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The Tregs' world according to GARP.

Battaglia M, Roncarolo MG.

Eur J Immunol. 2009 Nov 10. [Epub ahead of print]PMID: 19904770 [PubMed - as supplied by publisher]Related articles

Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia.

Frugnoli I, Cappelli B, Chiesa R, Biral E, Noè A, Evangelio C, Fossati M, Napolitano S, Ciceri F, Roncarolo MG, Marktel S.

Bone Marrow Transplant. 2009 Nov 2. [Epub ahead of print]PMID: 19881553 [PubMed - as supplied by publisher]Related articles

In vivo delivery of a microRNA regulated transgene induces antigen-specific regulatory T cells and promotes immunological tolerance.

Annoni A, Brown BD, Cantore A, Sergi Sergi L, Naldini L, Roncarolo MG.

Blood. 2009 Sep 30. [Epub ahead of print]PMID: 19794140 [PubMed - as supplied by publisher]Related articles

Absence of VOD in paediatric thalassaemic HSCT recipients using defibrotide prophylaxis and intravenous Busulphan.

Cappelli B, Chiesa R, Evangelio C, Biffi A, Roccia T, Frugnoli I, Biral E, Noè A, Fossati M, Finizio V, Miniero R, Napolitano S, Ferrua F, Soliman C, Ciceri F, Roncarolo MG, Marktel S.

Br J Haematol. 2009 Nov;147(4):554-60. Epub 2009 Aug 31.PMID: 19747363 [PubMed - in process]Related articles

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.

Di Nunzio S, Cecconi M, Passerini L, McMurchy AN, Baron U, Turbachova I, Vignola S, Valencic E, Tommasini A, Junker A, Cazzola G, Olek S, Levings MK, Perroni L, Roncarolo MG, Bacchetta R.

Blood. 2009 Nov 5;114(19):4138-41. Epub 2009 Sep 8.PMID: 19738030 [PubMed - in process]Related articles

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells.

Gregori S, Magnani CF, Roncarolo MG.

Hum Immunol. 2009 Dec;70(12):966-9. Epub 2009 Aug 4.PMID: 19664675 [PubMed - in process]Related articles

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

Cassani B, Montini E, Maruggi G, Ambrosi A, Mirolo M, Selleri S, Biral E, Frugnoli I, Hernandez-Trujillo V, Di Serio C, Roncarolo MG, Naldini L, Mavilio F, Aiuti A.

Blood. 2009 Oct 22;114(17):3546-56. Epub 2009 Aug 3.PMID: 19652199 [PubMed - indexed for MEDLINE]Related articles

Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?

Gagliani N, Ferraro A, Roncarolo MG, Battaglia M.

Immunol Lett. 2009 Dec 2;127(1):1-7. Epub 2009 Jul 28.PMID: 19643137 [PubMed - in process]Related articles

Loss of mismatched HLA in leukemia after stem-cell transplantation.

Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Stanghellini MT, Perrelli NF, Cosentino C, Torri F, Angius A, Forno B, Casucci M, Bernardi M, Peccatori J, Corti C, Bondanza A, Ferrari M, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K.

N Engl J Med. 2009 Jul 30;361(5):478-88.PMID: 19641204 [PubMed - indexed for MEDLINE]Related articles

ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.

Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A.

Blood. 2009 Oct 8;114(15):3216-26. Epub 2009 Jul 24.PMID: 19633200 [PubMed - indexed for MEDLINE]Related articles

Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia.

Serafini G, Andreani M, Testi M, Battarra M, Bontadini A, Biral E, Fleischhauer K, Marktel S, Lucarelli G, Roncarolo MG, Bacchetta R.

Haematologica. 2009 Oct;94(10):1415-26. Epub 2009 Jul 16.PMID: 19608686 [PubMed - in process]Related articlesFree article

Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy.

Cesani M, Capotondo A, Plati T, Sergi LS, Fumagalli F, Roncarolo MG, Naldini L, Comi G, Sessa M, Biffi A.

Hum Mutat. 2009 Oct;30(10):E936-45.PMID: 19606494 [PubMed - in process]Related articles

The fate of human Treg cells.

Battaglia M, Roncarolo MG.

Immunity. 2009 Jun 19;30(6):763-5.PMID: 19538927 [PubMed - indexed for MEDLINE]Related articles

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

Locci M, Draghici E, Marangoni F, Bosticardo M, Catucci M, Aiuti A, Cancrini C, Marodi L, Espanol T, Bredius RG, Thrasher AJ, Schulz A, Litzman J, Roncarolo MG, Casorati G, Dellabona P, Villa A.

J Exp Med. 2009 Apr 13;206(4):735-42. Epub 2009 Mar 23.PMID: 19307326 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.

Marangoni F, Bosticardo M, Charrier S, Draghici E, Locci M, Scaramuzza S, Panaroni C, Ponzoni M, Sanvito F, Doglioni C, Liabeuf M, Gjata B, Montus M, Siminovitch K, Aiuti A, Naldini L, Dupré L, Roncarolo MG, Galy A, Villa A.

Mol Ther. 2009 Jun;17(6):1073-82. Epub 2009 Mar 3. Erratum in: Mol Ther. 2009 Jul;17(7):1300. PMID: 19259069 [PubMed - indexed for MEDLINE]Related articles

Hematopoietic stem cell gene therapy for adenosine deaminase deficient-SCID.

Aiuti A, Brigida I, Ferrua F, Cappelli B, Chiesa R, Marktel S, Roncarolo MG.

Immunol Res. 2009;44(1-3):150-9.PMID: 19224139 [PubMed - indexed for MEDLINE]Related articles

Re-establishing immune tolerance in type 1 diabetes via regulatory T cells.

Gregori S, Battaglia M, Roncarolo MG.

Novartis Found Symp. 2008;292:174-83; discussion 183-6, 202-3.PMID: 19203099 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, Scaramuzza S, Andolfi G, Mirolo M, Brigida I, Tabucchi A, Carlucci F, Eibl M, Aker M, Slavin S, Al-Mousa H, Al Ghonaium A, Ferster A, Duppenthaler A, Notarangelo L, Wintergerst U, Buckley RH, Bregni M, Marktel S, Valsecchi MG, Rossi P, Ciceri F, Miniero R, Bordignon C, Roncarolo MG.

N Engl J Med. 2009 Jan 29;360(5):447-58.PMID: 19179314 [PubMed - indexed for MEDLINE]Related articlesFree article

Comment on M. Guillot-Delost et al. (2008;10:834-846): Clinical-grade preparation of human natural regulatory T cells encoding the thymidine kinase suicide gene as a safety gene.

Battaglia M, Strauss L, Roncarolo MG.

J Gene Med. 2009 Feb;11(2):180-1. No abstract available. PMID: 19172613 [PubMed - indexed for MEDLINE]Related articles

Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice.

Valle A, Jofra T, Stabilini A, Atkinson M, Roncarolo MG, Battaglia M.

Diabetes. 2009 Apr;58(4):875-81. Epub 2009 Jan 16.PMID: 19151201 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity.

Gambineri E, Perroni L, Passerini L, Bianchi L, Doglioni C, Meschi F, Bonfanti R, Sznajer Y, Tommasini A, Lawitschka A, Junker A, Dunstheimer D, Heidemann PH, Cazzola G, Cipolli M, Friedrich W, Janic D, Azzi N, Richmond E, Vignola S, Barabino A, Chiumello G, Azzari C, Roncarolo MG, Bacchetta R.

J Allergy Clin Immunol. 2008 Dec;122(6):1105-1112.e1. Epub 2008 Oct 25.PMID: 18951619 [PubMed - indexed for MEDLINE]Related articles

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome.

Benninghoff U, Cattaneo F, Aiuti A, Flores-D'Arcais A, Gelmetti C, Viscardi M, Callegaro L, Mirolo M, Ambrosi A, Roncarolo MG, Bacchetta R.

Pediatr Allergy Immunol. 2008 Sep;19(6):564-8.PMID: 18844858 [PubMed - indexed for MEDLINE]Related articles

Metachromatic leukodystrophy - mutation analysis provides further evidence of genotype-phenotype correlation.

Biffi A, Cesani M, Fumagalli F, Del Carro U, Baldoli C, Canale S, Gerevini S, Amadio S, Falautano M, Rovelli A, Comi G, Roncarolo MG, Sessa M.

Clin Genet. 2008 Oct;74(4):349-57. Epub 2008 Sep 11.PMID: 18786133 [PubMed - indexed for MEDLINE]Related articles

Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation.

Vago L, Forno B, Sormani MP, Crocchiolo R, Zino E, Di Terlizzi S, Lupo Stanghellini MT, Mazzi B, Perna SK, Bondanza A, Middleton D, Palini A, Bernardi M, Bacchetta R, Peccatori J, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K.

Blood. 2008 Oct 15;112(8):3488-99. Epub 2008 Jul 21.PMID: 18645039 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+ T-regulatory cells: toward therapy for human diseases.

Allan SE, Broady R, Gregori S, Himmel ME, Locke N, Roncarolo MG, Bacchetta R, Levings MK.

Immunol Rev. 2008 Jun;223:391-421. Review.PMID: 18613849 [PubMed - indexed for MEDLINE]Related articles

Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft.

Gaziev J, Sodani P, Lucarelli G, Polchi P, Marktel S, Paciaroni K, Marziali M, Isgrò A, Simone MD, Roveda A, Montuoro A, Lanti A, Alfieri C, De Angelis G, Gallucci C, Ciceri F, Roncarolo MG.

Bone Marrow Transplant. 2008 Sep;42(6):397-404. Epub 2008 Jun 23.PMID: 18574445 [PubMed - indexed for MEDLINE]Related articles

Multiple BM harvests in pediatric donors for thalassemic siblings: safety, efficacy and ethical issues.

Biral E, Chiesa R, Cappelli B, Roccia T, Frugnoli I, Noè A, Soliman C, Fiori R, Cursi L, Cattaneo F, Evangelio C, Miniero R, Ciceri F, Roncarolo MG, Marktel S.

Bone Marrow Transplant. 2008 Sep;42(6):379-84. Epub 2008 Jun 23.PMID: 18574444 [PubMed - indexed for MEDLINE]Related articles

Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells.

Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, Bonifacio E, Roncarolo MG, Battaglia M.

Diabetes. 2008 Sep;57(9):2341-7. Epub 2008 Jun 16.PMID: 18559659 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells.

Hauben E, Gregori S, Draghici E, Migliavacca B, Olivieri S, Woisetschläger M, Roncarolo MG.

Blood. 2008 Aug 15;112(4):1214-22. Epub 2008 Jun 11.PMID: 18550851 [PubMed - indexed for MEDLINE]Related articlesFree article

Construction of human-SCID chimeric mice.

Roncarolo MG, Carballido JM.

Curr Protoc Immunol. 2001 May;Chapter 4:Unit 4.8.PMID: 18432798 [PubMed - indexed for MEDLINE]Related articles

Is FOXP3 a bona fide marker for human regulatory T cells?

Roncarolo MG, Gregori S.

Eur J Immunol. 2008 Apr;38(4):925-7. Review.PMID: 18395862 [PubMed - indexed for MEDLINE]Related articles

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

Passerini L, Allan SE, Battaglia M, Di Nunzio S, Alstad AN, Levings MK, Roncarolo MG, Bacchetta R.

Int Immunol. 2008 Mar;20(3):421-31. Epub 2008 Feb 12.PMID: 18270368 [PubMed - indexed for MEDLINE]Related articles

Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.

Cassani B, Mirolo M, Cattaneo F, Benninghoff U, Hershfield M, Carlucci F, Tabucchi A, Bordignon C, Roncarolo MG, Aiuti A.

Blood. 2008 Apr 15;111(8):4209-19. Epub 2008 Jan 24.PMID: 18218852 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of lentiviral gene therapy for Wiskott Aldrich syndrome.

Galy A, Roncarolo MG, Thrasher AJ.

Expert Opin Biol Ther. 2008 Feb;8(2):181-90. Review.PMID: 18194074 [PubMed - indexed for MEDLINE]Related articles

In vivo neutralization of inflammatory cytokines might not be necessary for regulatory T-cell immunotherapy.

Battaglia M, Roncarolo MG.

Nat Rev Immunol. 2007 Nov 30. [Epub ahead of print] No abstract available. PMID: 18049488 [PubMed - as supplied by publisher]Related articles

The role of tissue adaptation and graft size in immune tolerance.

Hauben E, Roncarolo MG, Draghici E, Nevo U.

Transpl Immunol. 2007 Nov;18(2):122-5. Epub 2007 Jun 15.PMID: 18005855 [PubMed - indexed for MEDLINE]Related articles

Progress and prospects: gene therapy clinical trials (part 2).

Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM.

Gene Ther. 2007 Nov;14(22):1555-63. Review. Erratum in: Gene Ther. 2007 Dec;14(24):1754. Alton, Eric [removed]; Ferrari, Stefano [removed]; Griesenbach, Uta [removed]; Aiuti, A [added]; Bachoud-Lévi, A C [added]; Blesch, A [added]; Brenner, M K [added]; Cattaneo, F [added]; Chiocca, E A [added]; Gao, G [added]; High, K A [added]; Leen, A M [added]; Lemoine, N R [added]; McNeish, I A [added]; Meneguzzi, G [added]; Peschanski, M [added]; Roncarolo, M G [added]; Strayer, D S [added]; Tuszynski, M H [added]; Waxman, D J [added]; Wilson, J M [added]. PMID: 17984995 [PubMed - indexed for MEDLINE]Related articles

Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

Allan SE, Alstad AN, Merindol N, Crellin NK, Amendola M, Bacchetta R, Naldini L, Roncarolo MG, Soudeyns H, Levings MK.

Mol Ther. 2008 Jan;16(1):194-202. Epub 2007 Nov 6.PMID: 17984976 [PubMed - indexed for MEDLINE]Related articles

Immunological lessons learnt from patients transplanted with fully mismatched stem cells.

Touraine JL, Plotnicky H, Roncarolo MG, Bacchetta R, Gebuhrer L.

Immunol Res. 2007;38(1-3):201-9.PMID: 17917026 [PubMed - indexed for MEDLINE]Related articles

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells.

Gregori S, Bacchetta R, Passerini L, Levings MK, Roncarolo MG.

Methods Mol Biol. 2007;380:83-105. Review.PMID: 17876089 [PubMed - indexed for MEDLINE]Related articles

Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.

Zino E, Vago L, Di Terlizzi S, Mazzi B, Zito L, Sironi E, Rossini S, Bonini C, Ciceri F, Roncarolo MG, Bordignon C, Fleischhauer K.

Biol Blood Marrow Transplant. 2007 Sep;13(9):1031-40. Epub 2007 Jul 20.PMID: 17697965 [PubMed - indexed for MEDLINE]Related articles

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy.

Aiuti A, Cassani B, Andolfi G, Mirolo M, Biasco L, Recchia A, Urbinati F, Valacca C, Scaramuzza S, Aker M, Slavin S, Cazzola M, Sartori D, Ambrosi A, Di Serio C, Roncarolo MG, Mavilio F, Bordignon C.

J Clin Invest. 2007 Aug;117(8):2233-40.PMID: 17671653 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of regulatory T cells and FOXP3 in human diseases.

Bacchetta R, Gambineri E, Roncarolo MG.

J Allergy Clin Immunol. 2007 Aug;120(2):227-35; quiz 236-7. Review.PMID: 17666212 [PubMed - indexed for MEDLINE]Related articles

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

Roncarolo MG, Battaglia M.

Nat Rev Immunol. 2007 Aug;7(8):585-98. Review.PMID: 17653126 [PubMed - indexed for MEDLINE]Related articles

Molecular purging of multiple myeloma cells by ex-vivo culture and retroviral transduction of mobilized-blood CD34+ cells.

Deola S, Scaramuzza S, Birolo RS, Cergnul M, Ficara F, Dando J, Voena C, Vai S, Monari M, Pogliani E, Corneo G, Peccatori J, Selleri S, Bordignon C, Roncarolo MG, Aiuti A, Bregni M.

J Transl Med. 2007 Jul 12;5:35.PMID: 17626627 [PubMed - in process]Related articlesFree article

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.

Annoni A, Battaglia M, Follenzi A, Lombardo A, Sergi-Sergi L, Naldini L, Roncarolo MG.

Blood. 2007 Sep 15;110(6):1788-96. Epub 2007 May 10.PMID: 17495135 [PubMed - indexed for MEDLINE]Related articlesFree article

A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome.

Marrella V, Poliani PL, Casati A, Rucci F, Frascoli L, Gougeon ML, Lemercier B, Bosticardo M, Ravanini M, Battaglia M, Roncarolo MG, Cavazzana-Calvo M, Facchetti F, Notarangelo LD, Vezzoni P, Grassi F, Villa A.

J Clin Invest. 2007 May;117(5):1260-9.PMID: 17476358 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG, Levings MK.

Int Immunol. 2007 Apr;19(4):345-54. Epub 2007 Feb 27.PMID: 17329235 [PubMed - indexed for MEDLINE]Related articlesFree article

WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells.

Marangoni F, Trifari S, Scaramuzza S, Panaroni C, Martino S, Notarangelo LD, Baz Z, Metin A, Cattaneo F, Villa A, Aiuti A, Battaglia M, Roncarolo MG, Dupré L.

J Exp Med. 2007 Feb 19;204(2):369-80. Epub 2007 Feb 12.PMID: 17296785 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.

Brown BD, Sitia G, Annoni A, Hauben E, Sergi LS, Zingale A, Roncarolo MG, Guidotti LG, Naldini L.

Blood. 2007 Apr 1;109(7):2797-805.PMID: 17170119 [PubMed - indexed for MEDLINE]Related articlesFree article