PubMed

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Stein CA, Hansen JB, Lai J, Wu S, Voskresenskiy A, Høg A, Worm J, Hedtjärn M, Souleimanian N, Miller P, Soifer HS, Castanotto D, Benimetskaya L, Orum H, Koch T.

Nucleic Acids Res. 2009 Oct 23. [Epub ahead of print]PMID: 19854938 [PubMed - as supplied by publisher]Related articlesFree article

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

Agarwala SS, Keilholz U, Gilles E, Bedikian AY, Wu J, Kay R, Stein CA, Itri LM, Suciu S, Eggermont AM.

Eur J Cancer. 2009 Jul;45(10):1807-14. Epub 2009 May 4.PMID: 19419855 [PubMed - indexed for MEDLINE]Related articles

G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis.

Stein CA, Wu S, Voskresenskiy AM, Zhou JF, Shin J, Miller P, Souleimanian N, Benimetskaya L.

Clin Cancer Res. 2009 Apr 15;15(8):2797-807. Epub 2009 Apr 7.PMID: 19351753 [PubMed - indexed for MEDLINE]Related articles

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease.

Benimetskaya L, Wu S, Voskresenskiy AM, Echart C, Zhou JF, Shin J, Iacobelli M, Richardson P, Ayyanar K, Stein CA.

Blood. 2008 Nov 15;112(10):4343-52. Epub 2008 Aug 18.PMID: 18711003 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific VDAC inhibitors: phosphorothioate oligonucleotides.

Stein CA, Colombini M.

J Bioenerg Biomembr. 2008 Jun;40(3):157-62. Review.PMID: 18654842 [PubMed - indexed for MEDLINE]Related articles

Antisense oligonucleotides in cancer: recent advances.

Lebedeva IV, Stein CA.

BioDrugs. 2000 Mar;13(3):195-216.PMID: 18034525 [PubMed - in process]Related articles

Genasense: it ain't over till the fat lady sings.

Stein CA.

Oligonucleotides. 2007 Winter;17(4):345-8. No abstract available. PMID: 17949263 [PubMed - indexed for MEDLINE]Related articles

The Genasense 'learning curve'.

Stein CA.

Nat Biotechnol. 2007 Sep;25(9):972-3; author reply 973. No abstract available. PMID: 17846618 [PubMed - indexed for MEDLINE]Related articles

Phosphorothioate oligonucleotides block the VDAC channel.

Tan W, Loke YH, Stein CA, Miller P, Colombini M.

Biophys J. 2007 Aug 15;93(4):1184-91. Epub 2007 May 4.PMID: 17483171 [PubMed - indexed for MEDLINE]Related articlesFree article

Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.

Zhao H, Peng P, Longley C, Zhang Y, Borowski V, Mehlig M, Reddy P, Xia J, Borchard G, Lipman J, Benimetskaya L, Stein CA.

J Control Release. 2007 Jun 4;119(2):143-52. Epub 2006 Dec 29.PMID: 17397960 [PubMed - indexed for MEDLINE]Related articles

Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency.

Lai JC, Brown BD, Voskresenskiy AM, Vonhoff S, Klussman S, Tan W, Colombini M, Weeratna R, Miller P, Benimetskaya L, Stein CA.

Mol Ther. 2007 Feb;15(2):270-8.PMID: 17235304 [PubMed - indexed for MEDLINE]Related articles

Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy.

Stein CA, Goel S, Ghavamian R.

Invest New Drugs. 2007 Jun;25(3):277-8. Epub 2007 Jan 11. No abstract available. PMID: 17216557 [PubMed - indexed for MEDLINE]Related articles

Phosphorothioate oligonucleotides reduce mitochondrial outer membrane permeability to ADP.

Tan W, Lai JC, Miller P, Stein CA, Colombini M.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1388-97. Epub 2006 Nov 29.PMID: 17135295 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.

Benimetskaya L, Ayyanar K, Kornblum N, Castanotto D, Rossi J, Wu S, Lai J, Brown BD, Popova N, Miller P, McMicken H, Chen Y, Stein CA.

Clin Cancer Res. 2006 Aug 15;12(16):4940-8.PMID: 16914583 [PubMed - indexed for MEDLINE]Related articlesFree article

Does "stubbornness" have a role in pediatric constipation?

Burket RC, Cox DJ, Tam AP, Ritterband L, Borowitz S, Sutphen J, Stein CA, Kovatchev B.

J Dev Behav Pediatr. 2006 Apr;27(2):106-11.PMID: 16682873 [PubMed - indexed for MEDLINE]Related articles

A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC.

Lai JC, Tan W, Benimetskaya L, Miller P, Colombini M, Stein CA.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7494-9. Epub 2006 Apr 28.PMID: 16648253 [PubMed - indexed for MEDLINE]Related articlesFree article

Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: clinical outcomes and potential mechanisms of action.

Kornblum N, Ayyanar K, Benimetskaya L, Richardson P, Iacobelli M, Stein CA.

Oligonucleotides. 2006 Spring;16(1):105-14. Review.PMID: 16584299 [PubMed - indexed for MEDLINE]Related articles

G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice.

Gekeler V, Gimmnich P, Hofmann HP, Grebe C, Römmele M, Leja A, Baudler M, Benimetskaya L, Gonser B, Pieles U, Maier T, Wagner T, Sanders K, Beck JF, Hanauer G, Stein CA.

Oligonucleotides. 2006 Spring;16(1):83-93.PMID: 16584297 [PubMed - indexed for MEDLINE]Related articles

Induction of apoptosis by G3139 in melanoma cells.

Benimetskaya L, Lai JC, Khvorova A, Wu S, Miller P, Stein CA.

Ann N Y Acad Sci. 2005 Nov;1058:235-45. Review.PMID: 16394140 [PubMed - indexed for MEDLINE]Related articles

Antisense strategies for oncogene inactivation.

Stein CA, Benimetskaya L, Mani S.

Semin Oncol. 2005 Dec;32(6):563-72. Review.PMID: 16338422 [PubMed - indexed for MEDLINE]Related articles

518A2 melanoma cells are protected by G3139 and other antineoplastic agents against the cytotoxic effects of DTIC.

Benimetskaya L, Miller P, Stein CA.

Oligonucleotides. 2005 Fall;15(3):206-14.PMID: 16201908 [PubMed - indexed for MEDLINE]Related articles

Gene profiling study of G3139- and Bcl-2-targeting siRNAs identifies a unique G3139 molecular signature.

Anderson EM, Miller P, Ilsley D, Marshall W, Khvorova A, Stein CA, Benimetskaya L.

Cancer Gene Ther. 2006 Apr;13(4):406-14.PMID: 16195754 [PubMed - indexed for MEDLINE]Related articles

Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells.

Lai JC, Benimetskaya L, Khvorova A, Wu S, Hua E, Miller P, Stein CA.

Mol Cancer Ther. 2005 Feb;4(2):305-15. Erratum in: Mol Cancer Ther. 2005 May;4(5):864. PMID: 15713901 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative Bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells.

Benimetskaya L, Lai JC, Khvorova A, Wu S, Hua E, Miller P, Zhang LM, Stein CA.

Clin Cancer Res. 2004 Dec 15;10(24):8371-9.PMID: 15623615 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.

Benimetskaya L, Wittenberger T, Stein CA, Hofmann HP, Weller C, Lai JC, Miller P, Gekeler V.

Clin Cancer Res. 2004 Jun 1;10(11):3678-88.PMID: 15173074 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen).

Raffo A, Lai JC, Stein CA, Miller P, Scaringe S, Khvorova A, Benimetskaya L.

Clin Cancer Res. 2004 May 1;10(9):3195-206.PMID: 15131061 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense therapy: recent advances and relevance to prostate cancer.

Benimetskaya L, Stein CA.

Clin Prostate Cancer. 2002 Jun;1(1):20-30. Review.PMID: 15046709 [PubMed - indexed for MEDLINE]Related articles

Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.

Lebedeva IV, Sarkar D, Su ZZ, Kitada S, Dent P, Stein CA, Reed JC, Fisher PB.

Oncogene. 2003 Nov 27;22(54):8758-73.PMID: 14647471 [PubMed - indexed for MEDLINE]Related articles

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.

Lai JC, Benimetskaya L, Santella RM, Wang Q, Miller PS, Stein CA.

Mol Cancer Ther. 2003 Oct;2(10):1031-43.PMID: 14578468 [PubMed - indexed for MEDLINE]Related articlesFree article

Progress in the delivery of therapeutic oligonucleotides: organ/cellular distribution and targeted delivery of oligonucleotides in vivo.

Wang L, Prakash RK, Stein CA, Koehn RK, Ruffner DE.

Antisense Nucleic Acid Drug Dev. 2003;13(3):169-89. Review.PMID: 12954117 [PubMed - indexed for MEDLINE]Related articles

Pulmonary tumor embolism: a review of the literature.

Roberts KE, Hamele-Bena D, Saqi A, Stein CA, Cole RP.

Am J Med. 2003 Aug 15;115(3):228-32. Review.PMID: 12935829 [PubMed - indexed for MEDLINE]Related articles

The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics.

Liu W, Bulgaru A, Haigentz M, Stein CA, Perez-Soler R, Mani S.

Curr Med Chem Anticancer Agents. 2003 May;3(3):217-23. Review.PMID: 12769779 [PubMed - indexed for MEDLINE]Related articles

Modulation of the activity of Bcl-2 in Waldenstrom's macroglobulinemia using antisense oligonucleotides.

Nichols GL, Stein CA.

Semin Oncol. 2003 Apr;30(2):297-9.PMID: 12720156 [PubMed - indexed for MEDLINE]Related articles

Antisense oligonucleotides: basic concepts and mechanisms.

Dias N, Stein CA.

Mol Cancer Ther. 2002 Mar;1(5):347-55. Review. No abstract available. PMID: 12489851 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides.

Dias N, Stein CA.

Eur J Pharm Biopharm. 2002 Nov;54(3):263-9. Review.PMID: 12445555 [PubMed - indexed for MEDLINE]Related articles

Antisense RNA down-regulation of bcl-xL Expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents.

Vilenchik M, Raffo AJ, Benimetskaya L, Shames D, Stein CA.

Cancer Res. 2002 Apr 1;62(7):2175-83.PMID: 11929841 [PubMed - indexed for MEDLINE]Related articlesFree article

Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells.

Benimetskaya L, Guzzo-Pernell N, Liu ST, Lai JC, Miller P, Stein CA.

Bioconjug Chem. 2002 Mar-Apr;13(2):177-87.PMID: 11906253 [PubMed - indexed for MEDLINE]Related articles

Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells.

Benimetskaya L, Miller P, Benimetsky S, Maciaszek A, Guga P, Beaucage SL, Wilk A, Grajkowski A, Halperin AL, Stein CA.

Mol Pharmacol. 2001 Dec;60(6):1296-307.PMID: 11723237 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles.

Berton M, Turelli P, Trono D, Stein CA, Allémann E, Gurny R.

Pharm Res. 2001 Aug;18(8):1096-101.PMID: 11587479 [PubMed - indexed for MEDLINE]Related articles

The experimental use of antisense oligonucleotides: a guide for the perplexed.

Stein CA.

J Clin Invest. 2001 Sep;108(5):641-4. No abstract available. PMID: 11544265 [PubMed - indexed for MEDLINE]Related articlesFree article

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.

Su Z, Lebedeva IV, Gopalkrishnan RV, Goldstein NI, Stein CA, Reed JC, Dent P, Fisher PB.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10332-7.PMID: 11526239 [PubMed - indexed for MEDLINE]Related articlesFree article

In defense of antisense.

Koehn RK, Rossi J, Stein CA.

Science. 2001 Aug 10;293(5532):1047-8. No abstract available. PMID: 11503637 [PubMed - indexed for MEDLINE]Related articles

The mononucleotide-dependent, nonantisense mechanism of action of phosphodiester and phosphorothioate oligonucleotides depends upon the activity of an ecto-5'-nucleotidase.

Koziolkiewicz M, Gendaszewska E, Maszewska M, Stein CA, Stec WJ.

Blood. 2001 Aug 15;98(4):995-1002.PMID: 11493444 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense that comes naturally.

Stein CA.

Nat Biotechnol. 2001 Aug;19(8):737-8. No abstract available. PMID: 11479564 [PubMed - indexed for MEDLINE]Related articles

Chemosensitization of bladder carcinoma cells by bcl-xL antisense oligonucleotides.

Lebedeva I, Raffo A, Rando R, Ojwang J, Cossum P, Stein CA.

J Urol. 2001 Aug;166(2):461-9.PMID: 11458048 [PubMed - indexed for MEDLINE]Related articles

Evidence for higher-order structure formation by the c-myb 18-mer phosphorothioate antisense (codons 2-7) oligodeoxynucleotide: potential relationship to antisense c-myb inhibition.

Vilenchik M, Benimetsky L, Kolbanovsky A, Miller P, Stein CA.

Antisense Nucleic Acid Drug Dev. 2001 Apr;11(2):87-97.PMID: 11334144 [PubMed - indexed for MEDLINE]Related articles

Antisense oligonucleotides: promise and reality.

Lebedeva I, Stein CA.

Annu Rev Pharmacol Toxicol. 2001;41:403-19. Review.PMID: 11264463 [PubMed - indexed for MEDLINE]Related articles

Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity.

Lebedeva I, Rando R, Ojwang J, Cossum P, Stein CA.

Cancer Res. 2000 Nov 1;60(21):6052-60.PMID: 11085527 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular delivery of antisense oligonucleotides.

Lebedeva I, Benimetskaya L, Stein CA, Vilenchik M.

Eur J Pharm Biopharm. 2000 Jul;50(1):101-19. Review.PMID: 10840195 [PubMed - indexed for MEDLINE]Related articles

Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments.

Stein CA.

Biochim Biophys Acta. 1999 Dec 10;1489(1):45-52. Review.PMID: 10806996 [PubMed - indexed for MEDLINE]Related articles