PubMed

Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium.

Okumura T, Wang SS, Takaishi S, Tu SP, Ng V, E Ericksen R, Rustgi AK, Wang TC.

Lab Invest. 2009 Dec;89(12):1410-22. Epub 2009 Oct 19.PMID: 19841619 [PubMed - in process]Related articles

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M.

Nat Genet. 2009 Nov;41(11):1238-42. Epub 2009 Oct 4.PMID: 19801978 [PubMed - in process]Related articles

Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor.

Wescott MP, Rovira M, Reichert M, von Burstin J, Means A, Leach SD, Rustgi AK.

Mol Biol Cell. 2009 Nov;20(22):4838-44. Epub 2009 Sep 30.PMID: 19793922 [PubMed - in process]Related articles

Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer.

Rangiah K, Tippornwong M, Sangar V, Austin D, Tétreault MP, Rustgi AK, Blair IA, Yu KH.

J Proteome Res. 2009 Nov;8(11):5153-64.PMID: 19769411 [PubMed - in process]Related articles

Gastroenterology year in review.

Dubnansky EC, Rustgi AK.

Gastroenterology. 2009 Aug;137(2):410-1. Epub 2009 Jun 23. No abstract available. PMID: 19555679 [PubMed - indexed for MEDLINE]Related articles

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.

Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA.

J Clin Invest. 2009 Jul;119(7):1888-98.PMID: 19487809 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium.

Wilkey JF, Buchberger G, Saucier K, Patel SM, Eisenberg E, Nakagawa H, Michaylira CZ, Rustgi AK, Mallya SM.

Mol Carcinog. 2009 Sep;48(9):853-61.PMID: 19263437 [PubMed - indexed for MEDLINE]Related articles

Low frequency of MLL3 mutations in colorectal carcinoma.

Vakoc CR, Wen YY, Gibbs RA, Johnstone CN, Rustgi AK, Blobel GA.

Cancer Genet Cytogenet. 2009 Mar;189(2):140-1. No abstract available. Erratum in: Cancer Genet Cytogenet. 2009 Jun;191(2):115. PMID: 19215798 [PubMed - indexed for MEDLINE]Related articles

Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery.

Yu KH, Barry CG, Austin D, Busch CM, Sangar V, Rustgi AK, Blair IA.

J Proteome Res. 2009 Mar;8(3):1565-76.PMID: 19199705 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic cancer: translating lessons from mouse models and hereditary syndromes.

Wescott MP, Rustgi AK.

Cancer Prev Res (Phila Pa). 2008 Dec;1(7):503-6. Review.PMID: 19138999 [PubMed - indexed for MEDLINE]Related articles

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.

Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK.

J Clin Invest. 2008 Dec;118(12):3860-9. doi: 10.1172/JCI35012. Epub 2008 Nov 6.PMID: 19033657 [PubMed - indexed for MEDLINE]Related articlesFree article

Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes.

Harada H, Nakagawa H, Takaoka M, Lee J, Herlyn M, Diehl JA, Rustgi AK.

Cell Cycle. 2008 Nov 15;7(22):3534-8. Epub 2008 Nov 18.PMID: 19001876 [PubMed - indexed for MEDLINE]Related articlesFree article

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD, Silberg DG, Tobias JW, Lynch JP, Rustgi AK.

PLoS One. 2008;3(10):e3534. Epub 2008 Oct 27.PMID: 18953412 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of intestinalization in human esophageal keratinocytes is a multistep process.

Kong J, Nakagawa H, Isariyawongse BK, Funakoshi S, Silberg DG, Rustgi AK, Lynch JP.

Carcinogenesis. 2009 Jan;30(1):122-30. Epub 2008 Oct 8.PMID: 18845559 [PubMed - indexed for MEDLINE]Related articles

Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium.

Kalabis J, Li G, Fukunaga-Kalabis M, Rustgi AK, Herlyn M.

Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1182-9. Epub 2008 Oct 2.PMID: 18832450 [PubMed - indexed for MEDLINE]Related articles

Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.

Lioni M, Noma K, Snyder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley KS.

Mol Cancer Ther. 2008 Sep;7(9):2866-75.PMID: 18790767 [PubMed - indexed for MEDLINE]Related articlesFree article

Gastroenterology 2007 in review.

Dubnansky EC, Rustgi AK.

Gastroenterology. 2008 Sep;135(3):729-30. Epub 2008 Aug 5. No abstract available. PMID: 18687333 [PubMed - indexed for MEDLINE]Related articles

Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA.

Cancer Cell. 2008 Jul 8;14(1):68-78.PMID: 18598945 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.

Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu CG, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis VA, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, Bützow R, Rustgi AK, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7004-9. Epub 2008 May 5.PMID: 18458333 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.

Aggarwal P, Lessie MD, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJ, Rustgi AK, Bassing CH, Diehl JA.

Genes Dev. 2007 Nov 15;21(22):2908-22.PMID: 18006686 [PubMed - indexed for MEDLINE]Related articlesFree article

Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.

Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, Rustgi AK.

Mol Cell Biol. 2008 Jan;28(2):687-704. Epub 2007 Nov 12.PMID: 17998334 [PubMed - indexed for MEDLINE]Related articlesFree article

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, Sutherland RL, Dlugosz A, Rustgi AK, Hebrok M.

PLoS One. 2007 Nov 7;2(11):e1155.PMID: 17982507 [PubMed - indexed for MEDLINE]Related articlesFree article

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.

Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK.

Genes Dev. 2007 Nov 1;21(21):2788-803.PMID: 17974918 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetics of hereditary colon cancer.

Rustgi AK.

Genes Dev. 2007 Oct 15;21(20):2525-38. Review.PMID: 17938238 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.

Plastaras JP, Kim SH, Liu YY, Dicker DT, Dorsey JF, McDonough J, Cerniglia G, Rajendran RR, Gupta A, Rustgi AK, Diehl JA, Smith CD, Flaherty KT, El-Deiry WS.

Cancer Res. 2007 Oct 1;67(19):9443-54.PMID: 17909054 [PubMed - indexed for MEDLINE]Related articlesFree article

Advances and challenges in aerodigestive epithelial cancer: meeting summary and research opportunities.

Grandis JR, Carbone DP, Rustgi AK.

Cancer Res. 2007 Aug 15;67(16):7556-8. Epub 2007 Aug 8. No abstract available. PMID: 17686829 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.

Guo M, House MG, Suzuki H, Ye Y, Brock MV, Lu F, Liu Z, Rustgi AK, Herman JG.

Int J Cancer. 2007 Sep 15;121(6):1219-26.PMID: 17534889 [PubMed - indexed for MEDLINE]Related articles

Conflicts of interest and disclosures in publications.

Camilleri M, Dubnansky EC, Rustgi AK.

Clin Gastroenterol Hepatol. 2007 Mar;5(3):268-73. Review. No abstract available. PMID: 17368225 [PubMed - indexed for MEDLINE]Related articles

Clinical trial resources on the internet must be designed to reach underrepresented minorities.

Wilson JJ, Mick R, Wei SJ, Rustgi AK, Markowitz SD, Hampshire M, Metz JM.

Cancer J. 2006 Nov-Dec;12(6):475-81.PMID: 17207317 [PubMed - indexed for MEDLINE]Related articles

Models of esophageal carcinogenesis.

Rustgi AK.

Semin Oncol. 2006 Dec;33(6 Suppl 11):S57-8. Review.PMID: 17178289 [PubMed - indexed for MEDLINE]Related articles

The molecular pathogenesis of pancreatic cancer: clarifying a complex circuitry.

Rustgi AK.

Genes Dev. 2006 Nov 15;20(22):3049-53. No abstract available. PMID: 17114578 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.

Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJ, Rustgi AK, El-Deiry WS.

Cancer Res. 2006 Nov 1;66(21):10415-24.PMID: 17079462 [PubMed - indexed for MEDLINE]Related articlesFree article

The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.

Deramaudt TB, Sachdeva MM, Wescott MP, Chen Y, Stoffers DA, Rustgi AK.

J Biol Chem. 2006 Dec 15;281(50):38385-95. Epub 2006 Oct 20.PMID: 17056599 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.

Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK.

Cancer Res. 2006 Oct 15;66(20):9878-85.PMID: 17047049 [PubMed - indexed for MEDLINE]Related articlesFree article

AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.

Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK.

Oncogene. 2007 Apr 5;26(16):2353-64. Epub 2006 Oct 9.PMID: 17043653 [PubMed - indexed for MEDLINE]Related articles

N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.

Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK.

Mol Cell Biol. 2006 Jun;26(11):4185-200.PMID: 16705170 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced imaging and technology in gastrointestinal neoplasia: summary of the AGA-NCI Symposium October 4-5, 2004.

Wallace MB, Sullivan D, Rustgi AK; AITGN Symposium Faculty.

Gastroenterology. 2006 Apr;130(4):1333-42.PMID: 16618424 [PubMed - indexed for MEDLINE]Related articles

Barrett's esophagus and its progression to adenocarcinoma.

Maley CC, Rustgi AK.

J Natl Compr Canc Netw. 2006 Apr;4(4):367-74. Review.PMID: 16569389 [PubMed - indexed for MEDLINE]Related articles

Pancreatic cancer in mice and man: the Penn Workshop 2004.

Hruban RH, Rustgi AK, Brentnall TA, Tempero MA, Wright CV, Tuveson DA.

Cancer Res. 2006 Jan 1;66(1):14-7.PMID: 16397208 [PubMed - indexed for MEDLINE]Related articlesFree article

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis.

Goessel G, Quante M, Hahn WC, Harada H, Heeg S, Suliman Y, Doebele M, von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15599-604. Epub 2005 Oct 20.PMID: 16239349 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.

Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C.

Cancer Res. 2005 Oct 15;65(20):9287-93.PMID: 16230390 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic cancer: novel approaches to diagnosis and therapy.

Rustgi AK.

Gastroenterology. 2005 Oct;129(4):1344-7. No abstract available. PMID: 16230087 [PubMed - indexed for MEDLINE]Related articles

Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry.

Yu KH, Rustgi AK, Blair IA.

J Proteome Res. 2005 Sep-Oct;4(5):1742-51.PMID: 16212428 [PubMed - indexed for MEDLINE]Related articles

Mutant KRAS in the initiation of pancreatic cancer.

Deramaudt T, Rustgi AK.

Biochim Biophys Acta. 2005 Nov 25;1756(2):97-101. Epub 2005 Sep 7. Review.PMID: 16169155 [PubMed - indexed for MEDLINE]Related articles

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates.

Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ Jr, Wright CV, Stoffers DA, Leach SD.

Development. 2005 Aug;132(16):3767-76. Epub 2005 Jul 14.PMID: 16020518 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.

Fu Z, Schroeder MJ, Shabanowitz J, Kaldis P, Togawa K, Rustgi AK, Hunt DF, Sturgill TW.

Mol Cell Biol. 2005 Jul;25(14):6047-64.PMID: 15988018 [PubMed - indexed for MEDLINE]Related articlesFree article

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA.

Cancer Cell. 2005 May;7(5):469-83.PMID: 15894267 [PubMed - indexed for MEDLINE]Related articles

PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas.

Johnstone CN, Castellví-Bel S, Chang LM, Sung RK, Bowser MJ, Piqué JM, Castells A, Rustgi AK.

Genomics. 2005 Mar;85(3):338-51.PMID: 15718101 [PubMed - indexed for MEDLINE]Related articles

No one-way street: cross-talk between e-cadherin and receptor tyrosine kinase (RTK) signaling: a mechanism to regulate RTK activity.

Andl CD, Rustgi AK.

Cancer Biol Ther. 2005 Jan;4(1):28-31. Epub 2005 Jan 15. Review.PMID: 15662113 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of patients into an internet-based clinical trials database: the experience of OncoLink and the National Colorectal Cancer Research Alliance.

Wei SJ, Metz JM, Coyle C, Hampshire M, Jones HA, Markowitz S, Rustgi AK.

J Clin Oncol. 2004 Dec 1;22(23):4730-6. Erratum in: J Clin Oncol. 2005 Jan 1;23(1):248. PMID: 15570073 [PubMed - indexed for MEDLINE]Related articles