PubMed

The cart before the horse?: health insurance reform before health care reform.

Shader RI.

J Clin Psychopharmacol. 2009 Oct;29(5):413-4. No abstract available. PMID: 19745638 [PubMed - in process]Related articles

Antidepressants as hydrobromide salts: are they a cause for concern?

Shader RI.

J Clin Psychopharmacol. 2009 Aug;29(4):317-8. No abstract available. PMID: 19593167 [PubMed - indexed for MEDLINE]Related articles

Some personal reflections on health care reform.

Shader RI.

J Clin Psychopharmacol. 2008 Dec;28(6):599-600. No abstract available. PMID: 19011426 [PubMed - indexed for MEDLINE]Related articles

Water, water everywhere: but is it safe to drink? Return to a muddy topic.

Shader RI.

J Clin Psychopharmacol. 2008 Jun;28(3):261-3. No abstract available. PMID: 18480680 [PubMed - indexed for MEDLINE]Related articles

Dose dumping and the dumping of doses.

Shader RI.

J Clin Psychopharmacol. 2007 Aug;27(4):327-8. No abstract available. PMID: 17632214 [PubMed - indexed for MEDLINE]Related articles

The effect of chronic lorazepam administration in aging mice.

Fahey JM, Pritchard GA, Reddi JM, Pratt JS, Grassi JM, Shader RI, Greenblatt DJ.

Brain Res. 2006 Nov 6;1118(1):13-24. Epub 2006 Sep 20.PMID: 16989785 [PubMed - indexed for MEDLINE]Related articles

Kynurenine--an old pathway retraced.

Shader RI.

J Clin Psychopharmacol. 2006 Aug;26(4):351-2. No abstract available. PMID: 16855450 [PubMed - indexed for MEDLINE]Related articles

Facts and public policy: should I keep my child on ADHD drugs?

Shader RI, Oesterheld JR.

J Clin Psychopharmacol. 2006 Jun;26(3):223-4. No abstract available. PMID: 16702885 [PubMed - indexed for MEDLINE]Related articles

Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test.

Greenblatt DJ, Gan L, Harmatz JS, Shader RI.

Br J Clin Pharmacol. 2005 Sep;60(3):244-8.PMID: 16120062 [PubMed - indexed for MEDLINE]Related articlesFree article

Demoralization revisited.

Shader RI.

J Clin Psychopharmacol. 2005 Aug;25(4):291-2. No abstract available. PMID: 16012269 [PubMed - indexed for MEDLINE]Related articles

Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.

Vitiello B, Shader RI, Parker CB, Ritz L, Harlan W, Greenblatt DJ, Gadde KM, Krishnan KR, Davidson JR.

J Clin Psychopharmacol. 2005 Jun;25(3):243-9.PMID: 15876903 [PubMed - indexed for MEDLINE]Related articles

The challenge of teaching psychopharmacology and improving clinical practice.

Glick ID, Zisook S, Shader RI.

J Clin Psychopharmacol. 2005 Jun;25(3):203-5. No abstract available. PMID: 15876896 [PubMed - indexed for MEDLINE]Related articles

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate.

Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Shader RI.

Clin Pharmacol Ther. 2004 Nov;76(5):467-79.PMID: 15536461 [PubMed - indexed for MEDLINE]Related articles

A controlled study of the effects of state surveillance on indicators of problematic and non-problematic benzodiazepine use in a Medicaid population.

Ross-Degnan D, Simoni-Wastila L, Brown JS, Gao X, Mah C, Cosler LE, Fanning T, Gallagher P, Salzman C, Shader RI, Inui TS, Soumerai SB.

Int J Psychiatry Med. 2004;34(2):103-23.PMID: 15387395 [PubMed - indexed for MEDLINE]Related articles

Kinetics and EEG effects of midazolam during and after 1-minute, 1-hour, and 3-hour intravenous infusions.

Greenblatt DJ, Ehrenberg BL, Culm KE, Scavone JM, Corbett KE, Friedman HL, Harmatz JS, Shader RI.

J Clin Pharmacol. 2004 Jun;44(6):605-11.PMID: 15145968 [PubMed - indexed for MEDLINE]Related articles

In memoriam: Louis Lasagna, MD 1923-2003.

Greenblatt DJ, Shader RI.

J Clin Psychopharmacol. 2004 Jun;24(3):243-4. No abstract available. PMID: 15118475 [PubMed - indexed for MEDLINE]Related articles

Drug-attributed hepatic failure: causality, risk assessment, consent, and confusion.

Shader RI.

J Clin Psychopharmacol. 2003 Dec;23(6):533-4. No abstract available. PMID: 14624181 [PubMed - indexed for MEDLINE]Related articles

The effect of age on sildenafil biotransformation in rat and mouse liver microsomes.

Warrington JS, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2003 Nov;31(11):1306-9.PMID: 14570760 [PubMed - indexed for MEDLINE]Related articlesFree article

Antagonists, inverse agonists, and protagonists.

Shader RI.

J Clin Psychopharmacol. 2003 Aug;23(4):321-2. No abstract available. PMID: 12920405 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

Olubodun JO, Ochs HR, von Moltke LL, Roubenoff R, Hesse LM, Harmatz JS, Shader RI, Greenblatt DJ.

Br J Clin Pharmacol. 2003 Sep;56(3):297-304.PMID: 12919178 [PubMed - indexed for MEDLINE]Related articlesFree article

Foods, genetics, and drug interactions.

Shader RI.

J Clin Psychopharmacol. 2003 Jun;23(3):221-2. Review. No abstract available. PMID: 12826982 [PubMed - indexed for MEDLINE]Related articles

Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.

Greenblatt DJ, von Moltke LL, Harmatz JS, Fogelman SM, Chen G, Graf JA, Mertzanis P, Byron S, Culm KE, Granda BW, Daily JP, Shader RI.

J Clin Pharmacol. 2003 Apr;43(4):414-22.PMID: 12723462 [PubMed - indexed for MEDLINE]Related articles

The safety of over-the-counter drugs: some reflections and unanswered questions.

Shader RI, Greenblatt DJ.

J Clin Psychopharmacol. 2003 Apr;23(2):111-2. No abstract available. PMID: 12640210 [PubMed - indexed for MEDLINE]Related articles

Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use.

Olubodun JO, Ochs HR, Trüten V, Klein A, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ.

J Clin Pharmacol. 2002 Oct;42(10):1142-6.PMID: 12362929 [PubMed - indexed for MEDLINE]Related articles

In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11.

Warrington JS, Von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2002 Jun;30(6):655-7.PMID: 12019191 [PubMed - indexed for MEDLINE]Related articlesFree article

Discontinue after last dose--an editorial and information about prescription writing.

Shader RI.

J Clin Psychopharmacol. 2002 Jun;22(3):235. No abstract available. PMID: 12006891 [PubMed - indexed for MEDLINE]Related articles

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.

Perloff MD, von Moltke LL, Störmer E, Shader RI, Greenblatt DJ.

Br J Pharmacol. 2001 Dec;134(8):1601-8.PMID: 11739235 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective serotonin reuptake inhibitor antidepressants: cardiovascular complications--sorting through findings.

Shader RI, Greenblatt DJ.

J Clin Psychopharmacol. 2001 Oct;21(5):467-8. No abstract available. PMID: 11593069 [PubMed - indexed for MEDLINE]Related articles

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.

Venkatakrishnan K, Schmider J, Harmatz JS, Ehrenberg BL, von Moltke LL, Graf JA, Mertzanis P, Corbett KE, Rodriguez MC, Shader RI, Greenblatt DJ.

J Clin Pharmacol. 2001 Oct;41(10):1043-54.PMID: 11583471 [PubMed - indexed for MEDLINE]Related articles

A retrospective study of children's perceptions of participation as clinical research subjects in a minimal risk study.

Fogas BS, Oesterheld JR, Shader RI.

J Dev Behav Pediatr. 2001 Aug;22(4):211-6.PMID: 11530893 [PubMed - indexed for MEDLINE]Related articles

Drug interactions with grapefruit juice: an update.

Greenblatt DJ, Patki KC, von Moltke LL, Shader RI.

J Clin Psychopharmacol. 2001 Aug;21(4):357-9. Review. No abstract available. PMID: 11476118 [PubMed - indexed for MEDLINE]Related articles

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.

von Moltke LL, Greenblatt DJ, Giancarlo GM, Granda BW, Harmatz JS, Shader RI.

Drug Metab Dispos. 2001 Aug;29(8):1102-9.PMID: 11454728 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacodynamic and receptor binding changes during chronic lorazepam administration.

Fahey JM, Pritchard GA, Grassi JM, Pratt JS, Shader RI, Greenblatt DJ.

Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):1-8.PMID: 11420062 [PubMed - indexed for MEDLINE]Related articles

A benzodiazepine mood effect scale: reliability and validity determined for alcohol-dependent subjects and adults with a parental history of alcoholism.

Ciraulo DA, Knapp CM, LoCastro J, Greenblatt DJ, Shader RI.

Am J Drug Alcohol Abuse. 2001 May;27(2):339-47.PMID: 11417943 [PubMed - indexed for MEDLINE]Related articles

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors.

von Moltke LL, Greenblatt DJ, Granda BW, Giancarlo GM, Duan SX, Daily JP, Harmatz JS, Shader RI.

J Clin Pharmacol. 2001 Jan;41(1):85-91.PMID: 11225565 [PubMed - indexed for MEDLINE]Related articles

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2001 Feb;29(2):133-40.PMID: 11159802 [PubMed - indexed for MEDLINE]Related articlesFree article

Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.

Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2001 Feb;29(2):100-2.PMID: 11159797 [PubMed - indexed for MEDLINE]Related articlesFree article

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2000 Oct;28(10):1176-83.PMID: 10997936 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4.

Störmer E, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2000 Oct;28(10):1168-75.PMID: 10997935 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinetics and dynamics of lorazepam during and after continuous intravenous infusion.

Greenblatt DJ, von Moltke LL, Ehrenberg BL, Harmatz JS, Corbett KE, Wallace DW, Shader RI.

Crit Care Med. 2000 Aug;28(8):2750-7.PMID: 10966246 [PubMed - indexed for MEDLINE]Related articles

Differential impairment of triazolam and zolpidem clearance by ritonavir.

Greenblatt DJ, von Moltke LL, Harmatz JS, Durol AL, Daily JP, Graf JA, Mertzanis P, Hoffman JL, Shader RI.

J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):129-36.PMID: 10935688 [PubMed - indexed for MEDLINE]Related articles

More on oral contraceptives, drug interactions, herbal medicines, and hormone replacement therapy.

Shader RI, Greenblatt DJ.

J Clin Psychopharmacol. 2000 Aug;20(4):397-8. No abstract available. PMID: 10917398 [PubMed - indexed for MEDLINE]Related articles

Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast.

Shader RI, Granda BW, von Moltke LL, Giancarlo GM, Greenblatt DJ.

Biopharm Drug Dispos. 1999 Nov;20(8):385-8.PMID: 10870095 [PubMed - indexed for MEDLINE]Related articles

Differences in pharmacodynamics but not pharmacokinetics between subjects with panic disorder and healthy subjects after treatment with a single dose of alprazolam.

Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI.

J Clin Psychopharmacol. 2000 Jun;20(3):338-46.PMID: 10831021 [PubMed - indexed for MEDLINE]Related articles

Alprazolam-ritonavir interaction: implications for product labeling.

Greenblatt DJ, von Moltke LL, Harmatz JS, Durol AL, Daily JP, Graf JA, Mertzanis P, Hoffman JL, Shader RI.

Clin Pharmacol Ther. 2000 Apr;67(4):335-41.PMID: 10801241 [PubMed - indexed for MEDLINE]Related articles

Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences.

Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Durol AL, Harrel-Joseph LM, Shader RI.

J Pharmacol Exp Ther. 2000 May;293(2):435-43.PMID: 10773013 [PubMed - indexed for MEDLINE]Related articlesFree article

Contraceptive effectiveness: cytochromes and induction.

Shader RI, Oesterheld JR.

J Clin Psychopharmacol. 2000 Apr;20(2):119-21. No abstract available. PMID: 10770447 [PubMed - indexed for MEDLINE]Related articles

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

Zalma A, von Moltke LL, Granda BW, Harmatz JS, Shader RI, Greenblatt DJ.

Biol Psychiatry. 2000 Apr 1;47(7):655-61.PMID: 10745059 [PubMed - indexed for MEDLINE]Related articles

In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions.

Warrington JS, Shader RI, von Moltke LL, Greenblatt DJ.

Drug Metab Dispos. 2000 Apr;28(4):392-7.PMID: 10725306 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes.

Warrington JS, Poku JW, von Moltke LL, Shader RI, Harmatz JS, Greenblatt DJ.

J Pharmacol Exp Ther. 2000 Mar;292(3):1024-31.PMID: 10688619 [PubMed - indexed for MEDLINE]Related articlesFree article