PubMed

Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes.

Strøm TB, Holla OL, Cameron J, Berge KE, Leren TP.

Clin Chim Acta. 2009 Nov 13. [Epub ahead of print]PMID: 19917273 [PubMed - as supplied by publisher]Related articles

A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9.

Holla OL, Strøm TB, Cameron J, Berge KE, Leren TP.

Mol Genet Metab. 2009 Sep 27. [Epub ahead of print]PMID: 19828345 [PubMed - as supplied by publisher]Related articles

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.

Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK.

Eur J Immunol. 2009 Sep;39(9):2492-501.PMID: 19676072 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations.

Zhou Q, Yan J, Putheti P, Wu Y, Sun X, Toxavidis V, Tigges J, Kassam N, Enjyoji K, Robson SC, Strom TB, Gao W.

Am J Transplant. 2009 Oct;9(10):2303-11. Epub 2009 Jul 28.PMID: 19656134 [PubMed - in process]Related articles

Recently discovered T cell subsets cannot keep their commitments.

Strom TB, Koulmanda M.

J Am Soc Nephrol. 2009 Aug;20(8):1677-80. Review.PMID: 19648467 [PubMed - indexed for MEDLINE]Related articles

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.

Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K.

Cancer Res. 2009 Jul 1;69(13):5490-7.PMID: 19570783 [PubMed - indexed for MEDLINE]Related articles

Can childhood viral infection protect from type 1 diabetes?

Strom TB.

J Clin Invest. 2009 Jun;119(6):1458-61.PMID: 19504721 [PubMed - indexed for MEDLINE]Related articles

TIM-1: a new player in transplant immunity.

Mariat C, Degauque N, Strom TB.

Transplantation. 2009 May 15;87(9 Suppl):S84-6.PMID: 19424017 [PubMed - indexed for MEDLINE]Related articles

Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.

Gao W, Thompson L, Zhou Q, Putheti P, Fahmy TM, Strom TB, Metcalfe SM.

Cell Cycle. 2009 May 1;8(9):1444-50. Epub 2009 May 4.PMID: 19342884 [PubMed - indexed for MEDLINE]Related articlesFree article

Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.

Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB.

J Immunol. 2009 Feb 1;182(3):1379-85.PMID: 19155484 [PubMed - indexed for MEDLINE]Related articles

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.

Nat Immunol. 2008 Dec;9(12):1347-55. Epub 2008 Nov 9. Erratum in: Nat Immunol. 2009 May;10(5):551. PMID: 18997793 [PubMed - indexed for MEDLINE]Related articles

Cytokine related therapies for autoimmune disease.

Strom TB, Koulmanda M.

Curr Opin Immunol. 2008 Dec;20(6):676-81. Epub 2008 Nov 5. Review.PMID: 18940257 [PubMed - indexed for MEDLINE]Related articles

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H Jr, Flier JS, Strom TB.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7. Epub 2008 Oct 13.PMID: 18852471 [PubMed - indexed for MEDLINE]Related articlesFree article

Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.

Feng G, Gao W, Strom TB, Oukka M, Francis RS, Wood KJ, Bushell A.

Eur J Immunol. 2008 Sep;38(9):2512-27.PMID: 18792404 [PubMed - indexed for MEDLINE]Related articles

Mechanisms underlying blockade of allograft acceptance by TLR ligands.

Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA.

J Immunol. 2008 Aug 1;181(3):1692-9.PMID: 18641305 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional Th1 cells are required for surgical adhesion formation in a murine model.

Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW.

J Immunol. 2008 May 15;180(10):6970-6.PMID: 18453619 [PubMed - indexed for MEDLINE]Related articlesFree article

CD39 and control of cellular immune responses.

Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC.

Purinergic Signal. 2007 Mar;3(1-2):171-180. Epub 2007 Feb 6.PMID: 18404431 [PubMed - as supplied by publisher]Related articlesFree article

TIM-4 expressed on APCs induces T cell expansion and survival.

Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK.

J Immunol. 2008 Apr 1;180(7):4706-13.PMID: 18354194 [PubMed - indexed for MEDLINE]Related articlesFree article

In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3.

Muthukumarana PA, Zheng XX, Rosengard BR, Strom TB, Metcalfe SM.

Transpl Int. 2008 Jun;21(6):593-7. Epub 2008 Feb 16.PMID: 18282245 [PubMed - indexed for MEDLINE]Related articles

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB.

J Clin Invest. 2008 Feb;118(2):735-41.PMID: 18079964 [PubMed - indexed for MEDLINE]Related articlesFree article

2006 Homer W. Smith Lecture: taming T cells.

Strom TB.

J Am Soc Nephrol. 2007 Nov;18(11):2824-32. Epub 2007 Oct 17. No abstract available. PMID: 17942948 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins.

Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB.

Transplantation. 2007 Jul 15;84(1 Suppl):S12-6.PMID: 17632405 [PubMed - indexed for MEDLINE]Related articles

Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells.

Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB, Rothstein TL.

Eur J Immunol. 2007 Sep;37(9):2400-4.PMID: 17683116 [PubMed - indexed for MEDLINE]Related articles

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.

Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H Jr, Zheng XX, Strom TB.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.PMID: 17670937 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.

Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK.

Nature. 2007 Jul 26;448(7152):484-7. Epub 2007 Jun 20.PMID: 17581588 [PubMed - indexed for MEDLINE]Related articles

Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells.

Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB.

Am J Transplant. 2007 Jul;7(7):1722-32. Epub 2007 May 19.PMID: 17511761 [PubMed - indexed for MEDLINE]Related articles

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.

Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC.

J Exp Med. 2007 Jun 11;204(6):1257-65. Epub 2007 May 14.PMID: 17502665 [PubMed - indexed for MEDLINE]Related articlesFree article

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK.

Nat Med. 2007 Apr;13(4):423-31. Epub 2007 Mar 25.PMID: 17384649 [PubMed - indexed for MEDLINE]Related articles

Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation.

Sánchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB.

Transpl Int. 2007 Jun;20(6):534-41. Epub 2007 Mar 16.PMID: 17362475 [PubMed - indexed for MEDLINE]Related articles

Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft.

Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T.

Am J Transplant. 2007 May;7(5):1055-61. Epub 2007 Feb 7.PMID: 17286617 [PubMed - indexed for MEDLINE]Related articles

CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein.

Ferrari-Lacraz S, Zheng XX, Fueyo AS, Maslinski W, Moll T, Strom TB.

Transplantation. 2006 Dec 15;82(11):1510-7.PMID: 17164724 [PubMed - indexed for MEDLINE]Related articles

Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance.

Kim YS, Yang SH, Kang HG, Seong EY, Lee SH, Gao W, Kenny J, Zheng XX, Strom TB.

Int Immunol. 2006 Dec;18(12):1771-7. Epub 2006 Oct 26.PMID: 17068105 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional profiling to assess the clinical status of kidney transplants.

Strom TB, Suthanthiran M.

Nat Clin Pract Nephrol. 2006 Mar;2(3):116-7. No abstract available. PMID: 16932404 [PubMed - indexed for MEDLINE]Related articles

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ.

Nature. 2006 Aug 31;442(7106):997-1002. Epub 2006 Aug 20.PMID: 16921386 [PubMed - indexed for MEDLINE]Related articles

Proteomic analysis of the allograft response.

El Essawy B, Otu HH, Choy B, Zheng XX, Libermann TA, Strom TB.

Transplantation. 2006 Jul 27;82(2):267-74.PMID: 16858291 [PubMed - indexed for MEDLINE]Related articles

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK.

Nature. 2006 May 11;441(7090):235-8. Epub 2006 Apr 30.PMID: 16648838 [PubMed - indexed for MEDLINE]Related articles

Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?

Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB.

Am J Transplant. 2006 Apr;6(4):687-96.PMID: 16539625 [PubMed - indexed for MEDLINE]Related articles

An antagonist mutant IL-15/Fc promotes transplant tolerance.

Zheng XX, Gao W, Donskoy E, Neuberg M, Ruediger M, Strom TB, Moll T.

Transplantation. 2006 Jan 15;81(1):109-16.PMID: 16421485 [PubMed - indexed for MEDLINE]Related articles

Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.

Sánchez-Fueyo A, Sandner S, Habicht A, Mariat C, Kenny J, Degauque N, Zheng XX, Strom TB, Turka LA, Sayegh MH.

J Immunol. 2006 Jan 1;176(1):329-34.PMID: 16365425 [PubMed - indexed for MEDLINE]Related articlesFree article

Rejection--more than the eye can see.

Strom TB.

N Engl J Med. 2005 Dec 1;353(22):2394-6. No abstract available. PMID: 16319390 [PubMed - indexed for MEDLINE]Related articles

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK.

Nat Immunol. 2005 Dec;6(12):1245-52. Epub 2005 Nov 13.PMID: 16286920 [PubMed - indexed for MEDLINE]Related articles

Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.

Sho M, Kishimoto K, Harada H, Livak M, Sanchez-Fueyo A, Yamada A, Zheng XX, Strom TB, Basadonna GP, Sayegh MH, Rothstein DM.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13230-5. Epub 2005 Sep 6.PMID: 16150717 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of T cell dependent immune responses by TIM family members.

Mariat C, Sánchez-Fueyo A, Alexopoulos SP, Kenny J, Strom TB, Zheng XX.

Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29;360(1461):1681-5. Review.PMID: 16147532 [PubMed - indexed for MEDLINE]Related articlesFree article

Saving islets from allograft rejection.

Strom TB.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12651-2. Epub 2005 Aug 29. No abstract available. PMID: 16129823 [PubMed - indexed for MEDLINE]Related articlesFree article

Tim-2 regulates T helper type 2 responses and autoimmunity.

Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK.

J Exp Med. 2005 Aug 1;202(3):437-44. Epub 2005 Jul 25. Erratum in: J Exp Med. 2005 Sep 19;202(6):877. PMID: 16043519 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol.

Domenig C, Sanchez-Fueyo A, Kurtz J, Alexopoulos SP, Mariat C, Sykes M, Strom TB, Zheng XX.

J Immunol. 2005 Jul 1;175(1):51-60.PMID: 15972631 [PubMed - indexed for MEDLINE]Related articlesFree article

On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes.

Avihingsanon Y, Ma N, Pavlakis M, Chon WJ, Uknis ME, Monaco AP, Ferran C, Stillman I, Schachter AD, Mottley C, Zheng XX, Strom TB.

J Am Soc Nephrol. 2005 Jun;16(6):1542-8. Epub 2005 May 11.PMID: 15888558 [PubMed - indexed for MEDLINE]Related articlesFree article

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK.

Nat Immunol. 2005 May;6(5):455-64. Epub 2005 Mar 27.PMID: 15793576 [PubMed - indexed for MEDLINE]Related articles

Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection.

Vu MD, Li Y, Strom TB, Li XC.

Transplantation. 2005 Mar 27;79(6):736. No abstract available. PMID: 15785384 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells.

McDaid J, Yamashita K, Chora A, Ollinger R, Strom TB, Li XC, Bach FH, Soares MP.

FASEB J. 2005 Mar;19(3):458-60. Epub 2005 Jan 7.PMID: 15640283 [PubMed - indexed for MEDLINE]Related articlesFree article