PubMed

Legacies of Garrod's brilliance. One hundred years--and counting.

Rosenberg LE.

J Inherit Metab Dis. 2008 Oct;31(5):574-9. Epub 2008 Oct 5. Review.PMID: 18836847 [PubMed - indexed for MEDLINE]Related articles

MD/PhD programs--a call for an accounting.

Rosenberg LE.

JAMA. 2008 Sep 10;300(10):1208-9. No abstract available. PMID: 18780852 [PubMed - indexed for MEDLINE]Related articles

Salicylic acid-based poly(anhydride esters) for control of biofilm formation in Salmonella enterica serovar Typhimurium.

Rosenberg LE, Carbone AL, Römling U, Uhrich KE, Chikindas ML.

Lett Appl Microbiol. 2008 May;46(5):593-9. Epub 2008 Mar 26.PMID: 18373656 [PubMed - indexed for MEDLINE]Related articles

2005 William Allan Award address. Introductory speech for Francis S. Collins.

Rosenberg LE.

Am J Hum Genet. 2006 Sep;79(3):419-20. No abstract available. PMID: 16909377 [PubMed - indexed for MEDLINE]Related articlesFree article

The physician-scientist career pipeline in 2005: build it, and they will come.

Ley TJ, Rosenberg LE.

JAMA. 2005 Sep 21;294(11):1343-51.PMID: 16174692 [PubMed - indexed for MEDLINE]Related articlesFree article

2004 Curt Stern Award Address. Introductory speech for Neil Risch.

Rosenberg LE.

Am J Hum Genet. 2005 Feb;76(2):219-20. No abstract available. PMID: 15714697 [PubMed - indexed for MEDLINE]Related articlesFree article

A gender gap in the next generation of physician-scientists: medical student interest and participation in research.

Guelich JM, Singer BH, Castro MC, Rosenberg LE.

J Investig Med. 2002 Nov;50(6):412-8.PMID: 12425427 [PubMed - indexed for MEDLINE]Related articles

Exceptional economic returns on investments in medical research.

Rosenberg LE.

Med J Aust. 2002 Oct 7;177(7):368-71.PMID: 12358580 [PubMed - indexed for MEDLINE]Related articlesFree article

Emerging opportunities and career paths for the young physician-scientist.

Varki A, Rosenberg LE.

Nat Med. 2002 May;8(5):437-9. No abstract available. PMID: 11984577 [PubMed - indexed for MEDLINE]Related articles

Removing career obstacles for young physician-scientists -- loan-repayment programs.

Ley TJ, Rosenberg LE.

N Engl J Med. 2002 Jan 31;346(5):368-72. No abstract available. PMID: 11821517 [PubMed - indexed for MEDLINE]Related articles

Gene therapist, heal thyself.

Rosenberg LE, Schechter AN.

Science. 2000 Mar 10;287(5459):1751. No abstract available. PMID: 10755924 [PubMed - indexed for MEDLINE]Related articlesFree article

Young physician-scientists: internal Medicine's challenge.

Rosenberg LE.

Ann Intern Med. 2000 Nov 21;133(10):831-2. No abstract available. PMID: 11085847 [PubMed - indexed for MEDLINE]Related articlesFree article

Where does performance measurement go from here?

Legnini MW, Rosenberg LE, Perry MJ, Robertson NJ.

Health Aff (Millwood). 2000 May-Jun;19(3):173-7. No abstract available. PMID: 10812796 [PubMed - indexed for MEDLINE]Related articlesFree article

The physician-scientist: an essential--and fragile--link in the medical research chain.

Rosenberg LE.

J Clin Invest. 1999 Jun;103(12):1621-6. No abstract available. PMID: 10377167 [PubMed - indexed for MEDLINE]Related articlesFree article

The implications of genetic diversity for nutrient requirements: the case of folate.

Rosenberg IH, Rosenberg LE.

Nutr Rev. 1998 Feb;56(2 Pt 2):s47-53; discussion s54-75. Review.PMID: 9564177 [PubMed - indexed for MEDLINE]Related articles

Building bridges between academia and industry: forms; foundations; functions.

Bander KW, Rosenberg LE.

Yale J Biol Med. 1997 May-Jun;70(3):213-7. No abstract available. PMID: 9544491 [PubMed - indexed for MEDLINE]Related articlesFree article

America's medical research enterprise: a time for rededication.

Rosenberg LE.

Proc Assoc Am Physicians. 1995 Apr;107(1):160-5. No abstract available. PMID: 8630738 [PubMed - indexed for MEDLINE]Related articles

Rat liver mitochondrial processing peptidase. Both alpha- and beta-subunits are required for activity.

Saavedra-Alanis VM, Rysavy P, Rosenberg LE, Kalousek F.

J Biol Chem. 1994 Mar 25;269(12):9284-8.PMID: 8132665 [PubMed - indexed for MEDLINE]Related articlesFree article

Human cystathionine beta-synthase cDNA: sequence, alternative splicing and expression in cultured cells.

Kraus JP, Le K, Swaroop M, Ohura T, Tahara T, Rosenberg LE, Roper MD, Kozich V.

Hum Mol Genet. 1993 Oct;2(10):1633-8.PMID: 7903580 [PubMed - indexed for MEDLINE]Related articles

The beta subunit of the mitochondrial processing peptidase from rat liver: cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases.

Paces V, Rosenberg LE, Fenton WA, Kalousek F.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5355-8.PMID: 8506385 [PubMed - indexed for MEDLINE]Related articlesFree article

GroEL, GroES, and ATP-dependent folding and spontaneous assembly of ornithine transcarbamylase.

Zheng X, Rosenberg LE, Kalousek F, Fenton WA.

J Biol Chem. 1993 Apr 5;268(10):7489-93.PMID: 8096512 [PubMed - indexed for MEDLINE]Related articlesFree article

Three independent mutations in the same exon of the PCCB gene: differences between Caucasian and Japanese propionic acidaemia.

Tahara T, Kraus JP, Ohura T, Rosenberg LE, Fenton WA.

J Inherit Metab Dis. 1993;16(2):353-60.PMID: 8411997 [PubMed - indexed for MEDLINE]Related articles

Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue.

Isaya G, Kalousek F, Rosenberg LE.

Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8317-21.PMID: 1518864 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat liver mitochondrial intermediate peptidase (MIP): purification and initial characterization.

Kalousek F, Isaya G, Rosenberg LE.

EMBO J. 1992 Aug;11(8):2803-9.PMID: 1322290 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat cystathionine beta-synthase. Gene organization and alternative splicing.

Swaroop M, Bradley K, Ohura T, Tahara T, Roper MD, Rosenberg LE, Kraus JP.

J Biol Chem. 1992 Jun 5;267(16):11455-61.PMID: 1597473 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase.

Isaya G, Kalousek F, Rosenberg LE.

J Biol Chem. 1992 Apr 15;267(11):7904-10.PMID: 1560019 [PubMed - indexed for MEDLINE]Related articlesFree article

The human genome project.

Rosenberg LE.

Bull N Y Acad Med. 1992 Jan-Feb;68(1):113-4. No abstract available. PMID: 1555017 [PubMed - indexed for MEDLINE]Related articlesFree article

Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation.

Purdue PE, Allsop J, Isaya G, Rosenberg LE, Danpure CJ.

Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10900-4.PMID: 1961759 [PubMed - indexed for MEDLINE]Related articlesFree article

The precursor of the biotin-binding subunit of mammalian propionyl-CoA carboxylase can be translocated into mitochondria as apo- or holoprotein.

Taroni F, Rosenberg LE.

J Biol Chem. 1991 Jul 15;266(20):13267-71.PMID: 2071602 [PubMed - indexed for MEDLINE]Related articlesFree article

Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide.

Isaya G, Kalousek F, Fenton WA, Rosenberg LE.

J Cell Biol. 1991 Apr;113(1):65-76.PMID: 1672532 [PubMed - indexed for MEDLINE]Related articlesFree article

[Molecular basis of organic acidemia--propionic acidemia]

Tahara T, Eto Y, Kraus JP, Rosenberg LE.

Hum Cell. 1990 Dec;3(4):311-7. Japanese. PMID: 2095843 [PubMed - indexed for MEDLINE]Related articles

The general mitochondrial matrix processing protease from rat liver: structural characterization of the catalytic subunit.

Kleiber J, Kalousek F, Swaroop M, Rosenberg LE.

Proc Natl Acad Sci U S A. 1990 Oct;87(20):7978-82.PMID: 2236012 [PubMed - indexed for MEDLINE]Related articlesFree article

Treating genetic diseases: lessons from three children.

Rosenberg LE.

Pediatr Res. 1990 Jun;27(6 Suppl):S10-6. Review. No abstract available. PMID: 2192347 [PubMed - indexed for MEDLINE]Related articles

Direct DNA sequencing of PCR amplified genomic DNA by the Maxam-Gilbert method.

Tahara T, Kraus JP, Rosenberg LE.

Biotechniques. 1990 Apr;8(4):366-8.PMID: 2340169 [PubMed - indexed for MEDLINE]Related articles

Mutation eliminating mitochondrial leader sequence of methylmalonyl-CoA mutase causes muto methylmalonic acidemia.

Ledley FD, Jansen R, Nham SU, Fenton WA, Rosenberg LE.

Proc Natl Acad Sci U S A. 1990 Apr;87(8):3147-50.PMID: 1970180 [PubMed - indexed for MEDLINE]Related articlesFree article

An unusual insertion/deletion in the gene encoding the beta-subunit of propionyl-CoA carboxylase is a frequent mutation in Caucasian propionic acidemia.

Tahara T, Kraus JP, Rosenberg LE.

Proc Natl Acad Sci U S A. 1990 Feb;87(4):1372-6.PMID: 2154743 [PubMed - indexed for MEDLINE]Related articlesFree article

Translocation of precursor proteins into the mitochondrial matrix occurs through an environment accessible to aqueous perturbants.

Sztul ES, Chu TW, Strauss AW, Rosenberg LE.

J Cell Sci. 1989 Dec;94 ( Pt 4):695-701.PMID: 2630564 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence analysis, biogenesis, and mitochondrial import of the alpha-subunit of rat liver propionyl-CoA carboxylase.

Browner MF, Taroni F, Sztul E, Rosenberg LE.

J Biol Chem. 1989 Jul 25;264(21):12680-5. Erratum in: J Biol Chem 1991 Mar 5;266(7):4660. PMID: 2745462 [PubMed - indexed for MEDLINE]Related articlesFree article

Unequal synthesis and differential degradation of propionyl CoA carboxylase subunits in cells from normal and propionic acidemia patients.

Ohura T, Kraus JP, Rosenberg LE.

Am J Hum Genet. 1989 Jul;45(1):33-40.PMID: 2741949 [PubMed - indexed for MEDLINE]Related articlesFree article

Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: leader peptides cleaved by two matrix proteases share a three-amino acid motif.

Hendrick JP, Hodges PE, Rosenberg LE.

Proc Natl Acad Sci U S A. 1989 Jun;86(11):4056-60.PMID: 2657736 [PubMed - indexed for MEDLINE]Related articlesFree article

The spfash mouse: a missense mutation in the ornithine transcarbamylase gene also causes aberrant mRNA splicing.

Hodges PE, Rosenberg LE.

Proc Natl Acad Sci U S A. 1989 Jun;86(11):4142-6.PMID: 2471197 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction.

Jansen R, Kalousek F, Fenton WA, Rosenberg LE, Ledley FD.

Genomics. 1989 Feb;4(2):198-205.PMID: 2567699 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial import and processing of mutant human ornithine transcarbamylase precursors in cultured cells.

Isaya G, Fenton WA, Hendrick JP, Furtak K, Kalousek F, Rosenberg LE.

Mol Cell Biol. 1988 Dec;8(12):5150-8.PMID: 3244350 [PubMed - indexed for MEDLINE]Related articlesFree article

Different structures in the amino-terminal domain of the ornithine transcarbamylase leader peptide are involved in mitochondrial import and carboxyl-terminal cleavage.

Kraus JP, Novotný J, Kalousek F, Swaroop M, Rosenberg LE.

Proc Natl Acad Sci U S A. 1988 Dec;85(23):8905-9.PMID: 3194398 [PubMed - indexed for MEDLINE]Related articlesFree article

Two mitochondrial matrix proteases act sequentially in the processing of mammalian matrix enzymes.

Kalousek F, Hendrick JP, Rosenberg LE.

Proc Natl Acad Sci U S A. 1988 Oct;85(20):7536-40.PMID: 3050998 [PubMed - indexed for MEDLINE]Related articlesFree article

Import of the malate dehydrogenase precursor by mitochondria. Cleavage within leader peptide by matrix protease leads to formation of intermediate-sized form.

Sztul ES, Chu TW, Strauss AW, Rosenberg LE.

J Biol Chem. 1988 Aug 25;263(24):12085-91.PMID: 3042789 [PubMed - indexed for MEDLINE]Related articlesFree article

Meiotic expression of human ornithine transcarbamylase in the testes of transgenic mice.

Kelley KA, Chamberlain JW, Nolan JA, Horwich AL, Kalousek F, Eisenstadt J, Herrup K, Rosenberg LE.

Mol Cell Biol. 1988 Apr;8(4):1821-5.PMID: 2837657 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward a molecular understanding of ornithine transcarbamylase deficiency.

Fox JE, Rosenberg LE.

Adv Neurol. 1988;48:71-81. No abstract available. PMID: 2891259 [PubMed - indexed for MEDLINE]Related articles

Import of rat ornithine transcarbamylase precursor into mitochondria: two-step processing of the leader peptide.

Sztul ES, Hendrick JP, Kraus JP, Wall D, Kalousek F, Rosenberg LE.

J Cell Biol. 1987 Dec;105(6 Pt 1):2631-9.PMID: 3693395 [PubMed - indexed for MEDLINE]Related articlesFree article

The ornithine transcarbamylase leader peptide directs mitochondrial import through both its midportion structure and net positive charge.

Horwich AL, Kalousek F, Fenton WA, Furtak K, Pollock RA, Rosenberg LE.

J Cell Biol. 1987 Aug;105(2):669-77.PMID: 3624306 [PubMed - indexed for MEDLINE]Related articlesFree article