PubMed

How do we define cure of diabetes?

Buse JB, Caprio S, Cefalu WT, Ceriello A, Del Prato S, Inzucchi SE, McLaughlin S, Phillips GL 2nd, Robertson RP, Rubino F, Kahn R, Kirkman MS.

Diabetes Care. 2009 Nov;32(11):2133-5. No abstract available. PMID: 19875608 [PubMed - in process]Related articles

beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.

Harmon JS, Bogdani M, Parazzoli SD, Mak SS, Oseid EA, Berghmans M, Leboeuf RC, Robertson RP.

Endocrinology. 2009 Nov;150(11):4855-62. Epub 2009 Oct 9.PMID: 19819955 [PubMed - indexed for MEDLINE]Related articles

KATP channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.

Slucca M, Harmon JS, Oseid EA, Bryan J, Robertson RP.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808893 [PubMed - as supplied by publisher]Related articles

2009 Presidential Address: mentoring ... touching the future.

Robertson RP.

Diabetes. 2009 Oct;58(10):2165-7. No abstract available. PMID: 19794072 [PubMed - indexed for MEDLINE]Related articles

2009 presidential address: mentoring ... touching the future.

Robertson RP.

Diabetes Care. 2009 Oct;32(10):1938-40. No abstract available. PMID: 19794005 [PubMed - in process]Related articles

Beta-cell deterioration during diabetes: what's in the gun?

Robertson RP.

Trends Endocrinol Metab. 2009 Oct;20(8):388-93. Epub 2009 Sep 11.PMID: 19748794 [PubMed - in process]Related articles

Editorial: Update on stem cell research.

Robertson RP, Giudice LC.

Endocr Rev. 2009 May;30(3):203. No abstract available. PMID: 19433633 [PubMed - indexed for MEDLINE]Related articles

ADA research funding in 2009: where will we be?

Robertson RP.

Diabetes. 2009 Jan;58(1):1. No abstract available. PMID: 19114720 [PubMed - indexed for MEDLINE]Related articlesFree article

ADA research funding in 2009: where will we be?

Robertson RP.

Diabetes Care. 2009 Jan;32(1):206. No abstract available. PMID: 19114629 [PubMed - in process]Related articlesFree article

Novel Nonimmunological Forms of {beta}-Cell Dysfunction: Diabetic Syndromes and Pathogenic Mechanisms.

Robertson RP, Aguilar-Bryan L.

Endocr Rev. 2008 May;29(3):253. No abstract available. PMID: 18480303 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia.

Zhou H, Zhang T, Bogdani M, Oseid E, Parazzoli S, Vantyghem MC, Harmon J, Slucca M, Robertson RP.

Diabetes. 2008 Jun;57(6):1567-74. Epub 2008 Mar 24.PMID: 18362210 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Poitout V, Robertson RP.

Endocr Rev. 2008 May;29(3):351-66. Epub 2007 Nov 29. Review.PMID: 18048763 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutathione peroxidase protein expression and activity in human islets isolated for transplantation.

Tonooka N, Oseid E, Zhou H, Harmon JS, Robertson RP.

Clin Transplant. 2007 Nov-Dec;21(6):767-72.PMID: 17988272 [PubMed - indexed for MEDLINE]Related articles

The islet transplant experiment: time for a reassessment.

Bromberg JS, Kaplan B, Halloran PF, Robertson RP.

Am J Transplant. 2007 Oct;7(10):2217-8. No abstract available. PMID: 17845557 [PubMed - indexed for MEDLINE]Related articles

Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient?

Robertson RP.

Diabetes. 2007 Oct;56(10):2420-4. Epub 2007 Jul 2.PMID: 17606873 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic syndrome: psychosocial, neuroendocrine, and classical risk factors in type 2 diabetes.

Abraham NG, Brunner EJ, Eriksson JW, Robertson RP.

Ann N Y Acad Sci. 2007 Oct;1113:256-75. Epub 2007 May 18. Review.PMID: 17513461 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase.

Robertson RP, Harmon JS.

FEBS Lett. 2007 Jul 31;581(19):3743-8. Epub 2007 Apr 9.PMID: 17433304 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats.

Zhou H, Zhang T, Oseid E, Harmon J, Tonooka N, Robertson RP.

Endocrinology. 2007 Jun;148(6):2863-9. Epub 2007 Mar 8.PMID: 17347310 [PubMed - indexed for MEDLINE]Related articlesFree article

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo.

Zhou H, Zhang T, Harmon JS, Bryan J, Robertson RP.

Diabetes. 2007 Apr;56(4):1107-12. Epub 2007 Feb 22. Erratum in: Diabetes. 2007 Jun;56(6):1747. PMID: 17317764 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and impaired insulin secretion in type 2 diabetes.

Robertson RP.

Curr Opin Pharmacol. 2006 Dec;6(6):615-9. Epub 2006 Oct 10. Review.PMID: 17045527 [PubMed - indexed for MEDLINE]Related articles

International trial of the Edmonton protocol for islet transplantation.

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR.

N Engl J Med. 2006 Sep 28;355(13):1318-30.PMID: 17005949 [PubMed - indexed for MEDLINE]Related articlesFree article

Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method.

Zhang G, Matsumoto S, Newman H, Strong DM, Robertson RP, Reems JA.

Cell Tissue Bank. 2006;7(3):195-201.PMID: 16933041 [PubMed - indexed for MEDLINE]Related articles

Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell.

Robertson RP, Harmon JS.

Free Radic Biol Med. 2006 Jul 15;41(2):177-84. Epub 2006 May 4. Review.PMID: 16814095 [PubMed - indexed for MEDLINE]Related articles

Pancreas and islet transplantation in type 1 diabetes.

Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE; American Diabetes Association.

Diabetes Care. 2006 Apr;29(4):935. No abstract available. PMID: 16567844 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the insulin gene by glucose and fatty acids.

Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS.

J Nutr. 2006 Apr;136(4):873-6. Review.PMID: 16549443 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets.

Robertson RP, Tanaka Y, Takahashi H, Tran PO, Harmon JS.

Ann N Y Acad Sci. 2005 Jun;1043:513-20.PMID: 16037273 [PubMed - indexed for MEDLINE]Related articles

Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets.

Wang W, Upshaw L, Strong DM, Robertson RP, Reems J.

J Endocrinol. 2005 Jun;185(3):445-55.PMID: 15930171 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.

Harmon JS, Stein R, Robertson RP.

J Biol Chem. 2005 Mar 25;280(12):11107-13. Epub 2005 Jan 20.PMID: 15664999 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress.

Tran PO, Parker SM, LeRoy E, Franklin CC, Kavanagh TJ, Zhang T, Zhou H, Vliet P, Oseid E, Harmon JS, Robertson RP.

J Biol Chem. 2004 Dec 24;279(52):53988-93. Epub 2004 Oct 12.PMID: 15485876 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes.

Robertson RP.

J Biol Chem. 2004 Oct 8;279(41):42351-4. Epub 2004 Jul 16. Review. No abstract available. PMID: 15258147 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas and islet transplants for patients with diabetes: taking positions and making decisions.

Robertson RP.

Endocr Pract. 1999 Jan-Feb;5(1):24-8.PMID: 15251699 [PubMed]Related articles

D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways.

Takahashi H, Tran PO, LeRoy E, Harmon JS, Tanaka Y, Robertson RP.

J Biol Chem. 2004 Sep 3;279(36):37316-23. Epub 2004 Jun 22.PMID: 15213233 [PubMed - indexed for MEDLINE]Related articlesFree article

AIRarg and AIRgluc as predictors of insulin secretory reserve.

Robertson RP.

Transplant Proc. 2004 May;36(4):1040-1.PMID: 15194361 [PubMed - indexed for MEDLINE]Related articles

Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis.

Hope KM, Tran PO, Zhou H, Oseid E, Leroy E, Robertson RP.

Diabetes. 2004 Jun;53(6):1488-95.PMID: 15161753 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis.

Zhou H, Tran PO, Yang S, Zhang T, LeRoy E, Oseid E, Robertson RP.

Diabetes. 2004 Jun;53(6):1482-7.PMID: 15161752 [PubMed - indexed for MEDLINE]Related articlesFree article

Consequences on beta-cell function and reserve after long-term pancreas transplantation.

Robertson RP.

Diabetes. 2004 Mar;53(3):633-44.PMID: 14988247 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet transplantation as a treatment for diabetes - a work in progress.

Robertson RP.

N Engl J Med. 2004 Feb 12;350(7):694-705. Review. No abstract available. PMID: 14960745 [PubMed - indexed for MEDLINE]Related articles

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

Robertson RP, Harmon J, Tran PO, Poitout V.

Diabetes. 2004 Feb;53 Suppl 1:S119-24. Review.PMID: 14749276 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnosis of diabetic autonomic neuropathy: a multivariate approach.

Diem P, Laederach-Hofmann K, Navarro X, Mueller B, Kennedy WR, Robertson RP.

Eur J Clin Invest. 2003 Aug;33(8):693-7.PMID: 12864779 [PubMed - indexed for MEDLINE]Related articles

Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments.

Robertson RP, Sutherland DE, Seaquist ER, Lanz KJ.

Diabetes. 2003 Jul;52(7):1689-94.PMID: 12829634 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplanted intrahepatic islets: enigmatic absence of the alpha-cell response to hypoglycaemia.

Robertson RP.

Diabetes Nutr Metab. 2002 Dec;15(6):433-7. Review. No abstract available. PMID: 12678464 [PubMed - indexed for MEDLINE]Related articles

Islet transplantation: travels up the learning curve.

Robertson RP.

Curr Diab Rep. 2002 Aug;2(4):365-70. Review.PMID: 12643197 [PubMed - indexed for MEDLINE]Related articles

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.

Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H.

Diabetes. 2003 Mar;52(3):581-7. Review.PMID: 12606496 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreas transplantation for patients with type 1 diabetes.

Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE; American Diabetes Association.

Diabetes Care. 2003 Jan;26 Suppl 1:S120. No abstract available. PMID: 12502636 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrahepatically transplanted islets--strangers in a strange land.

Robertson RP.

J Clin Endocrinol Metab. 2002 Dec;87(12):5416-7. No abstract available. PMID: 12466328 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence.

Paty BW, Ryan EA, Shapiro AM, Lakey JR, Robertson RP.

Diabetes. 2002 Dec;51(12):3428-34.PMID: 12453896 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.

Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong DM, Robertson RP, Reems JA.

Transplantation. 2002 Nov 27;74(10):1414-9.PMID: 12451242 [PubMed - indexed for MEDLINE]Related articles

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.

Tanaka Y, Tran PO, Harmon J, Robertson RP.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12363-8. Epub 2002 Sep 6.PMID: 12218186 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.

Tran PO, Gleason CE, Robertson RP.

Diabetes. 2002 Jun;51(6):1772-8.PMID: 12031964 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients.

Robertson RP, Lanz KJ, Sutherland DE, Seaquist ER.

Transplantation. 2002 Mar 15;73(5):736-41.PMID: 11907419 [PubMed - indexed for MEDLINE]Related articles