PubMed

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Dev Biol. 2009 Nov 15;335(2):305-16. Epub 2009 Sep 3.PMID: 19733164 [PubMed - in process]Related articles

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.

Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Development. 2009 May;136(10):1741-50. Epub 2009 Apr 15.PMID: 19369394 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.

Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG.

J Biol Chem. 2009 May 1;284(18):12246-57. Epub 2009 Mar 5.PMID: 19265200 [PubMed - indexed for MEDLINE]Related articles

Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism.

Stuelten CH, Barbul A, Busch JI, Sutton E, Katz R, Sato M, Wakefield LM, Roberts AB, Niederhuber JE.

Cancer Res. 2008 Sep 15;68(18):7278-82.PMID: 18794114 [PubMed - indexed for MEDLINE]Related articlesFree article

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

Rajagopal R, Dattilo LK, Kaartinen V, Deng CX, Umans L, Zwijsen A, Roberts AB, Bottinger EP, Beebe DC.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4953-60. Epub 2008 Jun 19.PMID: 18566469 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.

Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB.

Am J Pathol. 2008 Jul;173(1):68-76. Epub 2008 May 23.PMID: 18502822 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

Orvis GD, Jamin SP, Kwan KM, Mishina Y, Kaartinen VM, Huang S, Roberts AB, Umans L, Huylebroeck D, Zwijsen A, Wang D, Martin JF, Behringer RR.

Biol Reprod. 2008 Jun;78(6):994-1001. Epub 2008 Mar 5.PMID: 18322278 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition.

Arany PR, Rane SG, Roberts AB.

Oncogene. 2008 Apr 10;27(17):2507-12. Epub 2007 Oct 22.PMID: 17952112 [PubMed - indexed for MEDLINE]Related articles

Lentiviral reporter constructs for fluorescence tracking of the temporospatial pattern of Smad3 signaling.

Stuelten CH, Kamaraju AK, Wakefield LM, Roberts AB.

Biotechniques. 2007 Sep;43(3):289-90, 292, 294.PMID: 17907571 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R.

Nat Med. 2007 Aug;13(8):952-61. Epub 2007 Jul 29.PMID: 17660828 [PubMed - indexed for MEDLINE]Related articles

Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts.

Arany PR, Flanders KC, DeGraff W, Cook J, Mitchell JB, Roberts AB.

J Dermatol Sci. 2007 Oct;48(1):35-42. Epub 2007 Jul 12.PMID: 17624738 [PubMed - indexed for MEDLINE]Related articlesFree article

Controlled study of brief personalized assessment-feedback for drinkers interested in self-help.

Wild TC, Cunningham JA, Roberts AB.

Addiction. 2007 Feb;102(2):241-50.PMID: 17222278 [PubMed - indexed for MEDLINE]Related articles

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.

Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB.

Mol Cell. 2006 Dec 8;24(5):771-83.PMID: 17157259 [PubMed - indexed for MEDLINE]Related articles

Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.

Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten C, Desai KV, Tuan R, Rennard SI, Roberts AB.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9250-5. Epub 2006 Jun 5.PMID: 16754864 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad4-expression is decreased in breast cancer tissues: a retrospective study.

Stuelten CH, Buck MB, Dippon J, Roberts AB, Fritz P, Knabbe C.

BMC Cancer. 2006 Jan 26;6:25.PMID: 16438724 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.

Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, Saika S, Flanders KC.

Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):19-27. Epub 2005 Nov 11. Review.PMID: 16290023 [PubMed - indexed for MEDLINE]Related articles

Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.

Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo J, Roberts AB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A.

Lab Invest. 2005 Jul;85(7):838-50.PMID: 15924151 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.

Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB.

Am J Pathol. 2005 May;166(5):1405-18.PMID: 15855641 [PubMed - indexed for MEDLINE]Related articlesFree article

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta.

Stuelten CH, DaCosta Byfield S, Arany PR, Karpova TS, Stetler-Stevenson WG, Roberts AB.

J Cell Sci. 2005 May 15;118(Pt 10):2143-53. Epub 2005 Apr 26.PMID: 15855236 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta and vitamin D3 utilize distinct pathways to suppress IL-12 production and modulate rapid differentiation of human monocytes into CD83+ dendritic cells.

Lyakh LA, Sanford M, Chekol S, Young HA, Roberts AB.

J Immunol. 2005 Feb 15;174(4):2061-70.PMID: 15699136 [PubMed - indexed for MEDLINE]Related articlesFree article

Exploring the social and cultural context of sexual health for young people in Mongolia: implications for health promotion.

Roberts AB, Oyun C, Batnasan E, Laing L.

Soc Sci Med. 2005 Apr;60(7):1487-98.PMID: 15652682 [PubMed - indexed for MEDLINE]Related articles

Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3.

Stramer BM, Austin JS, Roberts AB, Fini ME.

J Cell Physiol. 2005 Apr;203(1):226-32.PMID: 15521071 [PubMed - indexed for MEDLINE]Related articles

Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo.

Kamaraju AK, Roberts AB.

J Biol Chem. 2005 Jan 14;280(2):1024-36. Epub 2004 Nov 1.PMID: 15520018 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis.

Sauer B, Vogler R, Zimmermann K, Fujii M, Anzano MB, Schäfer-Korting M, Roberts AB, Kleuser B.

J Invest Dermatol. 2004 Nov;123(5):840-9.PMID: 15482469 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression.

Tan NS, Michalik L, Di-Poï N, Ng CY, Mermod N, Roberts AB, Desvergne B, Wahli W.

EMBO J. 2004 Oct 27;23(21):4211-21. Epub 2004 Oct 7.PMID: 15470497 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, Letterio JJ.

N Engl J Med. 2004 Aug 5;351(6):552-9.PMID: 15295048 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice.

Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB.

Lab Invest. 2004 Oct;84(10):1245-58.PMID: 15273699 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.

Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J.

J Immunol. 2004 Aug 1;173(3):2099-108.PMID: 15265946 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.

Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A, Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB.

Lab Invest. 2004 Oct;84(10):1259-70.PMID: 15258599 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes.

Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB, Schäfer-Korting M, Roberts AB, Kleuser B.

J Biol Chem. 2004 Sep 10;279(37):38471-9. Epub 2004 Jul 9.PMID: 15247277 [PubMed - indexed for MEDLINE]Related articlesFree article

RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.

Piek E, Van Dinther M, Parks WT, Sallee JM, Böttinger EP, Roberts AB, Ten Dijke P.

Biochem J. 2004 Oct 1;383(Pt 1):187-99.PMID: 15239668 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.

Tian F, Byfield SD, Parks WT, Stuelten CH, Nemani D, Zhang YE, Roberts AB.

Cancer Res. 2004 Jul 1;64(13):4523-30.PMID: 15231662 [PubMed - indexed for MEDLINE]Related articlesFree article

Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice.

Falanga V, Schrayer D, Cha J, Butmarc J, Carson P, Roberts AB, Kim SJ.

Wound Repair Regen. 2004 May-Jun;12(3):320-6.PMID: 15225210 [PubMed - indexed for MEDLINE]Related articles

Alcohol problems and interest in self-help: a population study of Alberta adults.

Wild TC, Roberts AB, Cunningham J, Schopflocher D, Pazderka-Robinson H.

Can J Public Health. 2004 Mar-Apr;95(2):127-32.PMID: 15074903 [PubMed - indexed for MEDLINE]Related articles

Lateral signaling enhances TGF-beta response complexity.

Byfield SD, Roberts AB.

Trends Cell Biol. 2004 Mar;14(3):107-11. Review.PMID: 15055198 [PubMed - indexed for MEDLINE]Related articles

The effect of methadone treatment on the quantity and quality of human fetal movement.

Wouldes TA, Roberts AB, Pryor JE, Bagnall C, Gunn TR.

Neurotoxicol Teratol. 2004 Jan-Feb;26(1):23-34.PMID: 15001211 [PubMed - indexed for MEDLINE]Related articles

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

DaCosta Byfield S, Major C, Laping NJ, Roberts AB.

Mol Pharmacol. 2004 Mar;65(3):744-52.PMID: 14978253 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.

Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Flanders KC, Yoo J, Anzano M, Liu CY, Kao WW, Roberts AB.

Am J Pathol. 2004 Feb;164(2):651-63.PMID: 14742269 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A.

J Biol Chem. 2004 Apr 9;279(15):15167-76. Epub 2004 Jan 19.PMID: 14732719 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis.

Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS.

J Biol Chem. 2004 Mar 5;279(10):9023-9. Epub 2003 Dec 29.PMID: 14701799 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.

Tian F, DaCosta Byfield S, Parks WT, Yoo S, Felici A, Tang B, Piek E, Wakefield LM, Roberts AB.

Cancer Res. 2003 Dec 1;63(23):8284-92.PMID: 14678987 [PubMed - indexed for MEDLINE]Related articlesFree article

Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin.

Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB.

Am J Pathol. 2003 Dec;163(6):2247-57.PMID: 14633599 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A.

J Clin Invest. 2003 Nov;112(10):1486-94.PMID: 14617750 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Smad3 in the hormonal modulation of in vivo wound healing responses.

Ashcroft GS, Mills SJ, Flanders KC, Lyakh LA, Anzano MA, Gilliver SC, Roberts AB.

Wound Repair Regen. 2003 Nov-Dec;11(6):468-73.PMID: 14617288 [PubMed - indexed for MEDLINE]Related articles

TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

Felici A, Wurthner JU, Parks WT, Giam LR, Reiss M, Karpova TS, McNally JG, Roberts AB.

EMBO J. 2003 Sep 1;22(17):4465-77.PMID: 12941698 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation.

Yoo J, Ghiassi M, Jirmanova L, Balliet AG, Hoffman B, Fornace AJ Jr, Liebermann DA, Bottinger EP, Roberts AB.

J Biol Chem. 2003 Oct 31;278(44):43001-7. Epub 2003 Aug 21.PMID: 12933797 [PubMed - indexed for MEDLINE]Related articlesFree article

Hierarchical model of gene regulation by transforming growth factor beta.

Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Böttinger EP.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10269-74. Epub 2003 Aug 20.PMID: 12930890 [PubMed - indexed for MEDLINE]Related articlesFree article

The two faces of transforming growth factor beta in carcinogenesis.

Roberts AB, Wakefield LM.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8621-3. Epub 2003 Jul 14. Review. No abstract available. PMID: 12861075 [PubMed - indexed for MEDLINE]Related articlesFree article

Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta.

Roberts AB, Russo A, Felici A, Flanders KC.

Ann N Y Acad Sci. 2003 May;995:1-10. Review.PMID: 12814934 [PubMed - indexed for MEDLINE]Related articles

Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy.

Fujimoto M, Maezawa Y, Yokote K, Joh K, Kobayashi K, Kawamura H, Nishimura M, Roberts AB, Saito Y, Mori S.

Biochem Biophys Res Commun. 2003 Jun 13;305(4):1002-7.PMID: 12767930 [PubMed - indexed for MEDLINE]Related articles