PubMed

Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.

Li DQ, Jing X, Salehi A, Collins SC, Hoppa MB, Rosengren AH, Zhang E, Lundquist I, Olofsson CS, Mörgelin M, Eliasson L, Rorsman P, Renström E.

Cell Metab. 2009 Oct;10(4):309-15.PMID: 19808023 [PubMed - in process]Related articles

NALCN: a regulated leak channel.

Gilon P, Rorsman P.

EMBO Rep. 2009 Sep;10(9):963-4. Epub 2009 Aug 7. No abstract available. PMID: 19662077 [PubMed - indexed for MEDLINE]Related articles

Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.

Williams SE, Reed AA, Galvanovskis J, Antignac C, Goodship T, Karet FE, Kotanko P, Lhotta K, Morinière V, Williams P, Wong W, Rorsman P, Thakker RV.

Hum Mol Genet. 2009 Aug 15;18(16):2963-74. Epub 2009 May 22.PMID: 19465746 [PubMed - indexed for MEDLINE]Related articles

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P.

Diabetologia. 2009 Aug;52(8):1566-78. Epub 2009 May 14.PMID: 19440689 [PubMed - indexed for MEDLINE]Related articles

The insulin receptor talks to glucagon?

Gromada J, Duttaroy A, Rorsman P.

Cell Metab. 2009 Apr;9(4):303-5.PMID: 19356709 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.

Gloyn AL, Braun M, Rorsman P.

Diabetes. 2009 Apr;58(4):800-2. No abstract available. PMID: 19336690 [PubMed - indexed for MEDLINE]Related articlesFree article

miR-375 maintains normal pancreatic alpha- and beta-cell mass.

Poy MN, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, Zavolan M, Stoffel M.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5813-8. Epub 2009 Mar 16.PMID: 19289822 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.

Olofsson CS, Håkansson J, Salehi A, Bengtsson M, Galvanovskis J, Partridge C, SörhedeWinzell M, Xian X, Eliasson L, Lundquist I, Semb H, Rorsman P.

Endocrinology. 2009 Jul;150(7):3067-75. Epub 2009 Feb 12.PMID: 19213846 [PubMed - indexed for MEDLINE]Related articles

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.

Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W.

J Physiol. 2009 Mar 15;587(Pt 6):1169-78. Epub 2009 Jan 26.PMID: 19171650 [PubMed - indexed for MEDLINE]Related articles

Exocytotic properties of human pancreatic beta-cells.

Braun M, Ramracheya R, Johnson PR, Rorsman P.

Ann N Y Acad Sci. 2009 Jan;1152:187-93.PMID: 19161389 [PubMed - indexed for MEDLINE]Related articles

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R.

Cell. 2009 Jan 23;136(2):235-48. Epub 2009 Jan 8.PMID: 19135240 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM.

J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.PMID: 19065048 [PubMed - indexed for MEDLINE]Related articlesFree article

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.

Genes Dev. 2008 Nov 15;22(22):3135-46.PMID: 19056893 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs.

Karanauskaite J, Hoppa MB, Braun M, Galvanovskis J, Rorsman P.

Pflugers Arch. 2009 Jun;458(2):389-401. Epub 2008 Nov 19.PMID: 19018564 [PubMed - indexed for MEDLINE]Related articles

Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM.

Endocrinology. 2009 Feb;150(2):687-98. Epub 2008 Oct 9.PMID: 18845638 [PubMed - indexed for MEDLINE]Related articles

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE.

Pflugers Arch. 2009 Apr;457(6):1343-50. Epub 2008 Sep 16.PMID: 18795319 [PubMed - indexed for MEDLINE]Related articles

K(ATP)-channels and glucose-regulated glucagon secretion.

Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE.

Trends Endocrinol Metab. 2008 Oct;19(8):277-84. Epub 2008 Sep 2. Review.PMID: 18771934 [PubMed - indexed for MEDLINE]Related articles

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, Gauguier D.

PLoS One. 2008 Aug 13;3(8):e2962.PMID: 18698428 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans.

Zhang Q, Galvanovskis J, Abdulkader F, Partridge CJ, Göpel SO, Eliasson L, Rorsman P.

Philos Transact A Math Phys Eng Sci. 2008 Oct 13;366(1880):3503-23.PMID: 18632454 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of mRNA in single cells and modelling of RT-qPCR induced noise.

Bengtsson M, Hemberg M, Rorsman P, Ståhlberg A.

BMC Mol Biol. 2008 Jul 17;9:63.PMID: 18631407 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P.

Diabetologia. 2008 Sep;51(9):1689-93. Epub 2008 Jul 12.PMID: 18622593 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel aspects of the molecular mechanisms controlling insulin secretion.

Eliasson L, Abdulkader F, Braun M, Galvanovskis J, Hoppa MB, Rorsman P.

J Physiol. 2008 Jul 15;586(14):3313-24. Epub 2008 May 29. Review.PMID: 18511483 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P.

Diabetes. 2008 Jun;57(6):1618-28. Epub 2008 Apr 4.PMID: 18390794 [PubMed - indexed for MEDLINE]Related articlesFree article

CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.

Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renström E, Rorsman P.

Cell Metab. 2008 Jan;7(1):57-67.PMID: 18177725 [PubMed - indexed for MEDLINE]Related articles

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.PMID: 17991826 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L; Hvidøre Study Group.

Eur J Endocrinol. 2007 Jun;156(6):663-71.PMID: 17535866 [PubMed - indexed for MEDLINE]Related articlesFree article

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P.

PLoS Biol. 2007 Jun;5(6):e143.PMID: 17503968 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P.

Diabetes. 2007 Jul;56(7):1888-97. Epub 2007 Apr 24.PMID: 17456851 [PubMed - indexed for MEDLINE]Related articlesFree article

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

MacDonald PE, Rorsman P.

Physiology (Bethesda). 2007 Apr;22:113-21. Review.PMID: 17420302 [PubMed - indexed for MEDLINE]Related articlesFree article

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P.

Nat Cell Biol. 2007 Apr;9(4):453-60. Epub 2007 Mar 18.PMID: 17369816 [PubMed - indexed for MEDLINE]Related articles

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

Braun M, Wendt A, Karanauskaite J, Galvanovskis J, Clark A, MacDonald PE, Rorsman P.

J Gen Physiol. 2007 Mar;129(3):221-31. Epub 2007 Feb 12.PMID: 17296927 [PubMed - indexed for MEDLINE]Related articlesFree article

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

Jeans AF, Oliver PL, Johnson R, Capogna M, Vikman J, Molnár Z, Babbs A, Partridge CJ, Salehi A, Bengtsson M, Eliasson L, Rorsman P, Davies KE.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2431-6. Epub 2007 Feb 5.PMID: 17283335 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: evidence for the existence of insulinotropic agents in the stomach.

Salehi A, Eliasson L, Ma X, Rorsman P, Håkanson R, Lundquist I.

Regul Pept. 2007 Mar 1;139(1-3):31-8. Epub 2006 Nov 15.PMID: 17109976 [PubMed - indexed for MEDLINE]Related articles

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

MacDonald PE, Braun M, Galvanovskis J, Rorsman P.

Cell Metab. 2006 Oct;4(4):283-90.PMID: 17011501 [PubMed - indexed for MEDLINE]Related articles

Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.

Vikman J, Ma X, Hockerman GH, Rorsman P, Eliasson L.

J Mol Endocrinol. 2006 Jun;36(3):503-15.PMID: 16720719 [PubMed - indexed for MEDLINE]Related articlesFree article

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

MacDonald PE, Rorsman P.

PLoS Biol. 2006 Feb;4(2):e49. Epub 2006 Feb 14. No abstract available. PMID: 16464129 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.

Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SE.

Diabetes. 2006 Feb;55(2):290-6.PMID: 16443759 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-sensing mechanisms in pancreatic beta-cells.

MacDonald PE, Joseph JW, Rorsman P.

Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2211-25. Review.PMID: 16321791 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

MacDonald PE, Eliasson L, Rorsman P.

J Cell Sci. 2005 Dec 15;118(Pt 24):5911-20. Epub 2005 Nov 29.PMID: 16317049 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels.

Bengtsson M, Ståhlberg A, Rorsman P, Kubista M.

Genome Res. 2005 Oct;15(10):1388-92.PMID: 16204192 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective nucleotide-release from dense-core granules in insulin-secreting cells.

Obermüller S, Lindqvist A, Karanauskaite J, Galvanovskis J, Rorsman P, Barg S.

J Cell Sci. 2005 Sep 15;118(Pt 18):4271-82. Epub 2005 Sep 1.PMID: 16141231 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

MacDonald PE, Obermüller S, Vikman J, Galvanovskis J, Rorsman P, Eliasson L.

Diabetes. 2005 Mar;54(3):736-43.PMID: 15734850 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the regulation of glucagon secretion by glucagon-like peptide-1.

Gromada J, Rorsman P.

Horm Metab Res. 2004 Nov-Dec;36(11-12):822-9. Review.PMID: 15655714 [PubMed - indexed for MEDLINE]Related articles

CaV2.3 calcium channels control second-phase insulin release.

Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E.

J Clin Invest. 2005 Jan;115(1):146-54.PMID: 15630454 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion: a high-affinity Ca2+ sensor after all?

Barg S, Rorsman P.

J Gen Physiol. 2004 Dec;124(6):623-5. No abstract available. PMID: 15572341 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Gromada J, Brock B, Schmitz O, Rorsman P.

Basic Clin Pharmacol Toxicol. 2004 Dec;95(6):252-62. Review.PMID: 15569269 [PubMed - indexed for MEDLINE]Related articles

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P.

Diabetes. 2004 Dec;53 Suppl 3:S181-9.PMID: 15561909 [PubMed - indexed for MEDLINE]Related articlesFree article

A pancreatic islet-specific microRNA regulates insulin secretion.

Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M.

Nature. 2004 Nov 11;432(7014):226-30.PMID: 15538371 [PubMed - indexed for MEDLINE]Related articles

Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.

Olofsson CS, Salehi A, Göpel SO, Holm C, Rorsman P.

Diabetes. 2004 Nov;53(11):2836-43.PMID: 15504963 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.

Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L.

Mol Endocrinol. 2005 Jan;19(1):198-212. Epub 2004 Sep 30.PMID: 15459251 [PubMed - indexed for MEDLINE]Related articlesFree article