PubMed

Potential role of autophagy in modulation of lipid metabolism.

Kovsan J, Bashan N, Greenberg A, Rudich A.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887596 [PubMed - as supplied by publisher]Related articles

Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity.

Blüher M, Bashan N, Shai I, Harman-Boehm I, Tarnovscki T, Avinaoch E, Stumvoll M, Dietrich A, Klöting N, Rudich A.

J Clin Endocrinol Metab. 2009 Jul;94(7):2507-15. Epub 2009 Apr 7.PMID: 19351724 [PubMed - indexed for MEDLINE]Related articles

Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.

Kachko I, Maissel A, Mazor L, Ben-Romano R, Watson RT, Hou JC, Pessin JE, Bashan N, Rudich A.

Endocrinology. 2009 Jun;150(6):2618-26. Epub 2009 Jan 29.PMID: 19179444 [PubMed - indexed for MEDLINE]Related articles

Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species.

Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A.

Physiol Rev. 2009 Jan;89(1):27-71. Review.PMID: 19126754 [PubMed - indexed for MEDLINE]Related articles

Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes--relevance for partial lipodystrophy.

Kovsan J, Osnis A, Maissel A, Mazor L, Tarnovscki T, Hollander L, Ovadia S, Meier B, Klein J, Bashan N, Rudich A.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E315-22. Epub 2008 Nov 25.PMID: 19033543 [PubMed - indexed for MEDLINE]Related articles

Changes in triglyceride levels over time and risk of type 2 diabetes in young men.

Tirosh A, Shai I, Bitzur R, Kochba I, Tekes-Manova D, Israeli E, Shochat T, Rudich A.

Diabetes Care. 2008 Oct;31(10):2032-7. Epub 2008 Jun 30.PMID: 18591400 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding.

Elgazar-Carmon V, Rudich A, Hadad N, Levy R.

J Lipid Res. 2008 Sep;49(9):1894-903. Epub 2008 May 23.PMID: 18503031 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in triglyceride levels and risk for coronary heart disease in young men.

Tirosh A, Rudich A, Shochat T, Tekes-Manova D, Israeli E, Henkin Y, Kochba I, Shai I.

Ann Intern Med. 2007 Sep 18;147(6):377-85.PMID: 17876021 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose stress-sensing kinases: linking obesity to malfunction.

Rudich A, Kanety H, Bashan N.

Trends Endocrinol Metab. 2007 Oct;18(8):291-9. Epub 2007 Sep 12. Review.PMID: 17855109 [PubMed - indexed for MEDLINE]Related articles

Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial.

Shai I, Wainstein J, Harman-Boehm I, Raz I, Fraser D, Rudich A, Stampfer MJ.

Diabetes Care. 2007 Dec;30(12):3011-6. Epub 2007 Sep 11.PMID: 17848609 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis.

Kovsan J, Ben-Romano R, Souza SC, Greenberg AS, Rudich A.

J Biol Chem. 2007 Jul 27;282(30):21704-11. Epub 2007 May 8.PMID: 17488708 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.

Harman-Boehm I, Blüher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, Shai I, Klöting N, Stumvoll M, Bashan N, Rudich A.

J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7. Epub 2007 Mar 20.PMID: 17374712 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue.

Konrad D, Rudich A, Schoenle EJ.

Diabetologia. 2007 Apr;50(4):833-9. Epub 2007 Feb 16.PMID: 17334653 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity.

Bashan N, Dorfman K, Tarnovscki T, Harman-Boehm I, Liberty IF, Blüher M, Ovadia S, Maymon-Zilberstein T, Potashnik R, Stumvoll M, Avinoach E, Rudich A.

Endocrinology. 2007 Jun;148(6):2955-62. Epub 2007 Feb 22.PMID: 17317777 [PubMed - indexed for MEDLINE]Related articlesFree article

Nelfinavir induces adipocyte insulin resistance through the induction of oxidative stress: differential protective effect of antioxidant agents.

Ben-Romano R, Rudich A, Etzion S, Potashnik R, Kagan E, Greenbaum U, Bashan N.

Antivir Ther. 2006;11(8):1051-60.PMID: 17302375 [PubMed - indexed for MEDLINE]Related articles

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.

JeBailey L, Wanono O, Niu W, Roessler J, Rudich A, Klip A.

Diabetes. 2007 Feb;56(2):394-403.PMID: 17259384 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N.

Diabetologia. 2006 Oct;49(10):2463-73. Epub 2006 Aug 3.PMID: 16896943 [PubMed - indexed for MEDLINE]Related articles

GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes.

Pessler-Cohen D, Pekala PH, Kovsan J, Bloch-Damti A, Rudich A, Bashan N.

Arch Physiol Biochem. 2006 Feb;112(1):3-12.PMID: 16754198 [PubMed - indexed for MEDLINE]Related articles

Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.

Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS.

J Biol Chem. 2006 Jun 9;281(23):15837-44. Epub 2006 Apr 4.PMID: 16595669 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).

Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A.

J Proteome Res. 2006 Jan;5(1):64-75.PMID: 16396496 [PubMed - indexed for MEDLINE]Related articles

Normal fasting plasma glucose levels and type 2 diabetes in young men.

Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, Kochba I, Rudich A; Israeli Diabetes Research Group.

N Engl J Med. 2005 Oct 6;353(14):1454-62. Erratum in: N Engl J Med. 2006 Jun 1;354(22):2401. PMID: 16207847 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells.

Konrad D, Rudich A, Bilan PJ, Patel N, Richardson C, Witters LA, Klip A.

Diabetologia. 2005 May;48(5):954-66. Epub 2005 Apr 15.PMID: 15834551 [PubMed - indexed for MEDLINE]Related articles

Cellular mechanisms of insulin resistance, lipodystrophy and atherosclerosis induced by HIV protease inhibitors.

Rudich A, Ben-Romano R, Etzion S, Bashan N.

Acta Physiol Scand. 2005 Jan;183(1):75-88. Review.PMID: 15654921 [PubMed - indexed for MEDLINE]Related articles

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

Randhawa VK, Thong FS, Lim DY, Li D, Garg RR, Rudge R, Galli T, Rudich A, Klip A.

Mol Biol Cell. 2004 Dec;15(12):5565-73. Epub 2004 Oct 6.PMID: 15469990 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.

Török D, Patel N, Jebailey L, Thong FS, Randhawa VK, Klip A, Rudich A.

J Cell Sci. 2004 Oct 15;117(Pt 22):5447-55. Epub 2004 Oct 5.PMID: 15466888 [PubMed - indexed for MEDLINE]Related articlesFree article

Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta.

Ben-Romano R, Rudich A, Tirosh A, Potashnik R, Sasaoka T, Riesenberg K, Schlaeffer F, Bashan N.

Diabetologia. 2004 Jun;47(6):1107-17. Epub 2004 May 28.PMID: 15168016 [PubMed - indexed for MEDLINE]Related articles

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.

Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A.

J Biol Chem. 2004 Jul 30;279(31):32233-42. Epub 2004 May 27.PMID: 15166230 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling.

JeBailey L, Rudich A, Huang X, Di Ciano-Oliveira C, Kapus A, Klip A.

Mol Endocrinol. 2004 Feb;18(2):359-72. Epub 2003 Nov 13.PMID: 14615606 [PubMed - indexed for MEDLINE]Related articlesFree article

Push/pull mechanisms of GLUT4 traffic in muscle cells.

Rudich A, Klip A.

Acta Physiol Scand. 2003 Aug;178(4):297-308. Review.PMID: 12864734 [PubMed - indexed for MEDLINE]Related articles

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells.

Patel N, Rudich A, Khayat ZA, Garg R, Klip A.

Mol Cell Biol. 2003 Jul;23(13):4611-26.PMID: 12808101 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.

Potashnik R, Bloch-Damti A, Bashan N, Rudich A.

Diabetologia. 2003 May;46(5):639-48. Epub 2003 May 15.PMID: 12750770 [PubMed - indexed for MEDLINE]Related articles

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.

Rudich A, Konrad D, Török D, Ben-Romano R, Huang C, Niu W, Garg RR, Wijesekara N, Germinario RJ, Bilan PJ, Klip A.

Diabetologia. 2003 May;46(5):649-58. Epub 2003 Apr 24.PMID: 12712244 [PubMed - indexed for MEDLINE]Related articles

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors.

Ben-Romano R, Rudich A, Török D, Vanounou S, Riesenberg K, Schlaeffer F, Klip A, Bashan N.

AIDS. 2003 Jan 3;17(1):23-32.PMID: 12478066 [PubMed - indexed for MEDLINE]Related articles

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

Konrad D, Bilan PJ, Nawaz Z, Sweeney G, Niu W, Liu Z, Antonescu CN, Rudich A, Klip A.

Diabetes. 2002 Sep;51(9):2719-26.PMID: 12196464 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter.

Pessler D, Rudich A, Bashan N.

Diabetologia. 2001 Dec;44(12):2156-64.PMID: 11793016 [PubMed - indexed for MEDLINE]Related articles

2001 Albert Renold Career Development Award of the European Foundation for the Study of Diabetes.

Rudich A.

Diabetologia. 2001 Oct;44(10):suppl 53-4. No abstract available. PMID: 11715934 [PubMed - indexed for MEDLINE]Related articles

An interdisciplinary course in the basic sciences for senior medical and PhD students.

Rudich A, Bashan N.

Acad Med. 2001 Oct;76(10):1072-5.PMID: 11597853 [PubMed - indexed for MEDLINE]Related articles

The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes.

Rudich A, Vanounou S, Riesenberg K, Porat M, Tirosh A, Harman-Boehm I, Greenberg AS, Schlaeffer F, Bashan N.

Diabetes. 2001 Jun;50(6):1425-31.PMID: 11375344 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes.

Tirosh A, Rudich A, Potashnik R, Bashan N.

Biochem J. 2001 May 1;355(Pt 3):757-63.PMID: 11311139 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats.

Khamaisi M, Rudich A, Beeri I, Pessler D, Friger M, Gavrilov V, Tritschler H, Bashan N.

Antioxid Redox Signal. 1999 Winter;1(4):523-35.PMID: 11233149 [PubMed - indexed for MEDLINE]Related articles

Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes.

Rosenstock M, Greenberg AS, Rudich A.

Diabetologia. 2001 Jan;44(1):55-62.PMID: 11206412 [PubMed - indexed for MEDLINE]Related articles

Effect of inhibition of glutathione synthesis on insulin action: in vivo and in vitro studies using buthionine sulfoximine.

Khamaisi M, Kavel O, Rosenstock M, Porat M, Yuli M, Kaiser N, Rudich A.

Biochem J. 2000 Jul 15;349(Pt 2):579-86.PMID: 10880357 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass.

Talmor D, Applebaum A, Rudich A, Shapira Y, Tirosh A.

Circ Res. 2000 May 12;86(9):1004-7.PMID: 10807874 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucose transporters--implications for insulin resistance states.

Tirosh A, Rudich A, Bashan N.

J Pediatr Endocrinol Metab. 2000 Feb;13(2):115-33. Review.PMID: 10711656 [PubMed - indexed for MEDLINE]Related articles

Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes.

Rudich A, Tirosh A, Potashnik R, Khamaisi M, Bashan N.

Diabetologia. 1999 Aug;42(8):949-57.PMID: 10491755 [PubMed - indexed for MEDLINE]Related articles

Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.

Khamaisi M, Rudich A, Potashnik R, Tritschler HJ, Gutman A, Bashan N.

Metabolism. 1999 Apr;48(4):504-10.PMID: 10206446 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation.

Tirosh A, Potashnik R, Bashan N, Rudich A.

J Biol Chem. 1999 Apr 9;274(15):10595-602.PMID: 10187855 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.

Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N.

Diabetes. 1998 Oct;47(10):1562-9.PMID: 9753293 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional activation of the Glut1 gene in response to oxidative stress in L6 myotubes.

Kozlovsky N, Rudich A, Potashnik R, Ebina Y, Murakami T, Bashan N.

J Biol Chem. 1997 Dec 26;272(52):33367-72.PMID: 9407130 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats.

Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, Wessel K, Bashan N.

Metabolism. 1997 Jul;46(7):763-8.PMID: 9225829 [PubMed - indexed for MEDLINE]Related articles