PubMed

Eflornithine for African sleeping sickness.

Sjoerdsma A, Schechter PJ.

Lancet. 1999 Jul 17;354(9174):254. No abstract available. PMID: 10421331 [PubMed - indexed for MEDLINE]Related articles

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Sjoerdsma A, Saric M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1994 Mar;38(3):563-9.PMID: 8203855 [PubMed - indexed for MEDLINE]Related articlesFree article

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti AJ, Sjoerdsma A.

Antimicrob Agents Chemother. 1992 Dec;36(12):2736-40.PMID: 1482141 [PubMed - indexed for MEDLINE]Related articlesFree article

Antimalarial polyamine analogues.

Edwards ML, Stemerick DM, Bitonti AJ, Dumont JA, McCann PP, Bey P, Sjoerdsma A.

J Med Chem. 1991 Feb;34(2):569-74.PMID: 1995879 [PubMed - indexed for MEDLINE]Related articles

Participation of T-lymphocytes in the curative effect of a novel synthetic polyamine analogue, N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine, against L1210 leukemia in vivo.

Bowlin TL, Prakash NJ, Edwards ML, Sjoerdsma A.

Cancer Res. 1991 Jan 1;51(1):62-6.PMID: 1988107 [PubMed - indexed for MEDLINE]Related articlesFree article

Antitumor activity of a novel synthetic polyamine analogue, N,N'-bis-[3-(ethylamino)-propyl]-1-7-heptane diamine: potentiation by polyamine oxidase inhibitors.

Prakash NJ, Bowlin TL, Edwards ML, Sunkara PS, Sjoerdsma A.

Anticancer Res. 1990 Sep-Oct;10(5A):1281-7.PMID: 2241104 [PubMed - indexed for MEDLINE]Related articles

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.

Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB Jr, McCann PP, Sjoerdsma A.

Antimicrob Agents Chemother. 1990 Aug;34(8):1485-90.PMID: 1977366 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog.

Baumann RJ, Hanson WL, McCann PP, Sjoerdsma A, Bitonti AJ.

Antimicrob Agents Chemother. 1990 May;34(5):722-7.PMID: 2360812 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical relevance of measuring GABA concentrations in cerebrospinal fluid.

Schechter PJ, Sjoerdsma A.

Neurochem Res. 1990 Apr;15(4):419-23. Review.PMID: 2201926 [PubMed - indexed for MEDLINE]Related articles

History of serotonin and serotinin disorders.

Sjoerdsma A, Palfreyman MG.

Ann N Y Acad Sci. 1990;600:1-7; discussion 7-8. Review. No abstract available. PMID: 2252303 [PubMed - indexed for MEDLINE]Related articles

Inhibition of glycoprotein processing and HIV replication by castanospermine analogues.

Sunkara PS, Kang MS, Bowlin TL, Liu PS, Tyms AS, Sjoerdsma A.

Ann N Y Acad Sci. 1990;616:90-6.PMID: 2078038 [PubMed - indexed for MEDLINE]Related articles

Anti-HIV activity of castanospermine analogues.

Sunkara PS, Taylor DL, Kang MS, Bowlin TL, Liu PS, Tyms AS, Sjoerdsma A.

Lancet. 1989 May 27;1(8648):1206. No abstract available. PMID: 2566768 [PubMed - indexed for MEDLINE]Related articles

Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.

Bitonti AJ, Dumont JA, Bush TL, Edwards ML, Stemerick DM, McCann PP, Sjoerdsma A.

Proc Natl Acad Sci U S A. 1989 Jan;86(2):651-5.PMID: 2463635 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

Bitonti AJ, Sjoerdsma A, McCann PP, Kyle DE, Oduola AM, Rossan RN, Milhous WK, Davidson DE Jr.

Science. 1988 Dec 2;242(4883):1301-3.PMID: 3057629 [PubMed - indexed for MEDLINE]Related articles

Antitumor activity of norspermidine, a structural homologue of the natural polyamine spermidine.

Prakash NJ, Bowlin TL, Davis GF, Sunkara PS, Sjoerdsma A.

Anticancer Res. 1988 Jul-Aug;8(4):563-8.PMID: 3140710 [PubMed - indexed for MEDLINE]Related articles

A multicenter, open study of the non-sedating antihistamine, terfenadine (Seldane), in the maintenance therapy of seasonal allergic rhinitis.

Kemp JP, Falliers CJ, Fox RW, Guill MF, Segal AT, Tsai TH, Sjoerdsma A.

Ann Allergy. 1988 Apr;60(4):349-54.PMID: 2895990 [PubMed - indexed for MEDLINE]Related articles

African sleeping sickness in the United States. Successful treatment with eflornithine.

Petru AM, Azimi PH, Cummins SK, Sjoerdsma A.

Am J Dis Child. 1988 Feb;142(2):224-8.PMID: 3124603 [PubMed - indexed for MEDLINE]Related articles

Design and early clinical evaluation of selective inhibitors of monoamine oxidase.

Palfreyman MG, McDonald IA, Bey P, Schechter PJ, Sjoerdsma A.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):967-87.PMID: 3266532 [PubMed - indexed for MEDLINE]Related articles

Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis.

McCann PP, Bacchi CJ, Bitonti AJ, Kierszenbaum F, Sjoerdsma A.

Adv Exp Med Biol. 1988;250:727-35. Review. No abstract available. PMID: 3151233 [PubMed - indexed for MEDLINE]Related articles

The effects of polyamine analogues on malaria parasites in vitro and in vivo.

Bitonti AJ, McCann PP, Sjoerdsma A.

Adv Exp Med Biol. 1988;250:717-26. No abstract available. PMID: 2475014 [PubMed - indexed for MEDLINE]Related articles

Treatment of human late stage gambiense trypanosomiasis with alpha-difluoromethylornithine (eflornithine): efficacy and tolerance in 14 cases in Côte d'Ivoire.

Doua F, Boa FY, Schechter PJ, Miézan TW, Diai D, Sanon SR, De Raadt P, Haegele KD, Sjoerdsma A, Konian K.

Am J Trop Med Hyg. 1987 Nov;37(3):525-33.PMID: 3120607 [PubMed - indexed for MEDLINE]Related articles

Antiretroviral activity of castanospermine and deoxynojirimycin, specific inhibitors of glycoprotein processing.

Sunkara PS, Bowlin TL, Liu PS, Sjoerdsma A.

Biochem Biophys Res Commun. 1987 Oct 14;148(1):206-10.PMID: 2960321 [PubMed - indexed for MEDLINE]Related articles

Impairment of macrophage function by inhibitors of ornithine decarboxylase activity.

Kierszenbaum F, Wirth JJ, McCann PP, Sjoerdsma A.

Infect Immun. 1987 Oct;55(10):2461-4.PMID: 3115898 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony.

Bitonti AJ, McCann PP, Sjoerdsma A.

Exp Parasitol. 1987 Oct;64(2):237-43.PMID: 3115816 [PubMed - indexed for MEDLINE]Related articles

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

Kierszenbaum F, Wirth JJ, McCann PP, Sjoerdsma A.

Proc Natl Acad Sci U S A. 1987 Jun;84(12):4278-82.PMID: 3295879 [PubMed - indexed for MEDLINE]Related articlesFree article

Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis. Results in five patients.

Taelman H, Schechter PJ, Marcelis L, Sonnet J, Kazyumba G, Dasnoy J, Haegele KD, Sjoerdsma A, Wery M.

Am J Med. 1987 Mar 23;82(3 Spec No):607-14.PMID: 3103442 [PubMed - indexed for MEDLINE]Related articles

Decarboxylated-S-adenosylmethionine excretion: a biochemical marker of ornithine decarboxylase inhibition by alpha-difluoromethylornithine.

Haegele KD, Splinter TA, Romijn JC, Schechter PJ, Sjoerdsma A.

Cancer Res. 1987 Feb 1;47(3):890-5.PMID: 3100028 [PubMed - indexed for MEDLINE]Related articlesFree article

Enzyme-activated/mechanism-based inhibitors.

Palfreyman MG, Bey P, Sjoerdsma A.

Essays Biochem. 1987;23:28-81. Review. No abstract available. PMID: 3331367 [PubMed - indexed for MEDLINE]Related articles

Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.

Bacchi CJ, Nathan HC, Clarkson AB Jr, Bienen EJ, Bitonti AJ, McCann PP, Sjoerdsma A.

Am J Trop Med Hyg. 1987 Jan;36(1):46-52.PMID: 3101528 [PubMed - indexed for MEDLINE]Related articles

Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes.

Kaur K, Emmett K, McCann PP, Sjoerdsma A, Ullman B.

J Protozool. 1986 Nov;33(4):518-21.PMID: 3098971 [PubMed - indexed for MEDLINE]Related articles

Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.

McCann PP, Bacchi CJ, Clarkson AB Jr, Bey P, Sjoerdsma A, Schecter PJ, Walzer PD, Barlow JL.

Am J Trop Med Hyg. 1986 Nov;35(6):1153-6.PMID: 3098121 [PubMed - indexed for MEDLINE]Related articles

Late-stage African trypanosomiasis and eflornithine.

di Bari C, Pastore G, Roscigno G, Schechter PJ, Sjoerdsma A.

Ann Intern Med. 1986 Nov;105(5):803-4. No abstract available. PMID: 3094420 [PubMed - indexed for MEDLINE]Related articles

Difiuoromethylornithine in the treatment of African trypanosomiasis.

Schechter PJ, Sjoerdsma A.

Parasitol Today. 1986 Aug;2(8):223-4. No abstract available. PMID: 15462844 [PubMed]Related articles

Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.

Abeloff MD, Rosen ST, Luk GD, Baylin SB, Zeltzman M, Sjoerdsma A.

Cancer Treat Rep. 1986 Jul;70(7):843-5.PMID: 3013400 [PubMed - indexed for MEDLINE]Related articles

Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.

Luk GD, Abeloff MD, McCann PP, Sjoerdsma A, Baylin SB.

Cancer Res. 1986 Apr;46(4 Pt 1):1849-53.PMID: 3004708 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of polyamines in the cochlea of the rat and their potential role in hearing.

Schweitzer L, Casseday JH, Sjoerdsma A, McCann PP, Bartolome JV.

Brain Res Bull. 1986 Feb;16(2):215-8.PMID: 3084042 [PubMed - indexed for MEDLINE]Related articles

Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei.

Bitonti AJ, Bacchi CJ, McCann PP, Sjoerdsma A.

Biochem Pharmacol. 1986 Jan 15;35(2):351-4. No abstract available. PMID: 3080009 [PubMed - indexed for MEDLINE]Related articles

Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine.

Bitonti AJ, McCann PP, Sjoerdsma A.

Biochem Pharmacol. 1986 Jan 15;35(2):331-4.PMID: 3080008 [PubMed - indexed for MEDLINE]Related articles

Marked and prolonged inhibition of mammalian ornithine decarboxylase in vivo by esters of (E)-2-(fluoromethyl)dehydroornithine.

Mamont PS, Danzin C, Kolb M, Gerhart F, Bey P, Sjoerdsma A.

Biochem Pharmacol. 1986 Jan 15;35(2):159-65.PMID: 3080004 [PubMed - indexed for MEDLINE]Related articles

Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.

Hollingdale MR, McCann PP, Sjoerdsma A.

Exp Parasitol. 1985 Aug;60(1):111-7.PMID: 2990989 [PubMed - indexed for MEDLINE]Related articles

Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.

Prakash NJ, Sunkara PS, Sjoerdsma A.

Biochem Pharmacol. 1985 Jun 1;34(11):1887-90.PMID: 3924051 [PubMed - indexed for MEDLINE]Related articles

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.

Bitonti AJ, Bacchi CJ, McCann PP, Sjoerdsma A.

Biochem Pharmacol. 1985 May 15;34(10):1773-7.PMID: 3924048 [PubMed - indexed for MEDLINE]Related articles

Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial.

Van Nieuwenhove S, Schechter PJ, Declercq J, Boné G, Burke J, Sjoerdsma A.

Trans R Soc Trop Med Hyg. 1985;79(5):692-8.PMID: 3938090 [PubMed - indexed for MEDLINE]Related articles

Inhibition of growth of Mycoplasma dispar by DL-alpha-difluoromethyllsine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane).

Pösö H, McCann PP, Tanskanen R, Bey P, Sjoerdsma A.

Biochem Biophys Res Commun. 1984 Nov 30;125(1):205-10.PMID: 6439203 [PubMed - indexed for MEDLINE]Related articles

Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.

Golden JA, Sjoerdsma A, Santi DV.

West J Med. 1984 Nov;141(5):613-23.PMID: 6440364 [PubMed - indexed for MEDLINE]Related articlesFree article

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.

Clarkson AB Jr, Bienen EJ, Bacchi CJ, McCann PP, Nathan HC, Hutner SH, Sjoerdsma A.

Am J Trop Med Hyg. 1984 Nov;33(6):1073-7.PMID: 6439061 [PubMed - indexed for MEDLINE]Related articles

Chemotherapeutic implications of polyamine biosynthesis inhibition.

Sjoerdsma A, Schechter PJ.

Clin Pharmacol Ther. 1984 Mar;35(3):287-300. Review. No abstract available. PMID: 6421528 [PubMed - indexed for MEDLINE]Related articles

Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy.

Schechter PJ, Hanke NF, Grove J, Huebert N, Sjoerdsma A.

Neurology. 1984 Feb;34(2):182-6.PMID: 6538006 [PubMed - indexed for MEDLINE]Related articles

Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.

Abeloff MD, Slavik M, Luk GD, Griffin CA, Hermann J, Blanc O, Sjoerdsma A, Baylin SB.

J Clin Oncol. 1984 Feb;2(2):124-30.PMID: 6422008 [PubMed - indexed for MEDLINE]Related articles

Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.

Sjoerdsma A, Golden JA, Schechter PJ, Barlow JL, Santi DV.

Trans Assoc Am Physicians. 1984;97:70-9. No abstract available. PMID: 6442954 [PubMed - indexed for MEDLINE]Related articles