PubMed

The final step of hygromycin a biosynthesis, oxidation of C-5''-dihydrohygromycin a, is linked to a putative proton gradient-dependent efflux.

Dhote V, Starosta AL, Wilson DN, Reynolds KA.

Antimicrob Agents Chemother. 2009 Dec;53(12):5163-72. Epub 2009 Sep 21.PMID: 19770276 [PubMed - in process]Related articles

Integrated capture and spectroscopic detection of viruses.

Vargas CA, Wilhelm AA, Williams J, Lucas P, Reynolds KA, Riley MR.

Appl Environ Microbiol. 2009 Oct;75(20):6431-40. Epub 2009 Aug 21.PMID: 19700543 [PubMed - in process]Related articles

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

Liu Y, Hazzard C, Eustáquio AS, Reynolds KA, Moore BS.

J Am Chem Soc. 2009 Aug 5;131(30):10376-7.PMID: 19601645 [PubMed - in process]Related articles

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

Li C, Hazzard C, Florova G, Reynolds KA.

Metab Eng. 2009 Nov;11(6):319-27. Epub 2009 Jul 10.PMID: 19595787 [PubMed - in process]Related articles

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12295-300. Epub 2009 Jul 9.PMID: 19590008 [PubMed - indexed for MEDLINE]Related articles

Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study.

Brennan BP, Fogarty KV, Roberts JL, Reynolds KA, Pope HG Jr, Hudson JI.

Hum Psychopharmacol. 2009 Jul;24(5):423-8.PMID: 19548294 [PubMed - indexed for MEDLINE]Related articles

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains.

Yan J, Gupta S, Sherman DH, Reynolds KA.

Chembiochem. 2009 Jun 15;10(9):1537-43.PMID: 19437523 [PubMed - indexed for MEDLINE]Related articles

Copper homeostasis.

Burkhead JL, Reynolds KA, Abdel-Ghany SE, Cohu CM, Pilon M.

New Phytol. 2009 Apr 23. [Epub ahead of print]PMID: 19402880 [PubMed - as supplied by publisher]Related articles

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes.

Katritch V, Reynolds KA, Cherezov V, Hanson MA, Roth CB, Yeager M, Abagyan R.

J Mol Recognit. 2009 Jul-Aug;22(4):307-18.PMID: 19353579 [PubMed - indexed for MEDLINE]Related articles

Point-of-Use drinking water devices for assessing microbial contamination in finished water and distribution systems.

Miles SL, Gerba CP, Pepper IL, Reynolds KA.

Environ Sci Technol. 2009 Mar 1;43(5):1425-9.PMID: 19350914 [PubMed - indexed for MEDLINE]Related articles

Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.

Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA.

Appl Environ Microbiol. 2009 Jun;75(11):3469-76. Epub 2009 Mar 20.PMID: 19304832 [PubMed - indexed for MEDLINE]Related articles

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.

Reynolds KA, Katritch V, Abagyan R.

J Comput Aided Mol Des. 2009 May;23(5):273-88. Epub 2009 Jan 16.PMID: 19148767 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

Buchholz TJ, Geders TW, Bartley FE 3rd, Reynolds KA, Smith JL, Sherman DH.

ACS Chem Biol. 2009 Jan 16;4(1):41-52.PMID: 19146481 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors.

Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. Epub 2008 Oct 25.PMID: 18996691 [PubMed - indexed for MEDLINE]Related articles

Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface.

Reynolds KA, Hanes MS, Thomson JM, Antczak AJ, Berger JM, Bonomo RA, Kirsch JF, Handel TM.

J Mol Biol. 2008 Oct 24;382(5):1265-75. Epub 2008 May 29.PMID: 18775544 [PubMed - indexed for MEDLINE]Related articles

cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.

Palaniappan N, Alhamadsheh MM, Reynolds KA.

J Am Chem Soc. 2008 Sep 17;130(37):12236-7. Epub 2008 Aug 21.PMID: 18714992 [PubMed - indexed for MEDLINE]Related articlesFree article

An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus.

Dhote V, Gupta S, Reynolds KA.

Antimicrob Agents Chemother. 2008 Oct;52(10):3580-8. Epub 2008 Jul 21.PMID: 18644964 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of novel pikromycin antibiotic products through mutasynthesis.

Gupta S, Lakshmanan V, Kim BS, Fecik R, Reynolds KA.

Chembiochem. 2008 Jul 2;9(10):1609-16.PMID: 18512859 [PubMed - indexed for MEDLINE]Related articlesFree article

Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay: principles and method.

Sachdeva S, Reynolds KA.

Methods Mol Med. 2008;142:205-13.PMID: 18437316 [PubMed - indexed for MEDLINE]Related articles

Memantine in the treatment of binge eating disorder: an open-label, prospective trial.

Brennan BP, Roberts JL, Fogarty KV, Reynolds KA, Jonas JM, Hudson JI.

Int J Eat Disord. 2008 Sep;41(6):520-6.PMID: 18433015 [PubMed - indexed for MEDLINE]Related articles

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.

Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA.

Chem Biol. 2008 Apr;15(4):402-12.PMID: 18420147 [PubMed - indexed for MEDLINE]Related articles

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.

Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL.

Chem Biol. 2008 Feb;15(2):137-48.PMID: 18291318 [PubMed - indexed for MEDLINE]Related articles

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.

Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA.

Bioorg Chem. 2008 Apr;36(2):85-90. Epub 2007 Dec 21.PMID: 18096200 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk of waterborne illness via drinking water in the United States.

Reynolds KA, Mena KD, Gerba CP.

Rev Environ Contam Toxicol. 2008;192:117-58. Review.PMID: 18020305 [PubMed - indexed for MEDLINE]Related articles

Parent and adolescent distribution of responsibility for diabetes self-care: links to health outcomes.

Helgeson VS, Reynolds KA, Siminerio L, Escobar O, Becker D.

J Pediatr Psychol. 2008 Jun;33(5):497-508. Epub 2007 Sep 10.PMID: 17848390 [PubMed - indexed for MEDLINE]Related articles

Antibacterial targets in fatty acid biosynthesis.

Wright HT, Reynolds KA.

Curr Opin Microbiol. 2007 Oct;10(5):447-53. Epub 2007 Aug 17. Review.PMID: 17707686 [PubMed - indexed for MEDLINE]Related articlesFree article

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA.

Chem Biol. 2007 May;14(5):513-24.PMID: 17524982 [PubMed - indexed for MEDLINE]Related articles

An object-oriented library for computational protein design.

Chowdry AB, Reynolds KA, Hanes MS, Voorhies M, Pokala N, Handel TM.

J Comput Chem. 2007 Nov 15;28(14):2378-88.PMID: 17471459 [PubMed - indexed for MEDLINE]Related articles

Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.

Liu D, Si H, Reynolds KA, Zhen W, Jia Z, Dillon JS.

Endocrinology. 2007 Jul;148(7):3068-76. Epub 2007 Mar 29.PMID: 17395704 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets.

Bassaganya-Riera J, Guri AJ, Noble AM, Reynolds KA, King J, Wood CM, Ashby M, Rai D, Hontecillas R.

Am J Clin Nutr. 2007 Mar;85(3):824-36.PMID: 17344506 [PubMed - indexed for MEDLINE]Related articlesFree article

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.

Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA.

J Am Chem Soc. 2007 Feb 21;129(7):1910-1. Epub 2007 Jan 27. No abstract available. PMID: 17256943 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):879-83. Epub 2006 Dec 1.PMID: 17189694 [PubMed - indexed for MEDLINE]Related articles

The role of friendship in the lives of male and female adolescents: does diabetes make a difference?

Helgeson VS, Reynolds KA, Escobar O, Siminerio L, Becker D.

J Adolesc Health. 2007 Jan;40(1):36-43. Epub 2006 Oct 5.PMID: 17185204 [PubMed - indexed for MEDLINE]Related articles

A meta-analytic review of benefit finding and growth.

Helgeson VS, Reynolds KA, Tomich PL.

J Consult Clin Psychol. 2006 Oct;74(5):797-816.PMID: 17032085 [PubMed - indexed for MEDLINE]Related articles

Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.

Palaniappan N, Ayers S, Gupta S, Habib el-S, Reynolds KA.

Chem Biol. 2006 Jul;13(7):753-64.PMID: 16873023 [PubMed - indexed for MEDLINE]Related articles

Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface.

Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM.

J Biol Chem. 2006 Sep 8;281(36):26745-53. Epub 2006 Jun 29.PMID: 16809340 [PubMed - indexed for MEDLINE]Related articlesFree article

Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway.

Liu D, Zhen W, Yang Z, Carter JD, Si H, Reynolds KA.

Diabetes. 2006 Apr;55(4):1043-50.PMID: 16567527 [PubMed - indexed for MEDLINE]Related articlesFree article

Brief report: friendships of adolescents with and without diabetes.

Helgeson VS, Reynolds KA, Shestak A, Wei S.

J Pediatr Psychol. 2006 Mar;31(2):194-9. Epub 2005 Mar 3.PMID: 16467319 [PubMed - indexed for MEDLINE]Related articles

A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products.

Choudhuri SD, Ayers S, Soine WH, Reynolds KA.

J Antibiot (Tokyo). 2005 Sep;58(9):573-82.PMID: 16323318 [PubMed - indexed for MEDLINE]Related articles

Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase.

Li C, Akopiants K, Reynolds KA.

J Ind Microbiol Biotechnol. 2006 Feb;33(2):75-83. Epub 2005 Nov 15.PMID: 16292556 [PubMed - indexed for MEDLINE]Related articles

The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.

Ghatge MS, Reynolds KA.

J Bacteriol. 2005 Dec;187(23):7970-6.PMID: 16291670 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple pathways for acetate assimilation in Streptomyces cinnamonensis.

Akopiants K, Florova G, Li C, Reynolds KA.

J Ind Microbiol Biotechnol. 2006 Feb;33(2):141-50. Epub 2005 Sep 27.PMID: 16187095 [PubMed - indexed for MEDLINE]Related articles

Occurrence of bacteria and biochemical markers on public surfaces.

Reynolds KA, Watt PM, Boone SA, Gerba CP.

Int J Environ Health Res. 2005 Jun;15(3):225-34.PMID: 16134485 [PubMed - indexed for MEDLINE]Related articles

Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).

Li Y, Florova G, Reynolds KA.

J Bacteriol. 2005 Jun;187(11):3795-9.PMID: 15901703 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.

Mo S, Kim BS, Reynolds KA.

Chem Biol. 2005 Feb;12(2):191-200.PMID: 15734646 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.

Musayev F, Sachdeva S, Scarsdale JN, Reynolds KA, Wright HT.

J Mol Biol. 2005 Mar 11;346(5):1313-21. Epub 2005 Jan 20.PMID: 15713483 [PubMed - indexed for MEDLINE]Related articles

Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation.

Li C, Florova G, Akopiants K, Reynolds KA.

Microbiology. 2004 Oct;150(Pt 10):3463-72.PMID: 15470123 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of electrochemically generated ozone for the disinfection of water and wastewater.

Tanner BD, Kuwahara S, Gerba CP, Reynolds KA.

Water Sci Technol. 2004;50(1):19-25.PMID: 15318481 [PubMed - indexed for MEDLINE]Related articles

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH).

He X, Reeve AM, Desai UR, Kellogg GE, Reynolds KA.

Antimicrob Agents Chemother. 2004 Aug;48(8):3093-102.PMID: 15273125 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrated cell culture/PCR for detection of enteric viruses in environmental samples.

Reynolds KA.

Methods Mol Biol. 2004;268:69-78.PMID: 15156019 [PubMed - indexed for MEDLINE]Related articles