PubMed

Mice with vestibular deficiency display hyperactivity, disorientation, and signs of anxiety.

Avni R, Elkan T, Dror AA, Shefer S, Eilam D, Avraham KB, Mintz M.

Behav Brain Res. 2009 Sep 14;202(2):210-7. Epub 2009 Apr 1.PMID: 19463703 [PubMed - indexed for MEDLINE]Related articles

Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis.

Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Hirayama T, Tint GS, Doy M, Shefer S.

J Lipid Res. 2005 Feb;46(2):287-96. Epub 2004 Dec 1.PMID: 15576845 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, SCH 58235, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto rats.

Batta AK, Xu G, Bollineni JS, Shefer S, Salen G.

Metabolism. 2005 Jan;54(1):38-48.PMID: 15562378 [PubMed - indexed for MEDLINE]Related articles

Role of CYP27A in cholesterol and bile acid metabolism.

Dubrac S, Lear SR, Ananthanarayanan M, Balasubramaniyan N, Bollineni J, Shefer S, Hyogo H, Cohen DE, Blanche PJ, Krauss RM, Batta AK, Salen G, Suchy FJ, Maeda N, Erickson SK.

J Lipid Res. 2005 Jan;46(1):76-85. Epub 2004 Nov 1.PMID: 15520450 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.

Li H, Xu G, Shang Q, Pan L, Shefer S, Batta AK, Bollineni J, Tint GS, Keller BT, Salen G.

Metabolism. 2004 Jul;53(7):927-32.PMID: 15254889 [PubMed - indexed for MEDLINE]Related articles

Red to Mediterranean Sea bioinvasion: natural drift through the Suez Canal, or anthropogenic transport?

Shefer S, Abelson A, Mokady O, Geffen E.

Mol Ecol. 2004 Aug;13(8):2333-43.PMID: 15245405 [PubMed - indexed for MEDLINE]Related articles

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.

Klett EL, Lu K, Kosters A, Vink E, Lee MH, Altenburg M, Shefer S, Batta AK, Yu H, Chen J, Klein R, Looije N, Oude-Elferink R, Groen AK, Maeda N, Salen G, Patel SB.

BMC Med. 2004 Mar 24;2:5.PMID: 15040800 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.

Tiemann M, Han Z, Soccio R, Bollineni J, Shefer S, Sehayek E, Breslow JL.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1846-51. Epub 2004 Feb 4.PMID: 14762172 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated.

Xu G, Pan LX, Li H, Shang Q, Honda A, Shefer S, Bollineni J, Matsuzaki Y, Tint GS, Salen G.

Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G730-5. Epub 2003 Dec 18.PMID: 14684380 [PubMed - indexed for MEDLINE]Related articlesFree article

Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.

Honda A, Yoshida T, Xu G, Matsuzaki Y, Fukushima S, Tanaka N, Doy M, Shefer S, Salen G.

Metabolism. 2004 Jan;53(1):42-8.PMID: 14681840 [PubMed - indexed for MEDLINE]Related articles

FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.

Xu G, Li H, Pan LX, Shang Q, Honda A, Ananthanarayanan M, Erickson SK, Shneider BL, Shefer S, Bollineni J, Forman BM, Matsuzaki Y, Suchy FJ, Tint GS, Salen G.

J Lipid Res. 2003 Oct;44(10):1956-62. Epub 2003 Aug 1.PMID: 12897188 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol.

Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, Vance DE, Ananthanarayanan M, Chait BT, Breslow JL.

J Lipid Res. 2003 Sep;44(9):1605-13. Epub 2003 Jun 16.PMID: 12810817 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.

Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G.

J Lipid Res. 2003 May;44(5):1001-9. Epub 2003 Feb 16.PMID: 12588950 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits.

Xu G, Pan LX, Li H, Forman BM, Erickson SK, Shefer S, Bollineni J, Batta AK, Christie J, Wang TH, Michel J, Yang S, Tsai R, Lai L, Shimada K, Tint GS, Salen G.

J Biol Chem. 2002 Dec 27;277(52):50491-6. Epub 2002 Oct 24.PMID: 12401785 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the effect of intestinal resection on rat ileal bile Acid transporter expression and on bile Acid and cholesterol homeostasis.

Al-Ansari N, Xu G, Kollman-Bauerly K, Coppola C, Shefer S, Ujhazy P, Ortiz D, Ma L, Yang S, Tsai R, Salen G, Vanderhoof J, Shneider BL.

Pediatr Res. 2002 Aug;52(2):286-91.PMID: 12149508 [PubMed - indexed for MEDLINE]Related articles

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.

Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP.

J Clin Invest. 2002 Jul;110(1):109-17.PMID: 12093894 [PubMed - indexed for MEDLINE]Related articlesFree article

Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits.

Xu G, Pan LX, Erickson SK, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G.

J Lipid Res. 2002 Jan;43(1):45-50.PMID: 11792721 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans.

Moghadasian MH, McManus BM, Nguyen LB, Shefer S, Nadji M, Godin DV, Green TJ, Hill J, Yang Y, Scudamore CH, Frohlich JJ.

FASEB J. 2001 Dec;15(14):2623-30.PMID: 11726538 [PubMed - indexed for MEDLINE]Related articlesFree article

Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis.

Johnston TP, Nguyen LB, Chu WA, Shefer S.

Int J Pharm. 2001 Oct 23;229(1-2):75-86.PMID: 11604260 [PubMed - indexed for MEDLINE]Related articles

Macrophage 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in sitosterolemia: effects of increased cellular cholesterol and sitosterol concentrations.

Nguyen LB, Salen G, Shefer S, Tint GS, Ruiz F.

Metabolism. 2001 Oct;50(10):1224-9.PMID: 11586498 [PubMed - indexed for MEDLINE]Related articles

7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome.

Fitzky BU, Moebius FF, Asaoka H, Waage-Baudet H, Xu L, Xu G, Maeda N, Kluckman K, Hiller S, Yu H, Batta AK, Shefer S, Chen T, Salen G, Sulik K, Simoni RD, Ness GC, Glossmann H, Patel SB, Tint GS.

J Clin Invest. 2001 Sep;108(6):905-15.PMID: 11560960 [PubMed - indexed for MEDLINE]Related articlesFree article

Plant stanol fatty acid esters inhibit cholesterol absorption and hepatic hydroxymethyl glutaryl coenzyme A reductase activity to reduce plasma levels in rabbits.

Xu G, Salen G, Shefer S, Tint GS, Nguyen LB, Batta AK, Pcolinsky M.

Metabolism. 2001 Sep;50(9):1106-12.PMID: 11555847 [PubMed - indexed for MEDLINE]Related articles

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7alpha-hydroxylase in rabbits fed cholesterol.

Xu G, Salen G, Shneider BL, Ananthanarayanan M, Shefer S, Ma L, Batta A, Nguyen LB, Lingutla JJ, Tint GS, Pcolinsky M, Suchy FJ.

J Lipid Res. 2001 Sep;42(9):1438-43.PMID: 11518763 [PubMed - indexed for MEDLINE]Related articlesFree article

[Critical state medicine. Surfactant therapy of adult respiratory distress syndrome (results of multicenter studies)]

Granov AM, Rozenberg OA, Tsybul'kin EK, Erokhin VV, Khubulava GG, Likhvantsev VV, Osovskikh VV, Bautin AE, Gavrilin SV, Kazennov VV, Zhilin IuN, Nabokova TS, Shefer SP, Vashkevich SM, Nefedov AV, Seĭliev AA, Volchkov VA.

Vestn Ross Akad Med Nauk. 2001;(5):34-8. Russian. PMID: 11510148 [PubMed - indexed for MEDLINE]Related articles

Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice.

Sehayek E, Ono JG, Duncan EM, Batta AK, Salen G, Shefer S, Neguyen LB, Yang K, Lipkin M, Breslow JL.

J Lipid Res. 2001 Aug;42(8):1250-6.PMID: 11483626 [PubMed - indexed for MEDLINE]Related articlesFree article

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, Tint GS, Erickson SK, Tanaka N, Shefer S.

J Biol Chem. 2001 Sep 14;276(37):34579-85. Epub 2001 Jul 13.PMID: 11454857 [PubMed - indexed for MEDLINE]Related articlesFree article

[Total intravenous anesthesia with propofol, fentanyl and clopheline in young children with occlusive hydrocephalus during ventriculoperitoneal shunting]

Shefer SP, Pelogeevskaia ZI, Liapin AP, Savvina IA, Portniagin IV, Zaĭtseva NV, Kuz'menko IG.

Anesteziol Reanimatol. 1999 Nov-Dec;(6):52-6. Russian. PMID: 11452770 [PubMed - indexed for MEDLINE]Related articles

Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance.

VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L, Cohen DE.

Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G393-404.PMID: 11447020 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment.

Moghadasian MH, Nguyen LB, Shefer S, Salen G, Batta AK, Frohlich JJ.

Metabolism. 2001 Jun;50(6):708-14.PMID: 11398149 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.

Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, Stoffel M.

Nat Genet. 2001 Apr;27(4):375-82.PMID: 11279518 [PubMed - indexed for MEDLINE]Related articles

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

Honda A, Salen G, Matsuzaki Y, Batta AK, Xu G, Leitersdorf E, Tint GS, Erickson SK, Tanaka N, Shefer S.

J Lipid Res. 2001 Feb;42(2):291-300.PMID: 11181760 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin.

Nguyen LB, Shefer S, Salen G, Tint GS, Ruiz F, Bullock J.

J Lipid Res. 2001 Feb;42(2):195-200.PMID: 11181748 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects.

Salen G, Xu G, Tint GS, Batta AK, Shefer S.

J Lipid Res. 2000 Nov;41(11):1883-9.PMID: 11060358 [PubMed - indexed for MEDLINE]Related articlesFree article

Is there a relationship between 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and forebrain pathology in the PKU mouse?

Shefer S, Tint GS, Jean-Guillaume D, Daikhin E, Kendler A, Nguyen LB, Yudkoff M, Dyer CA.

J Neurosci Res. 2000 Sep 1;61(5):549-63.PMID: 10956425 [PubMed - indexed for MEDLINE]Related articles

Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome.

Honda M, Tint GS, Honda A, Salen G, Shefer S, Batta AK, Matsuzaki Y, Tanaka N.

J Inherit Metab Dis. 2000 Jul;23(5):464-74.PMID: 10947201 [PubMed - indexed for MEDLINE]Related articles

Abnormal hepatic sinusoidal bile acid transport in an Amish kindred is not linked to FIC1 and is improved by ursodiol.

Morton DH, Salen G, Batta AK, Shefer S, Tint GS, Belchis D, Shneider B, Puffenberger E, Bull L, Knisely AS.

Gastroenterology. 2000 Jul;119(1):188-95.PMID: 10889168 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.

Sehayek E, Shefer S, Nguyen LB, Ono JG, Merkel M, Breslow JL.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3433-7.PMID: 10725355 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of 25- and 27-hydroxylation side chain cleavage pathways for cholic acid biosynthesis in humans, rabbits, and mice. Assay of enzyme activities by high-resolution gas chromatography;-mass spectrometry.

Honda A, Salen G, Shefer S, Matsuzaki Y, Xu G, Batta AK, Tint GS, Tanaka N.

J Lipid Res. 2000 Mar;41(3):442-51.PMID: 10706592 [PubMed - indexed for MEDLINE]Related articlesFree article

3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts.

Honda A, Salen G, Honda M, Batta AK, Tint GS, Xu G, Chen TS, Tanaka N, Shefer S.

J Lab Clin Med. 2000 Feb;135(2):174-9.PMID: 10695663 [PubMed - indexed for MEDLINE]Related articles

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits.

Xu G, Shneider BL, Shefer S, Nguyen LB, Batta AK, Tint GS, Arrese M, Thevananther S, Ma L, Stengelin S, Kramer W, Greenblatt D, Pcolinsky M, Salen G.

J Lipid Res. 2000 Feb;41(2):298-304.PMID: 10681414 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7alpha-hydroxylase activities in the rat, guinea pig, and rabbit: effects of cholesterol and bile acids.

Nguyen LB, Xu G, Shefer S, Tint GS, Batta A, Salen G.

Metabolism. 1999 Dec;48(12):1542-8.PMID: 10599986 [PubMed - indexed for MEDLINE]Related articles

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver.

Honda A, Salen G, Shefer S, Batta AK, Honda M, Xu G, Tint GS, Matsuzaki Y, Shoda J, Tanaka N.

J Lipid Res. 1999 Aug;40(8):1520-8.PMID: 10428990 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermodynamic prediction of active ingredient loading in polymeric microparticles.

Tse G, Blankschtein D, Shefer A, Shefer S.

J Control Release. 1999 Jun 28;60(1):77-100.PMID: 10370173 [PubMed - indexed for MEDLINE]Related articles

[Our experience in the use of a Russian preparation of pulmonary surfactant in the treatment of acute respiratory distress syndrome and severe pneumonia in children]

Tsybul'kin EK, Rozenberg OA, Seĭliev AA, Volchkov VA, Zaĭtseva NV, Kuz'menko IG, Loshakova LV, Pelogievskaia ZI, Portniagin IV, Shefer SP, et al.

Anesteziol Reanimatol. 1999 Mar-Apr;(2):61-5. Russian. PMID: 10360078 [PubMed - indexed for MEDLINE]Related articles

Campestanol (24-methyl-5alpha-cholestan-3beta-ol) absorption and distribution in New Zealand White rabbits: effect of dietary sitostanol.

Xu G, Salen G, Tint GS, Batta AK, Shefer S.

Metabolism. 1999 Mar;48(3):363-8.PMID: 10094114 [PubMed - indexed for MEDLINE]Related articles

Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: effects of dietary cholesterol and phytosterols.

Moghadasian MH, Nguyen LB, Shefer S, McManus BM, Frohlich JJ.

Lab Invest. 1999 Mar;79(3):355-64.PMID: 10092072 [PubMed - indexed for MEDLINE]Related articles

Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis.

Xu G, Salen G, Shefer S, Tint GS, Nguyen LB, Chen TS, Greenblatt D.

J Clin Invest. 1999 Jan;103(1):89-95.PMID: 9884338 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol and oxygenated cholesterol concentrations are markedly elevated in peripheral tissue but not in brain from mice with the Niemann-Pick type C phenotype.

Tint GS, Pentchev P, Xu G, Batta AK, Shefer S, Salen G, Honda A.

J Inherit Metab Dis. 1998 Dec;21(8):853-63.PMID: 9870211 [PubMed - indexed for MEDLINE]Related articles

Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation.

Shefer S, Salen G, Honda A, Batta AK, Nguyen LB, Tint GS, Ioannou YA, Desnick R.

J Lipid Res. 1998 Dec;39(12):2471-6.PMID: 9831636 [PubMed - indexed for MEDLINE]Related articlesFree article

Accurate detection of Smith-Lemli-Opitz syndrome carriers by measurement of the rate of reduction of the ergosterol C-7 double bond in cultured skin fibroblasts.

Honda M, Tint GS, Shefer S, Honda A, Batta AK, Xu G, Chen TS, Salen G.

J Inherit Metab Dis. 1998 Oct;21(7):761-8.PMID: 9819706 [PubMed - indexed for MEDLINE]Related articles