PubMed

Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension.

Oudiz RJ, Galiè N, Olschewski H, Torres F, Frost A, Ghofrani HA, Badesch DB, McGoon MD, McLaughlin VV, Roecker EB, Harrison BC, Despain D, Dufton C, Rubin LJ; ARIES Study Group.

J Am Coll Cardiol. 2009 Nov 17;54(21):1971-81.PMID: 19909879 [PubMed - in process]Related articles

Longterm survival among patients with scleroderma-associated pulmonary arterial hypertension treated with intravenous epoprostenol.

Badesch DB, McGoon MD, Barst RJ, Tapson VF, Rubin LJ, Wigley FM, Kral KM, Raphiou IH, Crater GD.

J Rheumatol. 2009 Oct;36(10):2244-9. Epub 2009 Sep 1.PMID: 19723905 [PubMed - in process]Related articles

Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma.

Kovacs G, Maier R, Aberer E, Brodmann M, Scheidl S, Tröster N, Hesse C, Salmhofer W, Graninger W, Gruenig E, Rubin LJ, Olschewski H.

Am J Respir Crit Care Med. 2009 Nov 1;180(9):881-6. Epub 2009 Aug 13.PMID: 19679693 [PubMed - in process]Related articles

Medical treatment of pulmonary arterial hypertension.

Adamali H, Gaine SP, Rubin LJ.

Semin Respir Crit Care Med. 2009 Aug;30(4):484-92. Epub 2009 Jul 24. Review.PMID: 19634087 [PubMed - indexed for MEDLINE]Related articles

Updated evidence-based treatment algorithm in pulmonary arterial hypertension.

Barst RJ, Gibbs JS, Ghofrani HA, Hoeper MM, McLaughlin VV, Rubin LJ, Sitbon O, Tapson VF, Galiè N.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S78-84. Review.PMID: 19555861 [PubMed - indexed for MEDLINE]Related articles

Future perspectives for the treatment of pulmonary arterial hypertension.

Ghofrani HA, Barst RJ, Benza RL, Champion HC, Fagan KA, Grimminger F, Humbert M, Simonneau G, Stewart DJ, Ventura C, Rubin LJ.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S108-17. Review.PMID: 19555854 [PubMed - indexed for MEDLINE]Related articles

Acute vasodilator testing in idiopathic pulmonary arterial hypertension: must we take NO for the answer?

Opitz CF, Rubin LJ.

Eur Respir J. 2009 Jun;33(6):1247-9. No abstract available. PMID: 19483043 [PubMed - indexed for MEDLINE]Related articles

ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association.

McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J; American College of Cardiology Foundation Task Force on Expert Consensus Documents; American Heart Association; American College of Chest Physicians; American Thoracic Society, Inc; Pulmonary Hypertension Association.

J Am Coll Cardiol. 2009 Apr 28;53(17):1573-619. No abstract available. PMID: 19389575 [PubMed - indexed for MEDLINE]Related articles

A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX.

Circulation. 2009 May 5;119(17):2313-22. Epub 2009 Apr 20.PMID: 19380626 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin and the systemic circulation a therapeutic target worth revisiting?

Rubin LJ.

J Am Coll Cardiol. 2009 Apr 14;53(15):1318-9. No abstract available. PMID: 19358947 [PubMed - indexed for MEDLINE]Related articles

ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association.

McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J, Harrington RA, Anderson JL, Bates ER, Bridges CR, Eisenberg MJ, Ferrari VA, Grines CL, Hlatky MA, Jacobs AK, Kaul S, Lichtenberg RC, Lindner JR, Moliterno DJ, Mukherjee D, Pohost GM, Rosenson RS, Schofield RS, Shubrooks SJ, Stein JH, Tracy CM, Weitz HH, Wesley DJ; ACCF/AHA.

Circulation. 2009 Apr 28;119(16):2250-94. Epub 2009 Mar 30. Review. No abstract available. Erratum in: Circulation. 2009 Jul 14;120(2):e13. PMID: 19332472 [PubMed - indexed for MEDLINE]Related articles

Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension.

Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L870-8. Epub 2009 Mar 13.PMID: 19286928 [PubMed - indexed for MEDLINE]Related articles

Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial.

Jaïs X, D'Armini AM, Jansa P, Torbicki A, Delcroix M, Ghofrani HA, Hoeper MM, Lang IM, Mayer E, Pepke-Zaba J, Perchenet L, Morganti A, Simonneau G, Rubin LJ; Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group.

J Am Coll Cardiol. 2008 Dec 16;52(25):2127-34.PMID: 19095129 [PubMed - indexed for MEDLINE]Related articles

Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.

Voswinckel R, Reichenberger F, Gall H, Schmehl T, Gessler T, Schermuly RT, Grimminger F, Rubin LJ, Seeger W, Ghofrani HA, Olschewski H.

Pulm Pharmacol Ther. 2009 Feb;22(1):50-6. Epub 2008 Nov 30.PMID: 19071225 [PubMed - indexed for MEDLINE]Related articles

Exercise-induced pulmonary arterial hypertension: a new addition to the spectrum of pulmonary vascular diseases.

Oudiz RJ, Rubin LJ.

Circulation. 2008 Nov 18;118(21):2120-1. No abstract available. PMID: 19015412 [PubMed - indexed for MEDLINE]Related articlesFree article

Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial.

Simonneau G, Rubin LJ, Galiè N, Barst RJ, Fleming TR, Frost AE, Engel PJ, Kramer MR, Burgess G, Collings L, Cossons N, Sitbon O, Badesch DB; PACES Study Group.

Ann Intern Med. 2008 Oct 21;149(8):521-30. Erratum in: Ann Intern Med. 2009 Jan 6;150(1):63. Ann Intern Med. 2009 Sep 15;151(6):435. PMID: 18936500 [PubMed - indexed for MEDLINE]Related articlesFree article

Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities.

McGoon MD, Frost AE, Oudiz RJ, Badesch DB, Galie N, Olschewski H, McLaughlin VV, Gerber MJ, Dufton C, Despain DJ, Rubin LJ.

Chest. 2009 Jan;135(1):122-9. Epub 2008 Sep 23.PMID: 18812445 [PubMed - indexed for MEDLINE]Related articles

Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension.

Chin KM, Channick RN, de Lemos JA, Kim NH, Torres F, Rubin LJ.

Chest. 2009 Jan;135(1):130-6. Epub 2008 Aug 21.PMID: 18719056 [PubMed - indexed for MEDLINE]Related articles

Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells.

Ogawa A, Firth AL, Yao W, Rubin LJ, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L648-57. Epub 2008 Aug 15.PMID: 18708631 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.

Voswinckel R, Reichenberger F, Enke B, Kreckel A, Krick S, Gall H, Schermuly RT, Grimminger F, Rubin LJ, Olschewski H, Seeger W, Ghofrani HA.

Pulm Pharmacol Ther. 2008 Oct;21(5):824-32. Epub 2008 Jul 9.PMID: 18657627 [PubMed - indexed for MEDLINE]Related articles

Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial.

Galiè N, Rubin Lj, Hoeper M, Jansa P, Al-Hiti H, Meyer G, Chiossi E, Kusic-Pajic A, Simonneau G.

Lancet. 2008 Jun 21;371(9630):2093-100.PMID: 18572079 [PubMed - indexed for MEDLINE]Related articles

BMPR2 mutation and outcome in pulmonary arterial hypertension: clinical relevance to physicians and patients.

Rubin LJ.

Am J Respir Crit Care Med. 2008 Jun 15;177(12):1300-1. No abstract available. PMID: 18522952 [PubMed - indexed for MEDLINE]Related articlesFree article

Defining appropriate outcome measures in pulmonary arterial hypertension related to systemic sclerosis: a Delphi consensus study with cluster analysis.

Distler O, Behrens F, Pittrow D, Huscher D, Denton CP, Foeldvari I, Humbert M, Matucci-Cerinic M, Nash P, Opitz CF, Rubin LJ, Seibold JR, Furst DE; EPOSS-Omeract Group.

Arthritis Rheum. 2008 Jun 15;59(6):867-75. Erratum in: Arthritis Rheum. 2008 Aug 15;59(8):1202. PMID: 18512721 [PubMed - indexed for MEDLINE]Related articlesFree article

Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.

Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, Badesch DB, McGoon MD, McLaughlin VV, Roecker EB, Gerber MJ, Dufton C, Wiens BL, Rubin LJ; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group.

Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.PMID: 18506008 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary arterial hypertension.

Chin KM, Rubin LJ.

J Am Coll Cardiol. 2008 Apr 22;51(16):1527-38. Review. Erratum in: J Am Coll Cardiol. 2008 Jul 8;52(2):169. PMID: 18420094 [PubMed - indexed for MEDLINE]Related articles

Treatment of pulmonary arterial hypertension due to scleroderma: challenges for the future.

Rubin LJ.

Rheum Dis Clin North Am. 2008 Feb;34(1):191-7; viii. Review.PMID: 18329540 [PubMed - indexed for MEDLINE]Related articles

Sildenafil for pulmonary arterial hypertension associated with connective tissue disease.

Badesch DB, Hill NS, Burgess G, Rubin LJ, Barst RJ, Galiè N, Simonneau G; SUPER Study Group.

J Rheumatol. 2007 Dec;34(12):2417-22. Epub 2007 Nov 1.PMID: 17985403 [PubMed - indexed for MEDLINE]Related articles

Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease.

Rubin LJ, Black CM, Denton CP, Seibold JR.

Arthritis Res Ther. 2007;9 Suppl 2:S10. Review.PMID: 17767739 [PubMed - indexed for MEDLINE]Related articlesFree article

Women domestic violence offenders: lessons of violence and survival.

Seamans CL, Rubin LJ, Stabb SD.

J Trauma Dissociation. 2007;8(2):47-68.PMID: 17804383 [PubMed - indexed for MEDLINE]Related articles

Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous IV epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels.

Chin KM, Channick RN, Kim NH, Rubin LJ.

Chest. 2007 Sep;132(3):786-92. Epub 2007 Jul 23.PMID: 17646224 [PubMed - indexed for MEDLINE]Related articlesFree article

Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines.

Badesch DB, Abman SH, Simonneau G, Rubin LJ, McLaughlin VV.

Chest. 2007 Jun;131(6):1917-28.PMID: 17565025 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of sex, high-fat diet, and exercise training on potassium currents of swine coronary smooth muscle.

Yang Y, Jones AW, Thomas TR, Rubin LJ.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1553-63. Epub 2007 May 25.PMID: 17526655 [PubMed - indexed for MEDLINE]Related articlesFree article

Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability.

Glinskii OV, Abraha TW, Turk JR, Rubin LJ, Huxley VH, Glinsky VV.

Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1131-7. Epub 2007 May 11.PMID: 17496211 [PubMed - indexed for MEDLINE]Related articlesFree article

Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension.

Anthi A, Machado RF, Jison ML, Taveira-Dasilva AM, Rubin LJ, Hunter L, Hunter CJ, Coles W, Nichols J, Avila NA, Sachdev V, Chen CC, Gladwin MT.

Am J Respir Crit Care Med. 2007 Jun 15;175(12):1272-9. Epub 2007 Mar 22.PMID: 17379852 [PubMed - indexed for MEDLINE]Related articlesFree article

Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.

Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX.

Am J Physiol Cell Physiol. 2007 May;292(5):C1837-53. Epub 2007 Jan 31.PMID: 17267549 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension.

Zhang S, Dong H, Rubin LJ, Yuan JX.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2297-305. Epub 2006 Dec 27.PMID: 17192285 [PubMed - indexed for MEDLINE]Related articlesFree article

Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers.

Hoeper MM, Lee SH, Voswinckel R, Palazzini M, Jais X, Marinelli A, Barst RJ, Ghofrani HA, Jing ZC, Opitz C, Seyfarth HJ, Halank M, McLaughlin V, Oudiz RJ, Ewert R, Wilkens H, Kluge S, Bremer HC, Baroke E, Rubin LJ.

J Am Coll Cardiol. 2006 Dec 19;48(12):2546-52. Epub 2006 Nov 28.PMID: 17174196 [PubMed - indexed for MEDLINE]Related articles

Is methamphetamine use associated with idiopathic pulmonary arterial hypertension?

Chin KM, Channick RN, Rubin LJ.

Chest. 2006 Dec;130(6):1657-63.PMID: 17166979 [PubMed - indexed for MEDLINE]Related articlesFree article

Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB; National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure.

Circulation. 2006 Oct 24;114(17):1883-91. No abstract available. PMID: 17060398 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary genistein stimulates anion secretion across female murine intestine.

Al-Nakkash L, Clarke LL, Rottinghaus GE, Chen YJ, Cooper K, Rubin LJ.

J Nutr. 2006 Nov;136(11):2785-90.PMID: 17056801 [PubMed - indexed for MEDLINE]Related articlesFree article

Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.

Voswinckel R, Enke B, Reichenberger F, Kohstall M, Kreckel A, Krick S, Gall H, Gessler T, Schmehl T, Ghofrani HA, Schermuly RT, Grimminger F, Rubin LJ, Seeger W, Olschewski H.

J Am Coll Cardiol. 2006 Oct 17;48(8):1672-81. Epub 2006 Sep 26.PMID: 17045906 [PubMed - indexed for MEDLINE]Related articles

Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension.

Channick RN, Olschewski H, Seeger W, Staub T, Voswinckel R, Rubin LJ.

J Am Coll Cardiol. 2006 Oct 3;48(7):1433-7. Epub 2006 Sep 14.PMID: 17010807 [PubMed - indexed for MEDLINE]Related articles

Endothelin-1 and the pulmonary vascular response to altitude: a new therapeutic target?

Rubin LJ.

Circulation. 2006 Sep 26;114(13):1350-1. No abstract available. PMID: 17000920 [PubMed - indexed for MEDLINE]Related articlesFree article

Current and future management of chronic thromboembolic pulmonary hypertension: from diagnosis to treatment responses.

Rubin LJ, Hoeper MM, Klepetko W, Galiè N, Lang IM, Simonneau G.

Proc Am Thorac Soc. 2006 Sep;3(7):601-7. Review.PMID: 16963541 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension.

McLaughlin VV, Oudiz RJ, Frost A, Tapson VF, Murali S, Channick RN, Badesch DB, Barst RJ, Hsu HH, Rubin LJ.

Am J Respir Crit Care Med. 2006 Dec 1;174(11):1257-63. Epub 2006 Aug 31.PMID: 16946127 [PubMed - indexed for MEDLINE]Related articlesFree article

Temporal trends and drug exposures in pulmonary hypertension: an American experience.

Walker AM, Langleben D, Korelitz JJ, Rich S, Rubin LJ, Strom BL, Gonin R, Keast S, Badesch D, Barst RJ, Bourge RC, Channick R, Frost A, Gaine S, McGoon M, McLaughlin V, Murali S, Oudiz RJ, Robbins IM, Tapson V, Abenhaim L, Constantine G.

Am Heart J. 2006 Sep;152(3):521-6.PMID: 16923424 [PubMed - indexed for MEDLINE]Related articles

Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil.

Barst RJ, Galie N, Naeije R, Simonneau G, Jeffs R, Arneson C, Rubin LJ.

Eur Respir J. 2006 Dec;28(6):1195-203. Epub 2006 Aug 9.PMID: 16899485 [PubMed - indexed for MEDLINE]Related articlesFree article

Submaximal exercise testing in the assessment of interstitial lung disease secondary to systemic sclerosis: reproducibility and correlations of the 6-min walk test.

Buch MH, Denton CP, Furst DE, Guillevin L, Rubin LJ, Wells AU, Matucci-Cerinic M, Riemekasten G, Emery P, Chadha-Boreham H, Charef P, Roux S, Black CM, Seibold JR.

Ann Rheum Dis. 2007 Feb;66(2):169-73. Epub 2006 Jul 25.PMID: 16868020 [PubMed - indexed for MEDLINE]Related articles

Chronic thromboembolic pulmonary hypertension.

Hoeper MM, Mayer E, Simonneau G, Rubin LJ.

Circulation. 2006 Apr 25;113(16):2011-20. Review. No abstract available. PMID: 16636189 [PubMed - indexed for MEDLINE]Related articlesFree article

Update in pulmonary hypertension 2005.

Hoeper MM, Rubin LJ.

Am J Respir Crit Care Med. 2006 Mar 1;173(5):499-505. Review. No abstract available. PMID: 16493163 [PubMed - indexed for MEDLINE]Related articlesFree article