PubMed

Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application.

Saghir SA, Frantz SW, Spence MW, Nolan RJ, Lowe ER, Rick DL, Bartels MJ.

Food Chem Toxicol. 2007 Oct;45(10):2047-56. Epub 2007 May 18.PMID: 17583405 [PubMed - indexed for MEDLINE]Related articles

Building a cathedral: neuroscience and the legacy of Leon Wolfe.

Spence MW.

Mol Neurobiol. 2005 Aug;32(1):5-13.PMID: 16077178 [PubMed - indexed for MEDLINE]Related articles

The determination of the ability of polyurethane foam to release toluene diisocyanate into air.

Hugo JM, Spence MW, Lickly TD.

Appl Occup Environ Hyg. 2000 Jun;15(6):512-9.PMID: 10853292 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the cost-effectiveness of various passive monitors and active monitors for industrial hygiene sampling.

Nothstein GL, Hahne RM, Spence MW.

AIHAJ. 2000 Jan-Feb;61(1):64-8.PMID: 10772616 [PubMed - indexed for MEDLINE]Related articles

Craniocervical injuries in judicial hangings: an anthropologic analysis of six cases.

Spence MW, Shkrum MJ, Ariss A, Regan J.

Am J Forensic Med Pathol. 1999 Dec;20(4):309-22.PMID: 10624922 [PubMed - indexed for MEDLINE]Related articles

Experience with nurturing clinical investigation in Alberta.

Magnan JW, Spence MW.

Clin Invest Med. 1997 Aug;20(4):273-6. No abstract available. PMID: 9258588 [PubMed - indexed for MEDLINE]Related articles

Alterations of membrane phospholipid metabolism in patients with schizophrenia assessed by phosphorus magnetic resonance spectroscopy.

George TP, Spence MW.

Arch Gen Psychiatry. 1996 Nov;53(11):1065-6. No abstract available. PMID: 8911233 [PubMed - indexed for MEDLINE]Related articles

Regulation of low density lipoprotein receptor and 3-hydroxy-3-methyl-glutaryl-CoA reductase activities are differentially affected in Niemann-Pick type C and type D fibroblasts.

Sidhu HS, Rastogi SA, Byers DM, Guernsey DL, Cook HW, Palmer FB, Spence MW.

Biochem Cell Biol. 1993 Sep-Oct;71(9-10):467-74.PMID: 8192899 [PubMed - indexed for MEDLINE]Related articles

Limited metabolic interaction of serine with ethanolamine and choline in the turnover of phosphatidylserine, phosphatidylethanolamine and plasmalogens in cultured glioma cells.

Xu Z, Byers DM, Palmer FB, Spence MW, Cook HW.

Biochim Biophys Acta. 1993 Jun 12;1168(2):167-74.PMID: 8504151 [PubMed - indexed for MEDLINE]Related articles

Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells.

Byers DM, Palmer FB, Spence MW, Cook HW.

J Neurochem. 1993 Apr;60(4):1414-21.PMID: 8455032 [PubMed - indexed for MEDLINE]Related articles

Sphingomyelinases.

Spence MW.

Adv Lipid Res. 1993;26:3-23. Review. No abstract available. PMID: 8379456 [PubMed - indexed for MEDLINE]Related articles

Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake.

Palmer FB, Byers DM, Spence MW, Cook HW.

Biochem J. 1992 Sep 1;286 ( Pt 2):505-12.PMID: 1530583 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acid incorporation into plasmalogens in plasma membrane of glioma cells is preceded temporally by acylation in microsomes.

Thomas SE, Morris SJ, Xu Z, Byers DM, Palmer FB, Spence MW, Cook HW.

Biochim Biophys Acta. 1992 Jun 22;1126(2):125-34.PMID: 1627614 [PubMed - indexed for MEDLINE]Related articles

Cultured fibroblasts from patients with Niemann-Pick disease type C and type D exhibit distinct defects in cholesterol esterification.

Sidhu HS, Rastogi SA, Byers DM, Cook HW, Palmer FB, Spence MW.

Biochim Biophys Acta. 1992 Feb 20;1124(1):29-35.PMID: 1543723 [PubMed - indexed for MEDLINE]Related articles

Niemann-Pick type II fibroblasts exhibit impaired cholesterol esterification in response to sphingomyelin hydrolysis.

Byers DM, Morgan MW, Cook HW, Palmer FB, Spence MW.

Biochim Biophys Acta. 1992 Jan 16;1138(1):20-6.PMID: 1737066 [PubMed - indexed for MEDLINE]Related articles

Alternate pathways in the desaturation and chain elongation of linolenic acid, 18:3(n-3), in cultured glioma cells.

Cook HW, Byers DM, Palmer FB, Spence MW, Rakoff H, Duval SM, Emken EA.

J Lipid Res. 1991 Aug;32(8):1265-73.PMID: 1770309 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: potential regulation of biosynthesis by Ca(2+)-dependent mechanisms.

George TP, Cook HW, Byers DM, Palmer FB, Spence MW.

Biochim Biophys Acta. 1991 Jul 9;1084(2):185-93.PMID: 1854804 [PubMed - indexed for MEDLINE]Related articles

Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+.

George TP, Cook HW, Byers DM, Palmer FB, Spence MW.

J Biol Chem. 1991 Jul 5;266(19):12419-23.PMID: 2061317 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of eukaryotic phospholipid metabolism.

Kent C, Carman GM, Spence MW, Dowhan W.

FASEB J. 1991 Jun;5(9):2258-66. Review.PMID: 1860617 [PubMed - indexed for MEDLINE]Related articlesFree article

Fabry disease in a large Nova Scotia kindred: carrier detection using leucocyte alpha-galactosidase activity and an NcoI polymorphism detected by an alpha-galactosidase cDNA clone.

Kirkilionis AJ, Riddell DC, Spence MW, Fenwick RG.

J Med Genet. 1991 Apr;28(4):232-40.PMID: 1677424 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine utilization as a precursor of phosphatidylserine and alkenyl-(plasmenyl)-, alkyl-, and acylethanolamine phosphoglycerides in cultured glioma cells.

Xu ZL, Byers DM, Palmer FB, Spence MW, Cook HW.

J Biol Chem. 1991 Feb 5;266(4):2143-50.PMID: 1899236 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of sphingomyelin in phosphatidylcholine metabolism in cultured human fibroblasts from control and sphingomyelin lipidosis patients and in Chinese hamster ovary cells.

Spence MW, Cook HW, Byers DM, Palmer FB.

Biochem J. 1990 Jun 15;268(3):719-24.PMID: 2363706 [PubMed - indexed for MEDLINE]Related articlesFree article

Incorporation of polyunsaturated fatty acids into plasmalogens, compared to other phospholipids of cultured glioma cells, is more dependent on chain length than on selectivity between (n - 3) and (n - 6) families.

Thomas SE, Byers DM, Palmer FB, Spence MW, Cook HW.

Biochim Biophys Acta. 1990 Jun 14;1044(3):349-56.PMID: 2364099 [PubMed - indexed for MEDLINE]Related articles

Discovery, recruitment, and public relations--some thoughts on the role and the future of clinical investigation in Canada.

Spence MW.

Clin Invest Med. 1990 Apr;13(2):92-7. No abstract available. PMID: 2354574 [PubMed - indexed for MEDLINE]Related articles

Phosphoinositide metabolism in cultured glioma and neuroblastoma cells: subcellular distribution of enzymes indicate incomplete turnover at the plasma membrane.

Morris SJ, Cook HW, Byers DM, Spence MW, Palmer FB.

Biochim Biophys Acta. 1990 Mar;1022(3):339-47.PMID: 2156558 [PubMed - indexed for MEDLINE]Related articles

Measurement of organic vapors at sub-TLV concentrations using fast gas chromatography.

Mouradian RF, Levine SP, Sacks RD, Spence MW.

Am Ind Hyg Assoc J. 1990 Feb;51(2):90-5.PMID: 2305678 [PubMed - indexed for MEDLINE]Related articles

Defective activity of acyl-CoA:cholesterol O-acyltransferase in Niemann-Pick type C and type D fibroblasts.

Byers DM, Rastogi SR, Cook HW, Palmer FB, Spence MW.

Biochem J. 1989 Sep 15;262(3):713-9.PMID: 2590161 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates.

George TP, Morash SC, Cook HW, Byers DM, Palmer FB, Spence MW.

Biochim Biophys Acta. 1989 Aug 22;1004(3):283-91.PMID: 2758024 [PubMed - indexed for MEDLINE]Related articles

Lysophosphatidylcholine as an intermediate in phosphatidylcholine metabolism and glycerophosphocholine synthesis in cultured cells: an evaluation of the roles of 1-acyl- and 2-acyl-lysophosphatidylcholine.

Morash SC, Cook HW, Spence MW.

Biochim Biophys Acta. 1989 Aug 8;1004(2):221-9.PMID: 2752020 [PubMed - indexed for MEDLINE]Related articles

Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.

Glanville NT, Byers DM, Cook HW, Spence MW, Palmer FB.

Biochim Biophys Acta. 1989 Aug 8;1004(2):169-79.PMID: 2546591 [PubMed - indexed for MEDLINE]Related articles

Cell-specific fatty acylation of proteins in cultured cells of neuronal and glial origin.

Byers DM, Cook HW, Palmer FB, Spence MW.

Neurochem Res. 1989 Jun;14(6):503-9.PMID: 2548106 [PubMed - indexed for MEDLINE]Related articles

A new Zn2+-stimulated sphingomyelinase in fetal bovine serum.

Spence MW, Byers DM, Palmer FB, Cook HW.

J Biol Chem. 1989 Apr 5;264(10):5358-63.PMID: 2538416 [PubMed - indexed for MEDLINE]Related articlesFree article

Dideoxycytidine, an anti-HIV drug, selectively inhibits growth but not phosphatidylcholine metabolism in neuroblastoma and glioma cells.

Cook HW, Spence MW.

Neurochem Res. 1989 Mar;14(3):279-84.PMID: 2542824 [PubMed - indexed for MEDLINE]Related articles

Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells.

Cook HW, Byers DM, Palmer FB, Spence MW.

J Biol Chem. 1989 Feb 15;264(5):2746-52.PMID: 2914928 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of plasma membranes from cultured glioma cells and application to evaluation of membrane sphingomyelin turnover.

Cook HW, Palmer FB, Byers DM, Spence MW.

Anal Biochem. 1988 Nov 1;174(2):552-60.PMID: 3239757 [PubMed - indexed for MEDLINE]Related articles

Sodium channel activation does not alter lipid metabolism in cultured neuroblastoma cells.

Glanville TN, Spence MW, Cook HW, Palmer FB.

Neurochem Res. 1988 Nov;13(11):1015-21.PMID: 2853304 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylcholine metabolism in cultured cells: catabolism via glycerophosphocholine.

Morash SC, Cook HW, Spence MW.

Biochim Biophys Acta. 1988 Jul 22;961(2):194-202.PMID: 3390456 [PubMed - indexed for MEDLINE]Related articles

Compartmentation of phosphorylated precursors of phospholipid biosynthesis in cultured neuroblastoma cells.

Glanville NT, Cook HW, Spence MW.

Biochim Biophys Acta. 1987 Nov 13;904(2):392-400.PMID: 3117115 [PubMed - indexed for MEDLINE]Related articles

Interaction of (n-3) and (n-6) fatty acids in desaturation and chain elongation of essential fatty acids in cultured glioma cells.

Cook HW, Spence MW.

Lipids. 1987 Sep;22(9):613-9.PMID: 3669924 [PubMed - indexed for MEDLINE]Related articles

Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells.

Cook HW, Spence MW.

Biochim Biophys Acta. 1987 Apr 24;918(3):217-29.PMID: 3105586 [PubMed - indexed for MEDLINE]Related articles

Prevalence of major mental retardation and associated disabilities in the Canadian Maritime Provinces.

McQueen PC, Spence MW, Garner JB, Pereira LH, Winsor EJ.

Am J Ment Defic. 1987 Mar;91(5):460-6.PMID: 2952009 [PubMed - indexed for MEDLINE]Related articles

Turnover of phospholipid fatty acyl chains in cultured neuroblastoma cells: involvement of deacylation-reacylation and de novo synthesis in plasma membranes.

Chakravarthy BR, Spence MW, Cook HW.

Biochim Biophys Acta. 1986 Dec 5;879(3):264-77.PMID: 3778920 [PubMed - indexed for MEDLINE]Related articles

Causal origins of major mental handicap in the Canadian Maritime provinces.

McQueen PC, Spence MW, Winsor EJ, Garner JB, Pereira LH.

Dev Med Child Neurol. 1986 Dec;28(6):697-707.PMID: 3817308 [PubMed - indexed for MEDLINE]Related articles

Acid and alkaline ceramidases of rat tissues.

Spence MW, Beed S, Cook HW.

Biochem Cell Biol. 1986 May;64(5):400-4.PMID: 3718708 [PubMed - indexed for MEDLINE]Related articles

Triacylglycerol as a precursor in phospholipid biosynthesis in cultured neuroblastoma cells: studies with labeled glucose, fatty acid, and triacylglycerol.

Cook HW, Spence MW.

Can J Biochem Cell Biol. 1985 Sep;63(9):919-26.PMID: 4075230 [PubMed - indexed for MEDLINE]Related articles

Catabolism of exogenous and endogenous sphingomyelin and phosphatidylcholine by homogenates and subcellular fractions of cultured neuroblastoma cells. Effects of anesthetics.

Mooibroek MJ, Cook HW, Clarke JT, Spence MW.

J Neurochem. 1985 May;44(5):1551-8.PMID: 3989549 [PubMed - indexed for MEDLINE]Related articles

Chemical protective clothing: determining good performance.

Coletta GC, Spence MW.

Occup Health Saf. 1985 Apr;54(4):20-1, 23, 72. No abstract available. PMID: 3157895 [PubMed - indexed for MEDLINE]Related articles

Studies on the turnover and subcellular localization of membrane gangliosides in cultured neuroblastoma cells.

Clarke JT, Cook HW, Spence MW.

Neurochem Res. 1985 Mar;10(3):427-38.PMID: 4000396 [PubMed - indexed for MEDLINE]Related articles

Rapid isolation of neuroblastoma plasma membranes on Percoll gradients. Characterization and lipid composition.

Chakravarthy BR, Spence MW, Clarke JT, Cook HW.

Biochim Biophys Acta. 1985 Jan 10;812(1):223-33.PMID: 3967013 [PubMed - indexed for MEDLINE]Related articles

Evidence that neutral sphingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane.

Das DV, Cook HW, Spence MW.

Biochim Biophys Acta. 1984 Nov 7;777(2):339-42.PMID: 6091759 [PubMed - indexed for MEDLINE]Related articles