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Current advances and travails in islet transplantation.

Harlan DM, Kenyon NS, Korsgren O, Roep BO; Immunology of Diabetes Society.

Diabetes. 2009 Oct;58(10):2175-84. Review. No abstract available. PMID: 19794074 [PubMed - indexed for MEDLINE]Related articles

Challenges in developing endpoints for type 1 diabetes intervention studies.

Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Fleming GA, Pozzilli P, Little R, Schloot NC, Leslie RD, Skyler JS, Palmer JP.

Diabetes Metab Res Rev. 2009 Nov;25(8):694-704.PMID: 19771545 [PubMed - in process]Related articles

Revisiting infant growth prior to childhood onset type 1 diabetes.

Kharagjitsingh AV, de Ridder MA, Roep BO, Koeleman BP, Bruining GJ, Veeze HJ.

Clin Endocrinol (Oxf). 2009 Sep 10. [Epub ahead of print]PMID: 19744109 [PubMed - as supplied by publisher]Related articles

Induction of Treg by monocyte-derived DC modulated by vitamin D(3) or dexamethasone: Differential role for PD-L1.

Unger WW, Laban S, Kleijwegt FS, van der Slik AR, Roep BO.

Eur J Immunol. 2009 Aug 17;39(11):3147-3159. [Epub ahead of print]PMID: 19688742 [PubMed - as supplied by publisher]Related articles

TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program.

Chamorro S, García-Vallejo JJ, Unger WW, Fernandes RJ, Bruijns SC, Laban S, Roep BO, 't Hart BA, van Kooyk Y.

J Immunol. 2009 Sep 1;183(5):2984-94. Epub 2009 Jul 31.PMID: 19648269 [PubMed - indexed for MEDLINE]Related articles

Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.

Hilbrands R, Huurman VA, Gillard P, Velthuis JH, De Waele M, Mathieu C, Kaufman L, Pipeleers-Marichal M, Ling Z, Movahedi B, Jacobs-Tulleneers-Thevissen D, Monbaliu D, Ysebaert D, Gorus FK, Roep BO, Pipeleers DG, Keymeulen B.

Diabetes. 2009 Oct;58(10):2267-76. Epub 2009 Jul 14.PMID: 19602536 [PubMed - indexed for MEDLINE]Related articles

Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies.

Gillard P, Huurman V, Van der Auwera B, Decallonne B, Poppe K, Roep BO, Gorus F, Mathieu C, Pipeleers D, Keymeulen B.

Diabetes Care. 2009 Oct;32(10):1817-9. Epub 2009 Jun 23.PMID: 19549735 [PubMed - in process]Related articles

Development of type 1 diabetes in a patient treated with anti-TNF-alpha therapy for active rheumatoid arthritis.

Tack CJ, Kleijwegt FS, Van Riel PL, Roep BO.

Diabetologia. 2009 Jul;52(7):1442-4. Epub 2009 May 14. No abstract available. PMID: 19440690 [PubMed - indexed for MEDLINE]Related articlesFree article

The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases.

Kurreeman FA, Goulielmos GN, Alizadeh BZ, Rueda B, Houwing-Duistermaat J, Sánchez E, Bevova M, Radstake TR, Vonk MC, Galanakis E, Ortego N, Verduyn W, Zervou MI, Consortium S, Roep BO, Dema B, Espino L, Urcelay E, Boumpas DT, van den Berg LH, Wijmenga C, Koeleman BP, Huizinga TW, Toes RE, Martin J.

Ann Rheum Dis. 2009 May 18. [Epub ahead of print]PMID: 19433411 [PubMed - as supplied by publisher]Related articles

Immune markers of disease and therapeutic intervention in type 1 diabetes.

Roep BO.

Novartis Found Symp. 2008;292:159-71; discussion 171-3, 202-3.PMID: 19203098 [PubMed - indexed for MEDLINE]Related articles

Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation.

Roelen DL, Huurman VA, Hilbrands R, Gillard P, Duinkerken G, van der Meer-Prins PW, Versteeg-van der Voort Maarschalk MF, Mathieu C, Keymeulen B, Pipeleers DG, Roep BO, Claas FH.

Clin Exp Immunol. 2009 Apr;156(1):141-8. Epub 2009 Jan 21.PMID: 19161445 [PubMed - indexed for MEDLINE]Related articles

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

Velthuis JH, Unger WW, van der Slik AR, Duinkerken G, Engelse M, Schaapherder AF, Ringers J, van Kooten C, de Koning EJ, Roep BO.

Diabetologia. 2009 Mar;52(3):494-503. Epub 2008 Dec 23.PMID: 19104770 [PubMed - indexed for MEDLINE]Related articles

Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation.

Huurman VA, Velthuis JH, Hilbrands R, Tree TI, Gillard P, van der Meer-Prins PM, Duinkerken G, Pinkse GG, Keymeulen B, Roelen DL, Claas FH, Pipeleers DG, Roep BO.

Am J Transplant. 2009 Feb;9(2):382-8. Epub 2008 Nov 27.PMID: 19067657 [PubMed - indexed for MEDLINE]Related articles

[Indications for a favourable effect of intensive insulin therapy for newly-diagnosed type 2 diabetes]

Roep BO, Pijl H.

Ned Tijdschr Geneeskd. 2008 Nov 1;152(44):2378-80. Dutch. PMID: 19055134 [PubMed - indexed for MEDLINE]Related articles

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M.

J Clin Invest. 2008 Oct;118(10):3390-402. Erratum in: J Clin Invest. 2009 Sep;119(9):2844. Unger, Wendy [corrected to Unger, Wendy W]. PMID: 18802479 [PubMed - indexed for MEDLINE]Related articlesFree article

Study of the association between the CAPSL-IL7R locus and type 1 diabetes.

Santiago JL, Alizadeh BZ, Martínez A, Espino L, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG, Roep BO, Koeleman BP, Urcelay E.

Diabetologia. 2008 Sep;51(9):1653-8. Epub 2008 Jun 18.PMID: 18563381 [PubMed - indexed for MEDLINE]Related articles

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.

Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, van de Linde P, van der Meer-Prins PM, Versteeg-van der Voort Maarschalk MF, Verbeeck K, Alizadeh BZ, Mathieu C, Gorus FK, Roelen DL, Claas FH, Keymeulen B, Pipeleers DG, Roep BO.

PLoS One. 2008 Jun 18;3(6):e2435.PMID: 18560516 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?

Roep BO.

Diabetes. 2008 May;57(5):1156. No abstract available. PMID: 18443371 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.

Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, Kolb H, Roep BO, Mortensen HB, Schloot NC; Hvidøre Study Group On Childhood Diabetes.

Clin Immunol. 2008 Jul;128(1):57-65. Epub 2008 Apr 22.PMID: 18434252 [PubMed - indexed for MEDLINE]Related articles

Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes.

Huurman VA, van der Meide PE, Duinkerken G, Willemen S, Cohen IR, Elias D, Roep BO.

Clin Exp Immunol. 2008 Jun;152(3):488-97. Epub 2008 Apr 16.PMID: 18422727 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes.

Sanda S, Roep BO, von Herrath M.

Clin Immunol. 2008 May;127(2):138-43. Epub 2008 Mar 4.PMID: 18304876 [PubMed - indexed for MEDLINE]Related articles

Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.

Pfleger C, Mortensen HB, Hansen L, Herder C, Roep BO, Hoey H, Aanstoot HJ, Kocova M, Schloot NC; Hvidøre Study Group on Childhood Diabetes.

Diabetes. 2008 Apr;57(4):929-37. Epub 2008 Feb 25.PMID: 18299313 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients.

Kharagjitsingh AV, Prinsen K, Lemkes HH, de Vries RR, Roep BO, Buschard K.

Diabet Med. 2008 Feb;25(2):236-8. Epub 2008 Jan 21.PMID: 18215173 [PubMed - indexed for MEDLINE]Related articles

Diabetes: missing links.

Roep BO.

Nature. 2007 Dec 6;450(7171):799-800. No abstract available. PMID: 18063992 [PubMed - indexed for MEDLINE]Related articles

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, van Heel DA, van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C.

Am J Hum Genet. 2007 Dec;81(6):1284-8. Epub 2007 Oct 24.PMID: 17999365 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y.

Huurman VA, Unger WW, Koeleman BP, Oaks MK, Chandraker AK, Terpstra OT, Roep BO.

Clin Exp Immunol. 2007 Dec;150(3):487-93. Epub 2007 Oct 9.PMID: 17924973 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies against multiple tissues in type 1 diabetes.

Roep BO.

Neth J Med. 2007 Jul-Aug;65(7):225-6. No abstract available. PMID: 17656808 [PubMed - indexed for MEDLINE]Related articlesFree article

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis.

Alizadeh BZ, Valdigem G, Coenen MJ, Zhernakova A, Franke B, Monsuur A, van Riel PL, Barrera P, Radstake TR, Roep BO, Wijmenga C, Koeleman BP.

Hum Mol Genet. 2007 Nov 1;16(21):2552-9. Epub 2007 Jul 25.PMID: 17652100 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Selective unresponsiveness to beta cell autoantigens after induction immunosuppression in pancreas transplantation with anti-interleukin-2 receptor antibody versus anti-thymocyte globulin.

van de Linde P, Vd Boog PJ, Tysma OM, Elliott JF, Roelen DL, Claas FH, de Fijter JW, Roep BO.

Clin Exp Immunol. 2007 Jul;149(1):56-62. Epub 2007 Apr 25.PMID: 17459076 [PubMed - indexed for MEDLINE]Related articlesFree article

Modelling KIR-HLA genotype disparities in type 1 diabetes.

van der Slik AR, Alizadeh BZ, Koeleman BP, Roep BO, Giphart MJ.

Tissue Antigens. 2007 Apr;69 Suppl 1:101-5.PMID: 17445178 [PubMed - indexed for MEDLINE]Related articles

Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.

van der Slik AR, van den Eng I, Eerligh P, Doxiadis II, Koeleman BP, Roep BO, Giphart MJ.

Tissue Antigens. 2007 Apr;69(4):348-53.PMID: 17389020 [PubMed - indexed for MEDLINE]Related articles

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.

Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T.

Diabet Med. 2007 May;24(5):512-20. Epub 2007 Mar 22.PMID: 17381505 [PubMed - indexed for MEDLINE]Related articles

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.PMID: 17376840 [PubMed - indexed for MEDLINE]Related articles

Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth.

Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:1-10. Epub 2007 Mar 21. Review.PMID: 17376838 [PubMed - indexed for MEDLINE]Related articles

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.

Dotta F, Censini S, van Halteren AG, Marselli L, Masini M, Dionisi S, Mosca F, Boggi U, Muda AO, Prato SD, Elliott JF, Covacci A, Rappuoli R, Roep BO, Marchetti P.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5115-20. Epub 2007 Mar 14.PMID: 17360338 [PubMed - indexed for MEDLINE]Related articlesFree article

MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis.

Alizadeh BZ, Eerligh P, van der Slik AR, Shastry A, Zhernakova A, Valdigem G, Bruining JG, Sanjeevi CB, Wijmenga C, Roep BO, Koeleman BP.

Mol Immunol. 2007 Apr;44(11):2806-12. Epub 2007 Mar 12.PMID: 17350686 [PubMed - indexed for MEDLINE]Related articles

Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.

Di Lorenzo TP, Peakman M, Roep BO.

Clin Exp Immunol. 2007 Apr;148(1):1-16. Review.PMID: 17349009 [PubMed - indexed for MEDLINE]Related articlesFree article

The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.

van Etten E, Verlinden L, Giulietti A, Ramos-Lopez E, Branisteanu DD, Ferreira GB, Overbergh L, Verstuyf A, Bouillon R, Roep BO, Badenhoop K, Mathieu C.

Eur J Immunol. 2007 Feb;37(2):395-405.PMID: 17274004 [PubMed - indexed for MEDLINE]Related articles

HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee.

Pinkse GG, Boitard C, Tree TI, Peakman M, Roep BO.

Ann N Y Acad Sci. 2006 Oct;1079:19-23.PMID: 17130527 [PubMed - indexed for MEDLINE]Related articles

A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop.

Tree TI, Roep BO, Peakman M.

Ann N Y Acad Sci. 2006 Oct;1079:9-18. Review.PMID: 17130526 [PubMed - indexed for MEDLINE]Related articles

Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients.

Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO.

Diabetes Metab Res Rev. 2007 May;23(4):269-75.PMID: 17024692 [PubMed - indexed for MEDLINE]Related articles

Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.

Alizadeh BZ, Hanifi-Moghaddam P, Eerligh P, van der Slik AR, Kolb H, Kharagjitsingh AV, Pereira Arias AM, Ronkainen M, Knip M, Bonfanti R, Bonifacio E, Devendra D, Wilkin T, Giphart MJ, Koeleman BP, Nolsøe R, Mandrup Poulsen T, Schloot NC, Roep BO; DIABMARKER Study Group.

Clin Exp Immunol. 2006 Sep;145(3):480-4.PMID: 16907917 [PubMed - indexed for MEDLINE]Related articlesFree article

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

Durinovic-Belló I, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hampl J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Kamradt T, Maeurer MJ, Nhan C, Roep BO, Boehm BO, Polychronakos C, Nepom GT, Karges W, McDevitt HO, Sønderstrup G.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11683-8. Epub 2006 Jul 25.PMID: 16868084 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.

Zhernakova A, Alizadeh BZ, Eerligh P, Hanifi-Moghaddam P, Schloot NC, Diosdado B, Wijmenga C, Roep BO, Koeleman BP.

Genes Immun. 2006 Oct;7(7):544-9. Epub 2006 Jul 20.PMID: 16855620 [PubMed - indexed for MEDLINE]Related articles

Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.

Niks EH, Kuks JB, Roep BO, Haasnoot GW, Verduijn W, Ballieux BE, De Baets MH, Vincent A, Verschuuren JJ.

Neurology. 2006 Jun 13;66(11):1772-4.PMID: 16769963 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of antibody immunotherapy on clonal islet reactive T cells.

van de Linde P, Tysma OM, Medema JP, Hale G, Waldmann H, Roelen DL, Roep BO.

Hum Immunol. 2006 Apr-May;67(4-5):264-73. Epub 2006 Apr 7.PMID: 16720206 [PubMed - indexed for MEDLINE]Related articles

Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity.

Bouwman LH, Roep BO, Roos A.

Hum Immunol. 2006 Apr-May;67(4-5):247-56. Epub 2006 Apr 17. Review.PMID: 16720204 [PubMed - indexed for MEDLINE]Related articles

Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.

Orozco G, Eerligh P, Sánchez E, Zhernakova S, Roep BO, González-Gay MA, López-Nevot MA, Callejas JL, Hidalgo C, Pascual-Salcedo D, Balsa A, González-Escribano MF, Koeleman BP, Martín J.

Hum Immunol. 2005 Dec;66(12):1235-41. Epub 2006 Mar 9.PMID: 16690410 [PubMed - indexed for MEDLINE]Related articles

Choice of antibody immunotherapy influences cytomegalovirus viremia in simultaneous pancreas-kidney transplant recipients.

Huurman VA, Kalpoe JS, van de Linde P, Vaessen N, Ringers J, Kroes AC, Roep BO, De Fijter JW.

Diabetes Care. 2006 Apr;29(4):842-7.PMID: 16567825 [PubMed - indexed for MEDLINE]Related articlesFree article