PubMed

Selective Enhancement of Nutrient-Induced Insulin Secretion by ATP-Sensitive K+ Channel-Blocking Imidazolines.

Hatlapatka K, Wienbergen A, Kühne C, Jörns A, Willenborg M, Rustenbeck I.

J Pharmacol Exp Ther. 2009 Dec;331(3):1033-41. Epub 2009 Sep 10.PMID: 19745109 [PubMed - in process]Related articlesFree article

Plasma membrane depolarization as a determinant of the first phase of insulin secretion.

Hatlapatka K, Willenborg M, Rustenbeck I.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E315-22. Epub 2009 May 26.PMID: 19470830 [PubMed - indexed for MEDLINE]Related articles

[Fixed drug combinations--the pros and the cons]

Rustenbeck I.

Med Monatsschr Pharm. 2009 Apr;32(4):141-6. Review. German. PMID: 19445271 [PubMed - indexed for MEDLINE]Related articles

Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue.

Willenborg M, Panten U, Rustenbeck I.

Eur J Pharmacol. 2009 Apr 1;607(1-3):41-6. Epub 2009 Feb 20.PMID: 19233162 [PubMed - indexed for MEDLINE]Related articles

The insulinotropic effect of fluoroquinolones.

Ghaly H, Kriete C, Sahin S, Pflöger A, Holzgrabe U, Zünkler BJ, Rustenbeck I.

Biochem Pharmacol. 2009 Mar 15;77(6):1040-52. Epub 2008 Nov 25.PMID: 19073153 [PubMed - indexed for MEDLINE]Related articles

Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio.

Panten U, Rustenbeck I.

Diabetologia. 2008 Jan;51(1):101-9. Epub 2007 Oct 25.PMID: 17960358 [PubMed - indexed for MEDLINE]Related articles

[Unconventional antidiabetic agents]

Rustenbeck I.

Med Monatsschr Pharm. 2007 Apr;30(4):131-7. Review. German. PMID: 17484443 [PubMed - indexed for MEDLINE]Related articles

Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels.

Wienbergen A, Bleck C, Lackmann TG, Rustenbeck I.

Biochem Pharmacol. 2007 Jan 1;73(1):94-102. Epub 2006 Sep 22.PMID: 17056015 [PubMed - indexed for MEDLINE]Related articles

Effects of fluoroquinolones on HERG channels and on pancreatic beta-cell ATP-sensitive K+ channels.

Zünkler BJ, Claassen S, Wos-Maganga M, Rustenbeck I, Holzgrabe U.

Toxicology. 2006 Dec 7;228(2-3):239-48. Epub 2006 Sep 8.PMID: 17027138 [PubMed - indexed for MEDLINE]Related articles

Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R.

Bleck C, Wienbergen A, Rustenbeck I.

Diabetologia. 2005 Dec;48(12):2567-75. Epub 2005 Nov 11.PMID: 16283242 [PubMed - indexed for MEDLINE]Related articles

Desensitization of insulin secretion by depolarizing insulin secretagogues.

Rustenbeck I, Wienbergen A, Bleck C, Jörns A.

Diabetes. 2004 Dec;53 Suppl 3:S140-50. Review.PMID: 15561902 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.

Bleck C, Wienbergen A, Rustenbeck I.

Diabetes. 2004 Dec;53 Suppl 3:S135-9.PMID: 15561901 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues.

Rustenbeck I, Krautheim A, Jörns A, Steinfelder HJ.

Biochem Pharmacol. 2004 May 1;67(9):1733-41.PMID: 15081872 [PubMed - indexed for MEDLINE]Related articles

Specificity of nonadrenergic imidazoline binding sites in insulin-secreting cells and relation to the block of ATP-sensitive K(+) channels.

Grosse-Lackmann T, Zunkler BJ, Rustenbeck I.

Ann N Y Acad Sci. 2003 Dec;1009:371-7.PMID: 15028615 [PubMed - indexed for MEDLINE]Related articles

Palmitate-induced Ca2+-signaling in pancreatic beta-cells.

Remizov O, Jakubov R, Düfer M, Krippeit Drews P, Drews G, Waring M, Brabant G, Wienbergen A, Rustenbeck I, Schöfl C.

Mol Cell Endocrinol. 2003 Dec 30;212(1-2):1-9.PMID: 14654245 [PubMed - indexed for MEDLINE]Related articles

Desensitization of insulin secretion.

Rustenbeck I.

Biochem Pharmacol. 2002 Jun 1;63(11):1921-35. Review.PMID: 12093468 [PubMed - indexed for MEDLINE]Related articles

Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies.

Rustenbeck I, Dickel C, Grimmsmanns T.

Biochem Pharmacol. 2001 Dec 15;62(12):1695-703.PMID: 11755123 [PubMed - indexed for MEDLINE]Related articles

Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies.

Rustenbeck I, Winkler M, Jörns A.

Biochem Pharmacol. 2001 Dec 15;62(12):1685-94.PMID: 11755122 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures.

Hirsch-Ernst KI, Ziemann C, Rustenbeck I, Kahl GF.

Toxicology. 2001 Oct 5;167(1):47-57.PMID: 11557129 [PubMed - indexed for MEDLINE]Related articles

Disopyramide block of K(ATP) channels is mediated by the pore-forming subunit.

Zünkler BJ, Kühne S, Rustenbeck I, Ott T, Hildebrandt AG.

Life Sci. 2000 Mar;66(17):PL 245-52.PMID: 11261596 [PubMed - indexed for MEDLINE]Related articles

Mechanism of terfenadine block of ATP-sensitive K(+) channels.

Zünkler BJ, Kühne S, Rustenbeck I, Ott T.

Br J Pharmacol. 2000 Aug;130(7):1571-4.PMID: 10928959 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria present in excised patches from pancreatic B-cells may form microcompartments with ATP-dependent potassium channels.

Rustenbeck I, Dickel C, Herrmann C, Grimmsmann T.

Biosci Rep. 1999 Apr;19(2):89-98.PMID: 10888471 [PubMed - indexed for MEDLINE]Related articles

Imidazolines and the pancreatic B-cell. Actions and binding sites.

Rustenbeck I, Köpp M, Ratzka P, Leupolt L, Hasselblatt A.

Ann N Y Acad Sci. 1999 Jun 21;881:229-40.PMID: 10415921 [PubMed - indexed for MEDLINE]Related articles

Heterogeneous characteristics of imidazoline-induced insulin secretion.

Rustenbeck I, Leupolt L, Kowalewski R, Hasselblatt A.

Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):235-42.PMID: 10208311 [PubMed - indexed for MEDLINE]Related articles

Phosphatase inhibitors induce defective hormone secretion in insulin-secreting cells and entry into apoptosis.

Krautheim A, Rustenbeck I, Steinfelder HJ.

Exp Clin Endocrinol Diabetes. 1999;107(1):29-34.PMID: 10077352 [PubMed - indexed for MEDLINE]Related articles

Polyamine modulation of mitochondrial calcium transport. II. Inhibition of mitochondrial permeability transition by aliphatic polyamines but not by aminoglucosides.

Rustenbeck I, Löptien D, Fricke K, Lenzen S, Reiter H.

Biochem Pharmacol. 1998 Oct 15;56(8):987-95.PMID: 9776309 [PubMed - indexed for MEDLINE]Related articles

Polyamine modulation of mitochondrial calcium transport. I. Stimulatory and inhibitory effects of aliphatic polyamines, aminoglucosides and other polyamine analogues on mitochondrial calcium uptake.

Rustenbeck I, Eggers G, Reiter H, Münster W, Lenzen S.

Biochem Pharmacol. 1998 Oct 15;56(8):977-85.PMID: 9776308 [PubMed - indexed for MEDLINE]Related articles

No evidence for PKC activation in stimulation of insulin secretion by phentolamine.

Rustenbeck I, Köpp M, Polzin C, Hasselblatt A.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):390-3.PMID: 9774228 [PubMed - indexed for MEDLINE]Related articles

Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.

Grimmsmann T, Rustenbeck I.

Br J Pharmacol. 1998 Mar;123(5):781-8.PMID: 9535004 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline/guanidinium binding sites and their relation to inhibition of K(ATP) channels in pancreatic B-cells.

Rustenbeck I, Herrmann C, Ratzka P, Hasselblatt A.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):410-7.PMID: 9303581 [PubMed - indexed for MEDLINE]Related articles

Energetic requirement of insulin secretion distal to calcium influx.

Rustenbeck I, Herrmann C, Grimmsmann T.

Diabetes. 1997 Aug;46(8):1305-11.PMID: 9231655 [PubMed - indexed for MEDLINE]Related articles

Relation between accumulation of phospholipase A2 reaction products and Ca2+ release in isolated liver mitochondria.

Rustenbeck I, Münster W, Lenzen S.

Biochim Biophys Acta. 1996 Nov 22;1304(2):129-38.PMID: 8954136 [PubMed - indexed for MEDLINE]Related articles

Dissociation between effects of polyamines on mitochondrial calcium uptake and mitochondrial permeability transition by elongation of polyamine methylene backbone.

Rustenbeck I, Reiter H, Lenzen S.

Biochem Mol Biol Int. 1996 Apr;38(5):1003-11.PMID: 9132147 [PubMed - indexed for MEDLINE]Related articles

A plug-in minielectrode for measurements in stirred photometric cuvettes.

Rustenbeck I, Lenzen S.

J Biochem Biophys Methods. 1996 Feb 5;31(3-4):105-12.PMID: 8675953 [PubMed - indexed for MEDLINE]Related articles

Degradation of dansyl polyamines on high-performance thin-layer chromatographic plates.

Rustenbeck I, Löptien D, Lenzen S.

J Chromatogr B Biomed Appl. 1995 May 5;667(1):185-7.PMID: 7663683 [PubMed - indexed for MEDLINE]Related articles

Effects of imidazoline compounds on cytoplasmic Ca2+ concentration and ATP-sensitive K+ channels in pancreatic B-cells.

Rustenbeck I, Kowalewski R, Herrmann C, Dickel C, Ratzka P, Hasselblatt A.

Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:42-5.PMID: 8839253 [PubMed - indexed for MEDLINE]Related articles

Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells.

Rustenbeck I, Matthies A, Lenzen S.

Lipids. 1994 Oct;29(10):685-92.PMID: 7861935 [PubMed - indexed for MEDLINE]Related articles

Effect of spermine on mitochondrial matrix calcium in relation to its enhancement of mitochondrial calcium uptake.

Rustenbeck I, Eggers G, Münster W, Lenzen S.

Biochem Biophys Res Commun. 1993 Aug 16;194(3):1261-8.PMID: 8352783 [PubMed - indexed for MEDLINE]Related articles

Dual effect of spermine on mitochondrial Ca2+ transport.

Lenzen S, Münster W, Rustenbeck I.

Biochem J. 1992 Sep 1;286 ( Pt 2):597-602.PMID: 1530590 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of lysophospholipids, arachidonic acid and other fatty acids on regulation of Ca2+ transport in permeabilized pancreatic islets.

Rustenbeck I, Lenzen S.

Cell Calcium. 1992 Apr;13(4):193-202.PMID: 1586937 [PubMed - indexed for MEDLINE]Related articles

Structural requirements of lysophospholipid-regulated mitochondrial Ca2+ transport.

Rustenbeck I, Eibl H, Lenzen S.

Biochim Biophys Acta. 1991 Oct 14;1069(1):99-109.PMID: 1932054 [PubMed - indexed for MEDLINE]Related articles

Effects of IP3, spermine, and Mg2+ on regulation of Ca2+ transport by endoplasmic reticulum and mitochondria in permeabilized pancreatic islets.

Lenzen S, Rustenbeck I.

Diabetes. 1991 Mar;40(3):323-6.PMID: 1999273 [PubMed - indexed for MEDLINE]Related articles

Quantitation of hexadecylphosphocholine by high-performance thin-layer chromatography with densitometry.

Rustenbeck I, Lenzen S.

J Chromatogr. 1990 Jan 26;525(1):85-91.PMID: 2338450 [PubMed - indexed for MEDLINE]Related articles

Regulation of transmembrane ion transport by reaction products of phospholipase A2. II. Effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport.

Rustenbeck I, Lenzen S.

Biochim Biophys Acta. 1989 Jun 26;982(1):147-55.PMID: 2500979 [PubMed - indexed for MEDLINE]Related articles

Regulation of transmembrane ion transport by reaction products of phospholipase A2. I. Effects of lysophospholipids on mitochondrial Ca2+ transport.

Lenzen S, Görlich JK, Rustenbeck I.

Biochim Biophys Acta. 1989 Jun 26;982(1):140-6.PMID: 2472836 [PubMed - indexed for MEDLINE]Related articles

Effects of lysophosphatidylcholine and arachidonic acid on the regulation of intracellular Ca2+ transport.

Rustenbeck I, Lenzen S.

Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb;339(1-2):37-41.PMID: 2498670 [PubMed - indexed for MEDLINE]Related articles

2-ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids.

Lenzen S, Schmidt W, Rustenbeck I, Panten U.

Biosci Rep. 1986 Feb;6(2):163-9.PMID: 3521757 [PubMed - indexed for MEDLINE]Related articles

Transamination of 3-phenylpyruvate in pancreatic B-cell mitochondria.

Lenzen S, Rustenbeck I, Panten U.

J Biol Chem. 1984 Feb 25;259(4):2043-6.PMID: 6142039 [PubMed - indexed for MEDLINE]Related articlesFree article