PubMed

The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury.

Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C.

Shock. 2009 Sep;32(3):258-62.PMID: 19174745 [PubMed - in process]Related articlesFree article

Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.

Maybauer DM, Maybauer MO, Szabó C, Westphal M, Traber LD, Enkhbaatar P, Murthy KG, Nakano Y, Salzman AL, Herndon DN, Traber DL.

Biochem Biophys Res Commun. 2008 Dec 19;377(3):786-91. Epub 2008 Oct 23.PMID: 18951875 [PubMed - indexed for MEDLINE]Related articles

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.

Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C.

J Endocrinol. 2008 Sep;198(3):581-9. Epub 2008 Jun 18.PMID: 18562629 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial.

Morrow DA, Brickman CM, Murphy SA, Baran K, Krakover R, Dauerman H, Kumar S, Slomowitz N, Grip L, McCabe CH, Salzman AL.

J Thromb Thrombolysis. 2009 May;27(4):359-64. Epub 2008 Jun 6.PMID: 18535785 [PubMed - in process]Related articles

Short-term effects of glipizide (an adenosine triphosphate-sensitive potassium channel inhibitor) on cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep.

Lange M, Szabo C, Van Aken H, Williams W, Traber DL, Daudel F, Bröking K, Salzman AL, Bone HG, Westphal M.

Shock. 2006 Nov;26(5):516-21.PMID: 17047524 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.

Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabo C, Li H, Salzman AL, Dolan ME, Modrich P, Bigner DD, Friedman HS.

Mol Cancer Ther. 2005 Sep;4(9):1364-8.PMID: 16170028 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

Jagtap PG, Baloglu E, Southan GJ, Mabley JG, Li H, Zhou J, van Duzer J, Salzman AL, Szabó C.

J Med Chem. 2005 Aug 11;48(16):5100-3.PMID: 16078828 [PubMed - indexed for MEDLINE]Related articles

Antibodies raised against N'-terminal Pseudomonas aeruginosa flagellin prevent mortality in lethal murine models of infection.

Neville LF, Barnea Y, Hammer-Munz O, Gur E, Kuzmenko B, Kahel-Raifer H, Eren R, Elkeles A, Murthy KG, Szabó C, Salzman AL, Dagan S, Carmeli Y, Navon-Venezia S.

Int J Mol Med. 2005 Jul;16(1):165-71.PMID: 15942694 [PubMed - indexed for MEDLINE]Related articles

Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one.

Jagtap PG, Baloglu E, Southan G, Williams W, Roy A, Nivorozhkin A, Landrau N, Desisto K, Salzman AL, Szabó C.

Org Lett. 2005 Apr 28;7(9):1753-6.PMID: 15844898 [PubMed - indexed for MEDLINE]Related articles

Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes.

Rosenstock J, Dailey G, Massi-Benedetti M, Fritsche A, Lin Z, Salzman A.

Diabetes Care. 2005 Apr;28(4):950-5.PMID: 15793205 [PubMed - indexed for MEDLINE]Related articlesFree article

Nebulized nitric oxide/nucleophile adduct reduces pulmonary vascular resistance in mechanically ventilated septicemic sheep.

Bjertnaes LJ, McGuire R, Jodoin J, Salzman AL, Traber LD, Passerini DJ, Smith DJ, Szabo C, Traber DL.

Crit Care Med. 2005 Mar;33(3):616-22.PMID: 15753755 [PubMed - indexed for MEDLINE]Related articles

Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase.

Murthy KG, Szabó C, Salzman AL.

Inflamm Res. 2004 Nov;53(11):604-8.PMID: 15693609 [PubMed - indexed for MEDLINE]Related articles

Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury.

Woolley SM, Farivar AS, Naidu BV, Salzman A, Szabo C, Thomas R, Fraga C, Mulligan MS.

J Heart Lung Transplant. 2004 Nov;23(11):1290-6.PMID: 15539128 [PubMed - indexed for MEDLINE]Related articles

The ATP-sensitive potassium-channel inhibitor glibenclamide improves outcome in an ovine model of hemorrhagic shock.

Maybauer DM, Salsbury JR, Westphal M, Maybauer MO, Salzman AL, Szabó C, Westphal-Varghese BB, Traber LD, Traber DL.

Shock. 2004 Oct;22(4):387-91.PMID: 15377897 [PubMed - indexed for MEDLINE]Related articles

Poly (ADP) ribose synthetase inhibition reduces obliterative airway disease in rat tracheal allografts.

Farivar AS, Woolley SM, Naidu BV, Fraga CH, Byrne K, Thomas R, Salzman AL, Szabo CS, Mulligan MS.

J Heart Lung Transplant. 2004 Aug;23(8):993-1002.PMID: 15312830 [PubMed - indexed for MEDLINE]Related articles

Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury.

Farivar AS, Woolley SM, Fraga CH, Thomas R, Salzman AL, Szabo C, Mulligan MS.

Ann Thorac Surg. 2004 Jun;77(6):1938-43.PMID: 15172241 [PubMed - indexed for MEDLINE]Related articles

The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro.

Mabley JG, Southan GJ, Salzman AL, Szabó C.

Pancreas. 2004 Mar;28(2):E39-44.PMID: 15028959 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.

Komjáti K, Mabley JG, Virág L, Southan GJ, Salzman AL, Szabó C.

Int J Mol Med. 2004 Mar;13(3):373-82.PMID: 14767566 [PubMed - indexed for MEDLINE]Related articles

Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.

Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, Komjáti K, Pacher P, Zsengellér Z, Szabó C, Traber DL.

Shock. 2004 Feb;21(2):126-33.PMID: 14752285 [PubMed - indexed for MEDLINE]Related articles

Winter warming.

Salzman A.

Rehab Manag. 2003 Dec;16(10):14-5, 44. No abstract available. PMID: 14743674 [PubMed - indexed for MEDLINE]Related articles

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Jagtap PG, Southan GJ, Baloglu E, Ram S, Mabley JG, Marton A, Salzman A, Szabó C.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):81-5.PMID: 14684303 [PubMed - indexed for MEDLINE]Related articles

Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats.

Pacher P, Mabley JG, Liaudet L, Evgenov OV, Southan GJ, Abdelkarim GE, Szabó C, Salzman AL.

Int J Impot Res. 2003 Dec;15(6):461-4.PMID: 14671668 [PubMed - indexed for MEDLINE]Related articles

Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro.

Murthy KG, Deb A, Goonesekera S, Szabó C, Salzman AL.

J Biol Chem. 2004 Feb 13;279(7):5667-75. Epub 2003 Nov 21.PMID: 14634022 [PubMed - indexed for MEDLINE]Related articlesFree article

Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats.

Evgenov OV, Pacher P, Williams W, Evgenov NV, Mabley JG, Cicila J, Sikó ZB, Salzman AL, Szabó C.

Crit Care Med. 2003 Oct;31(10):2429-36.PMID: 14530747 [PubMed - indexed for MEDLINE]Related articles

An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors.

Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL, Boons GJ, Leibovich SJ.

Am J Pathol. 2003 Aug;163(2):711-21.PMID: 12875990 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.

Naidu BV, Fraga C, Salzman AL, Szabo C, Verrier ED, Mulligan MS.

J Heart Lung Transplant. 2003 Jul;22(7):784-93.PMID: 12873547 [PubMed - indexed for MEDLINE]Related articles

Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes.

Mabley JG, Rabinovitch A, Suarez-Pinzon W, Haskó G, Pacher P, Power R, Southan G, Salzman A, Szabó C.

Mol Med. 2003 Mar-Apr;9(3-4):96-104.PMID: 12865945 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis.

Naidu BV, Farivar AS, Woolley SM, Fraga C, Salzman AL, Szabo C, Groves JT, Mulligan MS.

Exp Mol Pathol. 2003 Aug;75(1):12-7.PMID: 12834621 [PubMed - indexed for MEDLINE]Related articles

The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis.

Mabley J, Soriano F, Pacher P, Haskó G, Marton A, Wallace R, Salzman A, Szabó C.

Eur J Pharmacol. 2003 Apr 18;466(3):323-9.PMID: 12694816 [PubMed - indexed for MEDLINE]Related articles

The Flagellin-TLR5 Axis: Therapeutic Opportunities.

Liaudet L, Deb A, Pacher P, Mabley JG, Murthy KG, Salzman AL, Szabo C.

Drug News Perspect. 2002 Sep;15(7):397-409.PMID: 12677175 [PubMed - as supplied by publisher]Related articles

Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep.

Shimoda K, Murakami K, Enkhbaatar P, Traber LD, Cox RA, Hawkins HK, Schmalstieg FC, Komjati K, Mabley JG, Szabo C, Salzman AL, Traber DL.

Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L240-9. Epub 2003 Mar 7.PMID: 12626333 [PubMed - indexed for MEDLINE]Related articlesFree article

Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis.

Liaudet L, Szabó C, Evgenov OV, Murthy KG, Pacher P, Virág L, Mabley JG, Marton A, Soriano FG, Kirov MY, Bjertnaes LJ, Salzman AL.

Shock. 2003 Feb;19(2):131-7.PMID: 12578121 [PubMed - indexed for MEDLINE]Related articles

Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis.

Mabley JG, Liaudet L, Pacher P, Southan GJ, Groves JT, Salzman AL, Szabó C.

Mol Med. 2002 Oct;8(10):581-90. Erratum in: Mol Med. 2002 Dec;8(12):885. PMID: 12477968 [PubMed - indexed for MEDLINE]Related articlesFree article

Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst.

Szabó C, Mabley JG, Moeller SM, Shimanovich R, Pacher P, Virag L, Soriano FG, Van Duzer JH, Williams W, Salzman AL, Groves JT.

Mol Med. 2002 Oct;8(10):571-80.PMID: 12477967 [PubMed - indexed for MEDLINE]Related articlesFree article

Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep.

Kirov MY, Evgenov OV, Kuklin VN, Virag L, Pacher P, Southan GJ, Salzman AL, Szabo C, Bjertnaes LJ.

Am J Respir Crit Care Med. 2002 Dec 1;166(11):1436-42.PMID: 12450933 [PubMed - indexed for MEDLINE]Related articlesFree article

Inosine reduces inflammation and improves survival in a murine model of colitis.

Mabley JG, Pacher P, Liaudet L, Soriano FG, Haskó G, Marton A, Szabo C, Salzman AL.

Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G138-44. Epub 2002 Aug 28.PMID: 12388199 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse.

Shanley TP, Zhao B, Macariola DR, Denenberg A, Salzman AL, Ward PA.

Crit Care Med. 2002 Sep;30(9):1960-8.PMID: 12352027 [PubMed - indexed for MEDLINE]Related articles

NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes.

Mabley JG, Haskó G, Liaudet L, Soriano F, Southan GJ, Salzman AL, Szabó C.

J Endocrinol. 2002 Jun;173(3):457-64.PMID: 12065235 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.

Jagtap P, Soriano FG, Virág L, Liaudet L, Mabley J, Szabó E, Haskó G, Marton A, Lorigados CB, Gallyas F Jr, Sümegi B, Hoyt DG, Baloglu E, VanDuzer J, Salzman AL, Southan GJ, Szabó C.

Crit Care Med. 2002 May;30(5):1071-82.PMID: 12006805 [PubMed - indexed for MEDLINE]Related articles

Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.

Goldfarb RD, Marton A, Szabó E, Virág L, Salzman AL, Glock D, Akhter I, McCarthy R, Parrillo JE, Szabó C.

Crit Care Med. 2002 May;30(5):974-80.PMID: 12006790 [PubMed - indexed for MEDLINE]Related articles

Nicotine reduces the incidence of type I diabetes in mice.

Mabley JG, Pacher P, Southan GJ, Salzman AL, Szabó C.

J Pharmacol Exp Ther. 2002 Mar;300(3):876-81.PMID: 11861793 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virág L, Szabó E, Soriano FG, Liaudet L, Abdelkarim GE, Haskó G, Marton A, Southan GJ, Szabó C.

Inflamm Res. 2001 Nov;50(11):561-9.PMID: 11766996 [PubMed - indexed for MEDLINE]Related articles

Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide.

Liaudet L, Murthy KG, Mabley JG, Pacher P, Soriano FG, Salzman AL, Szabó C.

Infect Immun. 2002 Jan;70(1):192-8.PMID: 11748182 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitric oxide in myocardial dysfunction after combined burn and smoke inhalation injury.

Soejima K, Schmalstieg FC, Traber LD, Szabo C, Salzman A, Traber DL.

Burns. 2001 Dec;27(8):809-15.PMID: 11718983 [PubMed - indexed for MEDLINE]Related articles

Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes.

Mabley JG, Suarez-Pinzon WL, Haskó G, Salzman AL, Rabinovitch A, Kun E, Szabó C.

Br J Pharmacol. 2001 Jul;133(6):909-19.PMID: 11454665 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury.

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Virag L, Salzman A, Traber DL.

Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):745-52. Erratum in: Am J Respir Crit Care Med 2001 Sep;164(5):909. Varig L [corrected to Virag L]. PMID: 11254534 [PubMed - indexed for MEDLINE]Related articlesFree article

Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes.

Phillips LS, Grunberger G, Miller E, Patwardhan R, Rappaport EB, Salzman A; Rosiglitazone Clinical Trials Study Group.

Diabetes Care. 2001 Feb;24(2):308-15. Erratum in: Diabetes Care 2001 May;24(5):973. PMID: 11213884 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial.

Fonseca V, Rosenstock J, Patwardhan R, Salzman A.

JAMA. 2000 Apr 5;283(13):1695-702. Erratum in: JAMA 2000 Sep 20;284(11):1384. PMID: 10755495 [PubMed - indexed for MEDLINE]Related articlesFree article

Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction.

Eaves-Pyles T, Murthy K, Liaudet L, Virág L, Ross G, Soriano FG, Szabó C, Salzman AL.

J Immunol. 2001 Jan 15;166(2):1248-60.PMID: 11145708 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.

Garcia Soriano F, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, Szabó C.

Nat Med. 2001 Jan;7(1):108-13.PMID: 11135624 [PubMed - indexed for MEDLINE]Related articles