PubMed

Suboptimal activation of protease-activated receptors enhances {alpha}2{beta}1 integrin-mediated platelet adhesion to collagen.

Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA.

J Biol Chem. 2009 Oct 8. [Epub ahead of print]PMID: 19815553 [PubMed - as supplied by publisher]Related articlesFree article

Negative regulation of activated alpha-2 integrins during thrombopoiesis.

Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML.

Blood. 2009 Jun 18;113(25):6428-39. Epub 2009 Mar 3.PMID: 19258597 [PubMed - indexed for MEDLINE]Related articles

The MD/PhD pathway to a career in laboratory medicine.

Santoro SA, Mosse CA, Young PP.

Clin Lab Med. 2007 Jun;27(2):425-34; abstract ix. Review.PMID: 17556094 [PubMed - indexed for MEDLINE]Related articles

Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression.

Grenache DG, Zhang Z, Wells LE, Santoro SA, Davidson JM, Zutter MM.

J Invest Dermatol. 2007 Feb;127(2):455-66. Epub 2006 Oct 26.PMID: 17068473 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta1 integrin mediates internalization of mammalian reovirus.

Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS.

J Virol. 2006 Mar;80(6):2760-70.PMID: 16501085 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel collectin/C1q receptor mediates mast cell activation and innate immunity.

Edelson BT, Stricker TP, Li Z, Dickeson SK, Shepherd VL, Santoro SA, Zutter MM.

Blood. 2006 Jan 1;107(1):143-50. Epub 2005 Sep 15.PMID: 16166590 [PubMed - indexed for MEDLINE]Related articlesFree article

GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.

Sarratt KL, Chen H, Zutter MM, Santoro SA, Hammer DA, Kahn ML.

Blood. 2005 Aug 15;106(4):1268-77. Epub 2005 May 10.PMID: 15886326 [PubMed - indexed for MEDLINE]Related articlesFree article

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, Zutter MM, Santoro SA, Kim JK, Höök M, Reed CC, Iozzo RV.

J Cell Biol. 2004 Jul 5;166(1):97-109.PMID: 15240572 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.

Wang H, Fu W, Im JH, Zhou Z, Santoro SA, Iyer V, DiPersio CM, Yu QC, Quaranta V, Al-Mehdi A, Muschel RJ.

J Cell Biol. 2004 Mar 15;164(6):935-41.PMID: 15024036 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk.

Grenache DG, Coleman T, Semenkovich CF, Santoro SA, Zutter MM.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2104-9. Epub 2003 Sep 25.PMID: 14512368 [PubMed - indexed for MEDLINE]Related articlesFree article

The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo.

He L, Pappan LK, Grenache DG, Li Z, Tollefsen DM, Santoro SA, Zutter MM.

Blood. 2003 Nov 15;102(10):3652-7. Epub 2003 Jul 31.PMID: 12893751 [PubMed - indexed for MEDLINE]Related articlesFree article

The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis.

Chen J, Diacovo TG, Grenache DG, Santoro SA, Zutter MM.

Am J Pathol. 2002 Jul;161(1):337-44.PMID: 12107118 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain.

Klekotka PA, Santoro SA, Ho A, Dowdy SF, Zutter MM.

Am J Pathol. 2001 Sep;159(3):983-92.PMID: 11549591 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways.

Klekotka PA, Santoro SA, Wang H, Zutter MM.

J Biol Chem. 2001 Aug 24;276(34):32353-61. Epub 2001 Jun 20.PMID: 11418614 [PubMed - indexed for MEDLINE]Related articlesFree article

Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.

Ohman T, King SL, Krithivas A, Cunningham J, Dickeson SK, Santoro SA, Bergelson JM.

Virus Res. 2001 Jul;76(1):1-8.PMID: 11376841 [PubMed - indexed for MEDLINE]Related articles

Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen.

Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC.

J Biol Chem. 2001 Aug 3;276(31):29368-74. Epub 2001 May 18.PMID: 11359786 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction.

Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA.

J Biol Chem. 2001 Aug 3;276(31):29375-81. Epub 2001 May 18.PMID: 11359774 [PubMed - indexed for MEDLINE]Related articlesFree article

alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK.

Klekotka PA, Santoro SA, Zutter MM.

J Biol Chem. 2001 Mar 23;276(12):9503-11. Epub 2000 Dec 19.PMID: 11121402 [PubMed - indexed for MEDLINE]Related articles

Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility.

Ding Q, Gladson CL, Guidry CR, Santoro SA, Dickeson SK, Shin JT, Thompson JA.

Growth Factors. 2000;18(2):93-107.PMID: 11019781 [PubMed - indexed for MEDLINE]Related articles

Decorin binds near the C terminus of type I collagen.

Keene DR, San Antonio JD, Mayne R, McQuillan DJ, Sarris G, Santoro SA, Iozzo RV.

J Biol Chem. 2000 Jul 21;275(29):21801-4.PMID: 10823816 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors.

Zutter MM, Sun H, Santoro SA.

J Mammary Gland Biol Neoplasia. 1998 Apr;3(2):191-200. Review.PMID: 10819527 [PubMed - indexed for MEDLINE]Related articles

Role of the alpha1 and alpha2 integrin cytoplasmic domains in cell morphology, motility and responsiveness to stimulation by the protein kinase C pathway.

Wang H, Gai Q, Yang X, Li Z, Linders B, Santoro SA, Zutter MM.

Cell Adhes Commun. 2000 Jan;7(4):281-97.PMID: 10714390 [PubMed - indexed for MEDLINE]Related articles

Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins.

Dickeson SK, Mathis NL, Rahman M, Bergelson JM, Santoro SA.

J Biol Chem. 1999 Nov 5;274(45):32182-91.PMID: 10542255 [PubMed - indexed for MEDLINE]Related articlesFree article

Collagen receptor control of epithelial morphogenesis and cell cycle progression.

Zutter MM, Santoro SA, Wu JE, Wakatsuki T, Dickeson SK, Elson EL.

Am J Pathol. 1999 Sep;155(3):927-40.PMID: 10487850 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk.

Santoro SA.

Blood. 1999 Jun 1;93(11):3575-7. Review. No abstract available. PMID: 10339460 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrins and the kidney: biology and pathobiology.

Hamerski DA, Santoro SA.

Curr Opin Nephrol Hypertens. 1999 Jan;8(1):9-14. Review.PMID: 9914855 [PubMed - indexed for MEDLINE]Related articles

Binding of the alpha 2 integrin I domain to extracellular matrix ligands: structural and mechanistic differences between collagen and laminin binding.

Dickeson SK, Walsh JJ, Santoro SA.

Cell Adhes Commun. 1998 Jun;5(4):273-81.PMID: 9762468 [PubMed - indexed for MEDLINE]Related articles

Alpha2beta1 integrin recognition of the carboxyl-terminal propeptide of type I procollagen: integrin recognition and feed-back regulation of matrix biosynthesis are mediated by distinct sequences.

Bhattacharyya-Pakrasi M, Dickeson SK, Santoro SA.

Matrix Biol. 1998 Jul;17(3):223-32.PMID: 9707345 [PubMed - indexed for MEDLINE]Related articles

Ligand binding results in divalent cation displacement from the alpha 2 beta 1 integrin I domain: evidence from terbium luminescence spectroscopy.

Dickeson SK, Bhattacharyya-Pakrasi M, Mathis NL, Schlesinger PH, Santoro SA.

Biochemistry. 1998 Aug 11;37(32):11280-8.PMID: 9698375 [PubMed - indexed for MEDLINE]Related articles

Ligand recognition by the I domain-containing integrins.

Dickeson SK, Santoro SA.

Cell Mol Life Sci. 1998 Jun;54(6):556-66. Review.PMID: 9676575 [PubMed - indexed for MEDLINE]Related articles

Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.

Sun H, Santoro SA, Zutter MM.

Cancer Res. 1998 May 15;58(10):2224-33.PMID: 9605770 [PubMed - indexed for MEDLINE]Related articlesFree article

A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling.

Xu J, Zutter MM, Santoro SA, Clark RA.

J Cell Biol. 1998 Feb 9;140(3):709-19.PMID: 9456329 [PubMed - indexed for MEDLINE]Related articlesFree article

The ups and downs of alpha 2 beta 1-integrin expression: contributions to epithelial cell differentiation and the malignant phenotype.

Zutter MM, Santoro SA.

Curr Top Microbiol Immunol. 1998;231:167-85. Review. No abstract available. PMID: 9479866 [PubMed - indexed for MEDLINE]Related articles

The alpha 2 beta 1 integrin binds to the CB4 peptide of the alpha 2(I) collagen chain.

Staatz WD, Walsh JJ, Santoro SA.

Biochem Mol Biol Int. 1997 Jul;42(3):577-82.PMID: 9247715 [PubMed - indexed for MEDLINE]Related articles

Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood.

Despotis GJ, Ikonomakou S, Levine V, Joiner-Maier D, Santoro SA, Joist JH.

Thromb Res. 1997 May 1;86(3):205-19.PMID: 9175242 [PubMed - indexed for MEDLINE]Related articles

ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction.

Dieckgraefe BK, Weems DM, Santoro SA, Alpers DH.

Biochem Biophys Res Commun. 1997 Apr 17;233(2):389-94.PMID: 9144545 [PubMed - indexed for MEDLINE]Related articles

Effects of antiplatelet drugs on dialysis-associated platelet deposition in polytetrafluoroethylene grafts.

Windus DW, Santoro SA, Atkinson R, Royal HD.

Am J Kidney Dis. 1997 Apr;29(4):560-4.PMID: 9100045 [PubMed - indexed for MEDLINE]Related articles

Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin.

Dickeson SK, Walsh JJ, Santoro SA.

J Biol Chem. 1997 Mar 21;272(12):7661-8.PMID: 9065422 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements.

Despotis GJ, Joist JH, Goodnough LT, Santoro SA, Spitznagel E.

J Thorac Cardiovasc Surg. 1997 Mar;113(3):611-3. No abstract available. PMID: 9081112 [PubMed - indexed for MEDLINE]Related articles

Multiple episodes of thrombosis with biventricular support devices with inadequate anticoagulation and evidence of accelerated intravascular coagulation.

Despotis GJ, Levine V, Joist H, Santoro SA, Mendeloff E.

J Thorac Cardiovasc Surg. 1997 Feb;113(2):419-22. No abstract available. PMID: 9040641 [PubMed - indexed for MEDLINE]Related articles

More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT.

Despotis GJ, Joist JH, Hogue CW Jr, Alsoufiev A, Joiner-Maier D, Santoro SA, Spitznagel E, Weitz JI, Goodnough LT.

Thromb Haemost. 1996 Dec;76(6):902-8.PMID: 8972009 [PubMed - indexed for MEDLINE]Related articles

Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients.

Despotis GJ, Levine V, Filos KS, Santoro SA, Joist JH, Spitznagel E, Goodnough LT.

Anesthesiology. 1996 Dec;85(6):1311-23.PMID: 8968178 [PubMed - indexed for MEDLINE]Related articlesFree article

PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta.

Xu J, Zutter MM, Santoro SA, Clark RA.

J Cell Biol. 1996 Sep;134(5):1301-11.PMID: 8794869 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of complete blood count results from a new, on-site hemocytometer compared with a laboratory-based hemocytometer.

Despotis GJ, Alsoufiev A, Hogue CW Jr, Zoys TN, Goodnough LT, Santoro SA, Kater KM, Barnes P, Lappas DG.

Crit Care Med. 1996 Jul;24(7):1163-7.PMID: 8674329 [PubMed - indexed for MEDLINE]Related articles

Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis.

Wu JE, Santoro SA.

Dev Dyn. 1996 Jun;206(2):169-81.PMID: 8725284 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis.

Dieckgraefe BK, Santoro SA, Alpers DH.

Gastroenterology. 1996 Jan;110(1):58-71.PMID: 8536889 [PubMed - indexed for MEDLINE]Related articles

Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis.

Saelman EU, Keely PJ, Santoro SA.

J Cell Sci. 1995 Nov;108 ( Pt 11):3531-40.PMID: 8586664 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of heparin on whole blood activated partial thromboplastin time using a portable, whole blood coagulation monitor.

Despotis GJ, Hogue CW Jr, Santoro SA, Joist JH, Barnes PW, Lappas DG.

Crit Care Med. 1995 Oct;23(10):1674-9.PMID: 7587232 [PubMed - indexed for MEDLINE]Related articles

The alpha 2 beta 1 integrin: a collagen receptor on platelets and other cells.

Santoro SA, Zutter MM.

Thromb Haemost. 1995 Sep;74(3):813-21. Review. No abstract available. PMID: 8571303 [PubMed - indexed for MEDLINE]Related articles

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.

Zutter MM, Santoro SA, Staatz WD, Tsung YL.

Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7411-5.PMID: 7638207 [PubMed - indexed for MEDLINE]Related articlesFree article