PubMed

Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.

Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, Lotz M.

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3094-9.PMID: 9501221 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation.

Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE, Lotz M.

Arthritis Rheum. 1997 Jul;40(7):1275-81.PMID: 9214428 [PubMed - indexed for MEDLINE]Related articles

Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.

Lotz M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, Solan J, Goding J, Seegmiller JE, Terkeltaub R.

Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10364-8.PMID: 7479785 [PubMed - indexed for MEDLINE]Related articlesFree article

Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase.

Barshop BA, Adamson DT, Vellom DC, Rosen F, Epstein BL, Seegmiller JE.

Anal Biochem. 1991 Aug 15;197(1):266-72.PMID: 1659248 [PubMed - indexed for MEDLINE]Related articles

Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects.

Tarlé SA, Davidson BL, Wu VC, Zidar FJ, Seegmiller JE, Kelley WN, Palella TD.

Genomics. 1991 Jun;10(2):499-501.PMID: 2071157 [PubMed - indexed for MEDLINE]Related articles

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji NN.

Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):16-20.PMID: 1702541 [PubMed - indexed for MEDLINE]Related articlesFree article

Fructose-induced aberration of metabolism in familial gout identified by 31P magnetic resonance spectroscopy.

Seegmiller JE, Dixon RM, Kemp GJ, Angus PW, McAlindon TE, Dieppe P, Rajagopalan B, Radda GK.

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8326-30.PMID: 2236043 [PubMed - indexed for MEDLINE]Related articlesFree article

An aberration of fructose metabolism in familial gout identified by 31P magnetic resonance spectroscopy of the liver.

Seegmiller JE, Dixon RM, Kemp GJ, Angus PW, McAlindon TE, Dieppe P, Rajagopalan B, Radda GK.

Trans Assoc Am Physicians. 1990;103:298-306. No abstract available. PMID: 2132540 [PubMed - indexed for MEDLINE]Related articles

Processing of Alzheimer's disease-associated beta-amyloid precursor protein.

Dewji NN, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C.

J Mol Neurosci. 1990;2(1):19-27.PMID: 2124135 [PubMed - indexed for MEDLINE]Related articles

Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy.

Wolff JA, Barshop B, Nyhan WL, Leslie J, Seegmiller JE, Gruber H, Garst M, Winter S, Michals K, Matalon R.

Pediatr Res. 1989 Aug;26(2):140-4.PMID: 2771520 [PubMed - indexed for MEDLINE]Related articles

Ochronosis: a report of a case and a review of literature.

Konttinen YT, Hoikka V, Landtman M, Saari H, Santavirta S, Metsärinne K, Seegmiller JE.

Clin Exp Rheumatol. 1989 Jul-Aug;7(4):435-44. Review.PMID: 2686878 [PubMed - indexed for MEDLINE]Related articles

Chondrocyte growth inhibition induced by homogentisic acid and its partial prevention with ascorbic acid.

Angeles AP, Badger R, Gruber HE, Seegmiller JE.

J Rheumatol. 1989 Apr;16(4):512-7.PMID: 2746590 [PubMed - indexed for MEDLINE]Related articles

Contributions of Lesch-Nyhan syndrome to the understanding of purine metabolism.

Seegmiller JE.

J Inherit Metab Dis. 1989;12(2):184-96. No abstract available. PMID: 2502677 [PubMed - indexed for MEDLINE]Related articles

2,8-dihydroxyadenine urolithiasis: report of a case first diagnosed after renal transplant.

Glicklich D, Gruber HE, Matas AJ, Tellis VA, Karwa G, Finley K, Salem C, Soberman R, Seegmiller JE.

Q J Med. 1988 Oct;68(258):785-93. Review.PMID: 3077470 [PubMed - indexed for MEDLINE]Related articles

Substrate inhibition of adenosine phosphorylation in adenosine deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine phosphoribosyltransferase deficient erythrocytes.

Snyder FF, Dyer C, Seegmiller JE, Goldblum RM, Mills GC, Schmalstieg FC.

J Inherit Metab Dis. 1988;11(2):174-83.PMID: 2459496 [PubMed - indexed for MEDLINE]Related articles

Clinical correlations in partial hypoxanthine guanine phosphoribosyltransferase deficiency.

Hersh JH, Page T, Hand ME, Seegmiller JE, Nyhan WL, Weisskopf B.

Pediatr Neurol. 1986 Sep-Oct;2(5):302-4.PMID: 3508703 [PubMed - indexed for MEDLINE]Related articles

Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity.

Laikind PK, Seegmiller JE, Gruber HE.

Anal Biochem. 1986 Jul;156(1):81-90.PMID: 3740420 [PubMed - indexed for MEDLINE]Related articles

The biochemical mechanism of metabolic cooperation.

Koenker R, Luchtman LA, Willis RC, Seegmiller JE, Gruber HE.

Adv Exp Med Biol. 1986;195 Pt A:183-7. No abstract available. PMID: 3728150 [PubMed - indexed for MEDLINE]Related articles

An appreciation of DeWitt Stetten, Jr.

Seegmiller JE.

Adv Exp Med Biol. 1986;195 Pt A:17-9. No abstract available. PMID: 3524133 [PubMed - indexed for MEDLINE]Related articles

Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus.

Gruber HE, Finley KD, Luchtman LA, Hershberg RM, Katzman SS, Laikind PK, Meyers EN, Seegmiller JE, Friedmann T, Yee JK, et al.

Adv Exp Med Biol. 1986;195 Pt A:171-5. No abstract available. PMID: 3014831 [PubMed - indexed for MEDLINE]Related articles

Purine biosynthesis in Chinese hamster cell mutants and human fibroblasts partially deficient in adenylosuccinate lyase.

Laikind PK, Gruber HE, Jansen I, Miller L, Hoffer M, Seegmiller JE, Willis RC, Jaeken J, Van den Berghe G.

Adv Exp Med Biol. 1986;195 Pt B:363-9. No abstract available. PMID: 2876593 [PubMed - indexed for MEDLINE]Related articles

Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells.

Gruber HE, Finley KD, Hershberg RM, Katzman SS, Laikind PK, Seegmiller JE, Friedmann T, Yee JK, Jolly DJ.

Science. 1985 Nov 29;230(4729):1057-61.PMID: 3864246 [PubMed - indexed for MEDLINE]Related articles

Glial cells metabolically cooperate: a potential requirement for gene replacement therapy.

Gruber HE, Koenker R, Luchtman LA, Willis RC, Seegmiller JE.

Proc Natl Acad Sci U S A. 1985 Oct;82(19):6662-6.PMID: 2995977 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations of inosinate branchpoint enzymes in cultured human lymphoblasts.

Gruber HE, Jansen I, Willis RC, Seegmiller JE.

Biochim Biophys Acta. 1985 Jul 30;846(1):135-44.PMID: 2861860 [PubMed - indexed for MEDLINE]Related articles

Overview of possible relation of defects in purine metabolism to immune deficiency.

Seegmiller JE.

Ann N Y Acad Sci. 1985;451:9-19. Review. No abstract available. PMID: 3935028 [PubMed - indexed for MEDLINE]Related articles

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency.

Albert D, Bluestein HG, Thompson L, Seegmiller JE.

Cell Immunol. 1984 Jul;86(2):510-7.PMID: 6610485 [PubMed - indexed for MEDLINE]Related articles

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency.

Albert D, Bluestein HG, Willis RC, Nette K, Seegmiller JE.

Cell Immunol. 1984 Jul;86(2):501-9.PMID: 6428752 [PubMed - indexed for MEDLINE]Related articles

Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.

Willis RC, Jolly DJ, Miller AD, Plent MM, Esty AC, Anderson PJ, Chang HC, Jones OW, Seegmiller JE, Friedmann T.

J Biol Chem. 1984 Jun 25;259(12):7842-9.PMID: 6203897 [PubMed - indexed for MEDLINE]Related articlesFree article

Purine nucleotide reutilization by human lymphoblast lines with aberrations of the inosinate cycle.

Willis RC, Kaufman AH, Seegmiller JE.

J Biol Chem. 1984 Apr 10;259(7):4157-61.PMID: 6423640 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and biochemical correlates of a new HPRT mutation.

Gruber HE, Vuchinich M, Marlow TA, Plent MM, Willis RC, Seegmiller JE, Bartley J, Hanson JW, Zellweger H.

Adv Exp Med Biol. 1984;165 Pt A:19-22. No abstract available. PMID: 6720378 [PubMed - indexed for MEDLINE]Related articles

Regulation of human lymphoblast ecto-5'-nucleotidase by zinc.

Pilz RB, Willis RC, Wanlass S, Seegmiller JE.

Adv Exp Med Biol. 1984;165 Pt B:147-52. No abstract available. PMID: 6326497 [PubMed - indexed for MEDLINE]Related articles

Synthesis of (14C)-ribose-5-phosphate and (14C)-phosphoribosylpyrophosphate and their use in new enzyme assays.

Boss GR, Idriss SD, Willis RC, Seegmiller JE.

Adv Exp Med Biol. 1984;165 Pt B:11-3. No abstract available. PMID: 6202119 [PubMed - indexed for MEDLINE]Related articles

In vitro stabilization of the unoccupied glucocorticoid receptor by adenosine 5'-diphosphate.

Barnett CA, Palmour RM, Litwack G, Seegmiller JE.

Endocrinology. 1983 Jun;112(6):2059-68.PMID: 6851939 [PubMed - indexed for MEDLINE]Related articles

Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate.

Boss GR, Idriss SD, Willis RC, Seegmiller JE.

Anal Biochem. 1983 Apr 1;130(1):283-6.PMID: 6191593 [PubMed - indexed for MEDLINE]Related articles

Regulation of human lymphoblast plasma membrane 5'-nucleotidase by zinc.

Pilz RB, Willis RC, Seegmiller JE.

J Biol Chem. 1982 Nov 25;257(22):13544-9. No abstract available. PMID: 6292194 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic defects in human purine and pyrimidine metabolism.

Boss GR, Seegmiller JE.

Annu Rev Genet. 1982;16:297-328. Review. No abstract available. PMID: 6297375 [PubMed - indexed for MEDLINE]Related articles

Age-related physiological changes and their clinical significance.

Boss GR, Seegmiller JE.

West J Med. 1981 Dec;135(6):434-40.PMID: 7336713 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of a generalized metabolic defect in patients with hereditary chondrocalcinosis. Increased inorganic pyrophosphate in cultured fibroblasts and lymphoblasts.

Lust G, Faure G, Netter P, Gaucher A, Seegmiller JE.

Arthritis Rheum. 1981 Dec;24(12):1517-21.PMID: 6275862 [PubMed - indexed for MEDLINE]Related articles

Increased pyrophosphate in fibroblasts and lymphoblasts from patients with hereditary diffuse articular chondrocalcinosis.

Lust G, Faure G, Netter P, Seegmiller JE.

Science. 1981 Nov 13;214(4522):809-10.PMID: 6270793 [PubMed - indexed for MEDLINE]Related articles

A long-term study of the absorption of large oral doses of folic acid.

Zettner A, Boss GR, Seegmiller JE.

Ann Clin Lab Sci. 1981 Nov-Dec;11(6):516-24.PMID: 7325593 [PubMed - indexed for MEDLINE]Related articles

Stethoscopes on airplanes.

Seegmiller JE.

N Engl J Med. 1981 Jul 30;305(5):289. No abstract available. PMID: 7242630 [PubMed - indexed for MEDLINE]Related articles

Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.

Boss GR, Thompson LF, O'Connor RD, Ziering RW, Seegmiller JE.

Clin Immunol Immunopathol. 1981 Apr;19(1):1-7. No abstract available. PMID: 6260402 [PubMed - indexed for MEDLINE]Related articles

Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia.

Boss GR, Ragsdale RA, Zettner A, Seegmiller JE.

J Lab Clin Med. 1980 Nov;96(5):783-9.PMID: 6893465 [PubMed - indexed for MEDLINE]Related articles

Elucidation of aberrant purine metabolism: application to hypoxanthine-guanine phosphoribosylstransferase- and adenosine kinase-deficient mutants, and IMP dehydrogenase- and adenosine deaminase-inhibited human lymphoblasts.

Snyder FF, Trafzer RJ, Hershfield MS, Seegmiller JE.

Biochim Biophys Acta. 1980 Oct 17;609(3):492-501.PMID: 6108130 [PubMed - indexed for MEDLINE]Related articles

An in vivo and in vitro evaluation of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine: an inhibitor of human lymphoblast purine nucleoside phosphorylase.

Willis RC, Robins RK, Seegmiller JE.

Mol Pharmacol. 1980 Sep;18(2):287-95. No abstract available. PMID: 6106888 [PubMed - indexed for MEDLINE]Related articles

Thymidine as a chemotherapeutic agent: pharmacologic, cytokinetic, and biochemical studies in a patient with T-cell acute lymphocytic leukemia.

Howell SB, Chu B, Mendelsohn J, Carson DA, Kung FH, Seegmiller JE.

J Natl Cancer Inst. 1980 Aug;65(2):277-84.PMID: 6967527 [PubMed - indexed for MEDLINE]Related articles

Age-dependency of lymphocyte ecto-5'-nucleotidase activity.

Boss GR, Thompson LF, Spiegelberg HL, Pichler WJ, Seegmiller JE.

J Immunol. 1980 Aug;125(2):679-82.PMID: 6248594 [PubMed - indexed for MEDLINE]Related articles

Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia.

Thompson LF, Boss GR, Spiegelberg HL, Bianchino A, Seegmiller JE.

J Immunol. 1980 Jul;125(1):190-3.PMID: 6247393 [PubMed - indexed for MEDLINE]Related articles

Detection of Lesch-Nyhan syndrome carriers: analysis of hair roots for HPRT by agarose gel electrophoresis and autoradiography.

Bakay B, Tucker-Pian C, Seegmiller JE.

Clin Genet. 1980 Jun;17(6):369-74.PMID: 7398108 [PubMed - indexed for MEDLINE]Related articles

Altered regulation of Epstein-Barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells.

Bardwick PA, Bluestein HG, Zvaifler NJ, Depper JM, Seegmiller JE.

Arthritis Rheum. 1980 Jun;23(6):626-32. No abstract available. PMID: 6248075 [PubMed - indexed for MEDLINE]Related articles