PubMed

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL.

Clin Exp Immunol. 2009 Jul;157(1):104-18.PMID: 19659776 [PubMed - indexed for MEDLINE]Related articles

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R.

PLoS One. 2009;4(5):e5468. Epub 2009 May 8.PMID: 19424493 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.

Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R.

In Vivo. 2009 Mar-Apr;23(2):195-201.PMID: 19414403 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.

Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL.

J Immunol. 2009 May 1;182(9):5547-59.PMID: 19380803 [PubMed - indexed for MEDLINE]Related articles

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.

Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE.

Cell Immunol. 2009;256(1-2):86-91. Epub 2009 Feb 23.PMID: 19230866 [PubMed - indexed for MEDLINE]Related articles

Role of innate immunity in transplantation tolerance.

Miller DM, Rossini AA, Greiner DL.

Crit Rev Immunol. 2008;28(5):403-39. Review.PMID: 19166387 [PubMed - indexed for MEDLINE]Related articles

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:149-51.PMID: 19120285 [PubMed - indexed for MEDLINE]Related articles

Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.

Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA.

Ann N Y Acad Sci. 2008 Dec;1150:112-22. Review.PMID: 19120279 [PubMed - indexed for MEDLINE]Related articles

Humanized mice for the study of type 1 diabetes and beta cell function.

King M, Pearson T, Rossini AA, Shultz LD, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:46-53. Review.PMID: 19120266 [PubMed - indexed for MEDLINE]Related articles

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL.

Diabetes. 2009 Jan;58(1):165-73. Epub 2008 Nov 4.PMID: 18984741 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral infection: a potent barrier to transplantation tolerance.

Miller DM, Thornley TB, Greiner DL, Rossini AA.

Clin Dev Immunol. 2008;2008:742810. Review.PMID: 18815618 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.

Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL.

Clin Exp Immunol. 2008 Nov;154(2):270-84. Epub 2008 Sep 8.PMID: 18785974 [PubMed - indexed for MEDLINE]Related articlesFree article

Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.

Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL.

Exp Biol Med (Maywood). 2008 Aug;233(8):997-1012.PMID: 18653783 [PubMed - indexed for MEDLINE]Related articlesFree article

A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL.

Diabetologia. 2008 Aug;51(8):1449-56. Epub 2008 Jun 19.PMID: 18563383 [PubMed - indexed for MEDLINE]Related articlesFree article

The BB rat as a model of human insulin-dependent diabetes mellitus.

Whalen BJ, Mordes JP, Rossini AA.

Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.3.PMID: 18432735 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Cell Stress Chaperones. 2008 Dec;13(4):421-34. Epub 2008 Apr 17.PMID: 18418732 [PubMed - indexed for MEDLINE]Related articlesFree article

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.PMID: 18096436 [PubMed - indexed for MEDLINE]Related articles

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.

Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2007 Nov 15;179(10):6620-9.PMID: 17982052 [PubMed - indexed for MEDLINE]Related articlesFree article

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.

Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Am J Transplant. 2007 Jul;7(7):1710-21.PMID: 17564635 [PubMed - indexed for MEDLINE]Related articles

Diabetes research in jeopardy: the extinction of clinical diabetes researchers.

Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:33-44. Epub 2007 Mar 21.PMID: 17376823 [PubMed - indexed for MEDLINE]Related articles

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21.PMID: 17376822 [PubMed - indexed for MEDLINE]Related articles

Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.

Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:77-89. Epub 2007 Mar 1.PMID: 17332083 [PubMed - indexed for MEDLINE]Related articles

Passing the baton--to whom?

Rossini AA.

J Clin Invest. 2007 Feb;117(2):285-8.PMID: 17273547 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.

Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2007 Jan 15;178(2):693-701.PMID: 17202329 [PubMed - indexed for MEDLINE]Related articlesFree article

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2006 Dec 1;177(11):7820-32.PMID: 17114453 [PubMed - indexed for MEDLINE]Related articlesFree article

Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.

Phillips NE, Greiner DL, Mordes JP, Rossini AA.

Transplantation. 2006 Oct 27;82(8):1085-92.PMID: 17060858 [PubMed - indexed for MEDLINE]Related articles

Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.

Brehm MA, Mangada J, Markees TG, Pearson T, Daniels KA, Thornley TB, Welsh RM, Rossini AA, Greiner DL.

Blood. 2007 Jan 15;109(2):819-26. Epub 2006 Sep 14.PMID: 16973964 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F.

Cell Metab. 2006 Sep;4(3):245-54.PMID: 16950141 [PubMed - indexed for MEDLINE]Related articles

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Biol Chem. 2006 Nov 3;281(44):33363-72. Epub 2006 Aug 24.PMID: 16931513 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.

Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA.

Xenotransplantation. 2006 May;13(3):224-32.PMID: 16756565 [PubMed - indexed for MEDLINE]Related articles

Costimulation and autoimmune diabetes in BB rats.

Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA.

Am J Transplant. 2006 May;6(5 Pt 1):894-902.PMID: 16611325 [PubMed - indexed for MEDLINE]Related articles

TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2006 Feb 1;176(3):1561-70.PMID: 16424185 [PubMed - indexed for MEDLINE]Related articlesFree article

A comprehensive review of interventions in the NOD mouse and implications for translation.

Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, Eisenbarth GS, Mathis D, Rossini AA, Campbell SE, Kahn R, Kreuwel HT.

Immunity. 2005 Aug;23(2):115-26. Review.PMID: 16111631 [PubMed - indexed for MEDLINE]Related articles

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.

Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6931-5. Epub 2005 May 2.PMID: 15867147 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.PMID: 15616017 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2005 Jan 1;174(1):131-42.PMID: 15611235 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.

Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

Transplantation. 2004 Dec 15;78(11):1601-8.PMID: 15591948 [PubMed - indexed for MEDLINE]Related articles

Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.

Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP.

J Immunol. 2004 Dec 15;173(12):7331-8.PMID: 15585857 [PubMed - indexed for MEDLINE]Related articlesFree article

From beast to bedside: a commentary.

Rossini AA.

Diabetologia. 2004 Oct;47(10):1647-9. Epub 2004 Oct 22. Review. No abstract available. PMID: 15502928 [PubMed - indexed for MEDLINE]Related articles

Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.

Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL.

Transplantation. 2004 Sep 15;78(5):660-7.PMID: 15371665 [PubMed - indexed for MEDLINE]Related articles

Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.

Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC.

Clin Immunol. 2004 Sep;112(3):273-83.PMID: 15308121 [PubMed - indexed for MEDLINE]Related articles

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2004 Aug;53(8):1972-8.PMID: 15277375 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat models of type 1 diabetes: genetics, environment, and autoimmunity.

Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL.

ILAR J. 2004;45(3):278-91. Review.PMID: 15229375 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.

Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA.

Transplantation. 2004 May 15;77(9):1341-9.PMID: 15167588 [PubMed - indexed for MEDLINE]Related articles

Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.

Todd DJ, Forsberg EM, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Immunol. 2004 May 1;172(9):5356-62.PMID: 15100275 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes and the circle of tolerance.

Rossini AA.

Diabetes. 2004 Feb;53(2):267-75.PMID: 14747275 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2003 Nov;1005:148-56.PMID: 14679049 [PubMed - indexed for MEDLINE]Related articles

Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.

Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC.

Exp Biol Med (Maywood). 2003 Oct;228(9):1096-104.PMID: 14530522 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Rev Endocr Metab Disord. 2003 Sep;4(3):255-61. Review. No abstract available. PMID: 14501176 [PubMed - indexed for MEDLINE]Related articles

Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.

Seung E, Mordes JP, Rossini AA, Greiner DL.

J Clin Invest. 2003 Sep;112(5):795-808.PMID: 12952928 [PubMed - indexed for MEDLINE]Related articlesFree article