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    Results: 1 to 50 of 67

    1.

    A Conjugated Linoleic Acid-Enriched Beef Diet Attenuates Lipopolysaccharide-Induced Inflammation in Mice in Part through PPAR{gamma}-Mediated Suppression of Toll-Like Receptor 4.

    Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM.

    J Nutr. 2009 Dec;139(12):2351-7. Epub 2009 Oct 21.PMID: 19846417 [PubMed - in process]Related articles

    2.

    Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome.

    Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM.

    Am J Clin Nutr. 2009 Dec;90(6):1665-73. Epub 2009 Oct 14.PMID: 19828715 [PubMed - in process]Related articles

    3.

    Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: From the LIPGENE study.

    Perez-Martinez P, Moreno-Conde M, Cruz-Teno C, Ruano J, Fuentes F, Delgado-Lista J, Garcia-Rios A, Marin C, Gomez-Luna MJ, Perez-Jimenez F, Roche HM, Lopez-Miranda J.

    Atherosclerosis. 2009 Sep 20. [Epub ahead of print]PMID: 19818442 [PubMed - as supplied by publisher]Related articles

    4.

    Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults.

    Phillips CM, Goumidi L, Bertrais S, Field MR, Peloso GM, Shen J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM.

    J Nutr. 2009 Nov;139(11):2011-7. Epub 2009 Sep 23.PMID: 19776189 [PubMed - in process]Related articles

    5.

    Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

    McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP.

    J Biol Chem. 2009 Nov 13;284(46):31936-44. Epub 2009 Sep 23.PMID: 19776010 [PubMed - in process]Related articles

    6.

    Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet.

    de Roos B, Rungapamestry V, Ross K, Rucklidge G, Reid M, Duncan G, Horgan G, Toomey S, Browne J, Loscher CE, Mills KH, Roche HM.

    Proteomics. 2009 Jun;9(12):3244-56.PMID: 19562798 [PubMed - indexed for MEDLINE]Related articles

    7.

    The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation - insights from the LIPGENE study.

    Hartwich J, Malec MM, Partyka L, Pérez-Martinez P, Marin C, López-Miranda J, Tierney AC, Mc Monagle J, Roche HM, Defoort C, Wolkow P, Dembinska-Kieć A.

    Clin Nutr. 2009 Oct;28(5):510-5. Epub 2009 May 28.PMID: 19481310 [PubMed - in process]Related articles

    8.

    Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages.

    Mullen A, Loscher CE, Roche HM.

    J Nutr Biochem. 2009 May 7. [Epub ahead of print]PMID: 19427777 [PubMed - as supplied by publisher]Related articles

    9.

    Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.

    Guillén N, Navarro MA, Arnal C, Noone E, Arbonés-Mainar JM, Acín S, Surra JC, Muniesa P, Roche HM, Osada J.

    Physiol Genomics. 2009 May 13;37(3):187-98. Epub 2009 Mar 3.PMID: 19258494 [PubMed - indexed for MEDLINE]Related articles

    10.

    The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation.

    Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, Brennan L, Caesar R, Cinti S, Coort SL, Crosley K, Daniel H, Drevon CA, Duthie S, Eijssen L, Elliott RM, van Erk M, Evelo C, Gibney M, Heim C, Horgan GW, Johnson IT, Kelder T, Kleemann R, Kooistra T, van Iersel MP, Mariman EC, Mayer C, McLoughlin G, Müller M, Mulholland F, van Ommen B, Polley AC, Pujos-Guillot E, Rubio-Aliaga I, Roche HM, de Roos B, Sailer M, Tonini G, Williams LM, de Wit N; For the NuGO PPS Team.

    Genes Nutr. 2008 Dec;3(3-4):147-151. Epub 2008 Nov 26. No abstract available. PMID: 19034556 [PubMed - as supplied by publisher]Related articlesFree article

    11.

    Session 2: Personalised nutrition. Transcriptomic signatures that have identified key features of metabolic syndrome.

    Morine MJ, O'Brien C, Roche HM.

    Proc Nutr Soc. 2008 Nov;67(4):395-403. Review.PMID: 18847516 [PubMed - indexed for MEDLINE]Related articles

    12.

    The challenges for molecular nutrition research 4: the "nutritional systems biology level".

    van Ommen B, Cavallieri D, Roche HM, Klein UI, Daniel H.

    Genes Nutr. 2008 Dec;3(3-4):107-13. Epub 2008 Sep 30.PMID: 18825427 [PubMed - in process]Related articlesFree article

    13.

    The Lipgene Food-Exchange Model: a tool to enable investigation of four diets distinct in fatty acid composition.

    Shaw DI, Tierney AC, McCarthy S, Uprichard J, Vermunt S, Roche HM, Lovegrove JA.

    Proc Nutr Soc. 2008 May;67(OCE):E86. Review. No abstract available. PMID: 18768093 [PubMed - indexed for MEDLINE]Related articles

    14.

    LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries.

    Shaw DI, Tierney AC, McCarthy S, Upritchard J, Vermunt S, Gulseth HL, Drevon CA, Blaak EE, Saris WH, Karlström B, Helal O, Defoort C, Gallego R, López-Miranda J, Siedlecka D, Malczewska-Malec M, Roche HM, Lovegrove JA.

    Br J Nutr. 2009 Mar;101(5):750-9. Epub 2008 Aug 5.PMID: 18680629 [PubMed - in process]Related articles

    15.

    Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2.

    Reynolds CM, Loscher CE, Moloney AP, Roche HM.

    Br J Nutr. 2008 Jul;100(1):13-7.PMID: 18275620 [PubMed - indexed for MEDLINE]Related articles

    16.

    Gene-nutrient interactions in the metabolic syndrome.

    Phillips CM, Tierney AC, Roche HM.

    J Nutrigenet Nutrigenomics. 2008;1(3):136-51. Epub 2008 Feb 20. Review.PMID: 19776623 [PubMed - indexed for MEDLINE]Related articles

    17.

    The potential role of olive oil-derived MUFA in insulin sensitivity.

    Tierney AC, Roche HM.

    Mol Nutr Food Res. 2007 Oct;51(10):1235-48. Review.PMID: 17912722 [PubMed - indexed for MEDLINE]Related articles

    18.

    Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males.

    Mullen A, Moloney F, Nugent AP, Doyle L, Cashman KD, Roche HM.

    J Nutr Biochem. 2007 Oct;18(10):658-66. Epub 2007 Mar 21.PMID: 17368881 [PubMed - indexed for MEDLINE]Related articles

    19.

    Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue.

    Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, Roche HM.

    Diabetes. 2007 Mar;56(3):574-82.PMID: 17327424 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Conjugated linoleic acid: a functional nutrient in the different pathophysiological components of the metabolic syndrome?

    Toomey S, McMonagle J, Roche HM.

    Curr Opin Clin Nutr Metab Care. 2006 Nov;9(6):740-7. Review.PMID: 17053429 [PubMed - indexed for MEDLINE]Related articles

    21.

    Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans.

    Walsh MC, Brennan L, Malthouse JP, Roche HM, Gibney MJ.

    Am J Clin Nutr. 2006 Sep;84(3):531-9.PMID: 16960166 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.

    Weldon SM, Mullen AC, Loscher CE, Hurley LA, Roche HM.

    J Nutr Biochem. 2007 Apr;18(4):250-8. Epub 2006 Jun 16.PMID: 16781858 [PubMed - indexed for MEDLINE]Related articles

    23.

    Genetic and nutrient determinants of the metabolic syndrome.

    Phillips C, Lopez-Miranda J, Perez-Jimenez F, McManus R, Roche HM.

    Curr Opin Cardiol. 2006 May;21(3):185-93. Review.PMID: 16601455 [PubMed - indexed for MEDLINE]Related articles

    24.

    Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells.

    Renaville B, Mullen A, Moloney F, Larondelle Y, Schneider YJ, Roche HM.

    Br J Nutr. 2006 Apr;95(4):688-95.PMID: 16571147 [PubMed - indexed for MEDLINE]Related articles

    25.

    Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice.

    Arbonés-Mainar JM, Navarro MA, Guzmán MA, Arnal C, Surra JC, Acín S, Carnicer R, Osada J, Roche HM.

    Atherosclerosis. 2006 Dec;189(2):318-27. Epub 2006 Mar 13.PMID: 16530768 [PubMed - indexed for MEDLINE]Related articles

    26.

    Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells.

    Shah SA, Mahmud N, Mftah M, Roche HM, Kelleher D.

    Eur J Cancer Prev. 2006 Apr;15(2):125-33.PMID: 16523009 [PubMed - indexed for MEDLINE]Related articles

    27.

    Trans-10, cis-12- and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice.

    Arbonés-Mainar JM, Navarro MA, Acín S, Guzmán MA, Arnal C, Surra JC, Carnicer R, Roche HM, Osada J.

    J Nutr. 2006 Feb;136(2):353-9.PMID: 16424111 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction.

    Loscher CE, Draper E, Leavy O, Kelleher D, Mills KH, Roche HM.

    J Immunol. 2005 Oct 15;175(8):4990-8.PMID: 16210601 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    Profound resolution of early atherosclerosis with conjugated linoleic acid.

    Toomey S, Harhen B, Roche HM, Fitzgerald D, Belton O.

    Atherosclerosis. 2006 Jul;187(1):40-9. Epub 2005 Sep 22.PMID: 16182300 [PubMed - indexed for MEDLINE]Related articles

    30.

    Metabolomics in human nutrition: opportunities and challenges.

    Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B.

    Am J Clin Nutr. 2005 Sep;82(3):497-503. Review.PMID: 16155259 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.

    de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE, Roche HM.

    FASEB J. 2005 Oct;19(12):1746-8. Epub 2005 Jul 29.PMID: 16055499 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    The metabolic syndrome: the crossroads of diet and genetics.

    Roche HM, Phillips C, Gibney MJ.

    Proc Nutr Soc. 2005 Aug;64(3):371-7. Review.PMID: 16048671 [PubMed - indexed for MEDLINE]Related articles

    33.

    Fatty acids and the metabolic syndrome.

    Roche HM.

    Proc Nutr Soc. 2005 Feb;64(1):23-9. Review.PMID: 15877919 [PubMed - indexed for MEDLINE]Related articles

    34.

    LPS induced tissue factor expression in the THP-1 monocyte cell line is attenuated by conjugated linoleic acid.

    Norris LA, Weldon S, Nugent A, Roche HM.

    Thromb Res. 2006;117(4):475-80. No abstract available. PMID: 15869788 [PubMed - indexed for MEDLINE]Related articles

    35.

    The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers.

    Nugent AP, Roche HM, Noone EJ, Long A, Kelleher DK, Gibney MJ.

    Eur J Clin Nutr. 2005 Jun;59(6):742-50.PMID: 15827560 [PubMed - indexed for MEDLINE]Related articles

    36.

    Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men.

    Doyle L, Jewell C, Mullen A, Nugent AP, Roche HM, Cashman KD.

    Eur J Clin Nutr. 2005 Mar;59(3):432-40.PMID: 15674313 [PubMed - indexed for MEDLINE]Related articles

    37.

    Increased intake of fruit and vegetables and a low-fat diet, with and without low-fat plant sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism.

    Colgan HA, Floyd S, Noone EJ, Gibney MJ, Roche HM.

    J Hum Nutr Diet. 2004 Dec;17(6):561-9; quiz 571-4.PMID: 15546434 [PubMed - indexed for MEDLINE]Related articles

    38.

    Dietary lipids and gene expression.

    Roche HM.

    Biochem Soc Trans. 2004 Dec;32(Pt 6):999-1002. Review.PMID: 15506946 [PubMed - indexed for MEDLINE]Related articles

    39.

    Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus.

    Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM.

    Am J Clin Nutr. 2004 Oct;80(4):887-95.PMID: 15447895 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Conjugated linoleic acid and atherosclerosis: no effect on molecular markers of cholesterol homeostasis in THP-1 macrophages.

    Weldon S, Mitchell S, Kelleher D, Gibney MJ, Roche HM.

    Atherosclerosis. 2004 Jun;174(2):261-73.PMID: 15136056 [PubMed - indexed for MEDLINE]Related articles

    41.

    Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study.

    Tully AM, Roche HM, Doyle R, Fallon C, Bruce I, Lawlor B, Coakley D, Gibney MJ.

    Br J Nutr. 2003 Apr;89(4):483-9.PMID: 12654166 [PubMed - indexed for MEDLINE]Related articles

    42.

    Acute-on-chronic effects of fatty acids on intestinal triacylglycerol-rich lipoprotein metabolism.

    Black IL, Roche HM, Tully AM, Gibney MJ.

    Br J Nutr. 2002 Dec;88(6):661-9.PMID: 12493088 [PubMed - indexed for MEDLINE]Related articles

    43.

    The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects.

    Noone EJ, Roche HM, Nugent AP, Gibney MJ.

    Br J Nutr. 2002 Sep;88(3):243-51.PMID: 12207834 [PubMed - indexed for MEDLINE]Related articles

    44.

    Chronic but not acute treatment with conjugated linoleic acid (CLA) isomers (trans-10, cis-12 CLA and cis-9, trans-11 CLA) affects lipid metabolism in Caco-2 cells.

    Black IL, Roche HM, Gibney MJ.

    J Nutr. 2002 Aug;132(8):2167-73.PMID: 12163657 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha.

    Roche HM, Noone E, Sewter C, Mc Bennett S, Savage D, Gibney MJ, O'Rahilly S, Vidal-Puig AJ.

    Diabetes. 2002 Jul;51(7):2037-44.PMID: 12086931 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population.

    Mynett-Johnson LA, Keenan C, Black IL, Livingstone WJ, Lawler M, Roche HM, White B, Gibney MJ, McKeon P, Smith OP.

    Ir J Med Sci. 2002 Jan-Mar;171(1):37-9.PMID: 11993593 [PubMed - indexed for MEDLINE]Related articles

    47.

    Conjugated linoleic acid: a novel therapeutic nutrient?

    Roche HM, Noone E, Gibney AN.

    Nutr Res Rev. 2001 Jun;14(1):173-88.PMID: 19087421 [PubMed - in process]Related articles

    48.

    Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells.

    Roche HM, Terres AM, Black IB, Gibney MJ, Kelleher D.

    Gut. 2001 Jun;48(6):797-802.PMID: 11358898 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids.

    Higgins S, Carroll YL, McCarthy SN, Corridan BM, Roche HM, Wallace JM, O'Brien NM, Morrissey PA.

    Br J Nutr. 2001 Jan;85(1):23-31.PMID: 11227030 [PubMed - indexed for MEDLINE]Related articles

    50.

    Olive oil, high-oleic acid sunflower oil and CHD.

    Roche HM.

    Br J Nutr. 2001 Jan;85(1):3-4. No abstract available. PMID: 11227027 [PubMed - indexed for MEDLINE]Related articles

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