PubMed

The protein kinase IKKepsilon regulates energy balance in obese mice.

Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR.

Cell. 2009 Sep 4;138(5):961-75.PMID: 19737522 [PubMed - indexed for MEDLINE]Related articles

T-ing up inflammation in fat.

Lumeng CN, Maillard I, Saltiel AR.

Nat Med. 2009 Aug;15(8):846-7. No abstract available. PMID: 19661987 [PubMed - indexed for MEDLINE]Related articles

Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis.

Xiao J, Chen XW, Davies BA, Saltiel AR, Katzmann DJ, Xu Z.

Mol Biol Cell. 2009 Aug;20(15):3514-24. Epub 2009 May 28.PMID: 19477918 [PubMed - in process]Related articlesFree article

Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions.

Cheng A, Zhang M, Okubo M, Omichi K, Saltiel AR.

Hum Mol Genet. 2009 Jun 1;18(11):2045-52. Epub 2009 Mar 19.PMID: 19299494 [PubMed - indexed for MEDLINE]Related articles

Von Gierke's disease adopts an orphan (and its partner).

Cheng A, Saltiel AR.

Sci Signal. 2009 Feb 17;2(58):pe8. Review.PMID: 19224896 [PubMed - indexed for MEDLINE]Related articles

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA Jr, Smith Y, Warmus JS, Tecle H.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. Epub 2008 Oct 15.PMID: 18952427 [PubMed - indexed for MEDLINE]Related articles

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.

Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR.

Diabetes. 2008 Dec;57(12):3239-46. Epub 2008 Oct 1.PMID: 18829989 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.

Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR.

Mol Biol Cell. 2008 Jul;19(7):2718-28. Epub 2008 Apr 23.PMID: 18434594 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.

Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR.

Genes Dev. 2007 Oct 1;21(19):2399-409.PMID: 17908927 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of CAP as a costameric protein that interacts with filamin C.

Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR.

Mol Biol Cell. 2007 Dec;18(12):4731-40. Epub 2007 Sep 26.PMID: 17898075 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c.

Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR.

Dev Cell. 2007 Sep;13(3):391-404.PMID: 17765682 [PubMed - indexed for MEDLINE]Related articles

Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.

Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM.

Nat Med. 2007 Apr;13(4):455-62. Epub 2007 Mar 11.PMID: 17351624 [PubMed - indexed for MEDLINE]Related articles

Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

Lumeng CN, Bodzin JL, Saltiel AR.

J Clin Invest. 2007 Jan;117(1):175-84.PMID: 17200717 [PubMed - indexed for MEDLINE]Related articlesFree article

TIRFing out studies on Glut4 trafficking.

Chen XW, Saltiel AR.

Dev Cell. 2007 Jan;12(1):4-5. No abstract available. PMID: 17199036 [PubMed - indexed for MEDLINE]Related articles

Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.

Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR.

Diabetes. 2007 Jan;56(1):16-23.PMID: 17192460 [PubMed - indexed for MEDLINE]Related articlesFree article

Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.

Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR.

Cell Metab. 2007 Jan;5(1):59-72.PMID: 17189207 [PubMed - indexed for MEDLINE]Related articlesFree article

CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility.

Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR.

EMBO J. 2006 Nov 15;25(22):5284-93. Epub 2006 Nov 2.PMID: 17082770 [PubMed - indexed for MEDLINE]Related articlesFree article

RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis.

Chen XW, Inoue M, Hsu SC, Saltiel AR.

J Biol Chem. 2006 Dec 15;281(50):38609-16. Epub 2006 Oct 6.PMID: 17028198 [PubMed - indexed for MEDLINE]Related articlesFree article

TC10alpha is required for insulin-stimulated glucose uptake in adipocytes.

Chang L, Chiang SH, Saltiel AR.

Endocrinology. 2007 Jan;148(1):27-33. Epub 2006 Sep 28.PMID: 17008399 [PubMed - indexed for MEDLINE]Related articlesFree article

GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.

Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M.

Dev Cell. 2006 Sep;11(3):411-21.PMID: 16950130 [PubMed - indexed for MEDLINE]Related articles

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

Lumeng CN, Deyoung SM, Saltiel AR.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E166-74. Epub 2006 Aug 22.PMID: 16926380 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.

Su X, Lodhi IJ, Saltiel AR, Stahl PD.

J Biol Chem. 2006 Sep 22;281(38):27982-90. Epub 2006 Jul 31.PMID: 16880210 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin htts on autophagy.

Lumeng CN, Saltiel AR.

Autophagy. 2006 Jul-Sep;2(3):250-3. Epub 2006 Jul 10. Review.PMID: 16874093 [PubMed - indexed for MEDLINE]Related articlesFree article

A pericellular collagenase directs the 3-dimensional development of white adipose tissue.

Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ.

Cell. 2006 May 5;125(3):577-91.PMID: 16678100 [PubMed - indexed for MEDLINE]Related articles

Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells.

Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel AR.

Endocrinology. 2006 Jul;147(7):3606-12. Epub 2006 Apr 20.PMID: 16627590 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid phosphatases as drug discovery targets for type 2 diabetes.

Lazar DF, Saltiel AR.

Nat Rev Drug Discov. 2006 Apr;5(4):333-42. Review.PMID: 16582877 [PubMed - indexed for MEDLINE]Related articles

Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering.

Inoue M, Chiang SH, Chang L, Chen XW, Saltiel AR.

Mol Biol Cell. 2006 May;17(5):2303-11. Epub 2006 Mar 8.PMID: 16525015 [PubMed - indexed for MEDLINE]Related articlesFree article

More TORC for the gluconeogenic engine.

Cheng A, Saltiel AR.

Bioessays. 2006 Mar;28(3):231-4.PMID: 16479585 [PubMed - indexed for MEDLINE]Related articles

TC10 and insulin-stimulated glucose transport.

Chiang SH, Chang L, Saltiel AR.

Methods Enzymol. 2006;406:701-14.PMID: 16472699 [PubMed - indexed for MEDLINE]Related articles

Insulin signaling and the regulation of glucose transport.

Chang L, Chiang SH, Saltiel AR.

Mol Med. 2004 Jul-Dec;10(7-12):65-71. Review.PMID: 16307172 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in integrin expression during adipocyte differentiation.

Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel AR.

Cell Metab. 2005 Sep;2(3):165-77.PMID: 16154099 [PubMed - indexed for MEDLINE]Related articles

Holding the line on hepatic fat.

Saltiel AR.

Cell Metab. 2005 Jul;2(1):1-2.PMID: 16054091 [PubMed - indexed for MEDLINE]Related articles

The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes.

Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR.

J Biol Chem. 2005 Apr 22;280(16):16125-34. Epub 2005 Feb 14.PMID: 15713660 [PubMed - indexed for MEDLINE]Related articlesFree article

Staying in SHIP shape.

Decker SJ, Saltiel AR.

Nat Med. 2005 Feb;11(2):123-4. No abstract available. PMID: 15692594 [PubMed - indexed for MEDLINE]Related articles

Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest.

Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW.

Circulation. 2004 Sep 14;110(11 Suppl 1):II280-6.PMID: 15364876 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways.

Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE.

J Cell Biol. 2004 Jan 19;164(2):279-90.PMID: 14734537 [PubMed - indexed for MEDLINE]Related articlesFree article

Putting the brakes on insulin signaling.

Saltiel AR.

N Engl J Med. 2003 Dec 25;349(26):2560-2. Review. No abstract available. PMID: 14695419 [PubMed - indexed for MEDLINE]Related articles

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.

Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR.

Mol Cell. 2003 Dec;12(6):1379-89.PMID: 14690593 [PubMed - indexed for MEDLINE]Related articles

Insulin signaling in microdomains of the plasma membrane.

Saltiel AR, Pessin JE.

Traffic. 2003 Nov;4(11):711-6. Review.PMID: 14617354 [PubMed - indexed for MEDLINE]Related articles

A TUG on glucose transport.

Saltiel AR.

Nat Med. 2003 Nov;9(11):1352. No abstract available. PMID: 14595425 [PubMed - indexed for MEDLINE]Related articles

The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.

Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR.

J Biol Chem. 2003 Sep 19;278(38):36754-62. Epub 2003 Jul 2.PMID: 12842890 [PubMed - indexed for MEDLINE]Related articlesFree article

TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport.

Chiang SH, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel AR.

EMBO J. 2003 Jun 2;22(11):2679-91.PMID: 12773384 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of Cbl-associated protein splicing isoforms.

Zhang M, Kimura A, Saltiel AR.

Mol Med. 2003 Jan-Feb;9(1-2):18-25.PMID: 12765336 [PubMed - indexed for MEDLINE]Related articlesFree article

PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance.

Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR.

J Clin Invest. 2003 May;111(9):1423-32.PMID: 12727934 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle or fat? Rho bridges the GAP.

Saltiel AR.

Cell. 2003 Apr 18;113(2):144-5. Review.PMID: 12705863 [PubMed - indexed for MEDLINE]Related articles

The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.

Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR.

Nature. 2003 Apr 10;422(6932):629-33.PMID: 12687004 [PubMed - indexed for MEDLINE]Related articles

The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes.

Watson RT, Furukawa M, Chiang SH, Boeglin D, Kanzaki M, Saltiel AR, Pessin JE.

Mol Cell Biol. 2003 Feb;23(3):961-74.PMID: 12529401 [PubMed - indexed for MEDLINE]Related articlesFree article

The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes.

Chang L, Adams RD, Saltiel AR.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12835-40. Epub 2002 Sep 19.PMID: 12242347 [PubMed - indexed for MEDLINE]Related articlesFree article

Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.

Kanzaki M, Watson RT, Hou JC, Stamnes M, Saltiel AR, Pessin JE.

Mol Biol Cell. 2002 Jul;13(7):2334-46.PMID: 12134073 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1.

Kimura A, Mora S, Shigematsu S, Pessin JE, Saltiel AR.

J Biol Chem. 2002 Aug 16;277(33):30153-8. Epub 2002 May 29. Erratum in: J Biol Chem 2002 Oct 18;277(42):40167. PMID: 12036959 [PubMed - indexed for MEDLINE]Related articlesFree article