PubMed

Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.

Gibson JR, Huber KM, Südhof TC.

J Neurosci. 2009 Nov 4;29(44):13883-97.PMID: 19889999 [PubMed - indexed for MEDLINE]Related articles

ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.

Kaeser PS, Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC.

Neuron. 2009 Oct 29;64(2):227-39.PMID: 19874790 [PubMed - indexed for MEDLINE]Related articles

Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.

Etherton MR, Blaiss CA, Powell CM, Südhof TC.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17998-8003. Epub 2009 Oct 12.PMID: 19822762 [PubMed - in process]Related articles

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.

Shin OH, Xu J, Rizo J, Südhof TC.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16469-74. Epub 2009 Sep 4.PMID: 19805322 [PubMed - indexed for MEDLINE]Related articles

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.

Ko J, Zhang C, Arac D, Boucard AA, Brunger AT, Südhof TC.

EMBO J. 2009 Oct 21;28(20):3244-55. Epub 2009 Sep 3.PMID: 19730411 [PubMed - indexed for MEDLINE]Related articles

A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export.

Zhang C, Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Südhof TC.

J Neurosci. 2009 Sep 2;29(35):10843-54.PMID: 19726642 [PubMed - indexed for MEDLINE]Related articles

Presenilins are essential for regulating neurotransmitter release.

Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.

Nature. 2009 Jul 30;460(7255):632-6.PMID: 19641596 [PubMed - indexed for MEDLINE]Related articles

Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery.

Deák F, Liu X, Khvotchev M, Li G, Kavalali ET, Sugita S, Südhof TC.

J Neurosci. 2009 Jul 8;29(27):8639-48.PMID: 19587270 [PubMed - indexed for MEDLINE]Related articles

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.

Tabuchi K, Chen G, Südhof TC, Shen J.

J Neurosci. 2009 Jun 3;29(22):7290-301.PMID: 19494151 [PubMed - indexed for MEDLINE]Related articles

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.

Xu J, Pang ZP, Shin OH, Südhof TC.

Nat Neurosci. 2009 Jun;12(6):759-66.PMID: 19412166 [PubMed - indexed for MEDLINE]Related articles

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.

Deák F, Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.

J Cell Biol. 2009 Mar 9;184(5):751-64. Epub 2009 Mar 2.PMID: 19255244 [PubMed - indexed for MEDLINE]Related articlesFree article

SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.

Chang WP, Südhof TC.

J Neurosci. 2009 Jan 28;29(4):883-97.PMID: 19176798 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.

Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W.

J Physiol. 2009 Mar 15;587(Pt 6):1169-78. Epub 2009 Jan 26.PMID: 19171650 [PubMed - indexed for MEDLINE]Related articles

Complexin controls the force transfer from SNARE complexes to membranes in fusion.

Maximov A, Tang J, Yang X, Pang ZP, Südhof TC.

Science. 2009 Jan 23;323(5913):516-21.PMID: 19164751 [PubMed - indexed for MEDLINE]Related articles

Membrane fusion: grappling with SNARE and SM proteins.

Südhof TC, Rothman JE.

Science. 2009 Jan 23;323(5913):474-7. Review.PMID: 19164740 [PubMed - indexed for MEDLINE]Related articles

Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.

Ho A, Liu X, Südhof TC.

J Neurosci. 2008 Dec 31;28(53):14392-400.PMID: 19118172 [PubMed - indexed for MEDLINE]Related articlesFree article

RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions.

Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC.

J Neurosci. 2008 Dec 10;28(50):13435-47.PMID: 19074017 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.

Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM.

Genes Brain Behav. 2009 Feb;8(1):114-26. Epub 2008 Nov 11.PMID: 19016888 [PubMed - indexed for MEDLINE]Related articles

Understanding synapses: past, present, and future.

Südhof TC, Malenka RC.

Neuron. 2008 Nov 6;60(3):469-76.PMID: 18995821 [PubMed - indexed for MEDLINE]Related articles

Neuroligins and neurexins link synaptic function to cognitive disease.

Südhof TC.

Nature. 2008 Oct 16;455(7215):903-11. Review.PMID: 18923512 [PubMed - indexed for MEDLINE]Related articlesFree article

RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.

Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14680-5. Epub 2008 Sep 17.PMID: 18799741 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.

Science. 2008 Sep 12;321(5895):1507-10. Epub 2008 Aug 14.PMID: 18703708 [PubMed - indexed for MEDLINE]Related articlesFree article

Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse.

Ruiz R, Casañas JJ, Südhof TC, Tabares L.

Eur J Neurosci. 2008 Jun;27(12):3118-31.PMID: 18598257 [PubMed - indexed for MEDLINE]Related articles

Unusually rapid evolution of Neuroligin-4 in mice.

Bolliger MF, Pei J, Maxeiner S, Boucard AA, Grishin NV, Südhof TC.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6421-6. Epub 2008 Apr 23.PMID: 18434543 [PubMed - indexed for MEDLINE]Related articlesFree article

CASK Functions as a Mg2+-independent neurexin kinase.

Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC.

Cell. 2008 Apr 18;133(2):328-39.PMID: 18423203 [PubMed - indexed for MEDLINE]Related articles

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.

Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC, Han W.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3992-7. Epub 2008 Feb 28.PMID: 18308938 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis.

Maximov A, Lao Y, Li H, Chen X, Rizo J, Sørensen JB, Südhof TC.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3986-91. Epub 2008 Feb 28.PMID: 18308933 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.

Schonn JS, Maximov A, Lao Y, Südhof TC, Sørensen JB.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3998-4003. Epub 2008 Feb 28.PMID: 18308932 [PubMed - indexed for MEDLINE]Related articlesFree article

A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.

Gallardo G, Schlüter OM, Südhof TC.

Nat Neurosci. 2008 Mar;11(3):301-8. Epub 2008 Feb 24.PMID: 18297066 [PubMed - indexed for MEDLINE]Related articles

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.

Araç D, Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT.

Neuron. 2007 Dec 20;56(6):992-1003.PMID: 18093522 [PubMed - indexed for MEDLINE]Related articles

A dual-Ca2+-sensor model for neurotransmitter release in a central synapse.

Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC.

Nature. 2007 Nov 29;450(7170):676-82.PMID: 18046404 [PubMed - indexed for MEDLINE]Related articles

Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.

Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.

J Neurosci. 2007 Nov 7;27(45):12147-55.PMID: 17989281 [PubMed - indexed for MEDLINE]Related articlesFree article

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.

Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC.

Science. 2007 Oct 5;318(5847):71-6. Epub 2007 Sep 6.PMID: 17823315 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane fusion as a team effort.

Südhof TC.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13541-2. Epub 2007 Aug 15. No abstract available. PMID: 17699625 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines.

Wu H, Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC, Sun YE.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13821-6. Epub 2007 Aug 10.PMID: 17693548 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.

Guan R, Dai H, Tomchick DR, Dulubova I, Machius M, Südhof TC, Rizo J.

Biochemistry. 2007 Aug 7;46(31):8988-98. Epub 2007 Jul 14.PMID: 17630786 [PubMed - indexed for MEDLINE]Related articlesFree article

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.

Chubykin AA, Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Südhof TC.

Neuron. 2007 Jun 21;54(6):919-31.PMID: 17582332 [PubMed - indexed for MEDLINE]Related articles

Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.

Bronk P, Deák F, Wilson MC, Liu X, Südhof TC, Kavalali ET.

J Neurophysiol. 2007 Aug;98(2):794-806. Epub 2007 Jun 6.PMID: 17553942 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.

Chevaleyre V, Heifets BD, Kaeser PS, Südhof TC, Castillo PE.

Neuron. 2007 Jun 7;54(5):801-12. Erratum in: Neuron. 2007 Jul 5;55(1):169. Purpura, Dominick P [removed]. PMID: 17553427 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.

Xu J, Mashimo T, Südhof TC.

Neuron. 2007 May 24;54(4):567-81.PMID: 17521570 [PubMed - indexed for MEDLINE]Related articles

E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.

Min SW, Chang WP, Südhof TC.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3823-8. Epub 2007 Feb 28.PMID: 17360437 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

Dudanova I, Tabuchi K, Rohlmann A, Südhof TC, Missler M.

J Comp Neurol. 2007 May 10;502(2):261-74.PMID: 17347997 [PubMed - indexed for MEDLINE]Related articles

Munc18-1 binds directly to the neuronal SNARE complex.

Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.PMID: 17301226 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of CASK in mice is lethal and impairs synaptic function.

Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2525-30. Epub 2007 Feb 7.PMID: 17287346 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map.

Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P.

Nat Neurosci. 2007 Mar;10(3):340-7. Epub 2007 Jan 28.PMID: 17259982 [PubMed - indexed for MEDLINE]Related articles

Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses.

Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC.

J Neurosci. 2006 Dec 27;26(52):13493-504.PMID: 17192432 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.

Maximov A, Shin OH, Liu X, Südhof TC.

J Cell Biol. 2007 Jan 1;176(1):113-24. Epub 2006 Dec 26.PMID: 17190793 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.

Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC.

J Neurosci. 2006 Dec 13;26(50):13089-101.PMID: 17167098 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification.

Juranek J, Mukherjee K, Rickmann M, Martens H, Calka J, Südhof TC, Jahn R.

Eur J Neurosci. 2006 Dec;24(11):3043-52.PMID: 17156365 [PubMed - indexed for MEDLINE]Related articles

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

Pang ZP, Shin OH, Meyer AC, Rosenmund C, Südhof TC.

J Neurosci. 2006 Nov 29;26(48):12556-65.PMID: 17135417 [PubMed - indexed for MEDLINE]Related articlesFree article