PubMed

Centrosome structure and function under normal and pathological conditions.

Sackett DL, Olivero O.

Environ Mol Mutagen. 2009 Oct;50(8):591-2. No abstract available. PMID: 19774609 [PubMed - indexed for MEDLINE]Related articles

Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.

Difilippantonio MJ, Ghadimi BM, Howard T, Camps J, Nguyen QT, Ferris DK, Sackett DL, Ried T.

Environ Mol Mutagen. 2009 Oct;50(8):672-96.PMID: 19768832 [PubMed - indexed for MEDLINE]Related articles

Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.

Meany HJ, Sackett DL, Maris JM, Ward Y, Krivoshik A, Cohn SL, Steinberg SM, Balis FM, Fox E.

Pediatr Blood Cancer. 2010 Jan;54(1):47-54.PMID: 19731320 [PubMed - indexed for MEDLINE]Related articles

New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue.

Frein JD, Taylor RE, Sackett DL.

Org Lett. 2009 Aug 6;11(15):3186-9.PMID: 19572566 [PubMed - indexed for MEDLINE]Related articles

Structural mass spectrometry of the alpha beta-tubulin dimer supports a revised model of microtubule assembly.

Bennett MJ, Chik JK, Slysz GW, Luchko T, Tuszynski J, Sackett DL, Schriemer DC.

Biochemistry. 2009 Jun 9;48(22):4858-70. Erratum in: Biochemistry. 2009 Oct 13;48(40):9704. PMID: 19388626 [PubMed - indexed for MEDLINE]Related articles

A landmark randomized health care trial: the Burlington Trial of the nurse practitioner.

Sackett DL.

J Clin Epidemiol. 2009 Jun;62(6):567-70. Epub 2009 Apr 8. No abstract available. PMID: 19356898 [PubMed - indexed for MEDLINE]Related articles

Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.

Balasubramanian R, Raghavan B, Begaye A, Sackett DL, Fecik RA.

J Med Chem. 2009 Jan 22;52(2):238-40.PMID: 19102699 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of tubulin assembly identified through screening a compound library.

Morgan RE, Ahn S, Nzimiro S, Fotie J, Phelps MA, Cotrill J, Yakovich AJ, Sackett DL, Dalton JT, Werbovetz KA.

Chem Biol Drug Des. 2008 Dec;72(6):513-24.PMID: 19090918 [PubMed - indexed for MEDLINE]Related articles

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration.

Rostovtseva TK, Sheldon KL, Hassanzadeh E, Monge C, Saks V, Bezrukov SM, Sackett DL.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18746-51. Epub 2008 Nov 24.PMID: 19033201 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells.

Liang XJ, Choi Y, Sackett DL, Park JK.

Cancer Res. 2008 Jul 1;68(13):5267-72.PMID: 18593927 [PubMed - indexed for MEDLINE]Related articlesFree article

Clathrin triskelia show evidence of molecular flexibility.

Ferguson ML, Prasad K, Boukari H, Sackett DL, Krueger S, Lafer EM, Nossal R.

Biophys J. 2008 Aug;95(4):1945-55. Epub 2008 May 23.PMID: 18502808 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

Poruchynsky MS, Sackett DL, Robey RW, Ward Y, Annunziata C, Fojo T.

Cell Cycle. 2008 Apr 1;7(7):940-9. Epub 2008 Jan 17.PMID: 18414063 [PubMed - indexed for MEDLINE]Related articles

Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.

Balasubramanian R, Raghavan B, Steele JC, Sackett DL, Fecik RA.

Bioorg Med Chem Lett. 2008 May 1;18(9):2996-9. Epub 2008 Mar 20.PMID: 18411048 [PubMed - indexed for MEDLINE]Related articles

A unique mode of microtubule stabilization induced by peloruside A.

Huzil JT, Chik JK, Slysz GW, Freedman H, Tuszynski J, Taylor RE, Sackett DL, Schriemer DC.

J Mol Biol. 2008 May 16;378(5):1016-30. Epub 2008 Mar 19.PMID: 18405918 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).

Pavlicek J, Coon SL, Ganguly S, Weller JL, Hassan SA, Sackett DL, Klein DC.

J Biol Chem. 2008 May 23;283(21):14552-8. Epub 2008 Mar 24.PMID: 18362150 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.

Sackett DL, Ozbun L, Zudaire E, Wessner L, Chirgwin JM, Cuttitta F, Martínez A.

Endocrinology. 2008 Jun;149(6):2888-98. Epub 2008 Mar 6.PMID: 18325988 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytotoxic simplified tubulysin analogues.

Raghavan B, Balasubramanian R, Steele JC, Sackett DL, Fecik RA.

J Med Chem. 2008 Mar 27;51(6):1530-3. Epub 2008 Mar 4.PMID: 18314944 [PubMed - indexed for MEDLINE]Related articles

Evaluating reproducibility and similarity of mass and intensity data in complex spectra--applications to tubulin.

Olson MT, Blank PS, Sackett DL, Yergey AL.

J Am Soc Mass Spectrom. 2008 Mar;19(3):367-74. Epub 2007 Nov 23.PMID: 18207417 [PubMed - indexed for MEDLINE]Related articles

Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel.

Sissung TM, Danesi R, Price DK, Steinberg SM, de Wit R, Zahid M, Gaikwad N, Cavalieri E, Dahut WL, Sackett DL, Figg WD, Sparreboom A.

Mol Cancer Ther. 2008 Jan;7(1):19-26. Epub 2008 Jan 9.PMID: 18187806 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for microtubule target engagement in tumors of patients receiving ixabepilone.

Zhuang SH, Hung YE, Hung L, Robey RW, Sackett DL, Linehan WM, Bates SE, Fojo T, Poruchynsky MS.

Clin Cancer Res. 2007 Dec 15;13(24):7480-6.PMID: 18094432 [PubMed - indexed for MEDLINE]Related articlesFree article

Fluorescence correlation spectroscopy and its application to the characterization of molecular properties and interactions.

Boukari H, Sackett DL.

Methods Cell Biol. 2008;84:659-78.PMID: 17964946 [PubMed - indexed for MEDLINE]Related articles

Commentary: Measuring the success of blinding in RCTs: don't, must, can't or needn't?

Sackett DL.

Int J Epidemiol. 2007 Jun;36(3):664-5. No abstract available. PMID: 17675306 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-walled tubulin ring polymers.

Boukari H, Sackett DL, Schuck P, Nossal RJ.

Biopolymers. 2007 Aug 5-15;86(5-6):424-36.PMID: 17480000 [PubMed - indexed for MEDLINE]Related articles

Histone deacetylase inhibitors and demethylating agents: clinical development of histone deacetylase inhibitors for cancer therapy.

Piekarz RL, Sackett DL, Bates SE.

Cancer J. 2007 Jan-Feb;13(1):30-9. Review.PMID: 17464244 [PubMed - indexed for MEDLINE]Related articles

Evidence based medicine: what it is and what it isn't. 1996.

Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS.

Clin Orthop Relat Res. 2007 Feb;455:3-5. No abstract available. PMID: 17340682 [PubMed - indexed for MEDLINE]Related articles

Noninferiority was not shown between stenting and endarterectomy in severe symptomatic carotid stenosis.

Sackett DL, Oczkowski W.

ACP J Club. 2007 Mar-Apr;146(2):32-3. No abstract available. PMID: 17335156 [PubMed]Related articles

Stenting led to more stroke or death than did endarterectomy in symptomatic carotid stenosis >/= 60%.

Sackett DL, Oczkowski W.

ACP J Club. 2007 Mar-Apr;146(2):32-3. No abstract available. PMID: 17335155 [PubMed]Related articles

Methods of blinding in reports of randomized controlled trials assessing pharmacologic treatments: a systematic review.

Boutron I, Estellat C, Guittet L, Dechartres A, Sackett DL, Hróbjartsson A, Ravaud P.

PLoS Med. 2006 Oct;3(10):e425. Review.PMID: 17076559 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligomerization of p53 precedes its association with dynein and nuclear accumulation.

Trostel SY, Sackett DL, Fojo T.

Cell Cycle. 2006 Oct;5(19):2253-9. Epub 2006 Oct 1.PMID: 16969106 [PubMed - indexed for MEDLINE]Related articles

Dealing with the media.

Sackett DL, Brian Haynes R, Guyatt GH, Tugwell P.

J Clin Epidemiol. 2006 Sep;59(9):907-13. No abstract available. PMID: 16895812 [PubMed - indexed for MEDLINE]Related articles

Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.

Pandit B, Sun Y, Chen P, Sackett DL, Hu Z, Rich W, Li C, Lewis A, Schaefer K, Li PK.

Bioorg Med Chem. 2006 Oct 1;14(19):6492-501. Epub 2006 Jul 24.PMID: 16860559 [PubMed - indexed for MEDLINE]Related articles

A surrealistic mega-analysis of redisorganization theories.

Oxman AD, Sackett DL, Chalmers I, Prescott TE.

Healthc Q. 2006;9(3):50-4.PMID: 16830401 [PubMed]Related articlesFree article

Leishmania tarentolae: purification and characterization of tubulin and its suitability for antileishmanial drug screening.

Yakovich AJ, Ragone FL, Alfonzo JD, Sackett DL, Werbovetz KA.

Exp Parasitol. 2006 Dec;114(4):289-96. Epub 2006 Jun 5.PMID: 16753146 [PubMed - indexed for MEDLINE]Related articlesFree article

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides.

George TG, Johnsamuel J, Delfín DA, Yakovich A, Mukherjee M, Phelps MA, Dalton JT, Sackett DL, Kaiser M, Brun R, Werbovetz KA.

Bioorg Med Chem. 2006 Aug 15;14(16):5699-710. Epub 2006 May 3.PMID: 16675220 [PubMed - indexed for MEDLINE]Related articles

Conformation of a clathrin triskelion in solution.

Ferguson ML, Prasad K, Sackett DL, Boukari H, Lafer EM, Nossal R.

Biochemistry. 2006 May 9;45(18):5916-22.PMID: 16669634 [PubMed - indexed for MEDLINE]Related articles

A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities.

Li PK, Pandit B, Sackett DL, Hu Z, Zink J, Zhi J, Freeman D, Robey RW, Werbovetz K, Lewis A, Li C.

Mol Cancer Ther. 2006 Feb;5(2):450-6.PMID: 16505120 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous patterning of confined granular rods.

Galanis J, Harries D, Sackett DL, Losert W, Nossal R.

Phys Rev Lett. 2006 Jan 20;96(2):028002. Epub 2006 Jan 19.PMID: 16486645 [PubMed - indexed for MEDLINE]Related articles

A surrealistic mega-analysis of redisorganization theories.

Oxman AD, Sackett DL, Chalmers I, Prescott TE.

J R Soc Med. 2005 Dec;98(12):563-8.PMID: 16319441 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of 12Cysbeta on tubulin as the binding site of tubulyzine.

Kim YJ, Sackett DL, Schapira M, Walsh DP, Min J, Pannell LK, Chang YT.

Bioorg Med Chem. 2006 Feb 15;14(4):1169-75. Epub 2005 Nov 2.PMID: 16266809 [PubMed - indexed for MEDLINE]Related articlesFree article

Applying a phase II futility study design to therapeutic stroke trials.

Palesch YY, Tilley BC, Sackett DL, Johnston KC, Woolson R.

Stroke. 2005 Nov;36(11):2410-4. Epub 2005 Oct 13.PMID: 16224086 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.

Li PK, Xiao Z, Hu Z, Pandit B, Sun Y, Sackett DL, Werbovetz K, Lewis A, Johnsamuel J.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5382-5. Epub 2005 Oct 6.PMID: 16213720 [PubMed - indexed for MEDLINE]Related articles

Participants in research.

Sackett DL.

BMJ. 2005 May 21;330(7501):1164. No abstract available. PMID: 15905233 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

Robbins AR, Jablonski SA, Yen TJ, Yoda K, Robey R, Bates SE, Sackett DL.

Cell Cycle. 2005 May;4(5):717-26. Epub 2005 May 28.PMID: 15846093 [PubMed - indexed for MEDLINE]Related articlesFree article

Need for expertise based randomised controlled trials.

Devereaux PJ, Bhandari M, Clarke M, Montori VM, Cook DJ, Yusuf S, Sackett DL, Cinà CS, Walter SD, Haynes B, Schünemann HJ, Norman GR, Guyatt GH.

BMJ. 2005 Jan 8;330(7482):88. Review. No abstract available. PMID: 15637373 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.

Poruchynsky MS, Kim JH, Nogales E, Annable T, Loganzo F, Greenberger LM, Sackett DL, Fojo T.

Biochemistry. 2004 Nov 9;43(44):13944-54.PMID: 15518543 [PubMed - indexed for MEDLINE]Related articles

Hydrodynamics of nanoscopic tubulin rings in dilute solutions.

Boukari H, Nossal R, Sackett DL, Schuck P.

Phys Rev Lett. 2004 Aug 27;93(9):098106. Epub 2004 Aug 26.PMID: 15447147 [PubMed - indexed for MEDLINE]Related articles

Editorial independence at the BMJ:.and the author apologises unreservedly.

Sackett DL.

BMJ. 2004 Sep 11;329(7466):624-5. No abstract available. PMID: 15361455 [PubMed - indexed for MEDLINE]Related articlesFree article

Mass spectrometric measurement of differential reactivity of cysteine to localize protein-ligand binding sites. Application to tubulin-binding drugs.

Kim YJ, Pannell LK, Sackett DL.

Anal Biochem. 2004 Sep 15;332(2):376-83.PMID: 15325307 [PubMed - indexed for MEDLINE]Related articles

Campaign to revitalise academic medicine: don't believe us.

Sackett DL.

BMJ. 2004 Jul 31;329(7460):294. No abstract available. PMID: 15284174 [PubMed - indexed for MEDLINE]Related articlesFree article

Turning a blind eye: why we don't test for blindness at the end of our trials.

Sackett DL.

BMJ. 2004 May 8;328(7448):1136. No abstract available. PMID: 15130997 [PubMed - indexed for MEDLINE]Related articlesFree article