PubMed

An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.

Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA.

Nat Med. 2009 Oct;15(10):1163-9. Epub 2009 Sep 6.PMID: 19734908 [PubMed - indexed for MEDLINE]Related articles

The beta3 integrin cytoplasmic tail: protein scaffold and control freak.

Shattil SJ.

J Thromb Haemost. 2009 Jul;7 Suppl 1:210-3.PMID: 19630802 [PubMed - in process]Related articles

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.

Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH.

J Biol Chem. 2009 Feb 20;284(8):5119-27. Epub 2008 Dec 19.PMID: 19098287 [PubMed - indexed for MEDLINE]Related articles

Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.

Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ.

Blood. 2009 Apr 9;113(15):3585-92. Epub 2008 Nov 12.PMID: 19005179 [PubMed - indexed for MEDLINE]Related articles

The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.

Coller BS, Shattil SJ.

Blood. 2008 Oct 15;112(8):3011-25. Review.PMID: 18840725 [PubMed - indexed for MEDLINE]Related articlesFree article

Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets.

Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ.

Blood. 2009 Jan 8;113(2):447-57. Epub 2008 Oct 7.PMID: 18840708 [PubMed - indexed for MEDLINE]Related articles

Microfluidic devices for studies of shear-dependent platelet adhesion.

Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A.

Lab Chip. 2008 Sep;8(9):1486-95. Epub 2008 Jul 23.PMID: 18818803 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.

Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ.

J Cell Biol. 2008 Jun 30;181(7):1211-22. Epub 2008 Jun 23.PMID: 18573917 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in regulation of Drosophila and vertebrate integrin affinity by talin.

Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ.

Mol Biol Cell. 2008 Aug;19(8):3589-98. Epub 2008 May 28.PMID: 18508915 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K.

Blood. 2008 Jan 15;111(2):596-604. Epub 2007 Oct 9.PMID: 17925492 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet integrin adhesive functions and signaling.

Prévost N, Kato H, Bodin L, Shattil SJ.

Methods Enzymol. 2007;426:103-15. Review.PMID: 17697882 [PubMed - indexed for MEDLINE]Related articles

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.

Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH.

J Clin Invest. 2007 Aug;117(8):2250-9.PMID: 17627302 [PubMed - indexed for MEDLINE]Related articlesFree article

The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development.

Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ.

Dev Dyn. 2007 Aug;236(8):2268-76.PMID: 17626277 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet integrins and immunoreceptors.

Kasirer-Friede A, Kahn ML, Shattil SJ.

Immunol Rev. 2007 Aug;218:247-64. Review.PMID: 17624957 [PubMed - indexed for MEDLINE]Related articles

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL.

J Cell Biol. 2007 Mar 12;176(6):877-88.PMID: 17353363 [PubMed - indexed for MEDLINE]Related articlesFree article

Bloodlines: the importance of mentoring for the future of hematology.

Kaushansky K, Shattil SJ.

Blood. 2007 Feb 15;109(4):1353-4. Epub 2006 Oct 17. No abstract available. PMID: 17047145 [PubMed - indexed for MEDLINE]Related articlesFree article

ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.

Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ.

Blood. 2007 Feb 1;109(3):1018-25. Epub 2006 Sep 26.PMID: 17003372 [PubMed - indexed for MEDLINE]Related articlesFree article

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH.

Curr Biol. 2006 Sep 19;16(18):1796-806.PMID: 16979556 [PubMed - indexed for MEDLINE]Related articles

Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA.

Mol Cell Biol. 2006 Sep;26(18):6936-49.PMID: 16943434 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix-specific suppression of integrin activation in shear stress signaling.

Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA.

Mol Biol Cell. 2006 Nov;17(11):4686-97. Epub 2006 Aug 23.PMID: 16928957 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.

J Thromb Haemost. 2006 Mar;4(3):648-55.PMID: 16460447 [PubMed - indexed for MEDLINE]Related articles

Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function.

Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt AD.

J Thromb Haemost. 2006 Feb;4(2):436-42.PMID: 16420577 [PubMed - indexed for MEDLINE]Related articles

Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.

Bunch TA, Helsten TL, Kendall TL, Shirahatti N, Mahadevan D, Shattil SJ, Brower DL.

J Biol Chem. 2006 Feb 24;281(8):5050-7. Epub 2005 Dec 21.PMID: 16371365 [PubMed - indexed for MEDLINE]Related articlesFree article

PTP-1B is an essential positive regulator of platelet integrin signaling.

Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ.

J Cell Biol. 2005 Aug 29;170(5):837-45. Epub 2005 Aug 22.PMID: 16115959 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin regulation.

Ginsberg MH, Partridge A, Shattil SJ.

Curr Opin Cell Biol. 2005 Oct;17(5):509-16. Review.PMID: 16099636 [PubMed - indexed for MEDLINE]Related articles

Integrins and Src: dynamic duo of adhesion signaling.

Shattil SJ.

Trends Cell Biol. 2005 Aug;15(8):399-403.PMID: 16005629 [PubMed - indexed for MEDLINE]Related articles

Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain.

Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH.

J Biol Chem. 2005 Aug 19;280(33):29699-707. Epub 2005 Jun 3.PMID: 15937333 [PubMed - indexed for MEDLINE]Related articlesFree article

Letter to authors and readers regarding the new NIH policy on public access.

George JN, Shattil SJ.

Blood. 2005 May 15;105(10):3767. Epub 2005 Apr 7. No abstract available. PMID: 15817680 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta.

Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ.

J Biol Chem. 2005 Jan 7;280(1):644-53. Epub 2004 Nov 9.PMID: 15536078 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-protein interactions in platelet alphaIIbbeta3 signaling.

Buensuceso CS, Arias-Salgado EG, Shattil SJ.

Semin Thromb Hemost. 2004 Aug;30(4):427-39. Review.PMID: 15354264 [PubMed - indexed for MEDLINE]Related articles

Integrins: dynamic scaffolds for adhesion and signaling in platelets.

Shattil SJ, Newman PJ.

Blood. 2004 Sep 15;104(6):1606-15. Epub 2004 Jun 17. Review.PMID: 15205259 [PubMed - indexed for MEDLINE]Related articlesFree article

Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells.

de Virgilio M, Kiosses WB, Shattil SJ.

J Cell Biol. 2004 May 10;165(3):305-11. Epub 2004 May 3.PMID: 15123737 [PubMed - indexed for MEDLINE]Related articlesFree article

Open access, yes! Open excess, no!

Shattil SJ.

Blood. 2004 May 1;103(9):3257. No abstract available. PMID: 15096439 [PubMed - indexed for MEDLINE]Related articlesFree article

Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation.

Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD.

Blood. 2004 Sep 1;104(5):1327-34. Epub 2004 Apr 1.PMID: 15059849 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.

Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ.

Blood. 2004 May 1;103(9):3403-11. Epub 2004 Jan 15.PMID: 14726383 [PubMed - indexed for MEDLINE]Related articlesFree article

Development and analysis of megakaryocytes from murine embryonic stem cells.

Eto K, Leavitt AL, Nakano T, Shattil SJ.

Methods Enzymol. 2003;365:142-58. No abstract available. PMID: 14696343 [PubMed - indexed for MEDLINE]Related articles

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.

Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13298-302. Epub 2003 Oct 30.PMID: 14593208 [PubMed - indexed for MEDLINE]Related articlesFree article

Talin binding to integrin beta tails: a final common step in integrin activation.

Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA.

Science. 2003 Oct 3;302(5642):103-6.PMID: 14526080 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion.

Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B.

J Thromb Haemost. 2003 Jun;1(6):1150-7.PMID: 12871313 [PubMed - indexed for MEDLINE]Related articles

A (blood) smear campaign.

Shattil SJ.

Blood. 2003 Apr 1;101(7):2453. No abstract available. PMID: 12642341 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of integrin alpha IIbbeta 3 clustering in living cells.

Buensuceso C, de Virgilio M, Shattil SJ.

J Biol Chem. 2003 Apr 25;278(17):15217-24. Epub 2003 Feb 20.PMID: 12595537 [PubMed - indexed for MEDLINE]Related articlesFree article

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12819-24. Epub 2002 Sep 18.PMID: 12239348 [PubMed - indexed for MEDLINE]Related articlesFree article

The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.

Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH.

J Biol Chem. 2002 Oct 18;277(42):39401-8. Epub 2002 Aug 8.PMID: 12171941 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets.

Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, Horejsí V, Shattil SJ, Watson SP.

Biochem J. 2002 Jun 15;364(Pt 3):755-65.PMID: 12049640 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.

Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ.

J Biol Chem. 2002 Jul 12;277(28):25715-21. Epub 2002 May 6.PMID: 11994301 [PubMed - indexed for MEDLINE]Related articlesFree article

The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins.

Baron W, Shattil SJ, ffrench-Constant C.

EMBO J. 2002 Apr 15;21(8):1957-66.PMID: 11953315 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ.

J Cell Biol. 2002 Apr 15;157(2):265-75. Epub 2002 Apr 8.PMID: 11940607 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.

Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA.

J Exp Med. 2002 Mar 18;195(6):705-17. Erratum in: J Exp Med 2002 Apr 15;195(8):1087. PMID: 11901197 [PubMed - indexed for MEDLINE]Related articlesFree article

Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.

Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ.

J Biol Chem. 2002 Apr 5;277(14):11949-56. Epub 2002 Jan 25.PMID: 11812775 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains.

Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH.

Curr Biol. 2001 Nov 13;11(22):1799-804.PMID: 11719224 [PubMed - indexed for MEDLINE]Related articles