PubMed

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA.

Nat Genet. 2009 Apr;41(4):415-23. Epub 2009 Mar 8.PMID: 19270708 [PubMed - indexed for MEDLINE]Related articles

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

Berger R, Zhu C, Hansen AR, Harper B, Chen Z, Holt TG, Hubert J, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, Wolff M, Macneil DJ, Weber AE, Edmondson SD.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4833-7. Epub 2008 Jul 24.PMID: 18684621 [PubMed - indexed for MEDLINE]Related articles

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4393-6. Epub 2008 Jun 20.PMID: 18614364 [PubMed - indexed for MEDLINE]Related articles

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

Qian S, Mumick S, Nizner P, Tota MR, Menetski J, Reitman ML, Macneil DJ.

Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):36-42. Epub 2008 Jul 1.PMID: 18346052 [PubMed - indexed for MEDLINE]Related articles

Genetics of gene expression and its effect on disease.

Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, Gudbjartsson D, Helgadottir A, Jonasdottir A, Jonasdottir A, Styrkarsdottir U, Gretarsdottir S, Magnusson KP, Stefansson H, Fossdal R, Kristjansson K, Gislason HG, Stefansson T, Leifsson BG, Thorsteinsdottir U, Lamb JR, Gulcher JR, Reitman ML, Kong A, Schadt EE, Stefansson K.

Nature. 2008 Mar 27;452(7186):423-8. Epub 2008 Mar 16.PMID: 18344981 [PubMed - indexed for MEDLINE]Related articles

FGF21: a missing link in the biology of fasting.

Reitman ML.

Cell Metab. 2007 Jun;5(6):405-7.PMID: 17550773 [PubMed - indexed for MEDLINE]Related articles

Pharmacogenetics of metformin response: a step in the path toward personalized medicine.

Reitman ML, Schadt EE.

J Clin Invest. 2007 May;117(5):1226-9. Review.PMID: 17476355 [PubMed - indexed for MEDLINE]Related articlesFree article

Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspective.

Heymsfield SB, Harp JB, Reitman ML, Beetsch JW, Schoeller DA, Erondu N, Pietrobelli A.

Am J Clin Nutr. 2007 Feb;85(2):346-54.PMID: 17284728 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

Chen A, Mumick S, Zhang C, Lamb J, Dai H, Weingarth D, Mudgett J, Chen H, MacNeil DJ, Reitman ML, Qian S.

Obes Res. 2005 Aug;13(8):1311-20.PMID: 16129712 [PubMed - indexed for MEDLINE]Related articles

The fat and thin of lipin.

Reitman ML.

Cell Metab. 2005 Jan;1(1):5-6.PMID: 16054038 [PubMed - indexed for MEDLINE]Related articles

Characterization of the bombesin-like peptide receptor family in primates.

Sano H, Feighner SD, Hreniuk DL, Iwaasa H, Sailer AW, Pan J, Reitman ML, Kanatani A, Howard AD, Tan CP.

Genomics. 2004 Jul;84(1):139-46.PMID: 15203211 [PubMed - indexed for MEDLINE]Related articles

Magic bullets melt fat.

Reitman ML.

Nat Med. 2004 Jun;10(6):581-2. No abstract available. PMID: 15170200 [PubMed - indexed for MEDLINE]Related articles

Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance.

Chen M, Haluzik M, Wolf NJ, Lorenzo J, Dietz KR, Reitman ML, Weinstein LS.

Endocrinology. 2004 Sep;145(9):4094-102. Epub 2004 May 27.PMID: 15166122 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.

Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML.

Endocrinology. 2004 Jul;145(7):3258-64. Epub 2004 Apr 1.PMID: 15059949 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoatrophy syndromes: when 'too little fat' is a clinical problem.

Arioglu E, Rother KI, Reitman ML, Premkumar A, Taylor SI.

Pediatr Diabetes. 2000 Sep;1(3):155-68. No abstract available. PMID: 15016227 [PubMed]Related articles

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

Kim H, Haluzik M, Asghar Z, Yau D, Joseph JW, Fernandez AM, Reitman ML, Yakar S, Stannard B, Heron-Milhavet L, Wheeler MB, LeRoith D.

Diabetes. 2003 Jul;52(7):1770-8.PMID: 12829645 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML.

J Biol Chem. 2003 Sep 5;278(36):34268-76. Epub 2003 Jun 11.PMID: 12805374 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.

Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI.

Diabetes. 2003 Jun;52(6):1311-8.PMID: 12765938 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.

Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ.

J Clin Invest. 2003 Mar;111(5):737-47.PMID: 12618528 [PubMed - indexed for MEDLINE]Related articlesFree article

Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance.

Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML.

J Biol Chem. 2003 Feb 7;278(6):3992-9. Epub 2002 Nov 26.PMID: 12456680 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML.

Diabetes. 2002 Sep;51(9):2727-33.PMID: 12196465 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase.

Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA, Kozak LP, MacDonald MJ.

J Biol Chem. 2002 Sep 6;277(36):32892-8. Epub 2002 Jul 1.PMID: 12093799 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity.

Haluzik M, Dietz KR, Kim JK, Marcus-Samuels B, Shulman GI, Gavrilova O, Reitman ML.

Diabetes. 2002 Jul;51(7):2113-8.PMID: 12086940 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic lessons from genetically lean mice.

Reitman ML.

Annu Rev Nutr. 2002;22:459-82. Epub 2002 Jan 4. Review.PMID: 12055354 [PubMed - indexed for MEDLINE]Related articles

WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML.

J Biol Chem. 2002 Jul 5;277(27):24484-9. Epub 2002 May 6.PMID: 11994294 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin-replacement therapy for lipodystrophy.

Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A.

N Engl J Med. 2002 Feb 21;346(8):570-8.PMID: 11856796 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of adiposity and metabolism in Lmna-deficient mice.

Cutler DA, Sullivan T, Marcus-Samuels B, Stewart CL, Reitman ML.

Biochem Biophys Res Commun. 2002 Mar 1;291(3):522-7.PMID: 11855819 [PubMed - indexed for MEDLINE]Related articles

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.

Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T.

Nat Med. 2001 Aug;7(8):941-6.PMID: 11479627 [PubMed - indexed for MEDLINE]Related articles

Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.

Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Gavrilova O, Reitman ML, Nakao K.

Diabetes. 2001 Jun;50(6):1440-8.PMID: 11375346 [PubMed - indexed for MEDLINE]Related articlesFree article

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity.

Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6494-9.PMID: 11371650 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin and its role in pregnancy and fetal development--an overview.

Reitman ML, Bi S, Marcus-Samuels B, Gavrilova O.

Biochem Soc Trans. 2001 May;29(Pt 2):68-72. Review.PMID: 11356129 [PubMed - indexed for MEDLINE]Related articles

A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes.

Reitman ML, Gavrilova O.

Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S11-4. Review.PMID: 11126232 [PubMed - indexed for MEDLINE]Related articles

Lipoatrophy revisited.

Reitman ML, Arioglu E, Gavrilova O, Taylor SI.

Trends Endocrinol Metab. 2000 Dec;11(10):410-6. Review.PMID: 11091118 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.

Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML.

J Clin Invest. 2000 Nov;106(10):1221-8.PMID: 11086023 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

Gavrilova O, Marcus-Samuels B, Reitman ML.

Diabetes. 2000 Nov;49(11):1910-6.PMID: 11078459 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes.

Arioglu E, Duncan-Morin J, Sebring N, Rother KI, Gottlieb N, Lieberman J, Herion D, Kleiner DE, Reynolds J, Premkumar A, Sumner AE, Hoofnagle J, Reitman ML, Taylor SI.

Ann Intern Med. 2000 Aug 15;133(4):263-74.PMID: 10929166 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta).

Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD, Gonzalez FJ.

Mol Cell Biol. 2000 Jul;20(14):5119-28.PMID: 10866668 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes.

Reitman ML, Mason MM, Moitra J, Gavrilova O, Marcus-Samuels B, Eckhaus M, Vinson C.

Ann N Y Acad Sci. 1999 Nov 18;892:289-96. Review.PMID: 10842669 [PubMed - indexed for MEDLINE]Related articles

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.

Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li C, Deng C, Harper ME, Reitman ML.

J Biol Chem. 2000 May 26;275(21):16251-7.PMID: 10748195 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice.

Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI.

J Biol Chem. 2000 Mar 24;275(12):8456-60.PMID: 10722680 [PubMed - indexed for MEDLINE]Related articlesFree article

Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism.

Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K, Parlow AF, Quon MJ, Reitman ML, Weinstein LS.

J Clin Invest. 2000 Mar;105(5):615-23.PMID: 10712433 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin and diabetes in lipoatrophic mice.

Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reitman ML.

Nature. 2000 Feb 24;403(6772):850; discussion 850-1. No abstract available. PMID: 10706272 [PubMed - indexed for MEDLINE]Related articles

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.

Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML.

J Clin Invest. 2000 Feb;105(3):271-8.PMID: 10675352 [PubMed - indexed for MEDLINE]Related articlesFree article

Torpor in mice is induced by both leptin-dependent and -independent mechanisms.

Gavrilova O, Leon LR, Marcus-Samuels B, Mason MM, Castle AL, Refetoff S, Vinson C, Reitman ML.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14623-8.PMID: 10588755 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone and other regulators of uncoupling proteins.

Reitman ML, He Y, Gong DW.

Int J Obes Relat Metab Disord. 1999 Jun;23 Suppl 6:S56-9. Review.PMID: 10454126 [PubMed - indexed for MEDLINE]Related articles

Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.

Gong DW, He Y, Reitman ML.

Biochem Biophys Res Commun. 1999 Mar 5;256(1):27-32.PMID: 10066417 [PubMed - indexed for MEDLINE]Related articles

Life without white fat: a transgenic mouse.

Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C.

Genes Dev. 1998 Oct 15;12(20):3168-81.PMID: 9784492 [PubMed - indexed for MEDLINE]Related articlesFree article

UDP-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.

Reitman ML, Lang L, Kornfeld S.

Methods Enzymol. 1984;107:163-72. No abstract available. PMID: 6094964 [PubMed - indexed for MEDLINE]Related articles

A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.

Reitman ML, Trowbridge IS, Kornfeld S.

J Biol Chem. 1982 Sep 10;257(17):10357-63.PMID: 7050108 [PubMed - indexed for MEDLINE]Related articlesFree article

Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts.

Varki A, Reitman ML, Vannier A, Kornfeld S, Grubb JH, Sly WS.

Am J Hum Genet. 1982 Sep;34(5):717-29.PMID: 6289658 [PubMed - indexed for MEDLINE]Related articlesFree article