PubMed

Structural determinants of GAD antigenicity.

Arafat Y, Fenalti G, Whisstock JC, Mackay IR, Garcia de la Banda M, Rowley MJ, Buckle AM.

Mol Immunol. 2009 Dec;47(2-3):493-505. Epub 2009 Sep 23.PMID: 19783309 [PubMed - in process]Related articles

The role of collagen antibodies in mediating arthritis.

Rowley MJ, Nandakumar KS, Holmdahl R.

Mod Rheumatol. 2008;18(5):429-41. Epub 2008 Jun 3. Review.PMID: 18521704 [PubMed - indexed for MEDLINE]Related articles

GAD65 as a prototypic autoantigen.

Fenalti G, Rowley MJ.

J Autoimmun. 2008 Nov;31(3):228-32. Epub 2008 Jun 2.PMID: 18514483 [PubMed - indexed for MEDLINE]Related articles

A tribute to an outstanding immunologist - Ian Reay Mackay.

Whittingham S, Rowley MJ, Gershwin ME.

J Autoimmun. 2008 Nov;31(3):197-200. Epub 2008 May 27.PMID: 18502096 [PubMed - indexed for MEDLINE]Related articles

Collagen of articular cartilage: the neglected autoantigen of rheumatoid arthritis.

Mackay IR, Rowley MJ.

J Rheumatol. 2008 May;35(5):731-3. No abstract available. PMID: 18464313 [PubMed - indexed for MEDLINE]Related articlesFree article

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.

Oak S, Gilliam LK, Landin-Olsson M, Törn C, Kockum I, Pennington CR, Rowley MJ, Christie MR, Banga JP, Hampe CS.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5471-6. Epub 2008 Mar 26.PMID: 18367670 [PubMed - indexed for MEDLINE]Related articlesFree article

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

Diabetes. 2008 May;57(5):1293-301. Epub 2008 Jan 9.PMID: 18184926 [PubMed - indexed for MEDLINE]Related articlesFree article

Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.

Nandakumar KS, Bajtner E, Hill L, Böhm B, Rowley MJ, Burkhardt H, Holmdahl R.

Arthritis Rheum. 2008 Jan;58(1):184-96.PMID: 18163493 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry.

Königs C, Pustowka A, Irving J, Kessel C, Klich K, Wegner V, Rowley MJ, Mackay IR, Kreuz W, Griesinger C, Dietrich U.

Immunol Cell Biol. 2007 Oct;85(7):511-7. Epub 2007 Jul 3.PMID: 17607321 [PubMed - indexed for MEDLINE]Related articles

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC.

Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25.PMID: 17384644 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.

Mol Immunol. 2007 Feb;44(6):1178-89. Epub 2006 Aug 22.PMID: 16930708 [PubMed - indexed for MEDLINE]Related articles

Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling.

O'Connor KH, Banga JP, Darmanin C, El-Kabbani O, Mackay IR, Rowley MJ.

J Autoimmun. 2006 May;26(3):172-81. Epub 2006 Mar 24.PMID: 16564157 [PubMed - indexed for MEDLINE]Related articles

Amino acids critical for binding of autoantibody to an immunodominant conformational epitope of the pyruvate dehydrogenase complex subunit E2: identification by phage display and site-directed mutagenesis.

Scealy M, Mackay IR, Rowley MJ.

Mol Immunol. 2006 Feb;43(6):745-53. Epub 2005 Apr 18.PMID: 16360019 [PubMed - indexed for MEDLINE]Related articles

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro.

Crombie DE, Turer M, Zuasti BB, Wood B, McNaughton D, Nandakumar KS, Holmdahl R, Van Damme MP, Rowley MJ.

Arthritis Res Ther. 2005;7(5):R927-37. Epub 2005 Jun 6.PMID: 16207334 [PubMed - indexed for MEDLINE]Related articlesFree article

Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP).

Outschoorn IM, Rose NR, Burek CL, Jones TW, Mackay IR, Rowley MJ.

Autoimmunity. 2005 Jun;38(4):325-6.PMID: 16206515 [PubMed - indexed for MEDLINE]Related articles

Clinical, laboratory and genetic markers associated with erosions and remission in patients with early inflammatory arthritis: a prospective cohort study.

Stockman A, Tait BD, Wolfe R, Brand CA, Rowley MJ, Varney MD, Buchbinder R, Muirden KD.

Rheumatol Int. 2006 Apr;26(6):500-9. Epub 2005 Sep 7.PMID: 16151812 [PubMed - indexed for MEDLINE]Related articles

Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells.

Amirahmadi SF, Whittingham S, Crombie DE, Nandakumar KS, Holmdahl R, Mackay IR, van Damme MP, Rowley MJ.

Arthritis Rheum. 2005 Jun;52(6):1897-906.PMID: 15934095 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

O'Connor KH, Königs C, Rowley MJ, Irving JA, Wijeyewickrema LC, Pustowka A, Dietrich U, Mackay IR.

J Immunol Methods. 2005 Apr;299(1-2):21-35. Epub 2005 Feb 1.PMID: 15914189 [PubMed - indexed for MEDLINE]Related articles

Images of interest. Hepatobiliary and pancreatic: Liver histopathology: Fourier transform infrared microspectroscopic imaging for objective and quantifiable assessment of liver biopsies.

Crombie DE, Mackay IR, Wood BR, McNaughton D, Rowley MJ.

J Gastroenterol Hepatol. 2005 Mar;20(3):485. Review. No abstract available. PMID: 15740498 [PubMed - indexed for MEDLINE]Related articles

Autoimmune epitopes: autoepitopes.

Mackay IR, Rowley MJ.

Autoimmun Rev. 2004 Nov;3(7-8):487-92. Review.PMID: 15546795 [PubMed - indexed for MEDLINE]Related articles

Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.

Rowley MJ, O'Connor K, Wijeyewickrema L.

Biotechnol Annu Rev. 2004;10:151-88. Review.PMID: 15504706 [PubMed - indexed for MEDLINE]Related articles

Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis.

Cook AD, Gray R, Ramshaw J, Mackay IR, Rowley MJ.

Arthritis Res Ther. 2004;6(5):R477-83. Epub 2004 Aug 11.PMID: 15380047 [PubMed - indexed for MEDLINE]Related articlesFree article

An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes.

Amirahmadi SF, Pho MH, Gray RE, Crombie DE, Whittingham SF, Zuasti BB, Van Damme MP, Rowley MJ.

Immunol Cell Biol. 2004 Aug;82(4):427-34.PMID: 15283854 [PubMed - indexed for MEDLINE]Related articlesFree article

Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.

Xu Y, Ramsland PA, Davies JM, Scealy M, Nandakumar KS, Holmdahl R, Rowley MJ.

Mol Immunol. 2004 Jun;41(4):411-9.PMID: 15163538 [PubMed - indexed for MEDLINE]Related articles

Measurement of antibodies to collagen II by inhibition of collagen fibril formation in vitro.

Gray RE, Seng N, Mackay IR, Rowley MJ.

J Immunol Methods. 2004 Feb 1;285(1):55-61.PMID: 14871534 [PubMed - indexed for MEDLINE]Related articles

A diabetes-related epitope of GAD65: a major diabetes-related conformational epitope on GAD65.

Myers MA, Fenalti G, Gray R, Scealy M, Tong JC, El-Kabbani O, Rowley MJ.

Ann N Y Acad Sci. 2003 Nov;1005:250-2.PMID: 14679070 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to the islet cell antigen SOX-13 are associated with duration but not type of diabetes.

Davis TM, Mehta Z, Mackay IR, Cull CA, Bruce DG, Fida S, Rowley MJ, Holman RR.

Diabet Med. 2003 Mar;20(3):198-204.PMID: 12675663 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases.

Fida S, Myers MA, Whittingham S, Rowley MJ, Ozaki S, Mackay IR.

J Autoimmun. 2002 Dec;19(4):251-7.PMID: 12473246 [PubMed - indexed for MEDLINE]Related articles

Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast.

Tong JC, Mackay IR, Chin J, Law RH, Fayad K, Rowley MJ.

J Biotechnol. 2002 Aug 7;97(2):183-90.PMID: 12067524 [PubMed - indexed for MEDLINE]Related articles

The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.

Tong JC, Myers MA, Mackay IR, Zimmet PZ, Rowley MJ.

Ann N Y Acad Sci. 2002 Apr;958:182-9.PMID: 12021103 [PubMed - indexed for MEDLINE]Related articles

Antimitochondrial autoantibodies in saliva and sera from patients with primary biliary cirrhosis.

Ikuno N, Mackay IR, Jois J, Omagari K, Rowley MJ.

J Gastroenterol Hepatol. 2001 Dec;16(12):1390-4.PMID: 11851838 [PubMed - indexed for MEDLINE]Related articles

Dietary microbial toxins and type 1 diabetes--a new meaning for seed and soil.

Myers MA, Mackay IR, Rowley MJ, Zimmet PZ.

Diabetologia. 2001 Sep;44(9):1199-200. No abstract available. PMID: 11596678 [PubMed - indexed for MEDLINE]Related articles

A comparative study of antibody expressions in primary biliary cirrhosis and autoimmune cholangitis using phage display.

Ikuno N, Scealy M, Davies JM, Whittingham SF, Omagari K, Mackay IR, Rowley MJ.

Hepatology. 2001 Sep;34(3):478-86.PMID: 11526532 [PubMed - indexed for MEDLINE]Related articles

Expression of protein tyrosine phosphatase-like molecule ICA512/IA-2 induces growth arrest in yeast cells and transfected mammalian cell lines.

Papakonstantinou T, Myers MA, Jois J, Roucou X, Prescott M, Rowley MJ, Mackay IR.

J Autoimmun. 2001 Aug;17(1):51-61.PMID: 11488637 [PubMed - indexed for MEDLINE]Related articles

Post-panning computer-aided analysis of phagotope collections selected with neurocysticercosis patient polyclonal antibodies: separation of disease-relevant and irrelevant peptide sequences.

Gazarian KG, Rowley MJ, Gazarian TG, Sotelo J, García-Mendoza E, Hernández R.

Comb Chem High Throughput Screen. 2001 May;4(3):221-35.PMID: 11375738 [PubMed - indexed for MEDLINE]Related articles

Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13.

Fida S, Myers M, Mackay IR, Zimmet PZ, Mohan V, Deepa R, Rowley MJ.

Diabetes Res Clin Pract. 2001 Jun;52(3):205-11.PMID: 11323090 [PubMed - indexed for MEDLINE]Related articles

Antibodies to SOX13 (ICA12) are associated with type 1 diabetes.

Kasimiotis H, Fida S, Rowley MJ, Mackay IR, Zimmet PZ, Gleason S, Rabin DU, Myers MA.

Autoimmunity. 2001;33(2):95-101.PMID: 11264788 [PubMed - indexed for MEDLINE]Related articles

Automated enzymatic mitochondrial antibody assay for the diagnosis of primary biliary cirrhosis.

Jensen WA, Jois JA, Murphy P, De Giorgio J, Brown B, Rowley MJ, Mackay IR.

Clin Chem Lab Med. 2000 Aug;38(8):753-8.PMID: 11071069 [PubMed - indexed for MEDLINE]Related articles

Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.

Myers MA, Davies JM, Tong JC, Whisstock J, Scealy M, Mackay IR, Rowley MJ.

J Immunol. 2000 Oct 1;165(7):3830-8.PMID: 11034389 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of epitopes for virus-neutralizing monoclonal antibodies to Ross River virus E2 using phage-displayed random peptide libraries.

Davies JM, Cai YP, Weir RC, Rowley MJ.

Virology. 2000 Sep 15;275(1):67-76.PMID: 11017788 [PubMed - indexed for MEDLINE]Related articles

Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets.

Kasimiotis H, Myers MA, Argentaro A, Mertin S, Fida S, Ferraro T, Olsson J, Rowley MJ, Harley VR.

Diabetes. 2000 Apr;49(4):555-61.PMID: 10871192 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris.

Papakonstantinou T, Law RH, Gardiner P, Rowley MJ, Mackay IR.

Enzyme Microb Technol. 2000 Jun 1;26(9-10):645-652.PMID: 10862868 [PubMed - as supplied by publisher]Related articles

Young Chinese adults with new onset of diabetic ketoacidosis--clinical course, autoimmune status and progression of pancreatic beta-cell function.

Li JK, Chan JC, Zimmet PZ, Rowley MJ, Mackay IR, Cockram CS.

Diabet Med. 2000 Apr;17(4):295-8.PMID: 10821296 [PubMed - indexed for MEDLINE]Related articles

The peculiar autoimmunity of primary biliary cirrhosis.

Mackay IR, Whittingham S, Fida S, Myers M, Ikuno N, Gershwin ME, Rowley MJ.

Immunol Rev. 2000 Apr;174:226-37. Review.PMID: 10807519 [PubMed - indexed for MEDLINE]Related articles

Primary biliary cirrhosis: an orchestrated immune response against epithelial cells.

Gershwin ME, Ansari AA, Mackay IR, Nakanuma Y, Nishio A, Rowley MJ, Coppel RL.

Immunol Rev. 2000 Apr;174:210-25. Review.PMID: 10807518 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibody screening of a phage-displayed random peptide library reveals mimotopes of chemokine receptor CCR5: implications for the tertiary structure of the receptor and for an N-terminal binding site for HIV-1 gp120.

Königs C, Rowley MJ, Thompson P, Myers MA, Scealy M, Davies JM, Wu L, Dietrich U, Mackay CR, Mackay IR.

Eur J Immunol. 2000 Apr;30(4):1162-71.PMID: 10760806 [PubMed - indexed for MEDLINE]Related articles

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.

Rowley MJ, Scealy M, Whisstock JC, Jois JA, Wijeyewickrema LC, Mackay IR.

J Immunol. 2000 Mar 15;164(6):3413-9.PMID: 10706737 [PubMed - indexed for MEDLINE]Related articlesFree article

Enzyme inhibitory antibody to pyruvate dehydrogenase: diagnostic utility in primary biliary cirrhosis.

Jois J, Omagari K, Rowley MJ, Anderson J, Mackay IR.

Ann Clin Biochem. 2000 Jan;37 ( Pt 1):67-73.PMID: 10672375 [PubMed - indexed for MEDLINE]Related articles

Antibodies to type II collagen and HLA disease susceptibility markers in rheumatoid arthritis.

Cook AD, Stockman A, Brand CA, Tait BD, Mackay IR, Muirden KD, Bernard CC, Rowley MJ.

Arthritis Rheum. 1999 Dec;42(12):2569-76.PMID: 10616002 [PubMed - indexed for MEDLINE]Related articlesFree article

Phagotopes derived by antibody screening of phage-displayed random peptide libraries vary in immunoreactivity: studies using an exemplary monoclonal antibody, CII-C1, to type II collagen.

Davies JM, Rowley MJ, MacKay IR.

Immunol Cell Biol. 1999 Dec;77(6):483-90.PMID: 10571668 [PubMed - indexed for MEDLINE]Related articlesFree article