal scintigraphy.

    Homma K, Hayashi K, Wakino S, Irie R, Mukai M, Kumagai H, Shibata H, Saruta T.

    Hypertens Res. 2006 Jul;29(7):551-4.PMID: 17044668 [PubMed - indexed for MEDLINE]Related articles

    45.

    [Comparison of guidelines for hypertension therapy in each country]

    Saruta T.

    Nippon Rinsho. 2006 Aug;64 Suppl 6:542-8. Japanese. No abstract available. PMID: 16981588 [PubMed - indexed for MEDLINE]Related articles

    46.

    [Background for the revision of JSH2004]

    Saruta T.

    Nippon Rinsho. 2006 Aug;64 Suppl 6:489-93. Review. Japanese. No abstract available. PMID: 16981582 [PubMed - indexed for MEDLINE]Related articles

    47.

    [Recent reports of the Framingham study]

    Saruta T.

    Nippon Rinsho. 2006 Aug;64 Suppl 6:87-90. Review. Japanese. No abstract available. PMID: 16981524 [PubMed - indexed for MEDLINE]Related articles

    48.

    [Extracellular matrix proteins and glycoproteins in the cardiovascular system]

    Sasamura H, Saruta T.

    Nippon Rinsho. 2006 Jul;64 Suppl 5:559-64. Review. Japanese. No abstract available. PMID: 16897888 [PubMed - indexed for MEDLINE]Related articles

    49.

    Comparison of health costs associated with treatment of hypertension with a calcium channel blocker and angiotensin-converting enzyme inhibitor in the United States and Japan.

    Sakamaki Y, Sasamura H, Ikeda S, Ikegami N, Saruta T.

    Hypertens Res. 2006 May;29(5):333-8.PMID: 16832153 [PubMed - indexed for MEDLINE]Related articles

    50.

    Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension.

    Sasamura H, Kitamura Y, Nakamura M, Ryuzaki M, Saruta T.

    Clin Exp Hypertens. 2006 Jul;28(5):511-20.PMID: 16820347 [PubMed - indexed for MEDLINE]Related articles

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