PubMed

Arrhythmia Pharmacogenomics: Methodological Considerations.

Roden DM, Kannankeri PJ, Darbar D.

Curr Pharm Des. 2009;15(32):3734-3741.PMID: 19925424 [PubMed - as supplied by publisher]Related articles

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI.

Circ Arrhythm Electrophysiol. 2009 Aug;2(4):417-26. Epub 2009 May 22.PMID: 19808498 [PubMed - indexed for MEDLINE]Related articles

Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.

Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM.

Circ Arrhythm Electrophysiol. 2009 Jun;2(3):268-75. Epub 2009 Mar 6.PMID: 19808477 [PubMed - indexed for MEDLINE]Related articles

Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study.

Watanabe H, Watanabe T, Sasaki S, Nagai K, Roden DM, Aizawa Y.

Am Heart J. 2009 Oct;158(4):629-36.PMID: 19781424 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular effects of noncardiovascular drugs.

Raj SR, Stein CM, Saavedra PJ, Roden DM.

Circulation. 2009 Sep 22;120(12):1123-32. Review. No abstract available. PMID: 19770411 [PubMed - indexed for MEDLINE]Related articles

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org).

Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, Wilde AA.

Heart Rhythm. 2009 Sep;6(9):1335-41. Epub 2009 Jul 8.PMID: 19716089 [PubMed - in process]Related articles

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.

Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA.

Circulation. 2009 Aug 18;120(7):553-9. Epub 2009 Aug 3.PMID: 19652097 [PubMed - indexed for MEDLINE]Related articles

ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling.

Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D.

Heart Rhythm. 2009 Sep;6(9):1327-32. Epub 2009 May 15.PMID: 19648063 [PubMed - in process]Related articlesFree article

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation.

Abraham RL, Yang T, Blair M, Roden DM, Darbar D.

J Mol Cell Cardiol. 2009 Jul 30. [Epub ahead of print]PMID: 19646991 [PubMed - as supplied by publisher]Related articles

Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.

Bush WS, Crawford DC, Alexander C, George AL Jr, Roden DM, Ritchie MD.

Pharmacogenomics. 2009 Jun;10(6):1043-53.PMID: 19530973 [PubMed - indexed for MEDLINE]Related articles

The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.

McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM.

J Cardiovasc Pharmacol. 2009 Jul;54(1):63-71.PMID: 19528813 [PubMed - in process]Related articles

Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation.

Yang T, Kanki H, Zhang W, Roden DM.

Br J Pharmacol. 2009 Jul;157(6):952-61. Epub 2009 Jun 12.PMID: 19522859 [PubMed - in process]Related articles

Clopidogrel and the concept of high-risk pharmacokinetics.

Roden DM, Stein CM.

Circulation. 2009 Apr 28;119(16):2127-30. No abstract available. PMID: 19398674 [PubMed - indexed for MEDLINE]Related articles

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.

Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC.

Nat Med. 2009 Apr;15(4):380-3. Epub 2009 Mar 29.PMID: 19330009 [PubMed - indexed for MEDLINE]Related articles

A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation.

Husser D, Stridh M, Sörnmo L, Roden DM, Darbar D, Bollmann A.

Circ Arrhythm Electrophysiol. 2009 Feb;2(1):24-8.PMID: 19305639 [PubMed - indexed for MEDLINE]Related articlesFree article

Estimation of the warfarin dose with clinical and pharmacogenetic data.

International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA.

N Engl J Med. 2009 Feb 19;360(8):753-64. Erratum in: N Engl J Med. 2009 Oct 15;361(16):1613. Dosage error in article text. PMID: 19228618 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG.

McBride BF, Yang T, Roden DM.

Pharmacogenomics J. 2009 Jun;9(3):194-201. Epub 2009 Feb 10.PMID: 19204737 [PubMed - indexed for MEDLINE]Related articles

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.

Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT.

Eur Heart J. 2009 Apr;30(7):813-9. Epub 2009 Jan 13.PMID: 19141561 [PubMed - indexed for MEDLINE]Related articles

Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.

Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D.

Blood. 2009 Apr 23;113(17):3925-30. Epub 2008 Dec 12.PMID: 19074728 [PubMed - indexed for MEDLINE]Related articlesFree article

Repolarization reserve: a moving target.

Roden DM.

Circulation. 2008 Sep 2;118(10):981-2. No abstract available. PMID: 18765386 [PubMed - indexed for MEDLINE]Related articlesFree article

Keep the QT interval: it is a reliable predictor of ventricular arrhythmias.

Roden DM.

Heart Rhythm. 2008 Aug;5(8):1213-5. Epub 2008 May 15. No abstract available. PMID: 18675237 [PubMed - indexed for MEDLINE]Related articles

Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise.

Kannankeril PJ, Harris PA, Norris KJ, Warsy I, Smith PD, Roden DM.

J Cardiovasc Electrophysiol. 2008 Dec;19(12):1284-8. Epub 2008 Jul 28.PMID: 18665873 [PubMed - indexed for MEDLINE]Related articles

Cellular basis of drug-induced torsades de pointes.

Roden DM.

Br J Pharmacol. 2008 Aug;154(7):1502-7. Epub 2008 Jun 16. Review.PMID: 18552874 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.

Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ.

Blood. 2008 Aug 15;112(4):1022-7. Epub 2008 Jun 5.PMID: 18535201 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a large-scale de-identified DNA biobank to enable personalized medicine.

Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, Masys DR.

Clin Pharmacol Ther. 2008 Sep;84(3):362-9. Epub 2008 May 21.PMID: 18500243 [PubMed - indexed for MEDLINE]Related articles

Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans.

Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kääb S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR.

J Clin Invest. 2008 Jun;118(6):2260-8.PMID: 18464934 [PubMed - indexed for MEDLINE]Related articlesFree article

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.

Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S, Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz PJ, George AL Jr, Roden DM.

J Clin Invest. 2008 Jun;118(6):2219-29.PMID: 18451998 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.

Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefield T, Haines JL, George AL Jr, Roden DM.

Circulation. 2008 Apr 15;117(15):1927-35. Epub 2008 Mar 31.PMID: 18378609 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged signal-averaged P-wave duration as an intermediate phenotype for familial atrial fibrillation.

Darbar D, Hardy A, Haines JL, Roden DM.

J Am Coll Cardiol. 2008 Mar 18;51(11):1083-9.PMID: 18342226 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic determinants of response to warfarin during initial anticoagulation.

Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM.

N Engl J Med. 2008 Mar 6;358(10):999-1008.PMID: 18322281 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome.

Darbar D, Kimbrough J, Jawaid A, McCray R, Ritchie MD, Roden DM.

J Am Coll Cardiol. 2008 Feb 26;51(8):836-42.PMID: 18294569 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic framework for improving arrhythmia therapy.

Knollmann BC, Roden DM.

Nature. 2008 Feb 21;451(7181):929-36. Review.PMID: 18288182 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study.

Watanabe H, Tanabe N, Watanabe T, Darbar D, Roden DM, Sasaki S, Aizawa Y.

Circulation. 2008 Mar 11;117(10):1255-60. Epub 2008 Feb 19.PMID: 18285562 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac potassium channel dysfunction in sudden infant death syndrome.

Rhodes TE, Abraham RL, Welch RC, Vanoye CG, Crotti L, Arnestad M, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Rognum T, Roden DM, Schwartz PJ, George AL Jr.

J Mol Cell Cardiol. 2008 Mar;44(3):571-81. Epub 2007 Dec 7.PMID: 18222468 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical practice. Long-QT syndrome.

Roden DM.

N Engl J Med. 2008 Jan 10;358(2):169-76. Review. No abstract available. PMID: 18184962 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the cardiac sodium channel promoter displaying variant in vitro expression activity.

Yang P, Koopmann TT, Pfeufer A, Jalilzadeh S, Schulze-Bahr E, Kääb S, Wilde AA, Roden DM, Bezzina CR.

Eur J Hum Genet. 2008 Mar;16(3):350-7. Epub 2007 Dec 5.PMID: 18059420 [PubMed - indexed for MEDLINE]Related articlesFree article

On the relationship among QT interval, atrial fibrillation, and torsade de pointes.

Roden DM, Kannankeril P, Darbar D.

Europace. 2007 Sep;9 Suppl 4:iv1-3. No abstract available. PMID: 17766319 [PubMed - indexed for MEDLINE]Related articlesFree article

A shock in time.

Fitch RW, Gregory A, Darbar D, Roden DM.

Clin J Sport Med. 2007 Nov;17(6):497-9. No abstract available. PMID: 17993795 [PubMed - indexed for MEDLINE]Related articles

Coinheritance of long QT syndrome and Kearns-Sayre syndrome.

Skinner JR, Yang T, Purvis D, Chung SK, Roden DM, Rees MI.

Heart Rhythm. 2007 Dec;4(12):1568-72. Epub 2007 Aug 15. No abstract available. PMID: 17980675 [PubMed - indexed for MEDLINE]Related articles

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM.

Nat Rev Drug Discov. 2007 Nov;6(11):904-16. Review. Erratum in: Nat Rev Drug Discov. 2008 Feb;7(2):185. PMID: 17971785 [PubMed - indexed for MEDLINE]Related articlesFree article

A memorable experience.

Monahan K, Clair W, Roden DM.

Europace. 2007 Nov;9(11):1091-2. Epub 2007 Oct 6.PMID: 17921515 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.

Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ.

Circulation. 2007 Sep 11;116(11 Suppl):I1-7.PMID: 17846288 [PubMed - indexed for MEDLINE]Related articlesFree article

Autonomic tone attenuates drug-induced QT prolongation.

Smith AH, Norris KJ, Roden DM, Kannankeril PJ.

J Cardiovasc Electrophysiol. 2007 Sep;18(9):960-4. Epub 2007 Jul 30.PMID: 17666066 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates.

Chopra SS, Watanabe H, Zhong TP, Roden DM.

BMC Evol Biol. 2007 Jul 10;7:113.PMID: 17623065 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation.

Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM.

Heart Rhythm. 2007 Jun;4(6):743-9. Epub 2007 Feb 9.PMID: 17556195 [PubMed - indexed for MEDLINE]Related articlesFree article

A rate-independent method of assessing QT-RR slope following conversion of atrial fibrillation.

Darbar D, Hardin B, Harris P, Roden DM.

J Cardiovasc Electrophysiol. 2007 Jun;18(6):636-41. Epub 2007 May 3.PMID: 17488270 [PubMed - indexed for MEDLINE]Related articles

When good drugs go bad.

Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y.

Nature. 2007 Apr 26;446(7139):975-7. No abstract available. PMID: 17460642 [PubMed - indexed for MEDLINE]Related articles

When should QT be measured? Summer solstice or Christmas Eve?

Kannankeril PJ, Roden DM.

Heart Rhythm. 2007 Mar;4(3):282-3. Epub 2006 Dec 6. No abstract available. PMID: 17341388 [PubMed - indexed for MEDLINE]Related articles

The pharmacogenetics research network: from SNP discovery to clinical drug response.

Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I; Pharmacogenetics Research Network.

Clin Pharmacol Ther. 2007 Mar;81(3):328-45. Review.PMID: 17339863 [PubMed - indexed for MEDLINE]Related articles

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes.

Mohler PJ, Le Scouarnec S, Denjoy I, Lowe JS, Guicheney P, Caron L, Driskell IM, Schott JJ, Norris K, Leenhardt A, Kim RB, Escande D, Roden DM.

Circulation. 2007 Jan 30;115(4):432-41. Epub 2007 Jan 22.PMID: 17242276 [PubMed - indexed for MEDLINE]Related articlesFree article