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The Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ Regulatory T-cells.

Yamanouchi J, Puertas MC, Verdaguer J, Lyons PA, Rainbow DB, Chamberlain G, Hunter KM, Peterson LB, Wicker LS, Santamaria P.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833887 [PubMed - as supplied by publisher]Related articles

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event.

Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DA.

Immunity. 2009 Oct 16;31(4):643-53. Epub 2009 Oct 8.PMID: 19818656 [PubMed - indexed for MEDLINE]Related articles

Evaluation of lysozyme to control vinification process and histamine production in rioja wines.

Isabel L, Santamaria P, Tenorio C, Garijo P, Gutierrez AR, Lopez R.

J Microbiol Biotechnol. 2009 Sep;19(9):1005-12.PMID: 19809259 [PubMed - in process]Related articlesFree article

Presence of lactic bacteria in the air of a winery during the vinification period.

Garijo P, López R, Santamaría P, Ocón E, Olarte C, Sanz S, Gutiérrez AR.

Int J Food Microbiol. 2009 Nov 30;136(1):142-6. Epub 2009 Aug 22.PMID: 19740562 [PubMed - in process]Related articles

Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A.

Dinarina A, Santamaria PG, Nebreda AR.

FEBS Lett. 2009 Sep 3;583(17):2772-8. Epub 2009 Jul 19.PMID: 19622356 [PubMed - indexed for MEDLINE]Related articles

[Production and implementation of predictive biological models]

Iris F, Gea M, Lampe PH, Santamaria P.

Med Sci (Paris). 2009 Jun-Jul;25(6-7):608-16. French. PMID: 19602358 [PubMed - in process]Related articles

Spontaneous autoimmunity sufficiently potent to induce diabetes mellitus is insufficient to protect against insulinoma.

Zwicker K, Chatten C, Gratton K, Demetrick D, Serra P, Shameli A, Santamaria P, Bathe OF.

J Immunol. 2009 Aug 1;183(3):1705-14. Epub 2009 Jul 1.PMID: 19570832 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.

Wang J, Cheng L, Wondimu Z, Swain M, Santamaria P, Yang Y.

J Immunol. 2009 Jun 1;182(11):6644-7.PMID: 19454657 [PubMed - indexed for MEDLINE]Related articles

IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity.

Wang J, Wicker LS, Santamaria P.

Semin Immunol. 2009 May 14. [Epub ahead of print]PMID: 19447046 [PubMed - as supplied by publisher]Related articles

Genetic and therapeutic control of diabetogenic CD8+ T cells.

Santamaria P.

Novartis Found Symp. 2008;292:130-6; discussion 136-45, 202-3.PMID: 19209463 [PubMed - indexed for MEDLINE]Related articles

CD8+ T cells in type 1 diabetes.

Tsai S, Shameli A, Santamaria P.

Adv Immunol. 2008;100:79-124. Review.PMID: 19111164 [PubMed - indexed for MEDLINE]Related articles

The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice.

Hultcrantz M, Jacobson S, Hill NJ, Santamaria P, Flodström-Tullberg M.

Diabetologia. 2009 Feb;52(2):299-305. Epub 2008 Nov 25.PMID: 19031069 [PubMed - indexed for MEDLINE]Related articles

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.

Angstetra E, Graham KL, Emmett S, Dudek NL, Darwiche R, Ayala-Perez R, Allison J, Santamaria P, Kay TW, Thomas HE.

Immunol Cell Biol. 2009 Feb;87(2):178-85. Epub 2008 Nov 18.PMID: 19015667 [PubMed - indexed for MEDLINE]Related articles

The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation.

Khadra A, Santamaria P, Edelstein-Keshet L.

J Theor Biol. 2009 Jan 7;256(1):126-41. Epub 2008 Oct 6.PMID: 18950644 [PubMed - indexed for MEDLINE]Related articles

The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.

Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P.

J Immunol. 2008 Jul 1;181(1):243-55.PMID: 18566390 [PubMed - indexed for MEDLINE]Related articlesFree article

The occurrence of fungi, yeasts and bacteria in the air of a Spanish winery during vintage.

Garijo P, Santamaría P, López R, Sanz S, Olarte C, Gutiérrez AR.

Int J Food Microbiol. 2008 Jul 15;125(2):141-5. Epub 2008 Apr 1.PMID: 18485508 [PubMed - indexed for MEDLINE]Related articles

Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response.

Norman MU, Hwang J, Hulliger S, Bonder CS, Yamanouchi J, Santamaria P, Kubes P.

Am J Pathol. 2008 Jun;172(6):1638-49. Epub 2008 May 8.PMID: 18467702 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP.

Clin Immunol. 2008 Jun;127(3):359-65. Epub 2008 Mar 20.PMID: 18358785 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, Kay TW.

J Immunol. 2008 Apr 1;180(7):4458-64.PMID: 18354167 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression.

Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A.

Magn Reson Med. 2008 Apr;59(4):712-20.PMID: 18302224 [PubMed - indexed for MEDLINE]Related articles

On the pathogenicity of autoantigen-specific T-cell receptors.

Burton AR, Vincent E, Arnold PY, Lennon GP, Smeltzer M, Li CS, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DA.

Diabetes. 2008 May;57(5):1321-30. Epub 2008 Feb 25.PMID: 18299317 [PubMed - indexed for MEDLINE]Related articlesFree article

B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes.

Brodie GM, Wallberg M, Santamaria P, Wong FS, Green EA.

Diabetes. 2008 Apr;57(4):909-17. Epub 2008 Jan 9.PMID: 18184927 [PubMed - indexed for MEDLINE]Related articlesFree article

How Drosophila change their combs: the Hox gene Sex combs reduced and sex comb variation among Sophophora species.

Randsholt NB, Santamaria P.

Evol Dev. 2008 Jan-Feb;10(1):121-33.PMID: 18184363 [PubMed - indexed for MEDLINE]Related articles

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M.

Mol Cell. 2007 Aug 3;27(3):462-73.PMID: 17679094 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine deamination sustains dendritic cell activation in inflammation.

Desrosiers MD, Cembrola KM, Fakir MJ, Stephens LA, Jama FM, Shameli A, Mehal WZ, Santamaria P, Shi Y.

J Immunol. 2007 Aug 1;179(3):1884-92.PMID: 17641055 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells.

Shameli A, Yamanouchi J, Thiessen S, Santamaria P.

Rev Diabet Stud. 2007 Spring;4(1):25-32. Epub 2007 May 10.PMID: 17565413 [PubMed - in process]Related articlesFree article

Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes.

Ueno A, Cho S, Cheng L, Wang J, Hou S, Nakano H, Santamaria P, Yang Y.

Diabetes. 2007 Jun;56(6):1686-93. Epub 2007 Mar 14.PMID: 17360980 [PubMed - indexed for MEDLINE]Related articlesFree article

CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses.

Meagher C, Arreaza G, Peters A, Strathdee CA, Gilbert PA, Mi QS, Santamaria P, Dekaban GA, Delovitch TL.

Diabetes. 2007 Mar;56(3):809-17.PMID: 17327452 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.

Nat Genet. 2007 Mar;39(3):329-37. Epub 2007 Feb 4.PMID: 17277778 [PubMed - indexed for MEDLINE]Related articles

The pRb-Cdh1-p27 autoamplifying network.

Santamaría PG, Pagano M.

Nat Cell Biol. 2007 Feb;9(2):137-8. No abstract available. PMID: 17268477 [PubMed - indexed for MEDLINE]Related articles

Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator.

Forestier C, Takaki T, Molano A, Im JS, Baine I, Jerud ES, Illarionov P, Ndonye R, Howell AR, Santamaria P, Besra GS, Dilorenzo TP, Porcelli SA.

J Immunol. 2007 Feb 1;178(3):1415-25.PMID: 17237389 [PubMed - indexed for MEDLINE]Related articlesFree article

TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.

Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM.

Cell. 2006 Dec 15;127(6):1123-35.PMID: 17174891 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW.

Diabetes. 2006 Sep;55(9):2412-8.PMID: 16936188 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

O'Sullivan BJ, Thomas HE, Pai S, Santamaria P, Iwakura Y, Steptoe RJ, Kay TW, Thomas R.

J Immunol. 2006 Jun 15;176(12):7278-87.PMID: 16751371 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy.

Marée AF, Santamaria P, Edelstein-Keshet L.

Int Immunol. 2006 Jul;18(7):1067-77. Epub 2006 May 25.PMID: 16728432 [PubMed - indexed for MEDLINE]Related articlesFree article

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P.

J Immunol. 2006 Jun 1;176(11):6752-61.PMID: 16709834 [PubMed - indexed for MEDLINE]Related articlesFree article

Lessons on autoimmune diabetes from animal models.

Yang Y, Santamaria P.

Clin Sci (Lond). 2006 Jun;110(6):627-39. Review.PMID: 16689681 [PubMed - indexed for MEDLINE]Related articles

Effect of the addition of inert cellulose substrates to grape must on Saccharomyces cerevisiae diversity and the evolution of alcoholic fermentation.

López R, Epifanio S, Garijo P, Santamaría P, Gutiérrez AR.

Lett Appl Microbiol. 2006 May;42(5):465-70.PMID: 16620204 [PubMed - indexed for MEDLINE]Related articles

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA.

Nat Immunol. 2006 Jan;7(1):83-92. Epub 2005 Nov 27.PMID: 16311599 [PubMed - indexed for MEDLINE]Related articles

To 'B' regulated: B cells as members of the regulatory workforce.

Serra P, Santamaria P.

Trends Immunol. 2006 Jan;27(1):7-10. Epub 2005 Nov 21.PMID: 16300995 [PubMed - indexed for MEDLINE]Related articles

CD8+ T cells in autoimmunity.

Walter U, Santamaria P.

Curr Opin Immunol. 2005 Dec;17(6):624-31. Epub 2005 Oct 13. Review.PMID: 16226438 [PubMed - indexed for MEDLINE]Related articles

Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1.

Bonder CS, Norman MU, Swain MG, Zbytnuik LD, Yamanouchi J, Santamaria P, Ajuebor M, Salmi M, Jalkanen S, Kubes P.

Immunity. 2005 Aug;23(2):153-63.PMID: 16111634 [PubMed - indexed for MEDLINE]Related articles

Analysis of yeast population during spontaneous alcoholic fermentation: effect of the age of the cellar and the practice of inoculation.

Santamaría P, Garijo P, López R, Tenorio C, Rosa Gutiérrez A.

Int J Food Microbiol. 2005 Aug 15;103(1):49-56.PMID: 16084265 [PubMed - indexed for MEDLINE]Related articles

Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes.

Han B, Serra P, Yamanouchi J, Amrani A, Elliott JF, Dickie P, Dilorenzo TP, Santamaria P.

J Clin Invest. 2005 Jul;115(7):1879-87. Epub 2005 Jun 2.PMID: 15937548 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide.

Han B, Serra P, Amrani A, Yamanouchi J, Marée AF, Edelstein-Keshet L, Santamaria P.

Nat Med. 2005 Jun;11(6):645-52. Epub 2005 May 22.PMID: 15908957 [PubMed - indexed for MEDLINE]Related articles

The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.

Schmidt M, Haas W, Crosas B, Santamaria PG, Gygi SP, Walz T, Finley D.

Nat Struct Mol Biol. 2005 Apr;12(4):294-303. Epub 2005 Mar 20.PMID: 15778719 [PubMed - indexed for MEDLINE]Related articles

Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous system elements.

Carrillo J, Puertas MC, Alba A, Ampudia RM, Pastor X, Planas R, Riutort N, Alonso N, Pujol-Borrell R, Santamaria P, Vives-Pi M, Verdaguer J.

Diabetes. 2005 Jan;54(1):69-77.PMID: 15616012 [PubMed - indexed for MEDLINE]Related articlesFree article

Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.

Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP.

J Immunol. 2004 Dec 1;173(11):6727-34.PMID: 15557165 [PubMed - indexed for MEDLINE]Related articlesFree article

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL.

Qin H, Trudeau JD, Reid GS, Lee IF, Dutz JP, Santamaria P, Verchere CB, Tan R.

Int Immunol. 2004 Nov;16(11):1657-62. Epub 2004 Oct 5.PMID: 15466911 [PubMed - indexed for MEDLINE]Related articlesFree article