PubMed

Deficiency of Electron Transport Chain in Human Skeletal Muscle Mitochondria in Type 2 Diabetes Mellitus and Obesity.

Ritov VB, Menshikova EV, Azuma K, Wood RJ, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887598 [PubMed - as supplied by publisher]Related articles

Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy.

Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M.

J Histochem Cytochem. 2009 Oct;57(10):963-71. Epub 2009 Jul 6.PMID: 19581628 [PubMed - indexed for MEDLINE]Related articles

Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization.

Kelly M, Gauthier MS, Saha AK, Ruderman NB.

Diabetes. 2009 Sep;58(9):1953-60. Epub 2009 Jun 5.PMID: 19502419 [PubMed - indexed for MEDLINE]Related articles

Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.

Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR.

Cell Metab. 2009 May;9(5):428-39. Erratum in: Cell Metab. 2009 Jun;9(6):565. PMID: 19416713 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M.

Endocrinology. 2009 Aug;150(8):3465-74. Epub 2009 Apr 30.PMID: 19406947 [PubMed - indexed for MEDLINE]Related articles

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.

Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.

J Biol Chem. 2009 Jun 19;284(25):16848-59. Epub 2009 Apr 22.PMID: 19389712 [PubMed - indexed for MEDLINE]Related articles

AMPK and the biochemistry of exercise: implications for human health and disease.

Richter EA, Ruderman NB.

Biochem J. 2009 Mar 1;418(2):261-75. Review.PMID: 19196246 [PubMed - indexed for MEDLINE]Related articles

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells.

Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB.

Biochem Biophys Res Commun. 2009 Jan 23;378(4):836-41. Epub 2008 Dec 9.PMID: 19071085 [PubMed - indexed for MEDLINE]Related articles

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.

Lan F, Cacicedo JM, Ruderman N, Ido Y.

J Biol Chem. 2008 Oct 10;283(41):27628-35. Epub 2008 Aug 7.PMID: 18687677 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.

Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB.

J Biol Chem. 2008 Jun 13;283(24):16514-24. Epub 2008 Apr 5.PMID: 18390901 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers.

Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2650-6. Epub 2007 Oct 11.PMID: 17932315 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome.

Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M.

Diabetes. 2006 Dec;55 Suppl 2:S48-54. Review.PMID: 17130644 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK regulation of the growth of cultured human keratinocytes.

Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):519-24. Epub 2006 Aug 28.PMID: 16949049 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.

Ruderman NB, Saha AK.

Obesity (Silver Spring). 2006 Feb;14 Suppl 1:25S-33S. Review.PMID: 16642960 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.

LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E175-81. Epub 2006 Feb 7.PMID: 16464908 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.

Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1296-303. Epub 2006 Jan 24.PMID: 16434556 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.

Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE.

J Biol Chem. 2006 Feb 3;281(5):2654-60. Epub 2005 Dec 2.PMID: 16326714 [PubMed - indexed for MEDLINE]Related articlesFree article

Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes?

LeBrasseur NK, Ruderman NB.

Diabetes Care. 2005 Dec;28(12):2975-7. No abstract available. PMID: 16306565 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.

Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N.

Diabetes. 2005 Dec;54(12):3458-65.PMID: 16306362 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.

Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M.

FEBS Lett. 2005 Dec 5;579(29):6581-6. Epub 2005 Nov 9.PMID: 16298369 [PubMed - indexed for MEDLINE]Related articles

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes.

Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB.

Biochem Biophys Res Commun. 2005 Oct 14;336(1):309-15.PMID: 16126172 [PubMed - indexed for MEDLINE]Related articles

Cardiorespiratory fitness attenuates mortality associated with the metabolic syndrome.

Ruderman N.

Clin J Sport Med. 2005 Jul;15(4):282-3. No abstract available. PMID: 16003046 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats.

Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E794-800. Epub 2005 Jun 14.PMID: 15956049 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.

Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y.

Diabetes. 2005 Jun;54(6):1838-45.PMID: 15919807 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK, the metabolic syndrome and cancer.

Luo Z, Saha AK, Xiang X, Ruderman NB.

Trends Pharmacol Sci. 2005 Feb;26(2):69-76. Review.PMID: 15681023 [PubMed - indexed for MEDLINE]Related articles

Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats.

Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW.

Biochem Biophys Res Commun. 2005 Jan 28;326(4):851-8.PMID: 15607747 [PubMed - indexed for MEDLINE]Related articles

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.

Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB.

Diabetologia. 2004 Nov;47(11):2012-21. Epub 2004 Dec 2.PMID: 15578153 [PubMed - indexed for MEDLINE]Related articles

AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

Cacicedo JM, Yagihashi N, Keaney JF Jr, Ruderman NB, Ido Y.

Biochem Biophys Res Commun. 2004 Nov 26;324(4):1204-9.PMID: 15504342 [PubMed - indexed for MEDLINE]Related articles

Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise.

Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, Wojtaszewski JF, Richter EA, Kiens B.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E133-42. Epub 2004 Sep 21.PMID: 15383373 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms.

Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z.

Biochem Biophys Res Commun. 2004 Aug 13;321(1):161-7.PMID: 15358229 [PubMed - indexed for MEDLINE]Related articles

Metabolic and hormonal interactions between muscle and adipose tissue.

Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB.

Proc Nutr Soc. 2004 May;63(2):381-5. Review.PMID: 15294059 [PubMed - indexed for MEDLINE]Related articles

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.

Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB.

Biochem Biophys Res Commun. 2004 Jul 23;320(2):449-54.PMID: 15219849 [PubMed - indexed for MEDLINE]Related articles

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome.

Ruderman N, Prentki M.

Nat Rev Drug Discov. 2004 Apr;3(4):340-51. Review. No abstract available. PMID: 15060529 [PubMed - indexed for MEDLINE]Related articles

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M.

Diabetes. 2004 Apr;53(4):1007-19.PMID: 15047616 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.

Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):580-5.PMID: 14733947 [PubMed - indexed for MEDLINE]Related articles

Physical activity/exercise and diabetes.

Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH; American Diabetes Association.

Diabetes Care. 2004 Jan;27 Suppl 1:S58-62. No abstract available. PMID: 14693927 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and AMP-activated protein kinase: an expanding partnership.

Saha AK, Ruderman NB.

Mol Cell Biochem. 2003 Nov;253(1-2):65-70. Review.PMID: 14619957 [PubMed - indexed for MEDLINE]Related articles

Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways.

Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF.

J Biol Chem. 2003 Dec 12;278(50):50810-7. Epub 2003 Sep 30.PMID: 14522956 [PubMed - indexed for MEDLINE]Related articlesFree article

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.

Ruderman NB, Saha AK, Kraegen EW.

Endocrinology. 2003 Dec;144(12):5166-71. Epub 2003 Sep 18. Review.PMID: 14500570 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK.

Acta Physiol Scand. 2003 Aug;178(4):435-42. Review.PMID: 12864749 [PubMed - indexed for MEDLINE]Related articles

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase.

Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB.

Diabetes. 2003 Jul;52(7):1635-40.PMID: 12829626 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.

Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y.

Biochem Soc Trans. 2003 Feb;31(Pt 1):202-6. Review.PMID: 12546685 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.

Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S.

J Clin Endocrinol Metab. 2003 Jan;88(1):82-7. Erratum in: J Clin Endocrinol Metab. 2003 May;88(5):2036. PMID: 12519834 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical activity/exercise and diabetes mellitus.

Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH; American Diabetes Association.

Diabetes Care. 2003 Jan;26 Suppl 1:S73-7. No abstract available. PMID: 12502622 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation.

Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF, Ruderman NB.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16309-13. Epub 2002 Nov 27.PMID: 12456889 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4. PMID: 12351423 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise and insulin signaling: a historical perspective.

Tomás E, Zorzano A, Ruderman NB.

J Appl Physiol. 2002 Aug;93(2):765-72.PMID: 12133890 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

Shafrir E, Ziv E, Saha AK, Ruderman NB.

Diabetes Metab Res Rev. 2002 May-Jun;18(3):217-23.PMID: 12112940 [PubMed - indexed for MEDLINE]Related articles