PubMed

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counter-regulation.

Fioramonti X, Marsollier N, Song Z, Fakira KA, Patel RM, Brown S, Duparc T, Pica-Mendez A, Sanders NM, Knauf C, Valet P, McCrimmon RJ, Beuve A, Magnan C, Routh VH.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934009 [PubMed - as supplied by publisher]Related articles

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.

Marsollier N, Kassis N, Mezghenna K, Soty M, Fioramonti X, Lacombe A, Joly A, Pillot B, Zitoun C, Vilar J, Mithieux G, Gross R, Lajoix AD, Routh V, Magnan C, Cruciani-Guglielmacci C.

PLoS One. 2009 Aug 14;4(8):e6649.PMID: 19680547 [PubMed - in process]Related articlesFree article

Motor unit number estimate as a predictor of motor dysfunction in an animal model of type 1 diabetes.

Souayah N, Potian JG, Garcia CC, Krivitskaya N, Boone C, Routh VH, McArdle JJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E602-8. Epub 2009 Jul 14.PMID: 19602580 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.

Murphy BA, Fakira KA, Song Z, Beuve A, Routh VH.

Am J Physiol Cell Physiol. 2009 Sep;297(3):C750-8. Epub 2009 Jul 1.PMID: 19570894 [PubMed - indexed for MEDLINE]Related articles

Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.

Cotero VE, Routh VH.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1101-9. Epub 2009 Feb 17. Erratum in: Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E560-1. PMID: 19223652 [PubMed - indexed for MEDLINE]Related articles

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose.

Murphy BA, Fioramonti X, Jochnowitz N, Fakira K, Gagen K, Contie S, Lorsignol A, Penicaud L, Martin WJ, Routh VH.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C746-56. Epub 2009 Feb 11.PMID: 19211911 [PubMed - indexed for MEDLINE]Related articles

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons.

Kang L, Sanders NM, Dunn-Meynell AA, Gaspers LD, Routh VH, Thomas AP, Levin BE.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R784-92. Epub 2007 Dec 19.PMID: 18094065 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus.

Canabal DD, Potian JG, Duran RG, McArdle JJ, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R592-600. Epub 2007 May 30.PMID: 17537841 [PubMed - indexed for MEDLINE]Related articles

Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?

Fioramonti X, Contié S, Song Z, Routh VH, Lorsignol A, Pénicaud L.

Diabetes. 2007 May;56(5):1219-27. Epub 2007 Jan 29.PMID: 17261674 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus.

Canabal DD, Song Z, Potian JG, Beuve A, McArdle JJ, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1418-28. Epub 2006 Dec 14.PMID: 17170237 [PubMed - indexed for MEDLINE]Related articles

Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus.

Song Z, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1283-7. Epub 2006 Jun 22.PMID: 16793940 [PubMed - indexed for MEDLINE]Related articles

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation.

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS.

J Clin Invest. 2006 Jun;116(6):1723-30.PMID: 16741581 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.

Kang L, Dunn-Meynell AA, Routh VH, Gaspers LD, Nagata Y, Nishimura T, Eiki J, Zhang BB, Levin BE.

Diabetes. 2006 Feb;55(2):412-20. Erratum in: Diabetes. 2006 Mar;55(3):862. PMID: 16443775 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels.

Wang R, Cruciani-Guglielmacci C, Migrenne S, Magnan C, Cotero VE, Routh VH.

J Neurophysiol. 2006 Mar;95(3):1491-8. Epub 2005 Nov 23.PMID: 16306178 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus.

Song Z, Routh VH.

Diabetes. 2005 Jan;54(1):15-22.PMID: 15616006 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal glucosensing: what do we know after 50 years?

Levin BE, Routh VH, Kang L, Sanders NM, Dunn-Meynell AA.

Diabetes. 2004 Oct;53(10):2521-8. Review.PMID: 15448079 [PubMed - indexed for MEDLINE]Related articlesFree article

The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides.

Wang R, Liu X, Hentges ST, Dunn-Meynell AA, Levin BE, Wang W, Routh VH.

Diabetes. 2004 Aug;53(8):1959-65.PMID: 15277373 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of glucosensing neurons in the detection of hypoglycemia.

Routh VH, Song Z, Liu X.

Diabetes Technol Ther. 2004 Jun;6(3):413-21. Review.PMID: 15198847 [PubMed - indexed for MEDLINE]Related articles

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons.

Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE.

Diabetes. 2004 Mar;53(3):549-59.PMID: 14988237 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) and hypoglycemia-associated autonomic failure (HAAF).

Routh VH.

Diabetes Metab Res Rev. 2003 Sep-Oct;19(5):348-56. Review.PMID: 12951642 [PubMed - indexed for MEDLINE]Related articles

CNS sensing and regulation of peripheral glucose levels.

Levin BE, Dunn-Meynell AA, Routh VH.

Int Rev Neurobiol. 2002;51:219-58. Review.PMID: 12420361 [PubMed - indexed for MEDLINE]Related articles

Glucose-sensing neurons: are they physiologically relevant?

Routh VH.

Physiol Behav. 2002 Jul;76(3):403-13. Review.PMID: 12117577 [PubMed - indexed for MEDLINE]Related articles

Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons.

Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE.

Diabetes. 2002 Jul;51(7):2056-65.PMID: 12086933 [PubMed - indexed for MEDLINE]Related articlesFree article

Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus.

Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH.

Diabetes. 2001 Dec;50(12):2673-81.PMID: 11723049 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain glucosensing and the K(ATP) channel.

Levin BE, Dunn-Meynell AA, Routh VH.

Nat Neurosci. 2001 May;4(5):459-60. No abstract available. PMID: 11319550 [PubMed - indexed for MEDLINE]Related articles

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats.

Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML.

Nat Neurosci. 2000 Aug;3(8):757-8.PMID: 10903566 [PubMed - indexed for MEDLINE]Related articles

Brain glucose sensing and body energy homeostasis: role in obesity and diabetes.

Levin BE, Dunn-Meynell AA, Routh VH.

Am J Physiol. 1999 May;276(5 Pt 2):R1223-31. Review.PMID: 10233011 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiposity and serum leptin increase in fatty (fa/fa) BNZ neonates without decreased VMH serotonergic activity.

Horwitz BA, Hamilton JS, Routh VH, Green K, Havel P, Chan A.

Am J Physiol. 1998 Jun;274(6 Pt 1):E1009-17.PMID: 9611150 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation modulates the activity of the ATP-sensitive K+ channel in the ventromedial hypothalamic nucleus.

Routh VH, McArdle JJ, Levin BE.

Brain Res. 1997 Dec 5;778(1):107-19.PMID: 9462882 [PubMed - indexed for MEDLINE]Related articles

A novel technique for producing antibody-coated microprobes using a thiol-terminal silane and a heterobifunctional crosslinker.

Routh VH, Helke CJ.

J Neurosci Methods. 1997 Feb;71(2):163-8.PMID: 9128151 [PubMed - indexed for MEDLINE]Related articles

Low-affinity sulfonylurea binding sites reside on neuronal cell bodies in the brain.

Dunn-Meynell AA, Routh VH, McArdle JJ, Levin BE.

Brain Res. 1997 Jan 16;745(1-2):1-9.PMID: 9037388 [PubMed - indexed for MEDLINE]Related articles

Role of the brain in energy balance and obesity.

Levin BE, Routh VH.

Am J Physiol. 1996 Sep;271(3 Pt 2):R491-500. Review.PMID: 8853368 [PubMed - indexed for MEDLINE]Related articles

Adrenalectomy increases serotonin turnover in brains of obese Zucker rats.

Routh VH, Stern JS, Horwitz BA.

Physiol Behav. 1995 Sep;58(3):491-9.PMID: 8587957 [PubMed - indexed for MEDLINE]Related articles

Tachykinin receptors in the spinal cord.

Routh VH, Helke CJ.

Prog Brain Res. 1995;104:93-108. Review.PMID: 8552786 [PubMed - indexed for MEDLINE]Related articles

Serotonergic activity is depressed in the ventromedial hypothalamic nucleus of 12-day-old obese Zucker rats.

Routh VH, Stern JS, Horwitz BA.

Am J Physiol. 1994 Sep;267(3 Pt 2):R712-9.PMID: 7522410 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic monoaminergic activity in 11-week-old cold-exposed female lean (Fa/Fa) and obese (fa/fa) Zucker rats.

Routh VH, Horwitz BA, Gietzen DW, Stern JS.

Obes Res. 1994 Jan;2(1):28-37.PMID: 16355483 [PubMed - indexed for MEDLINE]Related articles

Altered alpha 1-adrenoceptor binding in intact and adrenalectomized obese Zucker rats (fa/fa).

Levin BE, Planas B, Routh VH, Hamilton J, Stern JS, Horwitz BA.

Brain Res. 1993 Jun 18;614(1-2):146-54.PMID: 8394183 [PubMed - indexed for MEDLINE]Related articles

Litter size, adrenalectomy and high fat diet alter hypothalamic monoamines in genetically lean (Fa/Fa) Zucker rats.

Routh VH, Hamilton JS, Stern JS, Horwitz BA.

J Nutr. 1993 Jan;123(1):74-84.PMID: 8421233 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal activity in hypothalamic nuclei of obese and lean Zucker rats.

Routh VH, Murakami DM, Stern JS, Fuller CA, Horwitz BA.

Int J Obes. 1990 Oct;14(10):879-91.PMID: 2176650 [PubMed - indexed for MEDLINE]Related articles