PubMed

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors.

Zask A, Kaplan J, Verheijen JC, Richard DJ, Curran K, Brooijmans N, Bennett EM, Toral-Barza L, Hollander I, Ayral-Kaloustian S, Yu K.

J Med Chem. 2009 Nov 16. [Epub ahead of print]PMID: 19916508 [PubMed - as supplied by publisher]Related articles

Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stability.

Richard DJ, Verheijen JC, Curran K, Kaplan J, Toral-Barza L, Hollander I, Lucas J, Yu K, Zask A.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6830-5. Epub 2009 Oct 25.PMID: 19896845 [PubMed - in process]Related articles

Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter.

Dawes MA, Roache JD, Javors MA, Bergeson SE, Richard DM, Mathias CW, Ait-Daoud N, Dougherty DM, Johnson BA.

J Stud Alcohol Drugs. 2009 Nov;70(6):899-907.PMID: 19895766 [PubMed - in process]Related articles

Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent.

Verheijen JC, Richard DJ, Curran K, Kaplan J, Lefever M, Nowak P, Malwitz DJ, Brooijmans N, Toral-Barza L, Zhang WG, Lucas J, Hollander I, Ayral-Kaloustian S, Mansour TS, Yu K, Zask A.

J Med Chem. 2009 Nov 6. [Epub ahead of print]PMID: 19894727 [PubMed - as supplied by publisher]Related articles

Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

Bolderson E, Richard DJ, Zhou BB, Khanna KK.

Clin Cancer Res. 2009 Oct 15;15(20):6314-20. Epub 2009 Oct 6.PMID: 19808869 [PubMed - in process]Related articles

Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat.

Timofeeva E, Baraboi ED, Poulin AM, Richard D.

J Neuroendocrinol. 2009 Dec;21(12):982-92. Epub 2009 Oct 6.PMID: 19807847 [PubMed - in process]Related articles

Additive effects of olanzapine and melanin-concentrating hormone agonism on energy balance.

Guesdon B, Denis RG, Richard D.

Behav Brain Res. 2010 Feb 11;207(1):14-20. Epub 2009 Sep 27.PMID: 19788900 [PubMed - in process]Related articles

INTS3 controls the hSSB1-mediated DNA damage response.

Skaar JR, Richard DJ, Saraf A, Toschi A, Bolderson E, Florens L, Washburn MP, Khanna KK, Pagano M.

J Cell Biol. 2009 Oct 5;187(1):25-32. Epub 2009 Sep 28.PMID: 19786574 [PubMed - indexed for MEDLINE]Related articles

Docosahexaenoic acid down-regulates endothelial Nox 4 through a sPLA2 signalling pathway.

Richard D, Wolf C, Barbe U, Kefi K, Bausero P, Visioli F.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):516-22. Epub 2009 Sep 6.PMID: 19737538 [PubMed - indexed for MEDLINE]Related articles

TGFbeta-induced GRK2 expression attenuates AngII-regulated Vascular Smooth Muscle Cell proliferation and migration.

Guo J, Chen H, Ho J, Mancini J, Sontag T, Laporte SA, Richard DE, Lebrun JJ.

Cell Signal. 2009 Feb 5. [Epub ahead of print]PMID: 19709610 [PubMed - as supplied by publisher]Related articles

ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.

Zask A, Verheijen JC, Curran K, Kaplan J, Richard DJ, Nowak P, Malwitz DJ, Brooijmans N, Bard J, Svenson K, Lucas J, Toral-Barza L, Zhang WG, Hollander I, Gibbons JJ, Abraham RT, Ayral-Kaloustian S, Mansour TS, Yu K.

J Med Chem. 2009 Jul 31. [Epub ahead of print]PMID: 19645448 [PubMed - as supplied by publisher]Related articles

Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence.

Benyamina A, Bonhomme-Faivre L, Picard V, Sabbagh A, Richard D, Blecha L, Rahioui H, Karila L, Lukasiewicz M, Farinotti R, Picard V, Marill C, Reynaud M.

Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1270-4. Epub 2009 Jul 20.PMID: 19625010 [PubMed - indexed for MEDLINE]Related articles

Factor Structure of the Denyes Self Care Practice Instrument (DSCPI-90).

Andrews DR, Richard D, Aroian K.

West J Nurs Res. 2009 Oct;31(6):799-811. Epub 2009 Jul 17.PMID: 19617581 [PubMed - in process]Related articles

HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.

Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W.

J Biol Chem. 2009 Aug 28;284(35):23525-31. Epub 2009 Jul 14.PMID: 19605351 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids and cardiovascular disease.

Richard D, Bausero P, Schneider C, Visioli F.

Cell Mol Life Sci. 2009 Oct;66(20):3277-88. Epub 2009 Jul 10.PMID: 19590823 [PubMed - indexed for MEDLINE]Related articles

11th Annual International Symposium in Obesity: 'Obesity in a modern world: when pleasure meets homeostasis'.

Richard D, Boisvert P.

Int J Obes (Lond). 2009 Jun;33 Suppl 2:S1-2. No abstract available. PMID: 19528972 [PubMed - in process]Related articles

Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells.

Michaud MD, Robitaille GA, Gratton JP, Richard DE.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):902-8. Epub 2009 May 7.PMID: 19423865 [PubMed - indexed for MEDLINE]Related articles

Weight and plasma lipid control by decaffeinated green tea.

Richard D, Kefi K, Barbe U, Poli A, Bausero P, Visioli F.

Pharmacol Res. 2009 May;59(5):351-4. Epub 2009 Feb 6.PMID: 19416635 [PubMed - indexed for MEDLINE]Related articles

TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration.

Guo J, Chen H, Ho J, Mancini J, Sontag T, Laporte SA, Richard DE, Lebrun JJ.

Cell Signal. 2009 Jun;21(6):899-905.PMID: 19385060 [PubMed - indexed for MEDLINE]Related articles

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis.

Richard DJ, Bolderson E, Khanna KK.

Crit Rev Biochem Mol Biol. 2009 Apr 14:1-19. [Epub ahead of print]PMID: 19367476 [PubMed - as supplied by publisher]Related articles

9th and 10th annual international symposia in obesity from the Merck Frosst/CIHR Research Chair in Obesity at Université Laval.

Richard D, Boisvert P.

Int J Obes (Lond). 2009 Apr;33 Suppl 1:S1-2. No abstract available. PMID: 19363499 [PubMed - in process]Related articles

Involvement of Exo1b in DNA damage-induced apoptosis.

Bolderson E, Richard DJ, Edelmann W, Khanna KK.

Nucleic Acids Res. 2009 Jun;37(10):3452-63. Epub 2009 Apr 1.PMID: 19339515 [PubMed - indexed for MEDLINE]Related articlesFree article

The brain endocannabinoid system in the regulation of energy balance.

Richard D, Guesdon B, Timofeeva E.

Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):17-32. Review.PMID: 19285258 [PubMed - indexed for MEDLINE]Related articles

Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum.

Richard D, Kats LM, Langer C, Black CG, Mitri K, Boddey JA, Cowman AF, Coppel RL.

PLoS Pathog. 2009 Mar;5(3):e1000328. Epub 2009 Mar 6.PMID: 19266084 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of post-traumatic stress disorder in veterans by videoconferencing and by face-to-face methods.

Porcari CE, Amdur RL, Koch EI, Richard DC, Favorite T, Martis B, Liberzon I.

J Telemed Telecare. 2009;15(2):89-94.PMID: 19246609 [PubMed - indexed for MEDLINE]Related articles

Olive Phenolics Increase Glutathione Levels in Healthy Volunteers.

Visioli F, Wolfram R, Richard D, Abdullah MI, Crea R.

J Agric Food Chem. 2009 Feb 16. [Epub ahead of print]PMID: 19219997 [PubMed - as supplied by publisher]Related articles

The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake.

Festuccia WT, Blanchard PG, Turcotte V, Laplante M, Sariahmetoglu M, Brindley DN, Richard D, Deshaies Y.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1327-35. Epub 2009 Feb 11.PMID: 19211718 [PubMed - indexed for MEDLINE]Related articles

Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure.

Guesdon B, Paradis E, Samson P, Richard D.

Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R469-75. Epub 2009 Jan 7.PMID: 19129377 [PubMed - indexed for MEDLINE]Related articles

Possible anisotropic s--f hybridization in a cubic heavy-fermion compound: CeIn1Sn2.

Murani AP, Severing A, Enderle M, Steffens P, Richard D.

Phys Rev Lett. 2008 Nov 14;101(20):206405. Epub 2008 Nov 14.PMID: 19113363 [PubMed]Related articles

Modulation of inflammation by nutritional interventions.

Visioli F, Poli A, Richard D, Paoletti R.

Curr Atheroscler Rep. 2008 Dec;10(6):451-3. Review. No abstract available. PMID: 18937889 [PubMed - indexed for MEDLINE]Related articles

Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte films.

Dimitrova M, Affolter C, Meyer F, Nguyen I, Richard DG, Schuster C, Bartenschlager R, Voegel JC, Ogier J, Baumert TF.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16320-5. Epub 2008 Oct 15.PMID: 18922784 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase in obesity: metabolic node and beyond--introduction.

Richard D, Boisvert P.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S1-2. No abstract available. PMID: 18719591 [PubMed - indexed for MEDLINE]Related articles

Prospective study of cannabis withdrawal in cannabis-using adolescents.

Dawes MA, Richard DM, Mathias CW, Dougherty DM.

J Am Acad Child Adolesc Psychiatry. 2008 Sep;47(9):1095-6; author reply 1096. No abstract available. PMID: 18714196 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.

MacDonald TM, Reginster JY, Littlejohn TW, Richard D, Lheritier K, Krammer G, Rebuli R.

J Hypertens. 2008 Aug;26(8):1695-702.PMID: 18622250 [PubMed - indexed for MEDLINE]Related articles

Polyunsaturated fatty acids as antioxidants.

Richard D, Kefi K, Barbe U, Bausero P, Visioli F.

Pharmacol Res. 2008 Jun;57(6):451-5. Epub 2008 May 18.PMID: 18583147 [PubMed - indexed for MEDLINE]Related articles

Filamentous condensation of DNA induced by pegylated poly-L-lysine and transfection efficiency.

Stanić V, Arntz Y, Richard D, Affolter C, Nguyen I, Crucifix C, Schultz P, Baehr C, Frisch B, Ogier J.

Biomacromolecules. 2008 Jul;9(7):2048-55. Epub 2008 Jun 24.PMID: 18572920 [PubMed - indexed for MEDLINE]Related articles

[Dementia syndrome in an elderly subject related to valproic acid use: a case report]

Manckoundia P, Disson-Dautriche A, Rouaud O, Richard D, Tavernier-Vidal B, Pfitzenmeyer P.

Rev Med Interne. 2008 Oct;29(10):827-9. Epub 2008 Jun 24. French. PMID: 18572280 [PubMed - indexed for MEDLINE]Related articles

Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence.

Song CK, Vaughan CH, Keen-Rhinehart E, Harris RB, Richard D, Bartness TJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R417-28. Epub 2008 Jun 11.PMID: 18550869 [PubMed - indexed for MEDLINE]Related articlesFree article

Quinine clearance during continuous veno-venous high-volume hemofiltration.

Liotier J, Richard D, Deteix P, Coudoré F, Souweine B.

Intensive Care Med. 2008 Oct;34(10):1925-6. Epub 2008 May 17. No abstract available. PMID: 18488191 [PubMed - indexed for MEDLINE]Related articles

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK.

Nature. 2008 May 29;453(7195):677-81. Epub 2008 Apr 30.PMID: 18449195 [PubMed - indexed for MEDLINE]Related articles

(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.

Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE.

Mol Pharmacol. 2008 Jul;74(1):282-8. Epub 2008 Apr 18.PMID: 18424552 [PubMed - indexed for MEDLINE]Related articlesFree article

Accuracy of retrospective memory and covariation estimation in patients with obsessive-compulsive disorder.

Gloster AT, Richard DC, Himle J, Koch E, Anson H, Lokers L, Thornton J.

Behav Res Ther. 2008 May;46(5):642-55.PMID: 18417100 [PubMed - indexed for MEDLINE]Related articles

Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet.

Roy C, Paglialunga S, Fisette A, Schrauwen P, Moonen-Kornips E, St-Onge J, Hesselink MK, Richard D, Joanisse DR, Cianflone K.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1051-9. Epub 2008 Apr 8.PMID: 18398012 [PubMed - indexed for MEDLINE]Related articlesFree article

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.

Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF.

Cell Host Microbe. 2008 Mar 13;3(3):188-98.PMID: 18329618 [PubMed - indexed for MEDLINE]Related articles

Clinical trial: comparison of the gastrointestinal safety of lumiracoxib with traditional nonselective nonsteroidal anti-inflammatory drugs early after the initiation of treatment--findings from the Therapeutic Arthritis Research and Gastrointestinal Event Trial.

Hawkey CJ, Weinstein WM, Stricker K, Murphy V, Richard D, Krammer G, Rebuli R.

Aliment Pharmacol Ther. 2008 May;27(9):838-45. Epub 2008 Jan 22.PMID: 18221410 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status.

Festuccia WT, Oztezcan S, Laplante M, Berthiaume M, Michel C, Dohgu S, Denis RG, Brito MN, Brito NA, Miller DS, Banks WA, Bartness TJ, Richard D, Deshaies Y.

Endocrinology. 2008 May;149(5):2121-30. Epub 2008 Jan 24.PMID: 18218698 [PubMed - indexed for MEDLINE]Related articlesFree article

GC-MS determined cotinine in an epidemiological study on smoking status at delivery.

Chazeron I, Daval S, Ughetto S, Richard D, Nicolay A, Lemery D, Llorca PM, Coudoré F.

Pulm Pharmacol Ther. 2008;21(3):485-8. Epub 2007 Nov 17.PMID: 18086544 [PubMed - indexed for MEDLINE]Related articles

Altered lipid response in hamsters fed cis-9,trans-11+trans-8,cis-10 conjugated linoleic acid mixture.

Bissonauth V, Chouinard PY, Marin J, Leblanc N, Richard D, Jacques H.

Lipids. 2008 Mar;43(3):251-8. Epub 2007 Dec 15.PMID: 18084787 [PubMed - indexed for MEDLINE]Related articles

Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii.

Arsenijevic D, de Bilbao F, Vallet P, Hemphill A, Gottstein B, Richard D, Giannakopoulos P, Langhans W.

Neuroscience. 2007 Dec 12;150(3):537-46. Epub 2007 Oct 11.PMID: 18006239 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE.

Mol Biol Cell. 2008 Jan;19(1):86-94. Epub 2007 Oct 17.PMID: 17942596 [PubMed - indexed for MEDLINE]Related articlesFree article