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    Results: 1 to 50 of 55

    1.

    Therapeutic applications of RNAi. Methods and protocols. Preface.

    Reidhaar-Olson JF, Rondinone CM.

    Methods Mol Biol. 2009;555:v-vi. No abstract available. PMID: 19725188 [PubMed - indexed for MEDLINE]Related articles

    2.

    PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

    González-Rodriguez A, Nevado C, Escrivá F, Sesti G, Rondinone CM, Benito M, Valverde AM.

    Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G338-47. Epub 2008 Jun 5.PMID: 18535291 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    RNA interference to target lipid disorders.

    Rondinone CM.

    Curr Opin Lipidol. 2008 Jun;19(3):285-8. Review.PMID: 18460920 [PubMed - indexed for MEDLINE]Related articles

    4.

    Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.

    Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK.

    J Biol Chem. 2007 Aug 3;282(31):22765-74. Epub 2007 Jun 5.PMID: 17550900 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Genetic association meets RNA interference: large-scale genomic screens for causation and mechanism of complex diseases.

    Martin M, Reidhaar-Olson JF, Rondinone CM.

    Pharmacogenomics. 2007 May;8(5):455-64. Review.PMID: 17465709 [PubMed - indexed for MEDLINE]Related articles

    6.

    Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes.

    González-Rodriguez A, Escribano O, Alba J, Rondinone CM, Benito M, Valverde AM.

    J Cell Physiol. 2007 Jul;212(1):76-88.PMID: 17323378 [PubMed - indexed for MEDLINE]Related articles

    7.

    Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.

    Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M.

    Diabetes. 2007 Feb;56(2):404-13.PMID: 17259385 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

    Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.

    Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2.PMID: 17107797 [PubMed - indexed for MEDLINE]Related articles

    9.

    Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.

    Fernández-Veledo S, Nieto-Vazquez I, Rondinone CM, Lorenzo M.

    Diabetologia. 2006 Dec;49(12):3038-48. Epub 2006 Oct 27.PMID: 17072583 [PubMed - indexed for MEDLINE]Related articles

    10.

    Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

    Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

    Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

    Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM.

    J Med Chem. 2006 Jun 15;49(12):3563-80.PMID: 16759099 [PubMed - indexed for MEDLINE]Related articles

    12.

    Therapeutic potential of RNAi in metabolic diseases.

    Rondinone CM.

    Biotechniques. 2006 Apr;Suppl:31-6. Review.PMID: 16629385 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Adipocyte-derived hormones, cytokines, and mediators.

    Rondinone CM.

    Endocrine. 2006 Feb;29(1):81-90. Review.PMID: 16622295 [PubMed - indexed for MEDLINE]Related articles

    14.

    Minireview: ribonucleic acid interference for the identification of new targets for the treatment of metabolic diseases.

    Rondinone CM.

    Endocrinology. 2006 Jun;147(6):2650-6. Epub 2006 Mar 23. Review.PMID: 16556759 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    RNAi: for functional analysis and target validation.

    Rondinone CM.

    Expert Opin Ther Targets. 2006 Apr;10(2):337-40.PMID: 16548782 [PubMed - indexed for MEDLINE]Related articles

    16.

    PKCtheta is a key player in the development of insulin resistance.

    Haasch D, Berg C, Clampit JE, Pederson T, Frost L, Kroeger P, Rondinone CM.

    Biochem Biophys Res Commun. 2006 May 5;343(2):361-8. Epub 2006 Mar 9.PMID: 16545776 [PubMed - indexed for MEDLINE]Related articles

    17.

    Delivery of RNAi reagents in murine models of obesity and diabetes.

    Wilcox DM, Yang R, Morgan SJ, Nguyen PT, Voorbach MJ, Jung PM, Haasch DL, Lin E, Bush EN, Opgenorth TJ, Jacobson PB, Collins CA, Rondinone CM, Surowy T, Landschulz KT.

    J RNAi Gene Silencing. 2006 Nov 29;3(1):225-36.PMID: 19771218 [PubMed - in process]Related articlesFree article

    18.

    JNK: bridging the insulin signaling and inflammatory pathway.

    Liu G, Rondinone CM.

    Curr Opin Investig Drugs. 2005 Oct;6(10):979-87. Review. Erratum in: Curr Opin Investig Drugs. 2005 Dec;6(12):1280. PMID: 16259218 [PubMed - indexed for MEDLINE]Related articles

    19.

    Endothelin antagonism improves hepatic insulin sensitivity associated with insulin signaling in Zucker fatty rats.

    Berthiaume N, Carlson CJ, Rondinone CM, Zinker BA.

    Metabolism. 2005 Nov;54(11):1515-23.PMID: 16253642 [PubMed - indexed for MEDLINE]Related articles

    20.

    Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.

    Carlson CJ, Rondinone CM.

    Metabolism. 2005 Jul;54(7):895-901.PMID: 15988698 [PubMed - indexed for MEDLINE]Related articles

    21.

    Diabetes: the latest developments in inhibitors, insulin sensitisers, new drug targets and novel approaches. October 18-19, 2004, The Hatton, London, UK.

    Rondinone CM.

    Expert Opin Ther Targets. 2005 Apr;9(2):415-8.PMID: 15934925 [PubMed - indexed for MEDLINE]Related articles

    22.

    Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

    Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR.

    Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6.PMID: 15482920 [PubMed - indexed for MEDLINE]Related articles

    23.

    Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms.

    Rondinone CM, Clampit J, Gum RJ, Zinker BA, Jirousek MR, Trevillyan JM.

    Biochem Biophys Res Commun. 2004 Oct 15;323(2):652-9.PMID: 15369800 [PubMed - indexed for MEDLINE]Related articles

    24.

    Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.

    Carlson CJ, White MF, Rondinone CM.

    Biochem Biophys Res Commun. 2004 Apr 2;316(2):533-9.PMID: 15020250 [PubMed - indexed for MEDLINE]Related articles

    25.

    Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

    Liu G, Xin Z, Pei Z, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Zhao H, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR.

    J Med Chem. 2003 Sep 25;46(20):4232-5.PMID: 13678400 [PubMed - indexed for MEDLINE]Related articles

    26.

    Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

    Liu G, Xin Z, Liang H, Abad-Zapatero C, Hajduk PJ, Janowick DA, Szczepankiewicz BG, Pei Z, Hutchins CW, Ballaron SJ, Stashko MA, Lubben TH, Berg CE, Rondinone CM, Trevillyan JM, Jirousek MR.

    J Med Chem. 2003 Jul 31;46(16):3437-40.PMID: 12877578 [PubMed - indexed for MEDLINE]Related articles

    27.

    PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

    Waring JF, Ciurlionis R, Clampit JE, Morgan S, Gum RJ, Jolly RA, Kroeger P, Frost L, Trevillyan J, Zinker BA, Jirousek M, Ulrich RG, Rondinone CM.

    Mol Cell Endocrinol. 2003 May 30;203(1-2):155-68.PMID: 12782412 [PubMed - indexed for MEDLINE]Related articles

    28.

    Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.

    Gum RJ, Gaede LL, Heindel MA, Waring JF, Trevillyan JM, Zinker BA, Stark ME, Wilcox D, Jirousek MR, Rondinone CM, Ulrich RG.

    Mol Endocrinol. 2003 Jun;17(6):1131-43. Epub 2003 Mar 20.PMID: 12649327 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

    Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM.

    Diabetes. 2003 Mar;52(3):634-41.PMID: 12606502 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

    Clampit JE, Meuth JL, Smith HT, Reilly RM, Jirousek MR, Trevillyan JM, Rondinone CM.

    Biochem Biophys Res Commun. 2003 Jan 10;300(2):261-7.PMID: 12504077 [PubMed - indexed for MEDLINE]Related articles

    31.

    Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

    Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

    Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.

    Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A.

    J Biol Chem. 2002 Dec 27;277(52):50386-95. Epub 2002 Oct 21.PMID: 12393894 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.

    Rondinone CM, Kramer D.

    Biochem Biophys Res Commun. 2002 Sep 6;296(5):1257-63.PMID: 12207909 [PubMed - indexed for MEDLINE]Related articles

    34.

    PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

    Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

    Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

    Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Rapamycin partially prevents insulin resistance induced by chronic insulin treatment.

    Berg CE, Lavan BE, Rondinone CM.

    Biochem Biophys Res Commun. 2002 May 10;293(3):1021-7.PMID: 12051762 [PubMed - indexed for MEDLINE]Related articles

    37.

    Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats.

    Kramer D, Shapiro R, Adler A, Bush E, Rondinone CM.

    Metabolism. 2001 Nov;50(11):1294-300.PMID: 11699047 [PubMed - indexed for MEDLINE]Related articles

    38.

    Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.

    Pederson TM, Kramer DL, Rondinone CM.

    Diabetes. 2001 Jan;50(1):24-31.PMID: 11147790 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Regulation of proteins involved in insulin signaling pathways in differentiating human adipocytes.

    Pederson T, Rondinone CM.

    Biochem Biophys Res Commun. 2000 Sep 16;276(1):162-8.PMID: 11006100 [PubMed - indexed for MEDLINE]Related articles

    40.

    On the control of lipolysis in adipocytes.

    Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR, Rondinone CM.

    Ann N Y Acad Sci. 1999 Nov 18;892:155-68. Review.PMID: 10842661 [PubMed - indexed for MEDLINE]Related articles

    41.

    Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.

    Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP.

    J Biol Chem. 2000 Apr 7;275(14):10093-8.PMID: 10744689 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus.

    Rondinone CM, Carvalho E, Wesslau C, Smith UP.

    Diabetologia. 1999 Jul;42(7):819-25.PMID: 10440123 [PubMed - indexed for MEDLINE]Related articles

    43.

    Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.

    Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U.

    Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4171-5.PMID: 9108124 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.

    Rondinone CM, Zarnowski MJ, Londos C, Smith UP.

    Biochim Biophys Acta. 1996 Nov 8;1314(1-2):49-56.PMID: 8972717 [PubMed - indexed for MEDLINE]Related articles

    45.

    Okadaic acid exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes. Evidence for a phosphatidylinositol 3-kinase-independent pathway.

    Rondinone CM, Smith U.

    J Biol Chem. 1996 Jul 26;271(30):18148-53.PMID: 8663361 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.

    Londos C, Gruia-Gray J, Brasaemle DL, Rondinone CM, Takeda T, Dwyer NK, Barber T, Kimmel AR, Blanchette-Mackie EJ.

    Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S97-101. Review.PMID: 8680486 [PubMed - indexed for MEDLINE]Related articles

    47.

    Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.

    Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C.

    J Lipid Res. 1995 Jun;36(6):1211-26.PMID: 7665999 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Role of insulin-like growth factor-1 on the kinetics of human lymphocytes stimulation in serum-free culture medium.

    Schillaci R, Ribaudo CM, Rondinone CM, Roldán A.

    Immunol Cell Biol. 1994 Aug;72(4):300-5.PMID: 7806263 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes.

    Rondinone CM, Rodbard D, Baker ME.

    Endocrinology. 1993 Jun;132(6):2421-6.PMID: 8504747 [PubMed - indexed for MEDLINE]Related articles

    50.

    Identification of a protein factor secreted by 3T3-L1 preadipocytes inhibitory for the human MCF-7 breast cancer cell line.

    Johnston PG, Rondinone CM, Voeller D, Allegra CJ.

    Cancer Res. 1992 Dec 15;52(24):6860-5.PMID: 1458474 [PubMed - indexed for MEDLINE]Related articlesFree article

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