PubMed

Fyn mediates leptin actions in the thymus of rodents.

Girasol A, Albuquerque GG, Mansour E, Araújo EP, Degasperi G, Denis RG, Carvalheira JB, Saad MJ, Velloso LA.

PLoS One. 2009 Nov 3;4(11):e7707.PMID: 19888448 [PubMed - in process]Related articlesFree article

Low-intensity Ultrasound Increases FAK, ERK-1/2, and IRS-1 Expression of Intact Rat Bones in a Noncumulative Manner.

de Gusmão CV, Pauli JR, Saad MJ, Alves JM, Belangero WD.

Clin Orthop Relat Res. 2009 Oct 23. [Epub ahead of print]PMID: 19851814 [PubMed - as supplied by publisher]Related articles

Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt.

Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DM, Silveira LR, Curi R, Carvalheira JB, Velloso LA, Saad MJ.

Diabetologia. 2009 Sep 3. [Epub ahead of print]PMID: 19730809 [PubMed - as supplied by publisher]Related articles

An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice.

Prada PO, Ropelle ER, Mourão RH, de Souza CT, Pauli JR, Cintra DE, Schenka A, Rocco SA, Rittner R, Franchini KG, Vassalo J, Velloso LA, Carvalheira JB, Saad MJ.

Diabetes. 2009 Aug 20. [Epub ahead of print]PMID: 19696185 [PubMed - as supplied by publisher]Related articles

Translational research into gut microbiota: new horizons in obesity treatment.

Tsukumo DM, Carvalho BM, Carvalho-Filho MA, Saad MJ.

Arq Bras Endocrinol Metabol. 2009 Mar;53(2):139-44.PMID: 19466205 [PubMed - in process]Related articlesFree article

Methotrexate is effective in reactivated colitis and reduces inflammatory alterations in mesenteric adipose tissue during intestinal inflammation.

Thomaz MA, Acedo SC, de Oliveira CC, Pereira JA, Priolli DG, Saad MJ, Pedrazzoli J Jr, Gambero A.

Pharmacol Res. 2009 Oct;60(4):341-6. Epub 2009 May 18.PMID: 19450685 [PubMed - in process]Related articles

Antiobesity Effects of yerba maté Extract (Ilex paraguariensis) in High-fat Diet-induced Obese Mice.

Arçari DP, Bartchewsky W, Dos Santos TW, Oliveira KA, Funck A, Pedrazzoli J, de Souza MF, Saad MJ, Bastos DH, Gambero A, Carvalho Pde O, Ribeiro ML.

Obesity (Silver Spring). 2009 Dec;17(12):2127-33. Epub 2009 May 14.PMID: 19444227 [PubMed - in process]Related articles

Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes.

Bagarolli RA, Saad MJ, Saad ST.

J Diabetes Complications. 2009 Apr 21. [Epub ahead of print]PMID: 19395279 [PubMed - as supplied by publisher]Related articles

Birth weight and type 2 diabetes in adults.

Saad MJ, Carvalheira JB, Velloso LA.

JAMA. 2009 Apr 15;301(15):1539; author reply 1540-1. No abstract available. PMID: 19366768 [PubMed - indexed for MEDLINE]Related articles

High-fat diet induces apoptosis of hypothalamic neurons.

Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, Romanatto T, Carvalheira JB, Oliveira AL, Saad MJ, Velloso LA.

PLoS One. 2009;4(4):e5045. Epub 2009 Apr 2.PMID: 19340313 [PubMed - indexed for MEDLINE]Related articlesFree article

Depot-specific alterations to insulin signaling in mesenteric adipose tissue during intestinal inflammatory response.

de Oliveira CC, Acedo SC, Pedrazzoli J Jr, Saad MJ, Gambero A.

Int Immunopharmacol. 2009 Apr;9(4):396-402. Epub 2009 Jan 23.PMID: 19168155 [PubMed - indexed for MEDLINE]Related articles

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA.

J Neurosci. 2009 Jan 14;29(2):359-70.PMID: 19144836 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropathy of gastrointestinal Chagas' disease: immune response to myelin antigens.

Oliveira EC, Fujisawa MM, Hallal Longo DE, Farias AS, Contin Moraes J, Guariento ME, de Almeida EA, Saad MJ, Langone F, Toyama MH, Andreollo NA, Santos LM.

Neuroimmunomodulation. 2009 Jan;16(1):54-62. Epub 2008 Dec 15.PMID: 19077446 [PubMed - indexed for MEDLINE]Related articles

Central exercise action increases the AMPK and mTOR response to leptin.

Ropelle ER, Fernandes MF, Flores MB, Ueno M, Rocco S, Marin R, Cintra DE, Velloso LA, Franchini KG, Saad MJ, Carvalheira JB.

PLoS One. 2008;3(12):e3856. Epub 2008 Dec 4.PMID: 19052642 [PubMed - indexed for MEDLINE]Related articlesFree article

The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention.

Muscogiuri G, Chavez AO, Gastaldelli A, Perego L, Tripathy D, Saad MJ, Velloso L, Folli F.

Curr Vasc Pharmacol. 2008 Oct;6(4):301-12. Review.PMID: 18855718 [PubMed - indexed for MEDLINE]Related articles

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet.

Caricilli AM, Nascimento PH, Pauli JR, Tsukumo DM, Velloso LA, Carvalheira JB, Saad MJ.

J Endocrinol. 2008 Dec;199(3):399-406. Epub 2008 Sep 11.PMID: 18787058 [PubMed - indexed for MEDLINE]Related articles

Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways.

Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG.

Circ Res. 2008 Oct 10;103(8):813-24. Epub 2008 Aug 28.PMID: 18757826 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report.

Almeida RM, Cezana L, Tsukumo DM, de Carvalho-Filho MA, Saad MJ.

J Med Case Reports. 2008 Aug 8;2:262.PMID: 18691418 [PubMed - in process]Related articlesFree article

Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats.

Cesquini M, Stoppa GR, Prada PO, Torsoni AS, Romanatto T, Souza A, Saad MJ, Velloso LA, Torsoni MA.

Life Sci. 2008 Jun 20;82(25-26):1262-71. Epub 2008 May 6.PMID: 18534630 [PubMed - indexed for MEDLINE]Related articles

Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis.

Leal RF, Coy CS, Ayrizono ML, Fagundes JJ, Milanski M, Saad MJ, Velloso LA, Góes JR.

Tech Coloproctol. 2008 Mar;12(1):33-8. Epub 2008 May 30.PMID: 18512010 [PubMed - indexed for MEDLINE]Related articles

Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling.

Stoppa GR, Cesquini M, Roman EA, Prada PO, Torsoni AS, Romanatto T, Saad MJ, Velloso LA, Torsoni MA.

J Endocrinol. 2008 Jul;198(1):157-68. Epub 2008 May 9.PMID: 18469022 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats.

Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ.

Endocrinology. 2008 Aug;149(8):3870-80. Epub 2008 May 8.PMID: 18467448 [PubMed - indexed for MEDLINE]Related articlesFree article

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus.

Coope A, Milanski M, Araújo EP, Tambascia M, Saad MJ, Geloneze B, Velloso LA.

FEBS Lett. 2008 Apr 30;582(10):1471-6. Epub 2008 Apr 3.PMID: 18394428 [PubMed - indexed for MEDLINE]Related articles

Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli.

De Souza CT, Pereira-da-Silva M, Araujo EP, Morari J, Alvarez-Rojas F, Bordin S, Moreira-Filho DC, Carvalheira JB, Saad MJ, Velloso LA.

Obesity (Silver Spring). 2008 Jun;16(6):1239-47. Epub 2008 Mar 20.PMID: 18356833 [PubMed - indexed for MEDLINE]Related articles

Interleukin-10 is a protective factor against diet-induced insulin resistance in liver.

Cintra DE, Pauli JR, Araújo EP, Moraes JC, de Souza CT, Milanski M, Morari J, Gambero A, Saad MJ, Velloso LA.

J Hepatol. 2008 Apr;48(4):628-37. Epub 2008 Jan 31.PMID: 18267346 [PubMed - indexed for MEDLINE]Related articles

Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.

Oliveira JC, Souza KK, Dias MM, Faria MC, Ropelle ER, Flores MB, Ueno M, Velloso LA, Saad ST, Saad MJ, Carvalheira JB.

J Cancer Res Clin Oncol. 2008 Aug;134(8):833-9. Epub 2008 Feb 9.PMID: 18264722 [PubMed - indexed for MEDLINE]Related articles

Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet.

Lalli CA, Pauli JR, Prada PO, Cintra DE, Ropelle ER, Velloso LA, Saad MJ.

Metabolism. 2008 Jan;57(1):57-65.PMID: 18078859 [PubMed - indexed for MEDLINE]Related articles

A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.

Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2008 Mar;57(3):594-605. Epub 2007 Dec 5.PMID: 18057094 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats.

Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ.

J Physiol. 2008 Jan 15;586(2):659-71. Epub 2007 Nov 1.PMID: 17974582 [PubMed - indexed for MEDLINE]Related articlesFree article

Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet.

Barbuio R, Milanski M, Bertolo MB, Saad MJ, Velloso LA.

J Endocrinol. 2007 Sep;194(3):539-50.PMID: 17761893 [PubMed - indexed for MEDLINE]Related articlesFree article

Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes.

Araújo EP, De Souza CT, Ueno M, Cintra DE, Bertolo MB, Carvalheira JB, Saad MJ, Velloso LA.

Endocrinology. 2007 Dec;148(12):5991-7. Epub 2007 Aug 30.PMID: 17761768 [PubMed - indexed for MEDLINE]Related articlesFree article

A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.

Ropelle ER, Pauli JR, Zecchin KG, Ueno M, de Souza CT, Morari J, Faria MC, Velloso LA, Saad MJ, Carvalheira JB.

Endocrinology. 2007 Nov;148(11):5220-9. Epub 2007 Aug 23.PMID: 17717055 [PubMed - indexed for MEDLINE]Related articlesFree article

L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ.

Diabetologia. 2007 Sep;50(9):1949-59. Epub 2007 Jun 29.PMID: 17604977 [PubMed - indexed for MEDLINE]Related articles

Acanthosis nigricans, tripe palms and the sign of Leser-Trelat in a patient with a benign hepatic neoplasia.

da Costa França AF, Siqueira NS, Carvalheira JB, Saad MJ, Souza EM.

J Eur Acad Dermatol Venereol. 2007 Jul;21(6):846-8. No abstract available. PMID: 17567332 [PubMed - indexed for MEDLINE]Related articles

Extra-pancreatic insulin production in RAt lachrymal gland after streptozotocin-induced islet beta-cells destruction.

Cunha DA, de Alves MC, Stoppiglia LF, Jorge AG, Módulo CM, Carneiro EM, Boschero AC, Saad MJ, Velloso LA, Rocha EM.

Biochim Biophys Acta. 2007 Aug;1770(8):1128-35. Epub 2007 May 21.PMID: 17561349 [PubMed - indexed for MEDLINE]Related articles

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22.PMID: 17519423 [PubMed - indexed for MEDLINE]Related articlesFree article

[Insulin and angiotensin II signaling pathways cross-talk: implications with the association between diabetes mellitus, arterial hypertension and cardiovascular disease]

Carvalho-Filho MA, Carvalheira JB, Velloso LA, Saad MJ.

Arq Bras Endocrinol Metabol. 2007 Mar;51(2):195-203. Review. Portuguese. PMID: 17505626 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic morphological alterations, glycogen content and cytochrome P450 activities in rats treated chronically with N(omega)-nitro-L-arginine methyl ester (L-NAME).

Tarsitano CA, Paffaro VA Jr, Pauli JR, da Silva GH, Saad MJ, Salgado I, da Cruz-Höfling MA, Hyslop S.

Cell Tissue Res. 2007 Jul;329(1):45-58. Epub 2007 Apr 14.PMID: 17436021 [PubMed - indexed for MEDLINE]Related articles

Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats.

Zecchin HG, Priviero FB, Souza CT, Zecchin KG, Prada PO, Carvalheira JB, Velloso LA, Antunes E, Saad MJ.

Diabetes. 2007 Apr;56(4):1014-24. Epub 2007 Jan 17.PMID: 17229938 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action.

De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

FASEB J. 2007 Apr;21(4):1153-63. Epub 2007 Jan 5.PMID: 17209127 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.

Ropelle ER, Pauli JR, Prada PO, de Souza CT, Picardi PK, Faria MC, Cintra DE, Fernandes MF, Flores MB, Velloso LA, Saad MJ, Carvalheira JB.

J Physiol. 2006 Dec 15;577(Pt 3):997-1007. Epub 2006 Sep 28.PMID: 17008371 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin.

Ueno M, Carvalheira JB, Oliveira RL, Velloso LA, Saad MJ.

Diabetologia. 2006 Oct;49(10):2449-52. Epub 2006 Aug 29.PMID: 16955211 [PubMed - indexed for MEDLINE]Related articles

Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats.

Caperuto LC, Anhê GF, Amanso AM, Ribeiro LM, Medina MC, Souza LC, Carvalho OM, Bordin S, Saad MJ, Carvalho CR.

Endocrine. 2006 Jun;29(3):391-8.PMID: 16943575 [PubMed - indexed for MEDLINE]Related articles

Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats.

Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2006 Sep;55(9):2554-61.PMID: 16936204 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.

Prada PO, Pauli JR, Ropelle ER, Zecchin HG, Carvalheira JB, Velloso LA, Saad MJ.

FEBS Lett. 2006 Sep 4;580(20):4889-94. Epub 2006 Aug 10.PMID: 16919274 [PubMed - indexed for MEDLINE]Related articles

Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight.

Bertelli DF, Araújo EP, Cesquini M, Stoppa GR, Gasparotto-Contessotto M, Toyama MH, Felix JV, Carvalheira JB, Michelini LC, Chiavegatto S, Boschero AC, Saad MJ, Lopes-Cendes I, Velloso LA.

Endocrinology. 2006 Nov;147(11):5385-99. Epub 2006 Aug 17.PMID: 16916951 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin.

Lima MH, Souza LC, Caperuto LC, Bevilacqua E, Gasparetti AL, Zanuto R, Saad MJ, Carvalho CR.

J Endocrinol. 2006 Aug;190(2):451-9.PMID: 16899578 [PubMed - indexed for MEDLINE]Related articlesFree article

Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.

Moraes JC, Amaral ME, Picardi PK, Calegari VC, Romanatto T, Bermúdez-Echeverry M, Chiavegatto S, Saad MJ, Velloso LA.

FEBS Lett. 2006 Aug 21;580(19):4625-31. Epub 2006 Jul 21.PMID: 16876161 [PubMed - indexed for MEDLINE]Related articles

[Insulin resistance/hyperinsulinemia associated diseases not included in the metabolic syndrome]

Carvalheira JB, Saad MJ.

Arq Bras Endocrinol Metabol. 2006 Apr;50(2):360-7. Epub 2006 May 23. Review. Portuguese. PMID: 16767302 [PubMed - indexed for MEDLINE]Related articlesFree article

[Metabolic syndrome: still undefined, but usefull to identify high risk for cardiovascular disease]

Saad MJ, Zanella MT, Ferreira SR.

Arq Bras Endocrinol Metabol. 2006 Apr;50(2):161-2. Epub 2006 May 23. Portuguese. No abstract available. PMID: 16767281 [PubMed - indexed for MEDLINE]Related articlesFree article